Yi Su

Yi Su

Visiting Scholar/Faculty/Researcher
  • [email protected]
  • Phone: 602-839-0722
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Long Bio

Dr. Yi Su is a Senior Scientist and the Director of the Computational Image Analysis Lab at the Banner Alzheimer's Institute (BAI), Phoenix, Arizona. He also holds affiliated appointments at the School of Computing and Augmented Intelligence, ASU and Department of Neurology at the University of Arizona-College of Medicine-Phoenix. Dr. Su currently directs the Data Management and Statistics Core and co-directs the Biomarker Core of the Arizona Alzheimer's Disease Research Center. He received his doctorate in Biomedical Engineering in 2005 from Mayo Graduate School, and had postdoctoral training at Mayo Clinic College of Medicine in Rochester, Minnesota, and the Mallinckrodt Institute of Radiology (MIR), Washington University School of Medicine in St. Louis, Missouri. Before joining BAI in 2018, he was a faculty with MIR.

Dr. Su's research focuses on the development and application of advanced data analysis techniques to investigate neurological disorders such as Alzheimer's disease. His research employs neuroimaging techniques to measure and quantify brain changes in healthy aging and diseases. NIH, the State of Arizona, and private foundations have supported Dr. Su's research.

Education
  • Ph.D. Biomedical Engineering, Mayo Graduate School
  • B.S. Chemistry, Univ. of Science and Technology of China
Google Scholar URL
https://scholar.google.com/citations?user=vdZKSEIAAAAJ&hl=en
ORCID Profile ID
https://orcid.org/0000-0002-1946-8063
Research Interests

Alzheimer's disease, neuroimaging, machine learning, deep learning

Publications

Recent publications:

  • Smith GS, Protas H, Kuwabara H, Savonenko A, Nassery N, Gould NF, Kraut M, Avramopoulos D, Holt D, Dannals RF, Nandi A, Su Y, Reiman EM, Chen K. Molecular imaging of the association between serotonin degeneration and beta-amyloid deposition in mild cognitive impairment. NeuroImage Clinical. 2023;37:103322. doi: 10.1016/j.nicl.2023.103322. PubMed PMID: 36680976; PMCID: 9869478 competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
  • Malek-Ahmadi M, Duff K, Chen K, Su Y, King JB, Koppelmans V, Schaefer SY. Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults. Exp Gerontol. 2023;173:112087. doi: 10.1016/j.exger.2023.112087. PubMed PMID: 36639062.
  • Wu J, Su Y, Zhu W, Jalili Mallak N, Lepore N, Reiman EM, Caselli RJ, Thompson PM, Chen K, Wang Y, Alzheimer's Disease Neuroimaging I. Improved Prediction of Amyloid-beta and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding. Journal of Alzheimer's disease : JAD. 2023;91(2):637-51. doi: 10.3233/JAD-220812. PubMed PMID: 36463452; PMCID: 9940990.
  • Alosco ML, Su Y, Stein TD, Protas H, Cherry JD, Adler CH, Balcer LJ, Bernick C, Pulukuri SV, Abdolmohammadi B, Coleman MJ, Palmisano JN, Tripodis Y, Mez J, Rabinovici GD, Marek KL, Beach TG, Johnson KA, Huber BR, Koerte I, Lin AP, Bouix S, Cummings JL, Shenton ME, Reiman EM, McKee AC, Stern RA, Project DCTER. Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players. Eur J Nucl Med Mol Imaging. 2023;50(2):435-52. doi: 10.1007/s00259-022-05963-x. PubMed PMID: 36152064; PMCID: 9816291.
  • Flores S, Chen CD, Su Y, Dincer A, Keefe SJ, McKay NS, Paulick AM, Perez-Carrillo GG, Wang L, Hornbeck RC, Goyal M, Vlassenko A, Schwarz S, Nickels ML, Wong DF, Tu Z, McConathy JE, Morris JC, Benzinger TLS, Gordon BA. Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023;64(2):287-93. doi: 10.2967/jnumed.122.263948. PubMed PMID: 35953305; PMCID: 9902848.
  • Luckett PH, Chen C, Gordon BA, Wisch J, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, Salloway S, Schofield PR, Brickman AM, Brooks WS, Cash DM, Fulham MJ, Ghetti B, Jack CR, Jr., Voglein J, Klunk WE, Koeppe R, Su Y, Weiner M, Wang Q, Marcus D, Koudelis D, Joseph-Mathurin N, Cash L, Hornbeck R, Xiong C, Perrin RJ, Karch CM, Hassenstab J, McDade E, Morris JC, Benzinger TLS, Bateman RJ, Ances BM, Dominantly Inherited Alzheimer N. Biomarker clustering in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023;19(1):274-84. doi: 10.1002/alz.12661. PubMed PMID: 35362200; PMCID: 9525451.
  • Aguillon D, Langella S, Chen Y, Sanchez JS, Su Y, Vila-Castelar C, Vasquez D, Zetterberg H, Hansson O, Dage JL, Janelidze S, Chen K, Fox-Fuller JT, Aduen P, Martinez JE, Garcia G, Baena A, Guzman C, Johnson KA, Sperling RA, Blennow K, Reiman EM, Lopera F, Quiroz YT. Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi: 10.1002/alz.12906. PubMed PMID: 36571821.
  • Weise CM, Chen K, Chen Y, Devadas V, Su Y, Reiman EM. Differential impact of body mass index and leptin on baseline and longitudinal positron emission tomography measurements of the cerebral metabolic rate for glucose in amnestic mild cognitive impairment. Front Aging Neurosci. 2022;14:1031189. doi: 10.3389/fnagi.2022.1031189. PubMed PMID: 36570534; PMCID: 9782536.
  • Suchy-Dicey A, Su Y, Buchwald DS, Manson SM, Reiman EM. Volume atrophy in medial temporal cortex and verbal memory scores in American Indians: Data from the Strong Heart Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi: 10.1002/alz.12889. PubMed PMID: 36453775.
  • Reiman EM, Pruzin JJ, Rios-Romenets S, Brown C, Giraldo M, Acosta-Baena N, Tobon C, Hu N, Chen Y, Ghisays V, Enos J, Goradia DD, Lee W, Luo J, Malek-Ahmadi M, Protas H, Thomas RG, Chen K, Su Y, Boker C, Mastroeni D, Alvarez S, Quiroz YT, Langbaum JB, Sink KM, Lopera F, Tariot PN, and the APIACTG. A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi: 10.1002/alz.12843. PubMed PMID: 36373344.
  • Lee HH, Blumberger DM, Lenze EJ, Anderson SJ, Barch DM, Black KJ, Cristancho P, Daskalakis ZJ, Eisenstein SA, Huang Y, Li S, Lissemore J, McConathy J, Mulsant BH, Rajji TK, Reynolds CF, 3rd, Su Y, Tu Z, Voineskos D, Karp JF. Low-Dose Augmentation With Buprenorphine for Treatment-Resistant Depression: A Multisite Randomized Controlled Trial With Multimodal Assessment of Target Engagement. Biol Psychiatry Glob Open Sci. 2022;2(2):127-35. doi: 10.1016/j.bpsgos.2021.09.003. PubMed PMID: 36325158; PMCID: 9616305.
  • Wu J, Su Y, Reiman EM, Caselli RJ, Chen K, Thompson PM, Wang J, Wang Y. Investigating the Effect of Tau Deposition and Apoe on Hippocampal Morphometry in Alzheimer's Disease: A Federated Chow Test Model. Proc IEEE Int Symp Biomed Imaging. 2022;2022. doi: 10.1109/isbi52829.2022.9761576. PubMed PMID: 36147309; PMCID: 9491515.
  • Wang Q, Chen G, Schindler SE, Christensen J, McKay NS, Liu J, Wang S, Sun Z, Hassenstab J, Su Y, Flores S, Hornbeck R, Cash L, Cruchaga C, Fagan AM, Tu Z, Morris JC, Mintun MA, Wang Y, Benzinger TLS. Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurol Neuroimmunol Neuroinflamm. 2022;9(3). doi: 10.1212/NXI.0000000000001152. PubMed PMID: 35260470; PMCID: PMC8906187.
  • Shah J, Gao F, Li B, Ghisays V, Luo J, Chen Y, Lee W, Zhou Y, Benzinger TLS, Reiman EM, Chen K, Su Y, Wu T. Deep residual inception encoder-decoder network for amyloid PET harmonization. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi: 10.1002/alz.12564. PubMed PMID: 35142053.
  • Vila-Castelar C, Tariot PN, Sink KM, Clayton D, Langbaum JB, Thomas RG, Chen Y, Su Y, Chen K, Hu N, Giraldo-Chica M, Tobon C, Acosta-Baena N, Luna E, Londono M, Ospina P, Tirado V, Munoz C, Henao E, Bocanegra Y, Alvarez S, Rios-Romenets S, Ghisays V, Goradia D, Lee W, Luo J, Malek-Ahmadi MH, Protas HD, Lopera F, Reiman EM, Quiroz YT, Group AACT. Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: Baseline findings from the API ADAD Colombia Trial. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi: 10.1002/alz.12552. PubMed PMID: 35103388.
  • Wang Q, Chen K, Su Y, Reiman EM, Dudley JT, Readhead B. Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer's disease. Brain Commun. 2022;4(1):fcab293. doi: 10.1093/braincomms/fcab293. PubMed PMID: 34993477; PMCID: PMC8728025.
  • Wang G, Zhou W, Kong D, Qu Z, Ba M, Hao J, Yao T, Dong Q, Su Y, Reiman EM, Caselli RJ, Chen K, Wang Y, Alzheimer's Disease Neuroimaging I. Studying APOE varepsilon4 Allele Dose Effects with a Univariate Morphometry Biomarker. Journal of Alzheimer's disease : JAD. 2022;85(3):1233-50. doi: 10.3233/JAD-215149. PubMed PMID: 34924383.
  • Chen K, Guo X, Pan R, Xiong C, Harvey DJ, Chen Y, Yao L, Su Y, Reiman EM, Alzheimer's Disease Neuroimaging I. Limitations of clinical trial sample size estimate by subtraction of two measurements. Stat Med. 2022;41(7):1137-47. doi: 10.1002/sim.9244. PubMed PMID: 34725853; PMCID: PMC8916961.
  • Wu J, Zhu W, Su Y, Gui J, Lepore N, Reiman EM, Caselli RJ, Thompson PM, Chen K, Wang Y. Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy. Proc SPIE Int Soc Opt Eng. 2021;12088. doi: 10.1117/12.2607169. PubMed PMID: 34961803; PMCID: PMC8710175.
  • Wu J, Dong Q, Zhang J, Su Y, Wu T, Caselli RJ, Reiman EM, Ye J, Lepore N, Chen K, Thompson PM, Wang Y. Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. Front Neurosci. 2021;15:762458. doi: 10.3389/fnins.2021.762458. PubMed PMID: 34899166; PMCID: PMC8655732.

 

Research Activity

Active

  • R01AG073424 (PI: Su) NIH/NIA 08/2022-07/2027 Tracer Harmonization for Amyloid and Tau PET Imaging Using Statistical and Deep Learning Techniques (Role: PI)
  • R01AG069453 (PI: Reiman/Ashton/Langbaum/Su/Woodruff) NIH/NIA 09/2020-03/2026 APOE IN THE PREDISPOSITION TO, PROTECTION FROM AND PREVENTION OF ALZHEIMER'S DISEASE (Role: MPI)
  • P30AG072980 (PI: Langbaum) NIH/NIA 09/2021-06/2026 ARIZONA ALZHEIMER'S DISEASE RESEARCH CENTER (Role: Biomarker Core Co-Leader, Data Management & Statistics Core Co-Leader)
  • R01AG086363 (PI: Alexander et. al.) NIH/NIA 09/2024-08/2029 Alzheimer's Prevention Initiative ADAD Colombia Trial Program (Role: Co-Investigator)
  • R01NS139383 (PI: Alosco et. al.) NIH/NINDS 08/2024-07/2029 Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II (Role: Co-Investigator)
  • R03AG077270 (PI: Malek-Ahmadi) NIH/NIA 06/2023-03/2026 (NCE) Cardiovascular Genotype and APOE ε4 Carrier Status Interaction Effects on Amyloid Load in Pre-Clinical Alzheimer's Disease (Role: Co-Investigator)
  • R01AG076566 (PI: Yu) NIH/NIA 07/2023-06/2028 Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic Fitness (Role: Co-Investigator)
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