Chad Borges
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Phone: 480-727-9928
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BDB 140B Biodesign Institute, Bldg. B TEMPE, AZ 85287-6401
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Mail code: 6401Campus: Tempe
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Chad Borges is an associate professor with joint appointments in the School of Molecular Sciences and The Biodesign Institute. He received a B.S. in chemistry from Walla Walla College (WA) in 1997. He went on to complete a Ph.D. in Analytical Toxicology (2001) at the University of Utah under Professor Douglas Rollins, the medical director in charge of doping control for the 2002 Olympic Games. His dissertation research focused on the role of hair pigments and cellular transport in drug incorporation into hair. He continued his education as a postdoctoral fellow at Michigan State University under pioneering mass spectrometrist J. Throck Watson, where he studied protein mass spectrometry with an emphasis on characterizing protein posttranslational modifications. In 2003, he returned to Utah where he helped establish the Olympic-level certified Sports Medicine Research and Testing Laboratory. Following successful laboratory accreditation, he transitioned to the Biodesign Institute at ASU in 2007 where he worked for several years as a research faculty member with Dr. Randall Nelson before joining the Department of Chemistry & Biochemistry (now School of Molecular Sciences) in 2013. Professor Borges’ research interests include development and application of a new form of bottom-up glycomics recently developed by his group; developing molecular markers of biospecimen integrity; and characterization of protein posttranslational modifications as indicators of disease and physiological function.
Ph.D. Analytical Toxicology, University of Utah 2001
B.S. Chemistry, Walla Walla College, WA 1997
1. Analysis of Protein and Lipid Glycosylation
For many years cancer biologists have recognized that, as a general rule, tumor cells display aberrant glycan (sugar polymer) structures. This means that if glycans can be analyzed in the right way(s), they should serve as excellent markers for the presence and progression of cancer. Altered activity of the enzymes that build glycans (glycotransferases, GTs) is the immediate upstream cause of abnormal glycan production. GTs build glycans in an opportunistic non-template driven, first-come-first-build way, with each type of GT adding a specific sugar residue to a specific position of a growing glycan "tree". Thus increased expression of a particular GT results in an increased number of specific glycan polymer branch points (or linear linkages) and a highly diverse set of final glycan structures. We have invented a new gas chromatography-mass spectrometry (GC-MS) based technique to quantify N-, O-, and lipid-linked glycans in whole biofluids and tissues on the basis of these specific glycan polymer branch points and linkages rather than on the basis of intact glycan structure. This provides a means for condensing interesting glycan features into single analytical signals as well as a direct surrogate readout for GT activity. As such, it represents a promising new angle by which to leverage glycans as cancer biomarkers.
2. Protein Posttranslational Modifications (PTMs)
Many if not most proteins are molecularly modified after translation. Abnormal protein modification may exist as either a cause or an effect of disease; it therefore warrants exploration as a potentially rich source of disease markers. In combination with optimized sample preparation techniques, modern bioanalytical tools such as mass spectrometry are now capable of routinely characterizing and quantifying the relative abundance of most protein PTMs. Yet caution is warranted as certain protein modifications-oxidative PTMs in particular-may arise as artifacts of less-than-optimal sample handling, potentially confounding their use as disease markers and interfering with conventional clinical laboratory tests based on binding interactions (e.g., ELISAs where protein quantification is based on interaction of the target protein with an antibody). We are interested in tracking protein modifications due to artifactual oxidation, determining how they affect conventional clinical laboratory tests, and figuring out how to prevent them from occurring.
Aguilar Diaz de león, J.S., Glenn, H.L., Knappenberger, M., Borges, C.R.: Oxidized-Desialylated Low-Density Lipoprotein Inhibits the Antitumor Functions of Lymphokine Activated Killer Cells. Journal of Cancer 12 (16): 4993-5004, 2021.
Kratz, M., Zelnick, L.R., Trenchevska, O., Jeffs, J.W., Borges, C.R., Tseng, H-H, Booth, S.L., Kestenbaum, B.R., Utzschneider, K., de Boer, I.H.: Relationship Between Chronic Kidney Disease, Glucose Homeostasis, and Plasma Osteocalcin Carboxylation and Fragmentation. Journal of Renal Nutrition 31 (3): 248-256, 2021.
Aguilar, J.S., de león, D., Borges, C.R.: Glycosylation Profiling of Glycoproteins Secreted from Cultured Cells Using Glycan Node Analysis and GC-MS. Mass Spectrometry of Glycoproteins 2271, 317-330, 2021.
Henderson, J.N., Simmons, C.R., Fahmi, N.E., Jeffs, J.W., Borges, C.R., Mills, J.H.: Structural Insights into How Protein Environments Tune the Spectroscopic Properties of a Noncanonical Amino Acid Fluorophore. Biochemistry 59 (37): 3401-3410, 2020.
Walker, S.A., Aguilar Diaz De Leon, J.S., Busatto, S., Wurtz, G.A., Zubair, A.C., Borges, C.R., Wolfram, J.; Glycan Node Analysis of Plasma-Derived Extracellular Vesicles. Cells 9 (9), 2020.
Hu, Y., Mulot, C., Bourreau, C., Martin, D., Laurent-Puig, P., Radoi, L., Guenel, P., Borges, C.R.; Biochemically Tracked Variability of Blood Plasma Thawed-State Exposure Times in a Multisite Collection Study. Biopreservation and Biobanking (2020).
De Leon, J.A.D., Borges, C.R.; Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay. Jove-Journal of Visualized Experiments 159 (2020).
Hu, Y., Ferdosi, S., Kapuruge, E.P., de Leon, J.A.D., Stucker, I., Radoi, L., Guenel, P., Borges, C.R.: Diagnostic and Prognostic Performance of Blood Plasma Glycan Features in the Women Epidemiology Lung Cancer (WELCA) Study. Journal of Proteome Research 18 (11): 3985-3998, 2019
Jeffs, J.W., Jehanathan, N., Thiber, S. M. F., Ferdosi, S., Pham, L., Wilson, Z.T., Breburda, C., Borges, C.R.: Delta-S-Cys-Albumin: A Lab Test that Quantifies Cumulative Exposure of Archived Human Blood Plasma and Serum Samples to Thawed Conditions. Molecular & Cellular Proteomics. 18 (10) 2121-2137, 2019
Ferdosi, S., Ho, T.H., Castle, E.P., Stanton, M.L., Borges, C.R.; Behavior of blood plasma glycan features in bladder cancer. PLOS One 13(7) (2018).
Ferdosi, S., Rehder, D.S., Maranian, P., Castle, E.P., Ho, T.H., Pass, H.I., Cramer, D.W., Hollingsworth, M.A., Anderson, K.S., Fu, L., Cole, D.E.C., Le, T., Wu, X., Borges, C.R.: Stage Dependence, Cell-Origin Independence and Prognostic Capacity of Serum Glycan Fucosylation, β1-4 Branching, β1-6 Branching and α2-6 Sialylation in Cancer. J Proteome Res, 17: 543-558, 2018.
Deb, A., Johnson, W.A., Kline, A.P., Scott, B.J., Meador, L.R., Srinivas, D., Martin-Garcia, J.M., Dorner, K., Borges, C.R., Misra, R., Hogue, B.G., Fromme, P., Mor, T.S.: Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide. PLoS One, 12:e0172529, 2017.
Ingram, T., Zuck, J., Borges, C.R., Redig, P., Sweazea, K.: Variations in native protein glycation and plasma antioxidants in several birds of prey. Comparative Biochemistry & Physiology Part B, 210: 18-28, 2017.
Hu, Y. and Borges, C.R.: A spin column-free approach to sodium hydroxide-based glycan permethylation. Analyst, 142: 2748-2759, 2017.
Jeffs, J.W., Ferdosi, S., Yassine, H.N., Borges, C.R.: Ex vivo instability of glycated albumin: A role for autoxidative glycation. Arch Biochem Biophys, 629: 36-42, 2017.
Biswas, S., Sen, S., Im, J., Biswas, S., Krstic, P., Ashcroft, B., Borges, C., Zhao, Y., Lindsay, S., Zhang, P.: Universal Readers Based on Hydrogen Bonding or π-π Stacking for Identification of DNA Nucleotides in Electron Tunnel Junctions. ACS Nano, 10: 11304-11316, 2016
Fu L, Borges CR, Rehder DS, Wong BY, Williams R, Carpenter TO, Cole DE.: Characterization of Additional Vitamin D Binding Protein Variants. J Steroid Biochem Mol Biol., 159: 54-59, 2016.
Zaare, S., Aguilar, J., Hu, Y., Ferdosi, S., Borges, C.R.: Glycan Node Analysis: A Bottom-Up Approach
to Glycomics. J Vis Exp (In Press)
Fu L, Borges CR, Rehder DS, Wong BY, Williams R, Carpenter TO, Cole DE. Characterization of Additional Vitamin D Binding Protein Variants. J Steroid Biochem Mol Biol. 2016 Feb 23. pii: S0960-0760(16)30036-X. doi: 10.1016/j.jsbmb.2016.02.022.
Borges C.R., Jeffs J.W., Kapuruge E.P.: Impact of Artifactual, Ex Vivo Oxidation on Biochemical
Research. In: Oxidative Stress: Diagnostics and Therapy Volume 2. Edited by Hepel M, Andreescu S:
American Chemical Society Books; pgs. 375-413, 2015. doi: 10.1021/bk-2015-1200.ch016 (Hardcopy In
Press)
Biswas S., Song W., Borges C.R., Lindsay S., Zhang P.: Click Addition of a DNA Thread to the N-termini
of Peptides for Their Translocation through Solid-State Nanopores. ACS Nano, 9(10): 9652-9664, 2015.
Hanavan, P.D., Borges, C.R., Katchman, B.A., Faigel, D.O., Ho, T.H., Meurice, N., Petit, J.L., Ma, C.-T.,
Sergienko, E.A., Lake, D.F. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic
and renal cancer cell lines. Oncotarget, 6(21): 18418-28, 2015.
Ho, T. H., Nateras, R. N., Yan, H., Park, J. G., Jensen, S., Borges, C., Lee, J. H., Champion, M. D., Tibes,
R., Bryce, A. H., Carballido, E. M., Todd, M. A., Joseph, R. W., Wong, W. W., Parker, A. S., Stanton, M. L.,
Castle, E. P. A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery
Platforms at Mayo Clinic, Scottsdale, Arizona. PloS One 10(7):e0132831, 2015.
Rehder, D.S., Gundberg, C.M., Booth, S.L., Borges, C.R. Gamma-Carboxylation and Fragmentation of Osteocalcin in Human Serum Defined by Mass Spectrometry. Mol Cell Proteomics 14(6): 1546-1555, 2015.
Yassine, H.N., Trenchevska, O., He, H., Borges, C.R., Nedelkov, D., Mack, W., Kono, N., Koska, J., Reaven, P.D., Nelson, R.W. Serum Amyloid A Truncations in Type 2 Diabetes Mellitus. PLoS One, 10(1):e0115320, 2015.
Sherma N.D., Borges C.R., Trenchevska O., Jarvis J.W., Rehder D.S., Oran P.E., Nelson R.W., Nedelkov D. Mass Spectrometric Immunoassay for the Qualitative and Quantitative Analysis of the Cytokine Macrophage Migration Inhibitory Factor (MIF). Proteome Science 12(1):52, 2014.
Borges C.R. and Lake D.F. Oxidative Protein Folding: Nature’s Knotty Challenge. Antioxid Redox Signal 21(3): 392-395, 2014.
Borges C.R., Rehder D.S., Jensen S., Schaab M.R., Sherma N.D., Yassine H., Nikolova B., Breburda C. Elevated Plasma Albumin and Apolipoprotein A-I Oxidation under Suboptimal Specimen Storage Conditions. Mol Cell Proteomics 13(7):1890-1899, 2014.
Zhao, Y., Ashcroft, B., Zhang, P., Liu, H., Sen, S., Song, W., Im, J., Gyarfas, B., Manna, S., Biswas, S., Borges, C., Lindsay, S. Single-molecule spectroscopy of amino acids and peptides by recognition tunneling. Nat Nanotechnol 9(6): 466-473, 2014.
Oran P.E., Trenchevska O., Nedelkov D., Borges C.R., Schaab M.R., Rehder D.S., Jarvis J.W., Sherma N.D., Shen L., Krastins B., Lopez M.F., Schwenke D.C., Reaven P.D., Nelson R.W. Parallel workflow for high-throughput (>1,000 samples/day) quantitative analysis of human insulin-like growth factor 1 using mass spectrometric immunoassay. PLoS One, 9(3): e92801, 2014. doi: 10.1371/journal.pone.0092801.
Borges C.R., Sherma N.D. Techniques for the Analysis of Cysteine Sulfhydryls and Oxidative Protein Folding. Antioxid Redox Signal, 21(3): 511-531, 2014.
Yassine H.N., Jackson A.M., Borges C.R., Billheimer D., Koh H., Smith D., Reaven P., Lau S.S., Borchers C.H. The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins. Lipids Health Dis 13(1): 8, 2014.
Yassine, H., Borges, C.R., Schaab, M.R., Billheimer, D., Stump, C., Reaven, P., Lau, S.S., Nelson, R.W. Mass Spectrometric Immunoassay and Multiple Reaction Monitoring as Targeted MS-based Quantitative Approaches in Biomarker Development: Potential Applications to Cardiovascular Disease and Diabetes. Proteomics Clin Appl, 7(7-8): 528-540, 2013.
Borges, C.R., Rehder, D.S., Boffetta, P. Multiplexed surrogate analysis of glycotransferase activity in whole biospecimens. Anal Chem, 85: 2927-2936, 2013.
Orsak, T., Smith, T.L., Eckert, D., Lindsley, J.E., Borges, C.R., Rutter, J. Revealing the Allosterome: Systematic Identification of Metabolite/Protein Interactions. Biochemistry, 51(1):225-32, 2012.
Bley, C.J., Qi, X., Rand, D.P., Borges, C.R., Nelson, R.W., Chen, J.J.L. RNA-protein binding interface in the telomerase ribonucleoprotein. PNAS, 108(51): 20333-8, 2011.
Oran, P.E., Jarvis, J.W., Borges, C.R., Sherma, N.D., Nelson, R.W. Mass Spectrometric Immunoassay of Intact Insulin and Related Variants for Population Proteomics Studies. Proteomics Clin Appl 5: 454-9, 2011.
Borges, C.R., Oran, P.E., Buddi, S., Jarvis, J.W., Schaab, M.R., Rehder, D.S., Rogers, S. P., Taylor, T. and Nelson, R.W. Building Multidimensional Biomarker Views of Type 2 Diabetes Based on Protein Microheterogeneity. Clin.Chem 57: 719-728, 2011.
Nelson, R.W., Borges, C.R. Mass spectrometric immunoassay revisited. J Am Soc Mass Spectrom 22: 960-968, 2011.
Rehder, D. S., Borges, C. R. Cysteine Sulfenic Acid as an Intermediate in Disulfide Bond Formation and Nonenzymatic Protein Folding, Biochemistry 49: 7748-7755, 2010.
Oran, P.E., Sherma, N.D., Borges, C.R., Jarvis, J.W., Nelson, R.W. Intrapersonal and Populational Heterogeneity of the Chemokine RANTES. Clin Chem 56: 1432-1441, 2010.
Rehder, D. S., Borges, C. R. Possibilities and pitfalls in quantifying the extent of cysteine sulfenic acid modification of specific proteins within complex biofluids. BMC Biochemistry 11: 25, 2010.
Lopez, M.F., Rezai, T., Sarracino, D.A., Prakash, A., Krastins, B., Athanas, M., Singh, R.J., Barnidge, D.R., Oran, P.E., Borges, C.R., Nelson, R.W. Selected Reaction Monitoring–Mass Spectrometric Immunoassay Responsive to Parathyroid Hormone and Related Variants Clin Chem 56: 281-290, 2010.
Borges, C.R., Rehder, D.S., Jarvis, J.W., Schaab, M.S., Oran, P.E., Nelson, R.W. Full length characterization of proteins in human populations Clin Chem 56: 202-211, 2010.
Oran, P.E., Jarvis, J.W., Borges, C.R., Nelson, R.W. C-peptide Microheterogeneity in Type 2 Diabetes Populations Proteomics Clin Appl 4: 1-6, 2010.
Rehder, D. S., Nelson, R. W., Borges, C. R. Glycosylation status of vitamin D binding protein in cancer patients. Protein Sci 18: 2036-2042, 2009.
Borges, C.R., Jarvis, J.W., Oran, P.E., Rogers, S.P., Nelson, R.W. “Population Studies of Vitamin D Binding Protein Microheterogeneity by Mass Spectrometry Lead to Characterization of its Genotype Dependent O-glycosylation Patterns” J. Proteom. Res. 7:4143-53, 2008.
Borges, C.R., Jarvis, J.W., Oran, P.E., Rogers, S.P., Nelson, R.W. “Population studies of intact Vitamin D binding protein by affinity capture ESI-TOF-MS” J Biomolecular Techniques 19(3): 167-176, 2008.
Hoggan, A.M., Shelby, M.K., Crouch, D.J., Borges, C.R., Slawson, M.H. “Detection of bumetanide in an over-the-counter dietary supplement” J. Anal. Toxicol. 31(9):601-4, 2007.
Borges C.R., “Concept for facilitating analyst-mediated interpretation of qualitative chromatographic-mass spectral data: an alternative to manual examination of extracted ion chromatograms.” Anal. Chem. 79(13):4805-13, 2007.
Borges C.R., Miller N., Shelby M., Hansen M., White C., Slawson M.H., Monti K., and Crouch D.J. “Analysis of a challenging subset of World Anti-Doping Agency-banned steroids and anti-estrogens by LC/MS/MS” J. Anal. Toxicol. 31(3):125-31, 2007.
Borges C.R., Taccogno J., Crouch D.J., Le L., Truong T.N. “Structure and Mechanism of Formation of an Important Ion in Doping Control.” Int. J. Mass Spectrom. 247: 48-54, 2005.
Borges C.R., Qi J., Wu W, Torng E., Hinck A.P., and Watson J.T. “Algorithm-Assisted Elucidation of Disulfide Structure: Application of the Negative Signature Mass Algorithm to Mass-Mapping the Disulfide Structure of the 12-Cysteine Transforming Growth Factor β Type II Receptor Extracellular Domain.” Anal Biochem. 329(1):91-103, 2004.
Rollins, D.E., Wilkins, D.G., Krueger, G.G., Augsburger, M.P., Mizuno, A., O’neal, C., Borges, C.R., Slawson, M.H. “The Effect of Hair Color on the Incorporation of Codeine into Hair.” J. Anal. Toxicol. 27: 545-551, 2003.
Qi, J., Hang, D., Rupp, M., Borges, C.R., Wu, W., Torng E., and Watson, J.T. “Automated Data Interpretation Based on the Concept of ‘Negative Signature Mass’ for Mass-Mapping Disulfide Structures of Cystinyl Proteins.” J. Amer. Soc. Mass Spectrom. 14(9): 1032-1038, 2003.
Borges, C.R., and Watson, J.T., “Recognition of Cysteine-Containing Peptides through Prompt Fragmentation of the 4-Dimethylaminophenylazophenyl-4’-maleimide Derivative During Analysis by MALDI-MS” Protein Sci. 12(7): 1567-72, 2003.
Borges, C.R., Kuhn, D.M., and Watson, J.T. “Mass Mapping Sites of Nitration in Tyrosine Hydroxylase: Random versus Selective Nitration of Three Tyrosine Residues” Chem. Res. Toxicol. 16(4): 536-40, 2003.
Borges, C.R., Roberts, J.C., Wilkins, D.G., and Rollins, D.E. “Cocaine, Benzoylecgonine, Amphetamine, and N-acetylamphetamine Binding to Melanin Subtypes.” J. Anal. Toxicol. 27(3): 125-34, 2003.
Wilkins, D.G., Mizuno, A., Borges, C.R., Slawson, M.H., and Rollins, D.E., “Ofloxacin as a reference marker in hair of various colors.” J. Anal. Toxicol. 27(3): 149-55, 2003.
Borges, C.R., Geddes, T., Watson, J.T., and Kuhn, D.M. “Dopamine biosynthesis is regulated by S-glutathionylation: Potential mechanism of tyrosine hydroxylase inhibition during oxidative stress.” J. Biol. Chem. 277(50): 48295-302, 2002.
Kuhn D.M., Sadidi M., Lu X., Kriepke C., Geddes T., Borges C., Watson J.T. “Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by MALDI-TOF mass spectrometry and tyrosine-scanning mutagenesis.” J. Biol. Chem. 277(16): 14336-42, 2002.
Borges, C.R., Martin, S.D., Meyer, L.J., Wilkins, D.G., and Rollins, D.E. “Influx and Efflux of Amphetamine and N-acetylamphetamine in Keratinocytes, Pigmented Melanocytes, and Non-Pigmented Melanocytes.” J. Pharm. Sci. 91(6): 1523-35, 2002.
Borges, C.R., Wilkins, D.G., and Rollins, D.E. “Amphetamine and N-acetylamphetamine incorporation into hair: an investigation of the potential role of drug basicity in hair color bias.” J. Anal. Toxicol. 25: 221-227, 2001.
Borges, C.R., Roberts, J.C., Wilkins, D.G., and Rollins, D.E. “Relationship of melanin degradation products to actual melanin content: Application to human hair.” Anal. Biochem. 290: 116-125, 2001.
Denkinger, D.J., Borges, C.R., Butler, C.L., Cushman, A.M., and Kawahara, R.S. "Genomic organization and regulation of the vav proto-oncogene." Biochim. Biophys. Acta 1491: 253-262, 2000.
Hold, K.M., Borges, C.R., Wilkins, D.G., Rollins, D.E., and Joseph, R.E. Jr. "Detection of nandrolone, testosterone and their esters in rat and human hair samples." J. Anal. Toxicol. 23: 416-423, 1999
Chen, H., Ambadapadi, S., Wakefield, D., Bartee, M., Yaron, J.R., Zhang, L., Archer-Hartmann, S.A., Azadi, P., Burgin, M., Borges, C., Zheng, D., Ergle, K., Muppala, V., Morshed, S., Rand, K., Clapp, W., Proudfoot, A., Lucas, A. "Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection." Science Reports 8: 13433. 2018
Ferdosi, S., Ho, T.H., Castle, E.P., Stanton, M.L., Borges, C.R. "Behavior of Blood Plasma Glycan Features in Bladder Cancer." PLoS One 13: e0201208. 2018
Ferdosi, S., Rehder, D.S., Maranian, P., Castle, E.P., Ho, T.H., Pass, H.I., Cramer, D.W., Hollingsworth, M.A., Anderson, K.S., Fu, L., Cole, D.E.C., Le, T., Wu, X., Borges, C.R. "Stage Dependence, Cell-Origin Independence and Prognostic Capacity of Serum Glycan Fucosylation, β 1-4 Branching, β 1-6 Branching and α 2-6 Sialylation in Cancer."Proteome Res 17: 543-558. 2018
- Anderson,Karen S*, Borges,Chad Randolph. Targeting Breast Cancer Tumor Antigens for Immunotherapy. BCRF(3/1/2015 - 2/29/2016).
- Borges,Chad Randolph*, Wallstrom,Garrick L. Validation and Advanced Development of Glycan Node Analysis in Lung Cancer Research. HHS-NIH-NCI(2/1/2015 - 1/31/2017).
- Borges,Chad Randolph*, Wallstrom,Garrick L. Development of a Peripheral Blood Test to Identify Invasive Bladder Cancer Using Standard Clinical Lab Equipment. FLINN FDN(10/1/2014 - 9/30/2016).
- Borges,Chad Randolph*. Epigenetic regulation of glycotransferase enzymes in urothelial carcinoma. MAYO CLINIC SCOTTSDALE(8/1/2013 - 7/31/2014).
- Nelson,Randall William*, Borges,Chad Randolph. Team Approach to Translate Novel Biomarkers for Diabetes. HHS-NIH-NIDDK(8/5/2011 - 7/31/2016).
- Nelson,Randall William*, Borges,Chad Randolph. Novel biomarkers for myocardial infarction based on protein heterogeneity. (3/1/2010 - 12/31/2015).
- Nelson,Randall William*, Borges,Chad Randolph. Population-Based Proteomic Investigation of Type 2 Diabetes Mellitus. HHS-NIH-NIDDK(3/1/2010 - 2/29/2016).
- Borges,Chad Randolph*, Nelson,Randall William, Nelson,Randall William. Site-Specific Analysis of Human Cysteine Sulfenic Acid Protein Modifications. HHS-NIH-NCRR(12/1/2007 - 11/30/2010).
Courses
2025 Spring
| Course Number | Course Title |
|---|---|
| BCH 493 | Honors Thesis |
| CHM 492 | Honors Directed Study |
| CHM 493 | Honors Thesis |
| BCH 392 | Intro to Research Techniques |
| BCH 492 | Honors Directed Study |
| CHM 392 | Intro to Research Techniques |
| CHM 499 | Individualized Instruction |
| MBB 495 | Undergraduate Research |
| CHM 392 | Intro to Research Techniques |
| BCH 392 | Intro to Research Techniques |
| BCH 392 | Intro to Research Techniques |
| CHM 494 | Special Topics |
| CHM 598 | Special Topics |
2024 Fall
| Course Number | Course Title |
|---|---|
| BCH 392 | Intro to Research Techniques |
| BCH 492 | Honors Directed Study |
| BCH 493 | Honors Thesis |
| CHM 325 | Analytical Chemistry |
| CHM 392 | Intro to Research Techniques |
| CHM 492 | Honors Directed Study |
| MBB 495 | Undergraduate Research |
| CHM 493 | Honors Thesis |
| BCH 392 | Intro to Research Techniques |
| CHM 392 | Intro to Research Techniques |
2024 Summer
| Course Number | Course Title |
|---|---|
| CHM 392 | Intro to Research Techniques |
2024 Spring
| Course Number | Course Title |
|---|---|
| BCH 493 | Honors Thesis |
| BCH 392 | Intro to Research Techniques |
| CHM 493 | Honors Thesis |
| CHM 499 | Individualized Instruction |
| MBB 495 | Undergraduate Research |
| BCH 484 | Internship |
| CHM 484 | Internship |
| CHM 392 | Intro to Research Techniques |
| CHM 484 | Internship |
| BCH 484 | Internship |
| BCH 392 | Intro to Research Techniques |
| BCH 392 | Intro to Research Techniques |
| CHM 325 | Analytical Chemistry |
| CHM 325 | Analytical Chemistry |
2023 Fall
| Course Number | Course Title |
|---|---|
| BCH 392 | Intro to Research Techniques |
| BCH 492 | Honors Directed Study |
| BCH 493 | Honors Thesis |
| CHM 325 | Analytical Chemistry |
| CHM 392 | Intro to Research Techniques |
| CHM 492 | Honors Directed Study |
| MBB 495 | Undergraduate Research |
| CHM 493 | Honors Thesis |
| BCH 392 | Intro to Research Techniques |
| CHM 392 | Intro to Research Techniques |
| BCH 392 | Intro to Research Techniques |
2023 Summer
| Course Number | Course Title |
|---|---|
| CHM 392 | Intro to Research Techniques |
2023 Spring
| Course Number | Course Title |
|---|---|
| BCH 492 | Honors Directed Study |
| BCH 493 | Honors Thesis |
| CHM 392 | Intro to Research Techniques |
| CHM 492 | Honors Directed Study |
| CHM 493 | Honors Thesis |
| CHM 499 | Individualized Instruction |
| MBB 495 | Undergraduate Research |
| CHM 392 | Intro to Research Techniques |
| BCH 392 | Intro to Research Techniques |
| CHM 598 | Special Topics |
| CHM 494 | Special Topics |
2022 Fall
| Course Number | Course Title |
|---|---|
| BCH 392 | Intro to Research Techniques |
| BCH 492 | Honors Directed Study |
| BCH 493 | Honors Thesis |
| CHM 325 | Analytical Chemistry |
| CHM 392 | Intro to Research Techniques |
| CHM 492 | Honors Directed Study |
| MBB 495 | Undergraduate Research |
| CHM 493 | Honors Thesis |
| BCH 392 | Intro to Research Techniques |
2022 Summer
| Course Number | Course Title |
|---|---|
| CHM 392 | Intro to Research Techniques |
2022 Spring
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
| CHM 598 | Special Topics |
| CHM 494 | Special Topics |
| BCH 392 | Intro to Research Techniques |
2021 Fall
| Course Number | Course Title |
|---|---|
| CHM 325 | Analytical Chemistry |
| MBB 495 | Undergraduate Research |
2021 Spring
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
| CHM 598 | Special Topics |
| CHM 494 | Special Topics |
2020 Fall
| Course Number | Course Title |
|---|---|
| CHM 325 | Analytical Chemistry |
| MBB 495 | Undergraduate Research |
2020 Spring
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
| CHM 325 | Analytical Chemistry |
| CHM 325 | Analytical Chemistry |
2019 Fall
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
| CHM 501 | Current Topics in Chemistry |
| CHM 598 | Special Topics |