Carol Huseby
-
NDRC Biodesign C Tempe, AZ 85281
-
Mail code: 7601Campus: Tempe
-
Dr. Carol Huseby is an Edson Endowed Assistant Professor of Research at the ASU Banner-Neurodegenerative Disease Research Center, Biodesign Institute committed to research toward understanding human neurodegenerative disease and developing subsequent therapeutic strategies to stop disease progression. Dr. Huseby studied biology and physics at the University of Washington, Seattle and then completed a Master of Applied Mathematics during which she compared mathematical computational models of neuron firing and networks. She continued her graduate education at The Ohio State University in the laboratory of Dr. Jeff Kuret where she earned her PhD. There she developed a mathematical model of tau protein aggregation to probe the kinetic mechanisms of filamentous tau assembly. Using both advanced computation and assays in the laboratory, she revealed that tau aggregation must include end-to-end annealing of short filaments to achieve long filaments in vitro and may explain filament length in neurons. This work was awarded the Editor’s Pick and featured in the Journal of Biological Chemistry. Next she was awarded a position as an NRSA T32 Postdoctoral trainee (Dr. Carol Barnes) through the Arizona Alzheimer’s Consortium where her research in Dr. Paul Coleman’s lab focused on comparing transcriptional changes occurring within and across neurodegenerative diseases. Her work showed that multiple neurodegenerative diseases have the same molecular process dysfunctions underscoring the importance of understanding the unique changes and vulnerabilities of each disease. This work, as corresponding author, received the distinction of being in the top 10% of articles downloaded after publication. Dr. Huseby's current independent lab research, at the NDRC, is directed toward identifying unique features of neurodegenerative diseases by focusing on structural aspects of the tau and asyn proteins in disease. We now know that each disease harbors unique structures at the core of pathological aggregates and delivers an endpoint of which replication can elucidate disease mechanisms. In Dr. Huseby's lab, she employs a multifaceted approach of biophysics, biochemistry and molecular cell biology to probe mechanisms leading to the structural misfolding of tau protein aggregate polymorphs in multiple microenvironments. One important direction her lab focuses on is the study of tau protein proteolysis, which when dysfunctional, leads to mis-located protein fragments acting as mediators of disease toxicity or protein misfolding.
Massive changes in gene expression and their cause(s) can be a unifying principle in the pathobiology of Alzheimer’s disease. P.D. Coleman, E. Delvaux, J.H. Kordower, A. Boehringer, C.J. Huseby, Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. 2025 Feb; 21(2):e14555. PMID: 39912452 PMCID: PMC11851168
Cellular models for the investigation of the structural dynamics and activity of human tau protein aggregate formation. E. Ranaweera, C.J. Huseby, D.T. Hansen, P.L. Chui, P.D. Coleman, P. Fromme, Feb. 10 2023, Biophysical journal. 122, 3S1, p. 41a-42a.
DJ-1 molecular chaperone activity depresses tau aggregation propensity through interaction with monomers. (2023) D.M. Jimenez-Harrison, C.J. Huseby, C.N. Hoffman, S. Sher, D. Snyder, B. Seal, C. Yuan, H. Fu, V. Wysocki, M. Repici, F. Giorgini, J. Kuret, Biochemistry.Mar 7; 62(5), 976-988. PMCID: PMC9997487
Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer’s disease and other neurodegenerative diseases. (2023) C.J. Huseby*, E. Delvaux, D. Brokaw, P.D. Coleman, Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. June; 19(6), 2618-2632. PMCID: PMC11633037, PMID: 36541444 https://www.eurekalert.org/news-releases/975156 *corresponding author.
Blood transcript biomarkers selected by machine learning algorithm classify neurodegenerative diseases including Alzheimer’s disease. (2022) C.J. Huseby*, E. Delvaux, D. Brokaw, P.D. Coleman, Biomolecules. Oct 29; 12(11). PMCID: PMC9687215 *corresponding author.
A theoretical study of polymorphism in tau protein peptide VQIVYK fibrils. (2021) J. Yang, M.V. Agnihotri, C.J. Huseby, J. Kuret, S.J. Singer, Biophysical Journal. 120(8), 1396-1416. PMCID: PMC8105716
Quantification of tau protein Lysine methylation in aging and Alzheimer’s disease. (2019) C.J. Huseby, C.N. Hoffman, G. L. Cooper, J.C. Cocuron, A.P. Alonso, S.N. Thomas, A.J. Yang, J. Kuret, Journal of Alzheimer’s Disease. 71(3), 979-991. PMCID: PMC6844542
The role of annealing and fragmentation in human tau aggregation dynamics. (2019) C.J. Huseby, R. Bundschuh, J. Kuret, Journal of Biological Chemistry. 294(13), 4728-37. PMCID: PMC6442056 https://www.eurekalert.org/pub_releases/2019-02/asfb-hdp020719.php
A liquid chromatography tandem mass spectroscopy approach for quantification of protein methylation stoichiometry. (2018) G. Cooper-Olson**, C.J. Huseby**, C.N. Chandler, J.C. Cocuron, A. Alonso, J. Kuret; Analytical Biochemistry. Feb 2, 545, 72-77. PMCID: PMC5849526 **equal contribution
Analyzing tau aggregation using electron microscopy. (2016) C.J. Huseby and J. Kuret; Methods in Molecular Biology. 1345, 101-12. PMID: 26453208
Structure and mechanism of action of tau aggregation inhibitors. (2014) K. Cisek, G. Cooper, C.J. Huseby, J. Kuret; Current Alzheimer Research. 11(10), 918-27. PMCID: PMC4289634
Structural determinants of Tau aggregation inhibitor potency. (2013) K. Schafer, K. Cisek, C.J. Huseby, E. Chang, J. Kuret; Journal of Biological Chemistry. 288 (45), 32599-32611. PMCID: PMC3820892
Courses
2026 Spring
| Course Number | Course Title |
|---|---|
| BIO 492 | Honors Directed Study |
| BIO 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
2025 Fall
| Course Number | Course Title |
|---|---|
| BIO 492 | Honors Directed Study |
| BIO 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| BIO 492 | Honors Directed Study |
2025 Spring
| Course Number | Course Title |
|---|---|
| BIO 493 | Honors Thesis |
| BIO 492 | Honors Directed Study |
| BIO 495 | Undergraduate Research |
2024 Fall
| Course Number | Course Title |
|---|---|
| BIO 492 | Honors Directed Study |
| BIO 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| BIO 492 | Honors Directed Study |
2024 Spring
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
2023 Fall
| Course Number | Course Title |
|---|---|
| BIO 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
2023 Spring
| Course Number | Course Title |
|---|---|
| BIO 492 | Honors Directed Study |
| BIO 495 | Undergraduate Research |
2022 Fall
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |