George Pettit

Retired Faculty or Staff

PSD -D301 PHYSICAL SCIENCE CENTER TEMPE, AZ 85287-1604
‌
‌

Long Bio

George Pettit was a Regents Professor and a leading figure in the development of anti-cancer drugs. He passed away on Sept. 21, 2021. Pettit received his B.S. degree in chemistry from Washington State University and master's degree and doctorate from Wayne State University, working with Carl Djerassi. He has more than 800 peer-reviewed publications, and has written 14 books and 17 book chapters in the area of organic chemistry and anti-cancer research. He is the recipient of the Ernest Guenther Award from the American Chemical Society and was the subject of a special issue of the Journal of Natural Products. He is a fellow of the American Institute of Chemists and the American Society of Pharmacognosy, and is a member of the New York Academy of Sciences and several scientific and academic journal boards. His scientific career is the subject of the biography "Waging War on Cancer. Dr. Pettit's Lifelong Quest to Find Cures" (Friesen Press, 2015).

His specific research interests include the chemistry of natural products (peptides, nucleotides, and steroids), cancer chemotherapy (anticancer agents from arthropods, marine animals and plants), and total synthesis of natural products.

Education

Ph.D. Wayne State University 1956
M.S. Wayne State University 1954
B.S. Chemistry, Washington State University 1952

Curriculum Vitae

Research Interests

Significant advances in the treatment of human cancer and other serious medical problems are becoming increasingly more dependent upon scientists well trained in organic chemistry, biochemistry and biology. Our group is organized to provide the specialized training necessary to undertake problems concerned with the discovery of anticancer substances for the treatment of cancer. Among various activities, we are pursuing a unique program concerned with isolation, structural identification and synthesis of naturally occurring anticancer agents from marine animals, plants, and arthropods. Studies concerned with synthetic methods, and routes to certain important biosynthetic products comprise related areas of interest.

Specific Research Interests: Chemistry of natural products (peptides, nucleotides, and steroids), cancer chemotherapy (anticancer agents from arthropods, marine animals and plants), and total synthesis of natural products.

Publications

George R. Pettit, Noeleen Melody, Jean-Charles Chapuis, "Antineoplastic Agents. 607. Emetine Auristatins," Journal of Natural Products, 83 (5) 1571-1576 (2020).
Ruoli Bai, Zobeida Cruz-Monserrate, William Fenical, George R. Pettit, Ernest Hamel, "Interaction of diazonamide A with tubulin," Archives of Biochemistry and Biophysics, 680 (2020).
George R. Pettit, Noeleen Melody, and Jean-Charles Chapuis,”Antineoplastic Agents 603. Quinstatins. Exceptional Cancer Cell Growth Inhibitors”, J. Nat. Prod., 80, 692-698, (2017). ACS editors’ choice award paper. Invited for special issue in honor of Phil Crews.
George R. Pettit, Qinghua Ye, John C. Knight, Fiona Hogan, Noeleen Melody, Venugopal J.R.V. Mukku,Dennis L. Doubek,and Jean-Charles Chapuis, “Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenes from the Zimbabwean Monadenium lugardae (Euphorbiaceae)1a ,” J. Nat. Prod. ,79, 1598-1603 (2016).
G. R. Pettit, J. D. Searcy, R. Tan, G. M. Cragg, Noeleen Melody, J. C. Knight, and J.-C. Chapuis, “Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins leading to the Synthesis of 4-Aza-Podophyllotoxin Structural Modifications,” J. Nat. Prod., 79, 507-518 (2016). Invited for special issue in honor of John Blunt and Murray Munro Revised August 3, 2017.
Pettit, George; Xu, Jun-Ping; Chapuis, Jean-Charles and Melody,Noeleen “The Cephalostatins 24. Isolation, Structure and Cancer Cell Growth Inhibition of Cephalostatin 20”, J. Nat. Prod., 78(6), 1446-1450 (2015).
G. R. Pettit, B. R. Moser, D. L. Herald, J. C. Knight, J-C Chapuis, X. Zheng “The Cephalostatins 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5,5]-nonane Synthon for Combretastatin 1,” J. Nat. Prod.,78(5), 1067-1072 (2015).
Noemi Kedei, Matthew B. Kraft, Gary E. Keck, Cherry Herald, Noeleen Melody, George R. Pettit, Peter M. Blumberg; “Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure-Function Relationships”; Journal of Natural Products ,78(4),896-900 (2015).
Pettit, George; Arce, Pablo; Chapuis, Jean-Charles; Macdonald, Christian “Antineoplastic Agents 600. From the South Pacific Ocean to the Silstatins”, J. Nat. Prod.,78(3),510-523 (2015).
George R. Pettit,* Thomas H. Smith, Pablo Arce, Erik J. Flahive, Collin R. Anderson, Jean-Charles Chapuis, Jun-Ping Xu, Thomas Groy, Paul E. Belcher, Christian Macdonald “Antineoplastic Agents 599. Total Synthesis of Dolastatin 16”, J. Nat.Prod.,78(3),476-485 (2015). Invited for March 2015 JNP special issue
George R. Pettit,*Rui Tan, Robin K. Pettit, Dennis L. Doubek, JeanCharles Chapuis,Christine Weber, “Antineoplastic Agents 596. Isolation and Structure of Chromomycin A5 From a Beaufort Sea Microorganism1,” RSC Advances, 5(12), 9116-9122 (2015).
Pettit, George; Melody, Noeleen; Hempenstall, Frank; Chapuis, JeanCharles; Groy, Thomas; Williams, Lee “Antineoplastic Agents. 595. Structureal Modifications of Betulin and the X-ray Crystal Structure of an Unusual Betulin Amine Dimer.1a,” J. Nat. Prod., 77(4), 863-872 (2014) .
G. R. Pettit, Y. Tang, Q. Zhang, G. T. Bourne, F. Hogan, C. Arm, J. C. Knight, R. K. Pettit, J-C. Chapuis, D. Doubek, F. Ward and J. N. A. Hooper. "Isolation and Structure of Axistatins 1-3 from the Republic of Palau Marine Sponge Agelas axifera,". Journal of Natural Products (2013).
Hadimani, Mallinath; MacDonough, Matthew; Strecker, Tracy; Lopez, Ramona; Sriram, Madhavi; Nguyen, Benson; Kessler, Raymond; Ghatak, Anjan; Shirali, Anupama; Liu, Li; Garner, Charles; Pettit, George; Hamel, Ernest; Chaplin, David; Mason, Ralph; Trawick, Mary Lynn; Pinney, Kevin. Synthesis of a 2-Aryl-3-Aroyl-Indole Salt (OXi8007)Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent". Journal of Natural Products (2013).
G. R. Pettit, G. H. Bao, N. Melody, R. Tan, D. L. Doubek, S. Gao, and L. Williams. "Antineoplastic Agents 587. Isolation and Structure of 3-Epipancratistatin from Narcissus v. Ice Follies". Journal of Natural Products (2012).
G. R. Pettit, H. J. Rosenberg, R. Dixon, J. C. Knight, E. Hamel, J-C. Chapuis, R. K. Pettit, F. Hogan, B. Sumner, K.B Ain, and B. B. Trickey-Platt. "Antineoplastic Agents 548. Synthesis of Iodo- and Di-iodocomstatin Phosphate Prodrugs". Journal of Natural Products (2012).
J. S. Park, M. M. Asuncion, J. R. Aspe, G. R. Pettit, N. R. Wall. "Auristatin Drugs Decrease Long-Term Survivin Levels and Induce Apoptosis in Human Pancreatic Cancer (Panc-1) Cells". J. Invest. Med (2012).
G. R. Pettit, A. Thornhill, N. Melody, and J. C. Knight. Antineoplastic Agents 578. Synthesis of Stilstatins 1 and 2 and Their Water-soluble Prodrugs. Journal of Natural Products (2009).
G. R. Pettit, J. C. Knight, D. L. Herald, R. K. Pettit, F. Hogan, V. J. R. V. Mukku, J. S. Hamblin, M. J. Dodson II, and J.-C. Chapuis. Antineoplastic Agents 570. Isolation and Structure Elucidation of Bacillistatins 1 and 2 from a Marine Bacillus sylvestris. Journal of Natural Products (2009).
G. R. Pettit, J. Du, R. K. Pettit, J. C. Knight, and D. L. Doubek. Antineoplastic Agents. 575. The Fungus Aspergillus phoenicis. Heterocycles (2009).
G. R. Pettit, M. D. Minardi, F. Hogan, and P. M. Price. An Efficient Synthetic Strategy for Obtaining 4.-Methoxy Carbon Isotope Labelled Combretastatin A-4 Phosphate and Other Z-Combretastatins. Journal of Natural Products (2009).
G. R. Pettit, N. Melody, A. Thornhill, J. C. Knight, T. L. Groy, and C. L. Herald. Antineoplastic Agents 579. Synthesis and Cancer cell Growth Evaluation of E-Stilstatin 3, a Resveratrol Structural Modification. Journal of Natural Products (2009).
G. R. Pettit, P. D. Quistorf, J. A. Fry, D. L. Herald, E. Hamel, and J.-C. Chapuis. Antineoplastic Agents 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2. Journal of Natural Products (2009).
G. R. Pettit, Q. Ye, D. L. Herald, F. Hogan, and R. K. Pettit. Antineoplastic Agents 573. Isolation and Structure of Papilistatin from the Papilionid Butterfly Byasa polyseuctas Termessa. Journal of Natural Products (2009).
G. R. Pettit, S. Hu, J. C. Knight, and J.-C. Chapuis. Antineoplastic Agents 571. Total Synthesis of Bacillistatin 2. Journal of Natural Products (2009).
G. R. Pettit, Y. Meng, R. K. Pettit, D. L. Herald, Z. A. Cichacz, D. L. Doubek, and L. Richert. Antineoplastic Agents. 556. Isolation and Structure of Coprinastatin 1 from Coprinus cinereus. Journal of Natural Products (2009).
G.R. Pettit, S. Ducki, S.A. Eastham, and N. Melody. Antineoplastic Agents 454. Synthesis of the Strong Cancer Cell Growth Inhibitors trans-Dihydronarciclasine and 7-Deoxy-trans-dihydronarciclasine. Journal of Natural Products (2009).
L. Padmaja, C. Ravikumar, D. Sajan, I. Hubert Joe, V. S. Jayakumar, G. R. Pettit, and O. Faurskov Nielsen. Density Functional Study on the Structural Conformations and Intramolecular Charge Transfer from the Vibrational Spectra of the Anticancer Drug Combretastatin-A2. Journal of Raman Spectroscopy (2009).
R. Bai, M. C. Edler, P. L. Bonate, T. D. Copeland, G. R. Pettit, R. F. Ludueña, and E. Hamel. "Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity. Molecular Pharmacology (2009).
R. K. Pettit, C. A. Weber, and G. R. Pettit. Application of a High Throughput Alamar Blue Biofilm Susceptibility Assay to Staphylococcus aureus Biofilms. Ann. Clin. Microbiol. Antimicrob (2009).
R. K. Pettit, C. A. Weber, S. B. Lawrence, G. R. Pettit, M. J. Kean, G. D. Cage. In Vivo Activity of Anprocide Alone, and In Vitro Activity in Combination With Conventional antibiotics Against Staphylococcus aureus and S. epidermidis Biofilms. Journal of Medical Microbiology (2009).
R. K. Pettit, G. R. Pettit, E. Hamel, F. Hogan, B. R. Moser, S. Wolf, S. Pon, J.-C. Chapuis, and J. M. Schmidt. E-Combretastatin and E-Resveratrol Structural Modifications: Antimicrobial and Cancer Cell Growth Inhibitory ß-E-Nitrostyrenes. Bioorg. Med. Chem (2009).
G. R. Pettit. Arizona State University Cancer Research Institute. The American Society of Pharmacognosy, 50 Years of Progress in Natural Products Research 1959-2009 (2009).
G. R. Pettit. Dolastatins. Marine Anticancer Compounds in the Era of Targeted Therapies (2009).
G. R. Pettit. The Dolastatins. The American Society of Pharmacognosy, 50 Years of Progress in Natural Products Research 1959-2009 (2009).
G. R. Pettit and C. L. Herald. The Bryostatins. The American Society of Pharmacognosy, 50 Years of Progress in Natural Products Research 1959-2009 (2009).
G. R. Pettit and K. G. Pinney. The Combretastatins. The American Society of Pharmacognosy, 50 Years of Progress in Natural Products Research 1959-2009 (2009).
A. B. Smith III, T. M. Razler, R. M. Meis, G. R. Pettit. Synthesis and Biological Evaluation of Phorboxazole Cogeners Leading to the Discovery and PReparative-Scale Synthesis of (+)-Chlorophorboxazole A Possessing Picomolar Human Solud Tumor Cell Growth Inhibitory Activity. J. Org. Chem (2008).
A. Rudy, N. Lopez-Anton, N. Barth, G. R. Pettit, V. M. Dirsch, K. Schulze-Osthoff, M. Rehm, J. H. Prehn, M. Vogler, S. Fulda, A. M. Vollmar. Role of Smac in Cephalostatin-Induced Cell Death. Cell Death and Differentiation (2008).
C. James, G. R. Pettit, O. F. Nielsen, V. S. Jayakumar, I. Hubert Joe. Vibrational Spectra and ab initio Molecular Orbital Calculations of the Novel Anticancer Drug Combretastatin A-4 Prodrug. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2008).
G. R. Pettit, F. Hogan, J-P. Xu, R. Tan, T. Nogawa, Z. A. Cichacz, R. K. Pettit, J. Du, Q-H. Ye, G. M. Cragg, C. L. Herald, M. S. Hoard, A. Goswami, J. Searcy, L. Tackett, D. L. Doubek, L. Williams, J. N. A. Hooper, J. M. Schmidt, J-C. Chapuis, D. N. Tackett, F. Craciunescu. Antineoplastic Agents 536. New Sources of Naturally Occurring Cancer Cell Growth Inhibitors from Marine Organisms, Terrestrial Plants, and Microorganisms. J. Nat. Prod (2008).
George Pettit, A Thornhill, B Moser. Antineoplastic Agents 552. Oxidation of Combretastatin A-1 and Trapping the Ortho-Quinone Intermediate Considered A Key Metabolic Product of the Corresponding Phosphate Prodrug. J. Nat. Prod (2008).
George Pettit, V Mukku, G Cragg, J Knight, C Herald, J Chapuis. Antineoplastic Agents 558. Ampelocissus sp. (Vitaceae) Cancer Cell Growth Inhibitory Constituents. Journal of Natural Products (2008).
J. J. Hall, M. Sriram, T. E. Strecker, J. K. Tidmore, C. J. Jelinek, G. D. Kishore Kumar, M. B. Hadimani, G. R. Pettit, D. J. Chaplin, M. L. Trawick, and K. G. Pinney. Design, Synthesis, Biochemical, and Biological Evaluation of Nitrogen-Containing Trifluoro Structural Modifications of Combretastatin A-4. Bioorg. Med. Chem. Lett (2008).
K. K. Repp, F. Hogan, G. R. Pettit, and R. K. Pettit. In vitro Interactions of Approved and Experimental Drugs against Candida albicans and Aspergillus spp. J. Chemotherapy (2008).
L. Schyschka, A. Rudy, I. Jeremias, N. Barth, G. R. Pettit, A. M. Vollmar. Spongistatin 1: A New Chemosensitizing Marine Compound that Degrades XIAP. Leukemia (2008).
M. R. Brennan, C. E. Costello, S. D. Maleknia, G. R. Pettit, K. L. Erickson. Stylopeptide 2, a Proline-Rich Cyclodecapeptide from the Sponge Stylotella sp. J. Nat. Prod (2008).
R. Siles, J. Freeland Ackley, M. B. Hadimani, J. J. Hall, B. E. Mugabe, R. Guddneppanavar, K. A. Monk. J-C. Chapuis, G. R. Pettit, D. J. Chaplin, K. Edvardsen, M. L. Trawick, C. M. Garner, K. G. Pinney. Combretastatin Dinitrogen-Substitued Stilbene Analogues as Tubulin-Binding and Vascular-Disrupting Agents. J. Nat. Prod (2008).
. Special Issue in Honor of G. Robert Pettit. (2008).
G. R. Pettit, R. Tan, R. K. Pettit, T. H. Smith, S. Feng, D. L. Doubek, L. Richert, J. Hamblin, C. Weber, J-C. Chapuis. Antineoplastic Agents 560. Isolation and structure of Kitastatin 1 from an Alaskan Kitasatospora sp. J. Nat. Prod (2007).
George Pettit, N Melody, D Herald. Antineoplastic Agents 550. Synthesis of 10b (S)-epipancratistatin from (+)-Narciclasine. J. Med. Chem (2007).
George Pettit, T Smith, S Feng, J Knight, R Tan, R Pettit. Antineoplastic Agents 561. Total Synthesis of Respirantin ¹ª. J. Nat. Prod (2007).
A Numata, George Pettit, D Herald, C Iwamoto, Y Usami, T Yamada, H Ohishi, G Cragg, D Doubek. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea. J. Nat. Prod (2006).
A Smith, T Razler, R Meis, George Pettit. Design and Synthesis of a Potent Phorboxazole C (11-15)Acetal Analogue. Organic Letters (2006).
D Dabydeen, M Munro, R Gussio, E Hamel, J Burnett, R Bai, P Verdier-Pinard, M Yu, B Littlefield, S Hickford, George Pettit, J Blunt. Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin. Molecular Pharmacology (2006).
George Pettit, A Numata, C Iwamoto, Y Usami, T Yamada, H Ohishi, G Cragg. Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Baihinia purpurea. J. Nat. Prod (2006).
George Pettit, J Bell, S Eastham, N Melody, B Orr, D Herald, J McGregor, J Knight, D Doubek, G Pettit III, L Garner. Isolation and Structural Modification of 7-Deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine. J. Nat. Prod (2006).
George Pettit, J Du, R Pettit, L Richert, V Mukku, M Hoard. Antineoplastic Agents 554. The Manitoba Bacterium Streptomyces sp. J. Nat. Prod (2006).
George Pettit, J Du, R Pettit, L Richert, V Mukku, M Hoard. Antineoplastic Agents 554. The Manitoba Bacterium Streptomyces sp. J. Nat. Prod (2006).
George Pettit, S. A. Eastham, N. Melody, B. Orr, D. L. Herald, J. McGregor, J. C. Knight, D. L. Doubek, G. R. Pettit III, L. C. Garner, and J. A. Bell. Isolation and Structural Modification of 7-Deoxynarciclasine and 7-deoxy-trans-Dihydronarciclasine. J. Nat. Prod (2006).
H LaMarca, C Morris, George Pettit, T Nogawa, J Puschett. Marinobufagenin Impairs First Trimester Cytotrophoblast Differentiation. Placenta (2006).
H LaMarca, C Morris, George Pettit, T Nogawa, J Puschett. Marinobufagenin Impairs First Trimester Cytotrophoblast Differentiation. Placenta (2006).
H Vu, M Ianosi-Irimie, S Danchuk, E Rabon, T Nogawa, Y Kamano, George Pettit, T Wiese, J Puschett. Resibufogenin Corrects Hypertension in a Rat Model of Human Preeclampsia. Exper. Biol. Med (2006).
K Monk, George Pettit, K Pinney, R Siles, M Hadimani, B Mugabe, F Ackley, K Edvardsen, M Trawick, C Garner, M Rhodes. Design, Synthesis, and Biological Evaluation of Combretastatin Nitrogen-Containing Derivatives as Inhibitors of Tubulin Assembly and Vascular Targeting Agents. BioOrg. Med. Chem (2006).
N Lopez-Anton, A Rudy, N Barth, I Mueller, L Schmitz, George Pettit, V Dirsch, A Vollmar. The Marine Invertebrate Constituent Cephalostatin 1 Activates an ER Stress- Specific and Apoptosome-Independent Apoptotic Signal Pathway. J. Biol. Chem (2006).
N. Lopez-Anton, A. Rudy, N. Barth, I. M. Mueller, L. Schmitz, G. R. Pettit, V. M. Dirsch, and A. M. Vollmar. The marine invertebrate constituent cephalostatin 1 activates an ER stress-specific and apoptosome-independent apoptotic signal pathway. J. Biol. Chem (2006).
A Smith, T Razler, George Pettit, J Chapuis. (+)-Phorboxazole A Synthetic Studies. Identification of a Series of Highly Cytotoxic C(45-46) Analogues. Org. Lett (2005).
G. R. Pettit and N. Melody. Antineoplastic Agents 527. Synthesis of 7- Deoxy-narcistatin, 7-deoxy-trans-dihydronarcistatin, and Trans-dihydro- narcistatin 1. J. Nat. Prod (2005).
G. R. Pettit, M. D. Minardi, H. J. Rosenberg, E. Hamel, M. C. Bibby, S. W. Martin, M. K. Jung, R. K. Pettit, T. J. Cuthbertson, and J-C. Chapuis. Antineoplastic Agents 509. Synthesis of Sodium Fluorcombstatin Phosphate and Related 3-Halo-Stilbenes. J. Nat. Prod (2005).
George Pettit, C Anderson, J Knight, E Hamel, R Pettit. Antineoplastic Agents 515. Synthesis of Human Cancer Cell growth Inhibitors derived from 3,4-Methylenedioxy-5,41-dimethoxy-31-amino-Z-stilbene. J. Nat. Prod (2005).
George Pettit, J Chapuis, M Minardi, H Rosenberg, E Hamel, M Bibby, S Martin, M Jung, R Pettit, T Cuthbertson. Antineoplastic Agents 509. Synthesis of Sodium Fluorcombstatin Phosphate and Related 3-Halo-StilbenesJ. Nat. Prod. J. Nat. Prod (2005).
George Pettit, M Rhodes, D Herald, E Hamel, J Schmidt, R Pettit. Antineoplastic Agents 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)- Combretastatin A-4. J. Med. Chem (2005).
George Pettit, M Rhodes, D Herald, E Hamel, J Schmidt, R Pettit. ntineoplastic Agents 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)-Combretastatin A-4. J. Med. Chem (2005).
George Pettit, N Melody. Antineoplastic Agents 527. Synthesis of 7-Deoxy-narcistatin, 7-deoxy-trans-dihydronarcistatin, and Trans-dihydro-narcistatin 1. J.Nat. Prod (2005).
George Pettit, Q Zhang, V Pinilla, H Hoffmann, D Doubek, J Chapuis, R Pettit, J Schmidt. Antineoplastic Agents 534. Isolation and Structure of Sansevistatins 1 and 2 from the African Sanseviera ehrenbergii. J. Nat. Prod (2005).
George Pettit, Q Zhang, V Pinilla, H Hoffmann, J Knight, D Doubek, J Chapuis, R Pettit, J Schmidt. Antineoplastic Agents 534. Isolation and Structure of Sansevistatins 1 and 2 from the African Sansevieria ehrenbergii. J. Nat. Prod (2005).
George Pettit, R Tan. Isolation and Structure of Phakellistatin 14 from the Western Pacific Marine Sponge Phakellia sp. J. Nat. Prod (2005).
George Pettit, R Tan, and Z. A. Cichacz. Antineoplastic Agents 542. The Isolation and Structure of Sesterstatin 6 from the Indian Ocean Sponge Hyrtios erecta. J. Natural Prod (2005).
George Pettit, R Tan, Z Cichacz. The Isolation and Structure of Sesterstatin 6 from the Indian Ocean Sponge Hyrtios erecta. J. Nat. Prod (2005).
George Pettit, S Ducki, D Herald, D Doubek, J Schmidt. Antineoplastic Agents 470. Absolute Configuration of the Marine Sponge Bromopyrrole Agelastatin A. Oncol. Res (2005).
George Pettit, S Ducki, D Herald, D Doubek, J Schmidt, J Chapuis. Antineoplastic Agents 470. Absolute Configuration of the Marine Sponge Bromopyrrole Agelastatin A. Oncol. Res (2005).
George Pettit, Y Meng, D Herald, A Stevens, R Pettit, D Doubek. Antineoplastic Agents 540. The Indian Gynandropsis gynandra (Capparidaceae). Oncol. Res (2005).
George Pettit, Y Meng, D Herald, A Stevens, R Pettit, D Doubek. Antineoplastic Agents 540. The Indian Gynandropsis gynandra(Capparidaceae). Oncol. Res (2005).
George Pettit, Y Meng, D Herald, J Knight, J Day. Antineoplastic Agents 553. The Texas Grasshopper Brachystola manga. J. Nat. Prod (2005).
George Pettit, Y Meng, D Herald, J Knight, J Day. Antineoplastic Agents 553. The Texas Grasshopper Brachystola manga. J. Natural Prod (2005).
George Pettit, Y Tang, J Knight. Antineoplastic Agents 545. Isolation and Structure of Turbostatins 1-4 from the Asian Marine Mollusc Turbo stenogyrus. J. Natural Prod (2005).
George Pettit, Y Tang, J Knight. Isolation and Structure of Turbostatins 1-4 from the Asian Marine Mollusc Turbo stenogyrus. J. Nat. Prod (2005).
I MÃ¼ller, V Dirsch, A Rudy, N Lopez-Anton, George Pettit, A Vollmar. Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-phase Arrest and DNA Damage. Mol. Pharmacol (2005).
M Ali, P Nakkiew, George Pettit, C Stessman, B Sufi, G Yarick, R Bates, Z Crane, C Dicus, M Gramme, E Hamel, J Marcischak, D Martinez, K McClure. Dolastatin 11 Conformations, Analogues and Pharmacophore. Bioorg. Med. Chem (2005).
R Pettit, C Weber, M Kean, H Hoffmann, George Pettit, R Tan, K Franks, M Horton. Microplate Alamar Blue Assay for Staphylococcus epidermidis Biofilm Susceptibility Testing. Antimicrobial Agents and Chemotherapy (2005).
R Pettit, S Pon, Z Cichacz, C Herald, George Pettit, T Woyke. In vitro and In vivo Antifungal Activities of the Marine Sponge Constituent Spongistatin 1. Medical Mycology (2005).
Pinney, K G (Author) ,Jelinek, C (Author) ,Edvardsen, K (Author) ,Chaplin, D J (Author) ,Pettit, George Robert (Author) . The Discovery and Development of the Combretastatins. Anticancer Agents from Natural Products (2005).
George Pettit, D Doubek, J Hooper, L Albright, J Schmidt, J Chapuis, L Tackett, H Hoffmann, J McNulty, K Higgs, A Murphy, D Molloy, D Herald, M williams, R Pettit. Antineoplastic Agents 380. Isolation and X-Ray Crystal Structure Determination of Isoaaptamine from the Republic of Singapore Hymeniacidon Sp. And Conversion to the Phosphate Prodrug Hystatin 1. J. Nat. Prod (2004).
George Pettit, F Hogan, D Herald. Synthesis and X-Ray Crystal Structure of the Dolabella auricularia Peptide Dolastatin 18. J. Org. Chem (2004).
George Pettit, J Xu, D Doubek, J Chapuis, J Schmidt. Antineoplastic Agents 510. Isolation and Structure of Dolastatin 19 from the Gulf of California Sea Hare Dolabella auricularia. J. Nat. Prod (2004).
George Pettit, J Xu, J Chapuis, R Pettit, L Tackett, D Doubek, J Hooper, J Schmidt. Antineoplastic Agents 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa. J. Med. Chem (2004).
George Pettit, L Pearce, H Hoffmann, D Herald, P Blumberg, E Hamel, J Schmidt, Y Chang, R Pettit, N Lewin. Antineoplastic Agents 499. Synthesis of Hystatin 2 and Related 1H-benzo[de][1,6]-Naphthyridinium Salts from Aaptamine. J. Med. Chem (2004).
George Pettit, N Melody, D Herald. Antineoplastic Agents 511. Direct Phosphorylation of Phenpanstatin and Pancratistatin. J. Nat. Prod (2004).
George Pettit, P Blumberg, R Pettit, J Knight, H Hoffmann, D Herald, J McNulty, A Murphy, K Higgs, E Hamel, N Lewin, L Pearce. Antineoplastic Agents 491. Synthetic Conversion of Aaptamine to Isoaaptamine, 9-Desmethylaaptamine,and 4-Methylaaptamine. J. Org. Chem (2004).
George Pettit, Q Zhang, V Pinilla, D Herald, D Doubek, J Duke. Isolation and Structure of Gustastatin from the Brazilian Nut Tree Gustavia hexapetala. J. Nat. Prod (2004).
George Pettit, R Tan, J Northen, D Herald, J Chapuis, R Pettit. Antineoplastic Agents 529. Isolation and Structure of Nootkastatins 1 and 2 from the Alaskan Yellow Cedar Chamaecyparis nootkatensis. J. Nat. Prod (2004).
George Pettit, T Nogawa, J Knight, D Doubek, J Hooper. Antineoplastic Agents 535. Isolation and Structure of Plakorstatins 1 and 2 from the Indo-Pacific Sponge Plakortis nigra. J. Nat. Prod (2004).
George Pettit, Y Meng, P Gearing, D Herald, R Pettit, D Doubek, J Chapuis, L Tackett. Antineoplastic Agents 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). J. Nat. Prod (2004).
I Kirwan, P Loadman, D Swaine, D Anthoney, George Pettit, J Lippert, S Shnyder, P Cooper, M Bibby. Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs: Combretastatin A4 Phosphate and A1 Phosphate. Clin. Cancer Res (2004).
J Binoy, J Abraham, I Joe, V Jayakumar, George Pettit, O Neilson. NIR-FT Raman and FT-IR Spectral Studies and Ab InitioCalculations of the Anti-cancer Drug Combretastatin A-4. J. Raman Spectroscopy (2004).
K Meilert, George Pettit, P Vogel. Non-iterative Asymmetric Synthesis of C15 Polyketide Spiroketals. Helv. Chim. Acta (2004).
L Dang, George Pettit, A Smith, H Gurulingappa, S Khan, G Parmigiani, K Kinzler, S Zhou, B Vogelstein, C Bettegowda, N Agrawal, I Cheong, D Huso, P Frost, F Loganzo, L Greenberger, J Barkoczy. Targeting Vascular and Avascular Compartments of Tumors with C. novyi-NT and Anti-Microtubule Agents. Cancer Biology and Therapy (2004).
M Suggitt, D Swaine, George Pettit, M Bibby. Characterization of the Hollow Fibre Assay for the Determination of Microtubule Disruption In Vivo. Clin. Cancer Res (2004).
R Bai, D Covell, J Kepler, T Copeland, N Nguyen, George Pettit, E Hamel. Direct Photoaffinity Labeling by Dolastatin 10 of the Amino Terminal Peptide of -Tubulin Containing Cysteine-12. J. Biol. Chem (2004).
R Pettit, B Fakoury, J Knight, C Weber, George Pettit, G Cage, S Pon. Antibacterial Activity of the Marine Sponge Constituent Cribrostatin 6. Journal of Medical Microbiology (2004).
T Woyke, M Berens, D Hoelzinger, George Pettit, G Winkelmann, R Pettit. Differential Gene Expression in Auristatin PHE- Treated Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy (2004).
U Rinner, H Hillebrenner, D Adams, T Hudlicky, George Pettit. Synthesis and Biological Activity of Some Structural Modifications of Pancratistatin. Bioorg. Med. Chem. Lett (2004).
U Rinner, T Hudlicky, H Gordon, George Pettit. A B-Carboline-1 - One Mimic of the Anticancer Amaryllidaceae Constituent Pancratistatin. Synthesis and Biological Evaluation. Angew. Chem (2004).
A Smith, Y Cho, George Pettit, R Hirschmann. Design, Synthesis and Evaluation of Azepine-based Cryptophycin Mimetics. Tetrahedron (2003).
B Fennell, S Carolan, George Pettit, A Bell. Effects of the Antimitotic Natural Product Dolastatin 10, and Related Peptides, on the Human Malarial Parasite Plasmodium falciparum. J. Antimicrobial Chemother (2003).
George Pettit, C Anderson, D Herald, M Jung, D Lee, E Hamel, R Pettit. Antineoplastic Agents 487. Synthesis and Biological Evaluation of the Antineoplastic Agent 3,4-Methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and Derived Amino Acid Amides. J. Med. Chem (2003).
George Pettit, Gordon Grado, Art Mollen, Gregory Muhammad, Philip Poling, Sid Rosen, James Sinek, Ralph Valle, Rex Zeiger, Daniel Hoff, Samuel Arutt, April Becker, C Gilberto Brito, Bert Chamberland, Gloria Dean, Gene Felker, Tom Fitch. Prostate Cancer. Medical White Paper/Assembled by Arizona Prostate Cancer Task Force (2003).
George Pettit, J Collins, J Knight, D Herald, R Nieman, M Williams, R Pettit. Antineoplastic Agents 485. The Isolation and Structure of Cribrostatin 6, a Dark Blue Cancer Cell Growth Inhibitor from the Marine Sponge Cribrochalina sp. J. Nat. Prod (2003).
George Pettit, N Melody, M Simpson, M Thompson, D Herald, J Knight. Antineoplastic Agents 500. Narcistatin. J. Nat. Prod (2003).
George Pettit, R Tan. Antineoplastic Agents 390. Isolation and Structure of Phakellistatin 12 from the Chuuk Archipelago Marine Sponge. Bioorg. Med. Chem. Lett (2003).
George Pettit, R Tan, D Herald, J Hamblin, R Pettit. Antineoplastic Agents 488. Isolation and Structure of Yukonin from a Yukon Territories Fungus. J. Nat. Prod (2003).
George Pettit, Y Meng, C Stevenson, D Doubek, J Knight, Z Cichacz, R Pettit, J Chapuis, J Schmidt. Isolation and Structure of Palstatin from the Amazon Tree Hymeneae palustris. J. Nat. Prod (2003).
George Pettit, Y Meng, D Herald, K Graham, R Pettit, D Doubek. Isolation and Structure of Reprechstyril from Ruprechtia tangarana. J. Nat. Prod (2003).
J Hua, Y Sheng, K Pinney, C Garner, R Kane, J Prezioso, George Pettit, D Chaplin, K Edvardsen. Oxi4503 A Novel Vascular Targeting Agent: Effects on Bloodflow and Antitumor Activity in Comparison to Combretastatin A-4 Phosphate. Anticancer Research (2003).
S Ali, O Aranha, Y Li, George Pettit, F Sarkar, P Philip. Sensitization of Human Breaast Cancer Cells to Gemcitabine by Protein Kinase C Modulator Bryostatin 1. Cancer Chemother. Pharmacol (2003).
S Shnyder, P Cooper, George Pettit, J Lippert, M Bibby. Combretastatin A-1 Phosphate Potentiates the Antitumour Activity of Cisplatin in a Murine Adenocarcinoma Model. Anticancer Res (2003).
V Dirsch, A Vollmar, I Muller, S Eichhorst, George Pettit, Y Kamano, M Inoue, J Xu, Y Ichihara, G Wanner. Cephalostatin 1 Selectivity Triggers the Release of Amac/DIABLO and Subsequent Apoptosis that is Characterized by an Increased Density of the Mitochondrial Matrix. Cancer Research (2003).
Z Cruz-Monserate, J Mullaney, P Harran, George Pettit, E Hamel. Dolastatin 15 Binds in the Vinca Domain of Tubulin As Demonstrated by Hummel-Dreyer Chromatography. Eur. J. Biochem (2003).
Z Cruz-Monserrate, W Fenical, E Hamel, H Vervoort, R Bai, D Newman, S Howell, G Los, J Mullaney, M Williams, George Pettit. Diazonamide A and A Synthetic Structural Analog: Disruptive Effocts on Mitosis and Cellular Microtubules and Analysis of their Interactions with Tubulin. Molecular Pharmacology (2003).
A Smith, R Corbett, George Pettit, J Chapuis, J Schmidt, E Hamel, M Jung. Synthesis and Biological Evaluation of a Spongistatin AB-Spiroketal Analog. Bioorg. Med. Chem. Lett (2002).
D Thamm, E MacEwen, B Phillips, A Hershey, K Burgess, George Pettit, D Vail. Preclinical Study of Dolastatin-10 in Dogs with Spontaneous Neoplasia. Cancer Chemother. Pharmacol (2002).
G Pettit, D Doubek, L Tackett, M Williams, S Ducki, R Tan, R Gardella, J McMahon, M Boyd, George Pettit, P Blumberg, N Lewin. Isolation and Structure of Pedilstatin from a Republic of Maldives Pedilanthus sp. J. Nat. Prod (2002).
George Pettit, A Numata, C Iwamoto, H Morito, T Yamada, A Goswami, P Clewlow, G Cragg, J Schmidt. Isolation and Structures of Meliastatins 1-5 and Related Euphane Triterpenes from the Philippine Tree Melia dubia. J. Nat. Prod (2002).
George Pettit, J Knight, D Herald, R Davenport, R Pettit, B Tucker, J Schmidt. Isolation of Labradorins 1 and 2 from Pseudomonas syringae p.v. coronafaciens. J. Nat. Prod (2002).
George Pettit, M Grealish, M Katherine Jung, E Hamel, R Pettit, J Chapuis, J Schmidt. Antineoplastic Agents 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate. J. Med. Chem (2002).
George Pettit, N Melody, D Herald, J Schmidt, R Pettit, J Chapuis. Synthesis of 10b(R)-Hydroxypancratistatin, 10b(S)-Hydroxy-1-Epipancratistatin, 10b(S)-Hydroxy-1,2-Diepipancratistatin and Related Isocarbostyrils. Heterocycles (2002).
R Bai, R Bates, E Hamel, R Moore, P Nakkiew, George Pettit, B Sufi. Lyngbyastatin 1 and Ibu-epilyngbyastatin 1: Synthesis, Stereochemistry and NMR Line Broadening. J. Nat. Prod (2002).
R Pettit, E Hamel, P Verdier-Pinard, R Roberson, K Hazen, George Pettit, L Crews. Antifungal and Cancer Cell Growth Inhibitory Activities of 1-(3',4',5-trimethoxyphenyl)-2-nitro-ethylene. Mycoses (2002).
S Hill, G Tozer, George Pettit, D Chaplin. Preclinical Evaluation of the Antitumour Activity of the Novel Vascular Targeting Agent Oxi 4503. Anticancer Research (2002).
S Holwell, P Cooper, K Grosios, J Lippert, George Pettit, S Shnyder, M Bibby. Combretastatin A-1 Phosphate a Novel Tubulin-Binding Agent with In Vivo Anti Vascular Effects in Experimental Tumours. Anticancer Research (2002).
S Holwell, P Cooper, M Thompson, George Pettit, J Lippert, S Martin, M Bibby. Anti-tumor and Anti-vascular Effects of the Novel Tubulin-binding Agent Combretastatin A-1 Phosphate. Anticancer Research (2002).
S Nabha, R Mohammad, M Dandashi, B Coupaye-Gerard, A Aboukameel, George Pettit, A Al-Katib. Combretastatin A-4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly (ADP-ribose) Polymerase Cleavage. Clinical Cancer Research (2002).
T Hudlicky, U Rinner, D Gonzalez, H Akgun, S Schilling, P Siengalewicz, T Martinot, George Pettit. Total Synthesis and Biological Evaluation of Amaryllidaceae Alkaloids: Narciclasine, ent-7-Deoxypancratistatin, Regioisomer of 7-Deoxypancratistatin, 10b-epi-Deoxypancratistatin, and Truncated Derivatives. J. Org. Chem (2002).
T Woyke, R Roberson, George Pettit, G Winkelmann, R Pettit. Effect of Auristatin PHE on Microtubule Integrity and Nuclear Localization in Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy (2002).
Y Kamano, M Katsuyama, George Pettit, A Yamashita, T Nogawa, H Morita, K Takeya, H Itokawa, T Segawa, A Yukita, K Saito. QSAR Evaluation of the Ch'an Su and Related Bufadienolides Against the Colchicine Resistant Primary Liver Carcinoma Cell Line PLC/PRF/5. Journal of Medicinal Chemistry (2002).
Y Kamano, T Nogawa, A Yamashita, M Hayashi, M Inoue, P Drasar, George Pettit. Isolation and Structure of a 20,21-Epoxybufenolide Series from Ch'an Su. J. Nat. Prod (2002).
Pettit, George Robert (Author) ,Herald, C L (Author) ,Hogan, F (Author) . Biosynthetic Products for Anticancer Drug Design and Treatment: The Bryostatins. Anticancer Drug Design (2002).
A Smith, Y Cho, L Zawacki, R Hirschmann, George Pettit. First Generation Design, Synthesis, and Evaluation of Azepine-Based Cryptophycin Analogs. Organic Letters (2001).
C Doerig, D Mazier, I Desportes-Livage, J Franetich, L Meijer, M Ouarzane-Amara, George Pettit. In Vitro Activities of Two Antimitotic Compounds, Pancratistatin and 7-Deoxynarciclasine, against Encephalitozoon intestinalis, a Microsporidium Causing Infections in Humans. Antimocrobial Agents and Chemotherapy (2001).
George Pettit, B Moser, M Boyd, J Schmidt, R Pettit, J Chapuis. Antineoplastic Agents 460. Synthesis of Combretastatin A-2 Prodrugs. Anticancer Drug Design (2001).
George Pettit, J Lippert, S Taylor, R Tan, M Williams. Synthesis of Phakellistatin 11: A Micronesia (Chuuk) Marine Sponge Cyclooctapeptide. J. Nat. Prod (2001).
George Pettit, M Grealish. Antineoplastic Agents 475. A Cobalt-Phosphine Complex Directed Reformatsky Approach to a Stereospecific Synthesis of the Dolastatin 10 Unit Dolaproine (Dap). J. Org. Chem (2001).
George Pettit, N Melody, D Herald. Antineoplastic Agents 450. Synthesis of (+)-Pancratistatin from (+)-Narciclasine as Relay. J. Org. Chem (2001).
J Duffield, George Pettit. Synthesis of (7S,15S)- and (7R,15S)-Dolatrienoic Acid. J. Nat. Prod (2001).
J McNulty, J Mao, R Gibe, R Mo, S Wolf, George Pettit, D Herald, M Boyd. Studies Directed Towards the Refinement of the Pancratistatin Pharmacophore. BioOrg. Med. Chem. Lett (2001).
R Bai, P Verdier-Pinard, S Gangwar, C Stressman, K McClure, E Sausville, George Pettit, R Bates, E Hamel. Dolastatin 11, a Marine Depsipeptide, Arrests Cells at Cytokinesis and Induces Hyperpolymerization of Purified Actin. Mol. Pharmacol (2001).
R Mohammad, N Adsay, P Philip, George Pettit, V Vaitkevicius, F Sarkar. Bryostatin 1 Induces Differentiation and Potentiates the Antitumor Effect of Auristatin PE in a Human Pancreatic Tumor (PANC-1) Xenograft Model. Anti-Cancer Drugs (2001).
S Nabha, R Mohammad, N Wall, J Dutcher, B Salkini, George Pettit, A Al-Katib. Evaluation of Combretastatin A-4 Prodrug in a Non-Hodgkin's Lymphoma Xenograft Model: Preclinical Efficacy. Anti-Cancer Drugs (2001).
T Nogawa, Y Kamano, A Yamashita, George Pettit. Isolation and Structure of Five New Cancer Cell Growth Inhibitory Bufadienolides from the Chinese Traditional Drug Ch'an Su. J. Nat. Prod (2001).
T Woyke, George Pettit, G Winkelmann, R Pettit. In Vitro Activities and Postantifungal Effects of the Potent Dolastatin 10 Derivative Auristatin PHE. Antimicrobial Agents and Chemotherapy (2001).
Y Kamano, T Nogawa, A Yamashita, George Pettit. The 1H-and 13C-NMR Chemical Shift Assignments for Thirteen Bufadienolides Isolated from the Traditional Chinese Drug Ch'an Su. Coll. Czech. Chem. Commun (2001).
Pettit, George Robert (Author) . Evolutionary Biosynthesis of Anticancer Drugs. Anticancer Agents: Frontiers in Cancer Chemotherapy (2001).
B Toki, D Brune, J Xu, George Pettit. Synthesis of the Marine Sponge Cyclo-Heptapeptide Phakellistatin 5. J. Nat. Prod (2000).
C Chen, C Karanes, George Pettit, B Chen. Human THP-1 Monocytic Leukemic Cells Induced to Undergo Monocytic Differentiation by Bryostatin 1 are Refractory to Proteasome Inhibitors-Induced Cytochrome C-Dependent Apoptosis. Cancer Research (2000).
George Pettit, A Goswami, A Numata, G Cragg, D Herald, T Takada, C Iwamoto, R Riesen, J Schmidt, D Doubek. Isolation and Structure of Schleicherastatins 1-7 and Schleicheols 1-2 from the Teak Forest Medicinal Tree Schleichera oleosa. J. Nat. Prod (2000).
George Pettit, J Knight, J Collins, D Herald, R Pettit, M Boyd, V Young. Antineoplastic Agents 430. Isolation and Structure of Cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina sp. (Porifera). J. Nat. Prod (2000).
George Pettit, J Lippert. Antineoplastic Agents 429. Synthesis of Combretastatin A-1 and Combretastatin B-1 Prodrugs. Anti-Cancer Drug Design (2000).
George Pettit, J Lippert, D Herald. A Pinacol Rearrangement/Oxidation Synthetic Route to Hydroxyphenstatin. J. Org. Chem (2000).
George Pettit, J Lippert, D Herald, E Hamel, R Pettit. Antineoplastic Agents 440. Asymmetric Synthesis and Evaluation of the Combretastatin A-1 SAR Probes (1S,2S) and 1R,2R)-1-2-Dihydroxy-1- (2',3'-dihydroxy-4'-methoxyphenyl)-2-(3",4",5"-trimethoxyphenyl)-ethane. J. Nat. Prod (2000).
George Pettit, J Lippert, M Boyd, P Verdier-Pinard, E Hamel. Antineoplastic Agents 442. Synthesis and Biological Activities of Dioxostatin. Anti-Cancer Drug Design (2000).
George Pettit, M Grealish, D Herald, M Boyd, E Hamel, R Pettit. Antineoplastic Agents 443. Synthesis of the Cancer Cell Growth Inhibitor Hydroxyphenstatin and Its Sodium Diphosphate Prodrug. J. Med. Chem (2000).
George Pettit, M Minardi, M Boyd, R Pettit. Antineoplastic Agents 463. Synthesis of Combretastatin A-3 Diphosphates. Anticancer Drug Design (2000).
George Pettit, S Ducki, B Orr. Antineoplastic Agents 453. Synthesis of Pancratistatin Prodrugs. Anti-Cancer Drug Design (2000).
H Clarke, N Ginanni, K Laughlin, J Smith, George Pettit, J Mullin. The Transient Increase of Tight Junction Permeability Induced by Bryostatin 1 Correlates with Rapid Downregulation of Protein Kinase C-. Exptl. Cell Res (2000).
J Beutler, K McCall, K Herbert, D Herald, George Pettit, T Johnson, R Shoemaker, M Boyd. Novel Cytotoxic Diterpenes from Casearia arborea (Flacourtiaceae). J. Nat. Prod (2000).
K Grosios, P Loadman, D Swaine, George Pettit, M Bibby. Combination Chemotherapy with Combretastatin A-4 Phosphate and 5-Fluorouracil in an Experimental Murine Colon Adenocarcinoma. Anticancer Res (2000).
K Pinney, M Mejia, V Villalobos, George Pettit, B Rosenquist, P Verdier-Pinard, E Hamel. Synthesis and Biological Evaluation of Aryl Azide Derivatives of Combretastatin A-4 as Molecular Probes for Tubulin. Bioorg. Med. Chem (2000).
L Meijer, Y Wu, J Biernat, E Mandelkow, S Kim, George Pettit, A H Thunissen, A White, M Garnier, M Nikolic, L Tsai, J Walter, K Cleverley, P Salinas. Inhibition of ciclin-dependent kinases, GSK-3 and CK1 by Hymenialdisine, a Marine Sponge Constituent. Chemistry and Biology (2000).
P Lorenzo, M Beheshti, George Pettit, J Stone, P Blumberg. The Guanine Nucleotide Exchange Factor RasGRP is a Novel, High Affinity Target for Diacylglycerol and Phorbol Esters. Molecular Pharmacology (2000).
P Verdier-Pinard, J Kepler, George Pettit, E Hamel. Sustained Intracellular Retention of Dolastatin 10 Causes its Potent Antimitotic Activity. Molecular Pharmacology (2000).
R Pettit, G Cage, George Pettit, J Liebman. Antimicrobial and Cancer Cell Growth Inhibitory Activities of 3 -acetoxy-17 -(L-propyl)amino-5 -androstane. Antimicrobial Agents and Chemotherapy (2000).
S Idso, B Kimball, George Pettit, L Garner, R Backhaus. Effects of Atmospheric CO2 Enrichment on the Growth and Development of Hymenocallis littoralis (Amaryllidaceae) and the Concentrations of Several Antineoplastic and Antiviral Constituents of its Bulbs. Amer. J. Botany (2000).
S Nabha, N Wall, R Mohammad, George Pettit, A Al-Katib. Effects of Combretastatin A-4 Prodrug Against a Panel of Malignant Human B-Lymphoid Cell Lines. Anticancer Drugs (2000).
Y Kamano, A Kotake, T Nogawa, H Hiraide, George Pettit, C Herald. Separation of the Bryostatin Derivatives by High Performance Liquid Chromatography. J. Liq. Chrom. And Rel. Technol (2000).
Y Kamano, A Yamashita, H Takeuchi, K Kohyama, T Nogawa, George Pettit. Analysis of the Toad Poison Bufadienolides by Rod-Thin-Layer Chromatography with Flame Ionization Detector. Research Institute for Integrated Science, Kanagawa University (Japan) (2000).
Z Chen, V Mocharla, J Farmer, George Pettit, P Verdier-Pinard, E Hamel, K Pinney. Preparation of New Anti-Tubulin Ligands Through a Dual-Mode, Addition-Elimination Reaction to a Bromo-Substituted , -Unsaturated Sulfoxide. J. Org. Chem (2000).
Z He, J Evelhoch, R Mohammad, N Adsay, George Pettit, V Vaitkevicius, F Sarkar. Magnetic Resonance Imaging to Measure Therapeutic Response Using an Orthotopic Model of Human Pancreatic Cancer. Pancreas (2000).
George R Pettit, Noeleen Melody, Jean-Charles Chapuis. Antineoplastic Agents 606. The Beulastatins. Journal of Natural Products (2018).
George R Pettit, Noeleen Melody, Jean-Charles Chapuis. Antineoplastic Agents 605. Isoquinstatins. Journal of Natural Products (2018).

Research Activity

Pettit,George Robert*, Melody,Noeleen. Discovery of Powerful Anticancer Drugs for Monoclonal Anticancer Drugs (ADC) Development Capable of Improving Cancer Treatments. AZ DEPT OF HEALTH SERVICES(10/23/2014 - 10/22/2017).
Pettit,George Robert*. Cancer Research. KIECKHEFER FDN(12/18/2009 - 4/30/2012).
Pettit,George Robert*. Molecular Targeting of Prostate Cancer Vasculature: A New Approach to Treatment. ABRC(7/1/2009 - 6/30/2010).
Pettit,George Robert*. Molecular Targeting of Prostate Cancer Vasculature: A New Approach to Treatment. ABRC(7/1/2008 - 9/30/2009).
Pettit,George Robert*. Molecular Target Focused Discovery of Anticancer Drugs. HHS-NIH-NCI(9/1/2007 - 9/30/2011).
Pettit,George Robert*. Molecular Targeting of Prostate Cancer Vasculature: A New Approach to Treatment. ABRC(7/1/2007 - 12/31/2008).
Pettit,George Robert*. Discovery of Naturally Occurring Anti-Cancer and Anti-Infective Drugs. RIPPEL (FANNIE) FDN(8/1/2005 - 7/31/2007).
Pettit,George Robert*. F&A for MPS0113-Discovery of Naturally Occurring Anti-Cancer and Anti-Infective Drugs. MISC PRIVATE INDIVIDUALS(8/1/2005 - 7/31/2007).
Pettit,George Robert*. ANTICANCER DRUG PRECLINICAL DEVELOPMENT (year 3). ABRC(7/1/2005 - 6/30/2006).
Pettit,George Robert*. DEVELOPMENT OF NEW ANTICANCER DRUGS FOR IMPROVING HUMAN CANCER TREATMENT (YEAR 3). ABRC(7/1/2004 - 6/30/2005).
Pettit,George Robert*. ANTICANCER DRUG PRECLINICAL DEVELOPMENT (YEAR 2). ABRC(7/1/2004 - 6/30/2005).
Pettit,George Robert*. Marine Animal Collecting and Recollecting. RIPPEL (FANNIE) FDN(5/1/2004 - 12/31/2006).
Pettit,George Robert*. Marine Animal Collecting and Recollecting; Continuation of MPS0031. RIPPEL (FANNIE) FDN(5/1/2004 - 12/31/2006).
Chang,Yung*, Brophy,Colleen M, Jacobs,Bertram Lewis, Misra,Rajeev, Pettit,George Robert, Sierks,Michael Richard, Zautra,Alex John. THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR(4/1/2004 - 3/31/2005).
Pettit,George Robert*. DEVELOPMENT OF NEW ANTICANCER DRUGS FOR IMPROVING HUMAN CANCER TREATMENT (YEAR 2). ABRC(7/1/2003 - 6/30/2004).
Pettit,George Robert*. ANTICANCER DRUG PRECLINICAL DEVELOPMENT (YEAR 1). ABRC(7/1/2003 - 6/30/2004).
Pettit,George Robert*. MARINE ANIMAL COLLECTING & RECOLLECTING. RIPPEL (FANNIE) FDN(9/17/2002 - 12/31/2004).
Pettit,George Robert*. ACCELERATED DISCOVERY & DEVELOPMENT TO CLINICAL TRIALS OF NEW ANTICANCER DRUGS. ABRC(7/1/2002 - 6/30/2003).
Pettit,George Robert*. DEVELOPMENT OF NEW ANTICANCER DRUGS FOR IMPROVING HUMAN CANCER TREATMENT (YEAR 1). ABRC(7/1/2002 - 6/30/2003).
Pettit,George Robert*. ACCELERATED DISCOVERY AND DEVELOPMENT TO CLINICAL TRIALS OF NEW ANTICANCER DRUGS: RENEWAL. ABRC(7/1/2001 - 6/30/2002).
Pettit,George Robert*. DEVELOPMENT OF NEW ANTICANCER DRUGS FOR IMPROVING TREATMENT OF TOBACCO RELATED CANCER. ABRC(7/1/2001 - 6/30/2002).
Pettit,George Robert*. MARINE ANIMAL COLLECTING & RECOLLECTING. RIPPEL (FANNIE) FDN(5/17/2001 - 12/31/2003).
Pettit,George Robert*, Pettit,George Robert*. MOLECULAR TARGET FOCUSED DISCOVERY OF ANTICANCER DRUGS. HHS-NIH-NCI(4/1/2001 - 3/31/2005).
Pettit,George Robert*. Molecular Target Focused Discovery of Anticancer Drugs Continuation of MPA8929. HHS-NIH-NCI(4/1/2001 - 3/31/2006).
Pettit,George Robert*, Herald,Cherry Lou. ACCELERATED DISCOVERY AND DEVELOPMENT TO CLINICAL TRIALS OF NEW ANTICANCER DRUGS. ABRC(7/1/2000 - 6/30/2001).
Pettit,George Robert*. MARINE ANIMAL COLLECTION. RIPPEL (FANNIE) FDN(12/10/1999 - 12/31/2003).
Pettit,George Robert*, Herald,Cherry Lou. ACCELERATED DISCOVERY AND DEVELOPMENT TO CLINICAL TRIALS OF NEW ANTICANCER DRUGS. ABRC(7/1/1999 - 6/30/2001).
Pettit,George Robert*. PRECLINICAL DEVELOPMENT OF NEW ANTICANCER DRUGS NECESSARY TO IMPROVING TREATMENT OF TOBACCO RELATED HUMAN CANCER. ABRC(7/1/1999 - 6/30/2000).
Pettit,George Robert*, Herald,Cherry Lou. ACCELERATED DISCOVERY AND DEVELOPMENT TO CLINICAL TRIALS OF NEW ANTICANCER DRUGS. ABRC(4/14/1999 - 6/30/2000).
Pettit,George Robert*. SYNTHESIS OF CEPHALOSTATIN 1. HHS-NIH-CSR(4/1/1999 - 9/26/2003).
Pettit,George Robert*. PRECLINICAL DEVELOPMENT OF NEW ANTICANCER DRUGS NECESSARY TO IMPROVING TREATMENT OF TOBACCO RELATED HUMAN CANCER. ABRC(7/1/1998 - 6/30/1999).
Pettit,George Robert*. MARINE ANIMAL COLLECTIONS. RIPPEL (FANNIE) FDN(6/16/1998 - 12/31/2002).
Pettit,George Robert*. PRECLINICAL DEVELOPMENT OF NEW ANTICANCER DRUGS NECESSARY TO IMPROVING TREATMENT. ABRC(5/16/1997 - 6/30/1998).
Pettit,George Robert*. MARINE ANIMAL COLLECTION. RIPPEL (FANNIE) FDN(3/21/1997 - 12/31/2001).
Pettit,George Robert*. EXPANSION OF THE CANCER RESEARCH INSTITUTE AT ASU (PHASE II & III). HHS-NIH-NCI(8/16/1996 - 12/31/2000).
Pettit,George Robert*. DISCOVERY AND DEVELOPMENT OF NEW ANTICANCER DRUGS (RENEWAL). ABRC(7/1/1996 - 6/30/1997).
Pettit,George Robert*. DISCOVERY AND DEVELOPMENT OF NEW ANTICNACER DRUGS: TOBACCO TAX RESERACH FUNDING SUPPLEMENT--SPONGISTATINS. ABRC(7/1/1996 - 6/30/1997).
Pettit,George Robert*. DISCOVERY AND DEVELOPMENT OF NEW ANTICANCER DRUGS: TOBACCO TAX RESERCH FUNDING SUPPLEMENT--DOLASTATIN CLINICAL SUPPLIES. ABRC(7/1/1996 - 6/30/1997).
Pettit,George Robert*. MARINE ANIMAL COLLECTION. RIPPEL (FANNIE) FDN(5/14/1996 - 12/31/1999).
Pettit,George Robert*. TOBACCO TAX RESEARCH FUNDING SUPPLEMENTAL PROPOSAL. ABRC(2/8/1996 - 6/30/1996).
Pettit,George Robert*. DISCOVERY & DEVELOPMENT OF NEW ANTI-CANCER DRUGS. ABRC(7/1/1995 - 6/30/1996).
Pettit,George Robert*. MARINE ANIMAL COLLECTIONS. RIPPEL (FANNIE) FDN(5/8/1995 - 12/31/1996).
Pettit,George Robert*. DISCOVERY & DEVELOPMENT OF NEW ANTICANCER DRUGS. ABRC(7/1/1994 - 6/30/1995).
Pettit,George Robert*. NIH P.O.-DOLASTATIN-10. HHS-NIH-NCI(1/24/1994 - 12/31/1995).
Pettit,George Robert*. MARINE ANIMAL COLLECTION. RIPPEL (FANNIE) FDN(12/7/1993 - 12/31/1997).
Pettit,George Robert*. NIH P.O.-DOLASTATIN 10. HHS(8/12/1993 - 12/31/1995).
Pettit,George Robert*. DISCOVERY & DEVELOPMENT OF NEW ANTICANCER DRUGS. ABRC(7/1/1993 - 6/30/1994).
Pettit,George Robert*. MARINE ANIMAL COLLECTION. RIPPEL (FANNIE) FDN(7/15/1992 - 12/31/1994).
Pettit,George Robert*. DISCOVERY AND DEVELOPEMENT OF NEW ANTICANCER DRUGS. ABRC(7/1/1992 - 6/30/1993).
Pettit,George Robert*. MIAMI-NATIONAL/COOPERATIVE DRUG DISCOVERY GROUP--AIDS. UNIV OF MIAMI(9/1/1991 - 8/31/1992).
Pettit,George Robert*. DISCOVERY AND DEVEL OF NEW ANTICANCER DRUGS. ABRC(7/1/1991 - 6/30/1992).
Pettit,George Robert*. DISCOVERY & DEVELPMT OF THERAPUTIC DRUGS AGST HUMAN RNA VIRU. DOD-ARMY(6/28/1991 - 9/30/1991).
Pettit,George Robert*. MARINE ANIMAL COLLECTIONS. RIPPEL (FANNIE) FDN(6/18/1991 - 12/31/1993).
Pettit,George Robert*. NIH PURCHASE ORDER-DOLOSTATIN 10. HHS(12/5/1990 - 12/4/1992).
Pettit,George Robert*. MIAMI-NATIONAL/COOPERATIVE DRUG DISCOVERY GROUP-AIDS. UNIV OF MIAMI(9/1/1990 - 8/31/1991).
Pettit,George Robert*. DISCOVERY AND DEVELOPMENT OF NEW ANTICANCER DRUGS. ABRC(7/1/1990 - 6/30/1991).
Pettit,George Robert*. NCI OUTSTANDING INVESTIGATOR GRANT. HHS-NIH-NCI(6/1/1990 - 3/31/2001).
Pettit,George Robert*. 1990 MARINE ANIMAL COLLECTIONS. RIPPEL (FANNIE) FDN(1/12/1990 - 2/19/1992).
Pettit,George Robert*. NATIONAL COOPERATION DRUG DISCOVERY GROUP-AIDS. UNIV OF MIAMI(9/1/1989 - 8/31/1990).
Pettit,George Robert*. NCI OUTSTANDING INVESTIGATOR AWARD. HHS(6/1/1989 - 3/31/2001).
Pettit,George Robert*. NCI OUTSTANDING INVESTIGATOR AWARD. HHS-NIH-NCI(6/1/1989 - 3/31/2001).
Pettit,George Robert*. DEPARTMENT OF ARMY (USA MR11D) PURCHASE ORDER. DOD-ARMY(5/15/1989 - 5/14/1990).
Pettit,George Robert*. DISCOVERY & DEVELPMT OF THERAPEUTIC DRUGS AGAINST LETHAL RNA. DOD-ARMY(2/6/1989 - 7/5/1991).
Pettit,George Robert*. MARINE COLLECTIONS. RIPPEL (FANNIE) FDN(1/12/1989 - 6/30/1991).
Pettit,George Robert*. MARINE ANIMAL ANTINEOPLASTIC CONSTITUENTS. HHS(12/1/1988 - 11/30/1989).
Pettit,George Robert*. NAT COOP DRUG DISCOVERY GROUP FOR TREATMENT OF AIDS. UNIV OF MIAMI(9/1/1988 - 8/31/1989).
Pettit,George Robert*. DISCOVERY & DEVELOPMENT OF NEW ANTICANCER DRUGS. ABRC(7/1/1988 - 6/30/1990).
Pettit,George Robert*. MARINE COLLECTIONS. RIPPEL (FANNIE) FDN(1/12/1988 - 6/30/1990).
Pettit,George Robert*. MARINE ANIMAL ANTINEOPLASTIC CONSTITUENTS. HHS(12/1/1987 - 11/30/1988).
Pettit,George Robert*. NATL COOP DRUG DISCOVERY GROUPS FOR TREATMENT OF AIDS SYNDRM. UNIV OF MIAMI(10/1/1987 - 8/31/1988).
Pettit,George Robert*. PLANT ANTINEOPLASTIC CONSTITUENTS. HHS(9/1/1987 - 11/30/1988).
Pettit,George Robert*. DISCOVERY AND DEVELOPMENT OF NEW ANTICANCER DRUGS. ABRC(7/1/1987 - 6/30/1988).
Pettit,George Robert*. CHEMICAL SPECIMEN EVALUATION. DUPONT-NEMOURS CO(12/20/1985 - 12/31/2001).
Pettit,George Robert*. MARINE ANIMALS. HHS(8/15/1984 - 9/30/1987).

Presentations

G. R. Pettit. "From Africa to New ADC Anticancer Candidates". World ADC San Francisco (Oct 2013).
G. R. Pettit. "From a Marine Mollusc to the Clinic: The Discovery of ADCETRIS and other ADC Frontiers". World ADC (Oct 2012).
G. R. Pettit. "From A Sea Hare To Global Clinics". ICNPR 2012 (Jul 2012).
Pettit, George. The Combretastins Marine Organism Anti-Cancer Drugs. (Oct 2006).
Pettit, George. The Bryostatins. Arizona Cancer Research Symposium (Nov 2004).
Pettit, George. Adventures in Chemistry. Central Arizona Local Section of American Chemical Society (Oct 2004).
Pettit, George. Temperature-Responsive Delivery systems for Phenstatin. Controlled Release Society Meeting

Service

Committee on General Chemistry Instructional Support, Member (2012 - Present)
Ohio State University College of Pharmacy, Research Advisory Board (2007 - Present)
Ohio State University College of Pharmacy, Research Advisory Board (2007 - Present)
Oregon State University, Advisor to the VP for Research (2006 - Present)
Oregon State University, Advisor to the VP for Research (2006 - Present)
Committee on Graduate Programs, Member (2006 - Present)
International Cancer Advocacy Network, Chairman Scientific Advisory Board (1998 - Present)
International Cancer Advocacy Network, Chairman, Scientific Advisory Council (1998 - Present)
International Cancer Advocacy Network, Chairman, Scientific Advisory Council (1998 - Present)
Current Organic Chemistry, Editorial board (1997 - Present)
Current Organic Chemistry, Editorial board (1997 - Present)
Oncology Research, Editorial Board (1995 - Present)
European Organization for Research and Treatment of Cancer (EORTC), Corresponding Member (1990 - Present)
European Organization for Research and Treatment of Cancer (EORTC), Corresponding Member (1990 - Present)
Oncology Research, Editorial board (1990 - Present)
Oncology Research, Editorial board (1990 - Present)
Journal of Natural Products, Editorial Board (1984 - Present)
Journal of Natural Products, Editorial Board (1984 - Present)
Synthetic Communications, Editorial Board (1976 - Present)
Synthetic Communications, Editorial Board (1976 - Present)
American Institute of Chemists, Fellow (1970 - Present)
American Institute of Chemists, Fellow (1970 - Present)
ASU/Arizona Technology Enterprise, Licensing Negotiations and assisting ASU and the public in litigation (2014 - 2014)
AzTE License, Assisted in Licensing negotiations/ASU Lawsuite (2013 - 2013)
Arizona Prostate Cancer Task, Co-Director, Chair in odd-numbered years (2003 - 2005)
American Association for Cancer Research, Member (2003 - 2004)
American Chemical Society, Member (2003 - 2004)
American Pharmacognosy Society, Member (2003 - 2004)
American Society of Clinical Oncology, Member (2003 - 2004)
Oncology Research, Editorial Board (2003 - 2004)
Phi Lambda Upsilon, Member (2003 - 2004)
The Chemical Society (London), Member (2003 - 2004)
Cancer Research Institute, Dir. 1/1/04 through 4/28/04 - Regent's Prof.of Chemistry/Dalton Prof. of Cancer Res. Medicinal Chemistry (2004)
Graduate Committee, member (2004)
U. S. National Cancer Institute and National Institutes of Health, Ad hoc Advisor (2004)
Bioorganic and Medicinal Chemistry, Reviewer (2003)
British Journal of Cancer, Reviewer (2003)
Cancer Research Institute, Director/Regent's Professor of Chemistry (2003)
Dean's Administrative Council and Biotech Committee, Member (2003)
Journal of Organic Chemistry, Reviewer (2003)
Journal of the American Chemical Society, Reviewer (2003)
U. S. National Cancer Institute and National Institutes of Health, Consultant (2003)
U.S. National Cancer Institute, Scientific Reviewer (2003)
Walter Reed Medical Research Institute, Scientific Reviewer (2003)

Expertise Areas

Cancer

Organic Chemistry