Michael Sierks
Professor,
School for Engineering of Matter, Transport and Energy
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Phone: 480-965-2828
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GWC 536 TEMPE, AZ 85287-6106
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Mail code: 6106Campus: Tempe
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Long Bio
Michael Sierks is a professor of chemical engineering in the School for Engineering of Matter, Transport and Energy at Arizona State University. Sierks' research interests include antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas of interest in the Sierks group include ligand/receptor interactions, catalytic antibodies and enzyme mechanisms.
Education
- Ph.D. Chemical Engineering, Iowa State University 1988
- M.S. Chemical Engineering, Colorado State 1982
- B.S. Chemical Engineering, Stanford University 1978
Research Interests
Antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas include Ligand/receptor interactions, catalytic antibodies and enzyme mechanisms. Expertise: Neurodegenerative Disease Protein Engineering Enymology.
Research Activity
- Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian. FY14: Arizona Alzheimer's Disease Consortium. AADC(12/22/2014 - 6/30/2014).
- Sierks,Michael Richard*. Oligomeric Protein Variants as Biomarkers for AD and TBI Susceptibility. DOD-ARMY-USAMRAA(9/15/2014 - 9/14/2017).
- Stabenfeldt,Sarah E*, Kleim,Jeffrey Allan, Kodibagkar,Vikram D, Rege,Kaushal, Sierks,Michael Richard. Detecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out. HHS-NIH-NICHD(9/15/2014 - 8/31/2019).
- Sierks,Michael Richard*. 14-3-3s as Regulators of Prion-like Mode of Alpha-Synuclein Toxicity. UNIV OF ALABAMA BIRMINGHAM(8/1/2014 - 7/31/2015).
- Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian, Wang,Yalin. FY15: Arizona Alzheimer's Consortium. AADC(7/1/2014 - 6/30/2015).
- Sierks,Michael Richard*. Nanobodies selective for oligomeric Tau species isolated from AD brain. HHS-NIH-NIA(9/30/2013 - 6/30/2016).
- Sierks,Michael Richard*. Development of nanobodies that target amyloid- oligomers for individual diagnosis in Alzheimers disease. Mayo Clinic, Fla(2/1/2013 - 1/31/2015).
- Sierks,Michael Richard*. Affinity Maturation of an Antibody Based Therapeutic Targeting Microglial Activation. ASU-Mayo Seed Grant(1/1/2013 - 12/31/2013).
- Sierks,Michael Richard*. Oligomeric Neuronal Protein Aggregates as Biomarkers for Traumatic Brain Injury (TBI) and Alzheimer Disease (AD). DOD-ARMY-USAMRMC(9/25/2012 - 3/24/2015).
- Sierks,Michael Richard*. Developing Diagnostic Nanobodies Against Aggregated TDP-43 Species. HHS-NIH-NIA(8/1/2012 - 7/31/2015).
- Gonzalez,Graciela H*, Bimonte-Nelson,Heather, Burleson,Mary, Coon,David Wayne, Mcclain,Darya Denise, Sierks,Michael Richard. FY 13: Arizona Alzheimer's Disease Consortium. AADC(7/1/2012 - 6/30/2013).
- Sierks,Michael Richard*. Intracellular Tools to Study Specific Misfolded Protein Variants in Human Disease. HHS-NIH-NIA(8/1/2011 - 7/31/2014).
- Gonzalez,Graciela H*, Gonzalez,Graciela H*, Sierks,Michael Richard*, Burleson,Mary, Burleson,Mary, Coon,David Wayne, Coon,David Wayne, Mcclain,Darya Denise, Mcclain,Darya Denise, Sierks,Michael Richard, Sierks,Michael Richard. CS: Arizona Alzheimer's Disease Core Center. AADC(7/1/2011 - 6/30/2012).
- Sierks,Michael Richard*. Morphology specific anti-synuclein nanobodies as therapeutics for PD. MJFF(11/1/2010 - 5/16/2013).
- Sierks,Michael Richard*, Prasad,Shalini. Identifying and localizing toxic oligomeric a-syn with morphology specific nanobodies. MJFF(11/1/2010 - 2/28/2012).
- Sierks,Michael Richard*. High Throughput Tau Oligomer Assay for Drug Screening for Alzheimer's Disease. OLIGOMERIX(8/1/2010 - 7/31/2012).
- Sierks,Michael Richard*. YR1: Intracellular Targeting and Clearance of Toxic Synuclein Aggregates. ABRC(7/1/2010 - 6/30/2012).
- Sierks,Michael Richard*. In vivo SPECT Imaging of synuclein aggregation with morphology specific antibody based ligands. MJFF(5/1/2010 - 8/23/2011).
- Renaut,Rosemary Anne*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Marchant,Gary E, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project - 12. AADC(7/1/2009 - 6/30/2010).
- Sierks,Michael Richard*. In vivo SPECT Imaging of synuclein aggregation with morphology specific antibody based ligands. MJFF(1/1/2009 - 3/31/2010).
- Sierks,Michael Richard*. Targeted Hydrolysis of B-amyloid with Engineered Antibody Fragments. ISOA(1/1/2009 - 12/31/2009).
- Renaut,Rosemary Anne*, Bimonte-Nelson,Heather, Coon,David Wayne, Johnston,Stephen Albert, Marchant,Gary E, Sierks,Michael Richard, Ye,Jieping. AZ ASU Alzheimer's Reserach Center Project- Year 11. AADC(7/1/2008 - 6/30/2009).
- Sierks,Michael Richard*. High Throughput Tau Oligomer Assay for Drug Screening for Alzheimer's Disease. OLIGOMERIX(6/16/2008 - 5/1/2009).
- Sierks,Michael Richard*. Conformation-specific Single-chain Antibodies as Neurodegeneration Research Tools. HHS-NIH-NINDS(4/1/2008 - 3/31/2011).
- Sierks,Michael Richard*. Intrabody Targeting of Toxic Huntington Aggregates. CHDI(2/1/2008 - 1/31/2009).
- Renaut,Rosemary Anne*, Aiken,Leona S, Bimonte-Nelson,Heather, Coon,David Wayne, Farin,Gerald E, Johnston,Stephen Albert, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project - Year 10. AADC(7/1/2007 - 6/30/2008).
- Sierks,Michael Richard*. Morphology Specific Antibodies to Beta-Amyloid. BrightFocus(4/1/2007 - 3/31/2009).
- Arntzen,Charles*, Jacobs,Bertram Lewis, Leket-Mor,Tsafrir Shlomo, Mason,Hugh S, Sierks,Michael Richard. BiaCore Instrument Purchase. HHS-NIH(3/1/2007 - 2/28/2009).
- Sierks,Michael Richard*. Intracellular Targeting of Oligomeric a-Synuclein as a Potential Therapeutic for Parkinson's Disease. MJFF(11/1/2006 - 10/31/2007).
- Sierks,Michael Richard*. Morphology Specific Antibodies for Treating Parkinson's - Year 3. ABRC(7/1/2006 - 6/30/2007).
- Alexander,Gene Evans*, Bimonte-Nelson,Heather, Coon,David Wayne, Farin,Gerald E, Johnston,Stephen Albert, Renaut,Rosemary Anne, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project. AZ ADCC(7/1/2006 - 6/30/2007).
- Booksh,Karl S*, Sierks,Michael Richard. Development of a Modular, Fiber Optic Surface Plasmon Resonance Sensor for Quantitation of Diagnostic Proteins for Healing of Burns and Wounds. NASA-NATL SPACE BIOMED RES INS(1/1/2006 - 1/31/2007).
- Sierks,Michael Richard*. Single Chain Antibody Binding Variable Domains (scFv) Development to Various Morphologies of Htt Aggregation. CHDI(10/1/2005 - 12/31/2006).
- Sierks,Michael Richard*. Translational Research on Abeta Metabolism, From Synthesis to Clearance. SUN HEALTH RESEARCH INST(9/1/2005 - 8/31/2008).
- Sierks,Michael Richard*. Morphology Specific Antibodies for Treating Parkinson's - Year 2. ABRC(7/1/2005 - 6/30/2006).
- Sierks,Michael Richard*. Development of an Early Diagnostic and Treatment for Alzheimer's Disease. MAYO CLINIC SCOTTSDALE(9/29/2004 - 12/31/2005).
- Booksh,Karl S*, Khairallah,Philip A, Nieman,Ronald A, Sierks,Michael Richard. Fiber Optic Surface Plasmon Resonance Sensor for Protein Biomarkers. HHS-NIH-NIBIB(9/1/2004 - 6/30/2008).
- Sierks,Michael Richard*, Lyubchenko,Yuri. Morphology Specific Antibodies for Treating Parkinson's. ABRC(7/1/2004 - 6/30/2005).
- Sierks,Michael Richard*. Role of Protein-Lipid Bilayer Interactiontism in a-Synuclein Aggregation. HHS-NIH-NIA(5/1/2004 - 4/30/2007).
- Chang,Yung*, Brophy,Colleen M, Jacobs,Bertram Lewis, Misra,Rajeev, Pettit,George Robert, Sierks,Michael Richard, Zautra,Alex John. THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR(4/1/2004 - 3/31/2005).
- Sierks,Michael Richard*, Lyubchenko,Yuri. Morphology Specific Antibodies as Potential Therapeutics. MJFF(12/18/2003 - 12/31/2005).
- Sierks,Michael Richard*, Lyubchenko,Yuri. Oligomers Against Huntington Aggregation Using Atomic Force Microscopy. HDF-HEREDITARY DISEASE FDN(11/1/2003 - 7/31/2005).
- Sierks,Michael Richard*, Lyubchenko,Yuri. CONTROLLING -SYNUCLEIN AGGREGATION AS A TOOL FOR STUDYING PARKINSON'S. ABRC(4/1/2002 - 3/31/2004).
- Sierks,Michael Richard*. TARGETED PROTEOLYTIC ANTIBODIES FOR TREATING ALZHEIMER'S DISEASE. ALZHEIMER'S ASSN(9/1/2001 - 8/31/2004).
- Sierks,Michael Richard*. BISPECIFIC PROTEOLYTIC ANTIBODIES FOR TREATING ALZHEIMER'S. BrightFocus(4/1/2001 - 12/31/2002).
- Sierks,Michael Richard*. INHIBITING AGGREGATION WITH PHAGE DISPLAY ANTIBODIES. HHS-NIH-NIA(5/1/2000 - 4/30/2005).
Courses
2025 Spring
| Course Number | Course Title |
|---|---|
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| CHE 593 | Applied Project |
| CHE 493 | Honors Thesis |
| CHE 592 | Research |
| BDE 799 | Dissertation |
| BDE 792 | Research |
| BDE 795 | Continuing Registration |
| BDE 799 | Dissertation |
| BDE 792 | Research |
2024 Fall
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 592 | Research |
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| BIO 495 | Undergraduate Research |
2024 Summer
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 792 | Research |
2024 Spring
| Course Number | Course Title |
|---|---|
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| CHE 593 | Applied Project |
| CHE 493 | Honors Thesis |
| CHE 592 | Research |
| BDE 799 | Dissertation |
| BDE 792 | Research |
| BDE 792 | Research |
| BDE 795 | Continuing Registration |
| BDE 799 | Dissertation |
2023 Fall
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 592 | Research |
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| BIO 495 | Undergraduate Research |
2023 Summer
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 792 | Research |
2023 Spring
| Course Number | Course Title |
|---|---|
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| CHE 593 | Applied Project |
| CHE 493 | Honors Thesis |
| CHE 592 | Research |
| BDE 799 | Dissertation |
| BDE 792 | Research |
| BDE 792 | Research |
| BDE 795 | Continuing Registration |
| BDE 799 | Dissertation |
| CHE 792 | Research |
2022 Fall
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| BIO 495 | Undergraduate Research |
| BDE 792 | Research |
2022 Summer
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 792 | Research |
2022 Spring
| Course Number | Course Title |
|---|---|
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| CHE 593 | Applied Project |
| CHE 493 | Honors Thesis |
| CHE 592 | Research |
| BDE 799 | Dissertation |
| BDE 792 | Research |
| BDE 792 | Research |
| BDE 795 | Continuing Registration |
| BDE 799 | Dissertation |
2021 Fall
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 492 | Honors Directed Study |
| CHE 592 | Research |
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| BIO 495 | Undergraduate Research |
2021 Summer
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 792 | Research |
2021 Spring
| Course Number | Course Title |
|---|---|
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| CHE 593 | Applied Project |
| CHE 493 | Honors Thesis |
| CHE 592 | Research |
| BDE 799 | Dissertation |
| BDE 792 | Research |
| BDE 792 | Research |
2020 Fall
| Course Number | Course Title |
|---|---|
| BME 592 | Research |
| BME 599 | Thesis |
| BME 792 | Research |
| BDE 792 | Research |
| CHE 492 | Honors Directed Study |
| CHE 592 | Research |
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| BIO 495 | Undergraduate Research |
| CHE 593 | Applied Project |
2020 Summer
| Course Number | Course Title |
|---|---|
| BDE 792 | Research |
| CHE 792 | Research |
2020 Spring
| Course Number | Course Title |
|---|---|
| BME 792 | Research |
| BME 592 | Research |
| BME 599 | Thesis |
| CHE 599 | Thesis |
| CHE 792 | Research |
| CHE 799 | Dissertation |
| CHE 593 | Applied Project |
| CHE 493 | Honors Thesis |
| CHE 592 | Research |
| BDE 799 | Dissertation |
| BDE 792 | Research |