Carlo Maley

• Walther, V., Hiley, C.T., Shibata, D., Swanton, C., Turner, P.E., and Maley C.C.: Can oncology recapitulate paleontology? Lessons from species extinctions. Nature Reviews Clinical Oncology, Published online: 17 February 2015 | doi:10.1038/nrclinonc.2015.12
• Aktipis, C.A., Boddy, A.M., Gatenby, R.A., Brown, J.S., Maley, C.C.: Life history tradeoffs in cancer evolution. Nature Reviews Cancer, 13:883-892, 2013.
• Kostadinov, R.L., Kuhner, M.K., Li, X., Sanchez, C.A., Galipeau, P.C., Paulson, T.G., Sather, C.L., Srivastava, A., Odze, R.D., Blount, P.L., Vaughan, T.L., Reid, B.J., Maley, C.C.: NSAIDs modulate clonal evolution in Barrett’s esophagus. PLOS Genetics, 9:e1003553, 2013. PMCID: PMC3681672
• Greaves, M. & Maley, C.C.: Clonal evolution in cancer. Nature. 481:306-313, 2012. PMCID: PMC3367003
• Caulin, A.F. and Maley, C.C.: Peto's Paradox: Evolution's Prescription for Cancer Prevention. Trends in Evolution and Ecology, 26:175-82, 2011. PMCID: PMC3060950

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• Maley, C.C., Koelble, K., Natrajan, R., Aktipis, A., Yuan, Y. An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer. Breast Cancer (2105).
• Andor, N., Graham, T.A., Jansen, M., Xia1, L.C., Aktipis, C.A., Petritsch, C., Ji*, H.P., Maley*, C.C. Pan-cancer analysis of the extent and consequences of intra-tumor heterogeneity. Nature Medicine (2016).
• Abegglen, L.M., Caulin, A.F., Chan, A., Lee, K., Robinson, R., Campbell, M.S., Kiso, W.K., Schmitt, D.L., Waddell, P.J., Bhaskara, S., Jensen, S.T., Maley*, C.C., Schiffman*, J. D. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA (2015).
• Aktipis, C.A., Boddy, A.M., Jansen, G., Hibner, U., Hochberg, M.E., Maley, C.C., Wilkinson, G.S. Cancer across the tree of life: Cooperation and cheating in multicellularity. Philosophical Transactions of the Royal Society of London B (2015).
• Caulin, A.F., Graham, T.A., Wang., L.-S., Maley, C.C. Solutions to Peto’s Paradox Revealed by Mathematical Modeling and Cross-Species Cancer Gene Analysis. Philosophical Transactions of the Royal Society of London B (2015).
• Li, X., Paulson, T.P., Galipeau, P.C., Sanchez, C.A., Liu, K., Kuhner, M.K., Maley, C.C., Self, S.G., Vaughan, T.L., Reid, B.J., Blount, P.L. Assessment of esophageal adenocarcinoma risk using somatic chromosome alterations in longitudinal samples in Barrett's esophagus. Cancer Prevention Research (2015).
• Nunney, L., Maley, C.C., Breen, M., Hochberg, M.E., Schiffman, J.D. Peto’s paradox and the promise of comparative oncology. Philosophical Transactions of the Royal Society of London B (2015).
• Paguirigan, A.L., Smith, J., Meshinchi, S., Carroll, M., Maley, C.C., Radich, J.P. Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia. Science Translational Medicine (2015).
• Timmer*, M.R., Martinez*,P., Lau, C.T., Westra, W.M., Silvia Calpe1, Rygiel, A.M., Rosmolen, W.D., Meijer, S.L., ten Kate, F.J.W., Dijkgraaf, M.G.W., Mallant-Hent, R.C., Naber, A.H.J., van Oijen, A.H.A.M., Baak, L.C., Scholten, P., Böhmer, C.J.M., Fockens, P., Maley, C.C., Graham, T.A., Bergman, J.J.G.H.M., Krishnadath, K.K. Derivation of Genetic Biomarkers for Cancer Risk Stratification in Barrett's Oesophagus: A Prospective Cohort Study. Gut (2015).
• Walther, V., Hiley, C.T., Shibata, D., Swanton, C., Turner, P.E., and Maley, C.C. Can oncology recapitulate paleontology? Lessons from species extinctions. Nature Reviews Clinical Oncology (2015).
• . Cancer across life: Peto's paradox and the promise of comparative oncology. (2015).
• Alcock, J., Maley, C.C., Aktipis, C.A. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays (2014).
• Li, X., Galipeau, P.C., Sanchez, C.A., Paulson, T.P., Arnaudo, J., Liu, K., Sather, C.L., Kostadinov, R.L., Odze, R.D., Kuhner, M.K., Maley, C.C., Self, S.G., Vaughan, T.L., Blount, P.L., Reid, B.J. Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus. Cancer Prevention Research (2014).
• Aktipis, C.A., Boddy, A.M., Gatenby, R.A., Brown, J.S., Maley, C.C. Life history tradeoffs in cancer evolution. Nature Reviews Cancer (2013).
• Datta, R.S., Gutteridge, A., Swanton, C., Maley, C.C., Graham, T.A. Modeling the evolution of genetic instability during tumour progression. Evolutionary Applications (2013).
• Kostadinov, R.L., Kuhner, M.K., Li, X., Sanchez, C.A., Galipeau, P.C., Paulson, T.G., Sather, C.L., Srivastava, A., Odze, R.D., Blount, P.L., Vaughan, T.L., Reid, B.J., Maley, C.C. NSAIDs modulate clonal evolution in Barrett’s esophagus. PLoS Genetics (2013).
• Sprouffske, K., Aktipis, C.A., Radich, J.P., Carroll, M., Nedelcu, A.M., Maley, C.C. An evolutionary explanation for the presence of cancer non-stem cells in neoplasms. Evolutionary Applications (2013).
• Greaves, M. and Maley, C.C. Clonal evolution in cancer. Nature (2012).
• Kosoff, R.E., Gardiner, K.L., Merlo, L.M.F., Pavlov, K., Rustgi, A.K., Maley, C.C. Development and Characterization of an Organotypic Model of Barrett’s Esophagus. Journal of Cellular Physiology (2012).
• Roche, B., Hochberg, M.E., Caulin, A.F., Maley, C.C., Gatenby, R.A., Missé, D., Thomas, F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer (2012).
• Sprouffske, K., Merlo, L.M.F., Gerrish, P.J., Maley, C.C., Sniegowski, P.D. Cancer in light of experimental evolution. Current Biology (2012).
• Aktipis, C.A., Kwan, V.S.Y., Johnson, K.A., Neuberg, S.L., Maley, C.C. Overlooking evolution: A systematic analysis of cancer relapse and therapeutic resistance research. PLoS ONE (2011).
• Aktipis, C.A., Maley, C.C., Pepper, J.W. Dispersal evolution in neoplasms: The role of disregulated metabolism in the evolution of cell motility. Cancer Prevention Research (2011).
• Chen, J., Sprouffske, K., Huang, Q., Maley C.C. Solving the puzzle of metastasis: The evolution of cell migration in neoplasms. PLoS ONE (2011).
• Martens, E.A., Kostadinov, R., Maley, C.C., Hallatschek, O. Spatial structure increases the waiting time for cancer. New Journal of Physics (2011).
• Merlo, L.M.F., Kosoff, R.E., Gardiner, K.L., Maley, C.C. An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition. BMC Cancer (2011).
• Sprouffske, K., Pepper, J. W. & Maley, C. C. Accurate reconstruction of the temporal order of mutations in neoplastic progression. Cancer Prevention Research (2011).
• Lai, L.A., Kostadinov, R., Barrett, M.T., Peiffer, D.A., Pokholok, D., Odze, R.D., Sanchez, C.A., Maley, C.C., Reid, B.J., Gunderson, K., Rabinovitch, P.S. Deletion at fragile sites is a common and early event in Barrett's Esophagus. Mol Cancer Res (2010).
• Merlo, L.M.F., Shah, N.A., Li, X., Blount, P., Vaughan, T.L., Reid, B.J., Maley, C.C. A comprehensive survey of clonal diversity measures in Barrett’s esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prevention Research (2010).
• Paulson, T.G., Maley, C.C., Chao, D., Li, X., Li, X., Zhang, G., Sanchez, C.A. Odze, R., Vaughan, T., Blount, P., Ayub, K., Reid, B.J. Copy number alterations in Barrett’s esophagus and esophageal adenocarcinoma. Clinical Cancer Research (2009).
• Pepper, J.W., Findlay, C.S., Kassen, R., Spencer, S.L., and Maley, C.C. Cancer research meets evolutionary biology. Evolutionary Applications (2009).
• Liu, Z., Venkatesh, S.S., Maley, C.C. Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples. BMC Genomics (2008).