Jitendran Muthuswamy

Associate Professor,

School of Biological and Health Systems Engineering

Other ASU affiliations

School of Life Sciences Interdisciplinary Graduate faculty

Biodesign Center for Biomaterials Innovation and Translation

ISTB1 181A ,
Mail code: 9709

Campus: Tempe
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Long Bio

Jitendran (Jit) Muthuswamy is an associate professor in the School of Biological and Health System's Engineering and directs the Neural Microsystems laboratory. He is focused on understanding the cellular and molecular mechanisms of pain transmission in migraine and neuromodulation approaches to mitigate migraine pain. He is also focused on methods and devices that interface with neurons and modulate their function under chronic conditions.

He obtained his BTech degree in Electronics and Electrical Communication Engineering from Indian Institute of Technology (IIT), Kharagpur, India and his Masters degrees in Electrical Engineering, and Biomedical Engineering and his PhD in Biomedical Engineering from Rensselaer Polytechnic Institute, Troy, NY. He did his post-doctoral fellowship in Biomedical Engineering at Johns Hopkins University, Baltimore, MD. His research interests are in the areas of Neural interfaces and Neuromodulation. He is also an Associate Editor of Frontiers in Neuroscience, and PLOS One and emeritus Associate editor of IEEE Transactions of Neural systems and Rehabilitation Engineering.

Education

Post-doctoral fellowship, Johns Hopkins University, Baltimore, MD
Ph.D. Rensselaer Polytechnic Institute, Troy, NY
M.S. Rensselaer Polytechnic Institute, Troy, NY
B. Tech. Indian Institute of Technology, India

Research Website URL

https://www.public.asu.edu/~jmuthus/lab/

Google Scholar URL

https://scholar.google.com/citations?user=kR9HOOkAAAAJ&hl=en&oi=ao

Research Interests

Neuromodulation therapies for migraine pain
Neural interfaces for long-term applications
Cellular and Molecular mechanisms of neuromodulation
Intracranial pressure - methods for monitoring and mechanics of brain tissue

Publications

M Khraiche*, J Rogul* and J Muthuswamy, “Design and Development of Microscale Thickness Shear Mode (TSM) Resonators for Sensing Neuronal Adhesion,” Frontiers in Neuroscience, 13:518, 2019, doi: 10.3389/fnins.2019.00518.
A Sridharan*, A Shah*, S Sampath Kumar*, J Kyeh*, J Smith, J Blain-Christen and J Muthuswamy, “Optogenetic modulation of cortical neurons using organic light emitting diodes (OLEDs),” Biomedical Physics and Engineering Express, 6, 2, 2020, 025003.
A Sridharan*, V Kodibagkar and J Muthuswamy, “Penetrating microindentation of hyper-soft, conductive silicone neural interfaces in vivo reveals significantly lower mechanical stresses,” MRS advances, 4(46-47):2551-2558, 2019.
S Sampath Kumar*, M Baker, M Okandan and J Muthuswamy, “Engineering microscale systems for fully autonomous intracellular neural interfaces,” Microsystems and Nanoengineering, 6, 1 (2020). https://doi.org/10.1038/s41378-019-0121-y (a nature publishing group journal).
A Sridharan* and J Muthuswamy, “Soft, conductive, brain-like coatings at tips of microelectrodes improve electrical stability under chronic in vivo conditions,” Micromachines, 12(7), 761; https://doi.org/10.3390/mi12070761, 2021.
D Atkinson, T D'Souza, J Rajput, N Tasnim, J Muthuswamy, H Marvi,
J Pancrazio, “Advances in Implantable Microelectrode Array Insertion and Positioning,” Neuromodulation, https://doi.org/10.1111/ner.13355, 2021.
J Duncan*, A Sridharan*, S Sampath Kumar*, D Iradukonda, J Muthuswamy, “Biomechanical micromotion at the neural interface modulates intracellular membrane potentials in vivo,” Journal of Neural Engineering, 18(4), doi: 10.1088/1741-2552/ac0a56, 2021.
A Sridharan*, J Duncan and J Muthuswamy, "Mechanosensitive Ion Channels Contribute to Micromotion Induced Membrane Potential Changes in Cells at the Neural Interface In Vivo," Proceedings of 10th International IEEE/EMBS Conference on Neural Engineering (NER), 2021, pp. 621-624, doi: 10.1109/NER49283.2021.9441094, 2021.
A Sridharan* and J Muthuswamy, “Penetrating micro-indentation: An experimental technique to determine the mechanical properties of brain tissue in vivo,” under review for Journal of Visualized Experiments, 2022.
B Schwartz, S Brown, J Muthuswamy and R Sadleir, “Analytic Modeling of Neural Tissue: II. Nonlinear Membrane Dynamics,” (in press) AIP Advances, Nov 14;12(11):115019. doi: 10.1063/5.0124414. PMID: 36397822; PMCID: PMC9665963, 2022.

Research Activity

“Wireless Injectable Neurostimulators WINS for treating Migraine”, NIH Blueprint Medtech Accelerator seedling, 11/9/23-08/31/2024
“Development of ultrasonically powered biosensor for intracranial pressure monitoring for hydrocephalus applications,” Arizona New Economy Initiative (NEI) Science and Technology Center (STC), 9/1/24 – 8/31/25
“Novel Microwave Induced Neuromodulation Therapy for Pain Relief”, Arizona New Economy Initiative (NEI) Science and Technology Center (STC), 5/1/23 – 4/30/24
“Minimally Invasive Neuromodulation of Occipital Nerve to Mitigate Chronic Migraine”, Flinn foundation, 02/01/2023-12/31/2024
“Neuromodulation by EM induced ultrasound”, NSF STTR Phase 1, 10/1/2022-09/30/2023
“EEG/fNIRS based closed-loop control of deep brain stimulation (DBS)”, NSF Industry-University Collaborative Research Centers (IUCRC), $50k, 5/1/21-2/28/22
“Minimally invasive neuromodulation of occipital nerve to mitigate chronic migraine”, Flinn foundation, 4/1/21 – 3/30/22
“Closed-loop control of deep brain stimulation (DBS)”, NSF Industry-University Collaborative Research Centers (IUCRC), 8/1/20-7/31/21
“Closed-loop control of deep brain stimulation (DBS) using models of electrode failure”, NSF Industry-University Collaborative Research Centers (IUCRC), 8/1/19-7/31/20
“Quantitative mapping of oxygenation around neural interfaces using novel PISTOL MR imaging”, NIH UF1NS107676 (BRAIN initiative), (co-PIs - Dr. Sridharan and Dr. Kodibagkar), 5/1/18-4/30/21

Courses

2026 Spring

Course Number	Course Title
BME 300	Bioengineering Product Design
BME 532	Biomed Innov II Product Design
BME 542	Clinical Innov II Prod Des Exp

2025 Fall

Course Number	Course Title
BME 493	Honors Thesis
BME 564	Cyber Biomedical Systems
BME 494	Special Topics

2025 Spring

Course Number	Course Title
BME 492	Honors Directed Study
BME 493	Honors Thesis
BME 300	Bioengineering Product Design

2024 Spring

Course Number	Course Title
BME 493	Honors Thesis
BME 490	Biomedical Engr Capstone II
BME 490	Biomedical Engr Capstone II
BME 490	Biomedical Engr Capstone II
BME 493	Honors Thesis
BME 564	Cyber Biomedical Systems

2023 Fall

Course Number	Course Title
CSE 590	Reading and Conference
BME 417	Biomed Engr Capstone Design I
BME 492	Honors Directed Study
BME 417	Biomed Engr Capstone Design I
BME 417	Biomed Engr Capstone Design I

2023 Spring

Course Number	Course Title
BME 370	Microcomputer Apps in BME
BME 370	Microcomputer Apps in BME
BME 564	Cyber Biomedical Systems

2022 Fall

Course Number	Course Title
BME 493	Honors Thesis
CSE 590	Reading and Conference
BME 493	Honors Thesis
ASU 101-BME	The ASU Experience
ASU 101-BME	The ASU Experience

2022 Spring

Course Number	Course Title
BME 492	Honors Directed Study
BME 370	Microcomputer Apps in BME
BME 370	Microcomputer Apps in BME
BME 370	Microcomputer Apps in BME
BME 564	Cyber Biomedical Systems

2021 Fall

Course Number	Course Title
CSE 590	Reading and Conference
ASU 101-BME	The ASU Experience
ASU 101-BME	The ASU Experience
ASU 101-BME	The ASU Experience

2021 Spring

Course Number	Course Title
BME 394	Special Topics
BME 370	Microcomputer Apps in BME
BME 598	Special Topics

Presentations

J Muthuswamy, “Nanocomposites and structures for precision interfaces with single neurons in vivo,” for a session on “Nano-bio-electronices” in the 13th Annual World Congress of the Society of Brain Mapping and Therapeutics, Miami, FL, April 8-10, 2016.
J Muthuswamy, “Biomechanical pathways influencing function of neural interfaces,” in Gordon conference on “Beyond Feasibility - Bridging the Gap in Neuroelectronic Interfaces,” March 25-30, 2018, Galveston, TX.
J. Muthuswamy, “Accelerated testing for neural implants,” in 2019 Advanced Technology Workshop on Advanced Packaging for Medical Microelectronics, International Microelectronics Assembly and Packaging Society, Jan. 22-23, 2019, San Diego, CA.
J Muthuswamy, “Brain talk – Engineering Solutions to Communicate with the Brain,” in St. Joseph’s College of Engineering, Chennai, India, June 29, 2020.
A. Sridharan, Y. Sugamura, L de Mesquita-Teixeira, V Kodibagkar and J Muthuswamy, “Assessing the impact of chronic mechanical stresses on oxygen tension around neural interfaces using a novel MR-based imaging technique”, invited to present a “Research highlight” talk. Talk presented by Dr. Arati Sridharan at the 7th Annual NIH BRAIN initiative investigators meeting, June 15-17, 2021.
Plenary session, J Muthuswamy, “Neural Interfaces – Engineering Solutions to Communicate with the Brain,” at International Workshop on Innovations and Trends in Brain Computing Techniques, at Indian Institute of Information Technology and Management, Kochi, April 25-29, 2022.
J Muthuswamy, “Biomechanics of Neural Interfaces and Neuromodulation,” at the Department of Mechanical Engineering seminar, University of New Mexico, Albuquerque, NM, Nov. 18, 2022.
J Muthuswamy, “Challenges and Opportunities in Neural Engineering,” at the Department of Biomedical Engineering seminar, Karunya University, Coimbatore, India, August 18, 2023.
J Muthuswamy, “Neural interfaces and neuromodulation – electromechanical events and systems that impact function,” at the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, August 28, 2024.

Service

IEEE Transactions on Neural Systems and Rehabilitation, Associate Editor (2006 - Present)
Annual meeting of the Biomedical Engineering Society, Co-chair of session on "Neural signal and information processing, " (2005 - Present)
Journal of Neurophysiology, Reviewer (2005 - Present)
Friends of International students, Faculty advisor (2004 - Present)
Graduate Committee, Member (2004 - Present)
Annual meeting of the Biomedical Engineering society, Oct. 1-4, 2003, Co-chair of "Neural recording and stimulation," session (2003 - Present)
Annual meeting of the IEEE Engineering in Medicine and Biology Society, Sept. 17-21, 2003, Co-chair of "Nano- and Micro-neurotechnology," session (2003 - Present)
Chi Alpha Christian fellowship, Faculty advisor (2003 - Present)
Annals of Biomedical Engineering, Reviewer (2000 - Present)
Brain Research, Reviewer (2000 - Present)
Experimental Brain Research, Reviewer (2000 - Present)
IEEE Transactions on Biomedical Engineering, Reviewer (2000 - Present)
Journal of Clinical Monitoring, Reviewer (2000 - Present)
Faculty search committee (Neural and Tissue engineering), member (2005 - 2006)
National Science Foundation, Member of IGERT pre-proposal review panel (2005 - 2005)
Faculty search committee (Neural Prosthesis), member (2002 - 2004)

Industry Positions

Founder of Serenity Neurotechnologies LLC, 2024-present
Founder of Grace Microsystems LLC, 2020-present
Collaborator for Hypersound Inc., and Anuncia Medical Inc.