Christy Kelley
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1475 N. Scottsdale Rd. SkySong 1 Suite 200 Scottsdale, AZ 85257
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Dr. Christy M. Kelley, Ph.D.
Dr. Kelley is a large-scale data analyst focusing on data-centric approaches unconfined by biases inherent in discipline- and disease-centric analyses. Starting with the dataset, patterns and models that explain relationships are derived absent labeling or structuring. With progressive iterations and model refinement, the data structures itself and patterns evolve which are then assessed by overlaying disease and demographic information. Trends in the overlay are extracted to formulate decision trees for diagnosis, treatment, economic impact, and other aims. Current work is being conducted on crisis detection including network failure through integration of population behavior such as spending data and daily geospatial movement with healthcare data and natural language processing of scientific literature and common press output.
With a history in neurodegenerative diseases of aging and development, Dr. Kelley approaches every pathology understanding that the long-term stress from a disease is multisystemic. Physiological and economic well-being in whole populations of health care providers as well as the individuals and immediate family living with the disease suffer. These issues need to be addressed in parallel with patient/disease data analysis to derive appropriate future directions. Dr. Kelley received a Bachelor of Arts in psychology in 2005 and a Doctorate of Philosophy in molecular neuroscience in 2013 studying the long-term genetic effects of perinatal maternal dietary choline supplementation in a murine model of Down syndrome. She joined IFH in November 2021 with the goal of working with health care partners to aide in disease understanding and patient care improvement.
Doctorate of Philosophy, Neuroscience, Molecular 2013
Rush University Medical Center
1735 West Harrison Street, Chicago, IL 60612, USA, (312) 563-2563
Bachelor of Arts, Psychology 2005
California State University, San Bernardino
5500 University Parkway, San Bernardino, CA 92407, USA, (909) 537-5000
Associate of Arts 2002
San Bernardino Valley College
701 South Mount Vernon Avenue, San Bernardino, CA 92410, USA, (909) 888-6511
Mental health:
Mental health monitoring in disengaged and geographically remote populations
Monitoring of mental health status using computer and mobile interfaces with visual, cognitive, linguistic, and mechanical tasks
Veteran mental health care:
SARS-CoV2 and COVID-19
Differentiation of sequelae from other specific (acute respiratory distress) and nonspecific (physiological response to biological stress) etiologies
Long-term consequences of illness
Neurocognitive and neurobiological consequences post-recovery from acute illness
Publications C. M. Kelley
23. Gautier MK, Kelley CM, Lee SH, Mufson EJ, Ginsberg SD. (2023) Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease. Neurobiol Dis
[In review]
22. Kelley CM, Ginsberg SD, Liang WS, Counts SE, Mufson EJ. (2022) Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders. Brain Commun. 4(4):fcac162. doi: 10.1093/braincomms/fcac162. PMID: 35813880; PMCID: PMC9263888.
[21 Jun 2022]
21. Mufson EJ, Kelley C, Perez SE. (2021) Chronic traumatic encephalopathy and the nucleus basalis of Meynert. Handb Clin Neurol. 182:9-29. doi: 10.1016/B978-0-12-819973-2.00002-2. PMID: 34266614.
[XX Oct 2021]
20. Kelley CM, Perez SE, Mufson EJ. (2019) Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study. Acta Neuropathol Commun. 7(1):207. doi: 10.1186/s40478-019-0861-9. PMID: 31831066; PMCID: PMC6909582.
[12 Dec 2019]
19. Kelley CM, Ginsberg SD, Alldred MJ, Strupp BJ, Mufson EJ. (2019) Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome. Dev Neurobiol. 79(7):664-683. doi: 10.1002/dneu.22700. PMID: 31120189; PMCID: PMC6756931.
[XX Jul 2019]
18. Bickhart DM, Rosen BD, Koren S, Sayre BL, Hastie AR, Chan S, Lee J, Lam ET, Liachko I, Sullivan ST, Burton JN, Huson HJ, Nystrom JC, Kelley CM, Hutchison JL, Zhou Y, Sun J, Crisà A, Ponce de León FA, Schwartz JC, Hammond JA, Waldbieser GC, Schroeder SG, Liu GE, Dunham MJ, Shendure J, Sonstegard TS, Phillippy AM, Van Tassell CP, Smith TP. (2017) Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome. Nat Genet. 49(4):643-650. doi: 10.1038/ng.3802. PMID: 28263316; PMCID: PMC5909822.
[XX Apr 2017]
17. Powers BE, Kelley CM, Velazquez R, Ash JA, Strawderman MS, Alldred MJ, Ginsberg SD, Mufson EJ, Strupp BJ. (2017) Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. Neuroscience. 340:501-514. doi: 10.1016/j.neuroscience.2016.11.001. PMID: 27840230; PMCID: PMC5177989.
[06 Jan 2017]
16. Powers BE, Velazquez R, Kelley CM, Ash JA, Strawderman MS, Alldred MJ, Ginsberg SD, Mufson EJ, Strupp BJ. (2016) Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome. Brain Struct Funct. 221(9):4337-4352. doi: 10.1007/s00429-015-1164-y. PMID: 26719290; PMCID: PMC4929047.
[XX Dec 2016]
15. Nguyen SV, Harhay DM, Bono JL, Smith TP, Fields PI, Dinsmore BA, Santovenia M, Kelley CM, Wang R, Bosilevac JM, Harhay GP. (2016) Complete, Closed Genome Sequences of 10 Salmonella enterica subsp. enterica Serovar Typhimurium Strains Isolated from Human and Bovine Sources. Genome Announc. 4(6):e01212-16. doi: 10.1128/genomeA.01212-16. PMID: 27811097; PMCID: PMC5095467.
[03 Nov 2016]
14. Massilamany C, Mohammed A, Loy JD, Purvis T, Krishnan B, Basavalingappa RH, Kelley CM, Guda C, Barletta RG, Moriyama EN, Smith TP, Reddy J. (2016) Whole genomic sequence analysis of Bacillus infantis: defining the genetic blueprint of strain NRRL B-14911, an emerging cardiopathogenic microbe. BMC Genomics. 17 Suppl 7(Suppl 7):511. doi: 10.1186/s12864-016-2900-2. PMID: 27557119; PMCID: PMC5001198.
[22 Aug 2016]
13. Nguyen SV, Harhay DM, Bono JL, Smith TP, Fields PI, Dinsmore BA, Santovenia M, Kelley CM, Wang R, Bosilevac JM, Harhay GP. (2016) Complete and Closed Genome Sequences of 10 Salmonella enterica subsp. enterica Serovar Anatum Isolates from Human and Bovine Sources. Genome Announc. 4(3):e00447-16. doi: 10.1128/genomeA.00447-16. PMID: 27257192; PMCID: PMC4891638.
[02 Jun 2016]
11. Strupp BJ, Powers BE, Velazquez R, Ash JA, Kelley CM, Alldred MJ, Strawderman M, Caudill MA, Mufson EJ, Ginsberg SD. (2016) Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. Curr Alzheimer Res. 13(1):97-106. doi: 10.2174/1567205012666150921100311. PMID: 26391046; PMCID: PMC4733524.
[XX Xxx 2016 Curr Alzheimer Res. 13(1):97-106.]
10. Kelley CM, Ash JA, Powers BE, Velazquez R, Alldred MJ, Ikonomovic MD, Ginsberg SD, Strupp BJ, Mufson EJ. (2016) Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. Curr Alzheimer Res. 13(1):84-96. doi: 10.2174/1567205012666150921100515. PMID: 26391045; PMCID: PMC4733527.
[XX Xxx 2016 Curr Alzheimer Res. 13(1):84-96.]
9. 12. Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC. (2016) Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 13(1):35-52. doi: 10.2174/1567205012666150921095505. PMID: 26391050; PMCID: PMC5034871.
[XX Xxx 2016 Curr Alzheimer Res. 13(1):35-52.]
Harhay DM, Bono JL, Smith TP, Fields PI, Dinsmore BA, Santovenia M, Kelley CM, Wang R, Harhay GP. (2016) Complete Closed Genome Sequences of Salmonella enterica subsp. enterica Serotypes Anatum, Montevideo, Typhimurium, and Newport, Isolated from Beef, Cattle, and Humans. Genome Announc. 4(1):e01683-15. doi: 10.1128/genomeA.01683-15. PMID: 26847891; PMCID: PMC4742688.
[04 Feb 2016]
8. Ash JA, Velazquez R, Kelley CM, Powers BE, Ginsberg SD, Mufson EJ, Strupp BJ. (2014) Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis. 70:32-42. doi: 10.1016/j.nbd.2014.06.001. PMID: 24932939; PMCID: PMC4133151.
[XX Oct 2014]
7. Kelley CM, Powers BE, Velazquez R, Ash JA, Ginsberg SD, Strupp BJ, Mufson EJ. (2014) Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. J Comp Neurol. 522(6):1390-410. doi: 10.1002/cne.23492. PMID: 24178831; PMCID: PMC3959592.
[15 Apr 2014]
6. Velazquez R, Ash JA, Powers BE, Kelley CM, Strawderman M, Luscher ZI, Ginsberg SD, Mufson EJ, Strupp BJ. (2013) Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 58:92-101. doi: 10.1016/j.nbd.2013.04.016. PMID: 23643842; PMCID: PMC4029409.
[XX Oct 2013]
5. Perez SE, Nadeem M, Sadleir KR, Matras J, Kelley CM, Counts SE, Vassar R, Mufson EJ. (2012) Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. Int J Physiol Pathophysiol Pharmacol. 4(3):115-27. PMID: 23071869; PMCID: PMC3466490.
[XX Xxx 2012]
4. Kelley CM, Perez SE, Overk CR, Wynick D, Mufson EJ. (2011) Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice. J Alzheimers Dis. 25(3):491-504. doi: 10.3233/JAD-2011-102097; PMID: 21471639; PMCID: PMC3307130.
[XX Jul 2011]
3. Kelley CM. (2011) Solomon Carter Fuller: Where My Caravan Has Rested by Mary Kaplan Lanham, MD: University Press of America, Inc., 2005 ISBN 0-7618-3265-3. J of the History of the Neurosciences. 20(2):166-168.
[08 Apr 2011]
2. Kelley CM. (2011) Consciousness and Mental Life by Daniel N. Robinson. New York and Chichester, West Sussex: Columbia University Press, 2008 ISBN: 978-0-231-14100-0. doi.org/10.1080/0964704X.2011.536946 J of the History of the Neurosciences. 20(2):168-169.
[08 Apr 2011]
1. Overk CR, Kelley CM, Mufson EJ. (2009) Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 35(3):415-25. doi: 10.1016/j.nbd.2009.06.004. PMID: 19524671; PMCID: PMC3085918.
[XX Sept 2009]
Current Projects
• Assessment of hospital performance with respect to local demographics and human behavior patterns such as foot traffic, spending data, and government assistance during the pandemic
• Natural language processing of scientific literature to extract data relevant to a disease or topic and demonstrate geographical trends in study and research focus
• Crisis detection using human behavior such as spending, movement, and general health trends to provide early warning for an economic or health collapse, and highlight network vulnerabilities
• Integration of social vulnerability index, general health data, specific acute and chronic disease conditions, and human behavior with organizational decision making, including spending decisions by governments and hospitals, with a focus on system assessment and recommendations for improvement
• In addition to original data analysis, Dr. Kelley is an advisor for students working on thesis projects as part of attainment for a Master of computer science