Josh Hihath

Center Director & Professor, Biodesign Center for Bioelectronics and Biosensors

Center Director & Professor, School of Electrical, Computer and Energy Engineering

Biodesign Institute Arizona State University 1001 S. McAllister Ave TEMPE, AZ 85287-5801
Mail code: 5801

Campus: Tempe
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Long Bio

Josh Hihath is director of the Biodesign Center for Bioelectronics and Biosensors and a professor in the School of Electrical, Computer, and Energy Engineering. He was previously a professor and Vice Chair for Undergraduate Studies in the Department of Electrical and Computer Engineering at the University of California Davis. Prior to moving to UC Davis he was a research professor and lab manager at ASU. Professor Hihath received a bachelor's degree in electrical engineering from Kettering University in Flint, Michigan, and master's and doctoral degrees in electrical engineering from Arizona State University. Professor Hihath is a senior member of the IEEE, was recently awarded the UC Davis Graduate Mentoring and Advising award and is an alum of the UC Davis Faculty Leadership Academy. Hihath’s work is centered at the nexus of engineering, chemistry, biology, and physics, and focuses on understanding the electrical and mechanical properties of nanoscale and molecular systems for applications in electronics, sensing and health care.

Education

Ph.D. Electrical Engineering, Arizona State University, 2008
M.S. Electrical Engineering, Arizona State University, 2005
B.S. Electrical Engineering, Kettering University, Michigan, 2003

Research Website URL

https://biodesign.asu.edu/bioelectronics-and-biosensors/

Google Scholar URL

https://scholar.google.com/citations?user=GK8ZKzYAAAAJ

Research Interests

Josh Hihath’s research focuses on the intersection of biology, chemistry, physics, and electronics. His team works to understand and control the interface between molecular and electronic systems to create new generations of electronic and biosensing systems. Integrating these systems will yield new biosensing platforms that can rapidly detect, identify, and track a variety of biomarkers, as well as lay a foundation for future generations of electronic systems that are lower energy, made with materials that are easily processed and renewable, and higher performance.

Publications

58. T. Ghomian, O. Kizilkaya, L. Domulevicz, and J. Hihath. “Molecular Quantum Interference Effects on Thermopower in Hybrid 2-Dimensional Monolayers,” Nanoscale, vol. 14, pp. 6248-6257, 2022. DOI: 10.1039/D2NR01731H

57. T. Ghomian and J. Hihath, "Review of Dielectrophoretic Manipulation of Micro and Nanomaterials: Fundamentals, Recent Developments, and Challenges," IEEE Transactions on Biomedical Engineering, 2022. DOI: 10.1109/TBME.2022.3183167

56. C. D. Aiello, J. M. Abendroth, M. Abbas, A. Afanasev, S. Agarwal, A. S. Banerjee, D. N. Beratan, J. N. Belling, B. Berche, A. Botana, J. R. Caram, G. L. Celardo, G. Cuniberti, A. Garcia-Etxarri, A. Dianat, I. Diez-Perez, Y. Guo, R. Gutierrez, C. Herrmann, J. Hihath, S. Kale, P. Kurian, Y.C. Lai, T. Liu, A. Lopez, E. Medina, V. Mujica, R. Naaman, M. Noormandipour, J. L. Palma, Y. Paltiel, W. Petuskey, J. C. Ribeiro-Silva, J. J. Saenz, E. J. G. Santos, M. Solyanik-Gorgone, V. J. Sorger, D. M. Stemer, J. M. Ugalde, A. Valdes-Curiel, S. Varela, D. H. Waldeck, M. R. Wasielewski, P. S. Weiss, H. Zacharias, and Q. H. Wang. “A Chirality-Based Quantum Leap,” ACS Nano, vol. 16, pp. 4989-5035, 2022. DOI: 10.1021/acsnano.1c01347

55. T. Ghomian, N. Darwish, J. Hihath. “Thickness-Dependent Seebeck Coefficient in Hybrid 2-Dimensional layers,” 2021 IEEE 16th Nanotechnology Materials and Devices Conference, pp. 1-4, 2021. DOI: 10.1109/NMDC50713.2021.9677528

54. J. True, X. Xi, Z. Khan, J. Hihath, and N. Asadizanjani. “PCB Netlist Obfuscation with Micro Electro Mechanical Systems and Additive Manufacturing Techniques,” ISTFA 2021, pp. 172-178, 2021. DOI: 10.31399/asm.cp.istfa2021p0172

53. Y. Wang, M. Alangari, J. Hihath, A. K. Das, and M.P. Anantram. “A machine learning approach for accurate and real-time DNA sequence identification,” BMC Genomics, vol. 22 pp. 525, 2021. DOI: 10.1186/s12864-021-07841-6

53. L. Domulevicz, H. Jeong, N. K. Paul, J. S. Gomez-Diaz, and J.Hihath. “Multidimensional Characterization of Single‐Molecule Dynamics in a Plasmonic Nanocavity,” Angewandte Chemie, vol. 60 pp. 16436-16441, 2021. DOI: 10.1002/anie.202100886

52. J. Marrs, T. Ghomian, L. Domulevicz, C. McCold, J. Hihath. “Gold Nanoparticle Synthesis,” Journal of Visualized Experiments, vol. 173, pp. e62176, 2021. DOI: 10.3791/62176

51. H. Mohammad, B. Demir, C. Akin, B. Luan, J. Hihath, E. E. Oren and M. P. Anantram. “Role of Intercalation on Electrical Properties of Nucleic Acids for use in Molecular Electronics,” Nanoscale Horizons, vol. 6, pp. 651-660, 2021. DOI: 10.1039/D1NH00211B

50. Z. Li, L. Mejia, J. Marrs, H. Jeong, J. Hihath, and I. Franco, “Understanding the Conductance Dispersion of Single-Molecule Junctions,” Journal of Physical Chemistry C, vol. 125, pp. 3406-3414, 2021. DOI: 10.1021/acs.jpcc.0c08428

49. H. B. Li, S. Chen, J. S. Shan, and J. Hihath, “Temperature Dependent Tunneling in Single-Molecule Junctions,” ACS Sensors, vol. 6, no. 2, pp. 565-572, 2021. DOI: 10.1021/acssensors.0c02278

48. T. Ghomian, H. Jeong, V. Pan, K. Celik, M. Alangari, Y. Ke, and J. Hihath, “High-throughput Dielectrophoretic Trapping and Detection of DNA Origami,” Advanced Materials Interfaces, vol. 8, pp. 2001476, 2021. DOI: 10.1002/admi.202001476

47. H. Jeong, L. Domulevicz, and J. Hihath, “Design and Fabrication of a MEMS-based Break Junction Device for Mechanical Strain-Correlated Optical Characterization of a Single-Molecule,” Journal of Microelectromechanical Systems, vol. 30, no. 1, pp. 126-136, 2021. DOI: 10.1109/JMEMS.2020.3038024

46. E. S. Forzani, H. He, J. Hihath, S. M. Lindsay, R. M. Penner, S. Wang, and B. Xu, “Moving Electrons Purposefully through Single Molecules and Nanostructures: A Tribute to the Science of Nongjian Tao,” ACS Nano, vol. 14, no. 10, pp. 12291-12312, 2020. DOI: 10.1021/acsnano.0c06017

45. H. B. Li, B. E. Tebikachew, C. Wiberg, K. Moth-Poulsen, and J. Hihath, “An Electrically Controllable Single-Molecule Memory Element,” Angewandte Chemie, vol. 59, pp. 11641-11646, 2020. DOI: 10.1002/anie.202002300

44. H. Jeong, H. B. Li, L. Domulevicz, and J. Hihath, “A Micro-ElectroMechanical System for Contacting and Probing Single-Molecule Junctions,” Advanced Functional Materials, vol. 30, pp. 2000615, 2020. DOI: 10.1002/adfm.202000615

43. J. Hihath and S.M. Lindsay, “Nongjian Tao (1963-2020),” Nature Nanotechnology, vol. 15 pp. 345, 2020. DOI: 10.1038/s41565-020-0686-5

42. L. Xiang, P. Zhang, C. Liu, X. He, H. B. Li, Y. Li, Z. Wang, J. Hihath, S. H. Kim, D. N. Beratan, and NJ Tao, “Conductance and Configuration of Molecular Gold-Water-Gold Junctions under Electric Fields,” Matter, vol. 3, pp. 166-179, 2020. DOI: 10.1016/j.matt.2020.03.023

41. C. E. McCold, L. Domulevicz, Z. Cai, W. Y. Lo, S. Hihath, K. March, H. M. Mohammad, M.P. Anantram, L. Yu, and J. Hihath, “Molecular Control of Charge Carrier and Seebeck Coefficient in Hybrid Two-Dimensional Nanoparticle Superlattices,” Journal of Physical Chemistry, C, vol. 124, pp. 17–24, 2020. DOI: 10.1021/acs.jpcc.9b08185

40. H. Jeong, W. T. Hwang, Y. Song, J. K. Kim, Y. Kim, J. Hihath, S. Chung, T. Lee, “Highly uniform monolayer graphene synthesis via a facile pretreatment of copper catalyst substrates using an ammonium persulfate solution,” RSC advances, vol. 9, pp. 20871-20878, 2019. DOI: 10.1039/C9RA02689D

39. J. Veselinovic, M. Alangari, Y. Li, Z. Matharu, J. M. Artés, E. Seker, J. Hihath, “Two-tiered electrical detection, purification, and identification of nucleic acids in complex media,” Electrochimica Acta, vol. 313, pp. 116-121, 2019. DOI: 10.1016/j.electacta.2019.05.036

38. Y. Li, J.M. Artés, B. Demir, S. Gokce, H. M. Mohammad, M. Alangari, M. P. Anantram, E. E. Oren and J. Hihath, “Detection and identification of genetic material via single-molecule conductance,” Nature Nanotechnology, vol. 13, pp. 1167, 2018. DOI: 10.1038/s41565-018-0285-x

37. H. Wang, Z. Wang, Y. Wang, J. Hihath, H.Y. Chen, Y. Li, and NJ Tao. ”Potential Dependence of Mechanical Stability and Electronic Coupling of Single S–Au Bonds” Journal of the American Chemical Society, vol. 140, pp. 18074, 2018. DOI: 10.1021/jacs.8b10857

36. R. Ramachandran, H. B. Li, W. Lo, A. Neshchadin, L. Yu, and J. Hihath, “An Electromechanical Approach to Understanding Binding Configurations in Single-Molecule Devices,” Nano Letters, vol. 18, pp. 6638. DOI: 10.1021/acs.nanolett.8b03415

35. J. Hihath. “Charge Transport in the Inverted Marcus Region,” Nature Nanotechnology, vol. 13, pp. 273-277, 2018. DOI: 10.1038/s41565-018-0115-1

34. K. Tabatabaei, H. Lu, B.M. Nolan, X. Cen, C.E. McCold, X. Zhang, R.L. Brutchey, K. van Benthem, J. Hihath, and S.M. Kauzlarich. “Bismuth Doping of Germanium Nanocrystals through Colloidal Chemistry,” Chemistry of Materials, vol. , pp. , 2017. DOI: acs.chemmater.7b02241

33. B.E. Tebikachew*, H.B. Li*, A. Pirrotta, K. Börjesson, G.C. Solomon, J. Hihath, and K. Moth-Poulsen. “Effect of Ring Strain on the Charge Transport of a Robust Norbornadiene–Quadricyclane-Based Molecular Photoswitch,” The Journal of Physical Chemistry C, vol. 121, pp. 7094-7100, 2017. DOI: 10.1021/acs.jpcc.7b00319

32. C.E. McCold*, Q. Fu*, S. Hihath, J. Han, Y. Halfon, R. Faller, K. van Benthem, L. Zang, and J. Hihath. “Ligand exchange based molecular doping in 2D hybrid molecule-nanoparticle arrays: length determines exchange efficiency and conductance,” Molecular Systems Design and Engineering, vol. 2, pp. 440-448, 2017. *Authors contributed equally. DOI: 10.1039/C7ME00033B

31. S. Hosseini, C. Madden, J. Hihath, S. Guo, L. Zang, and Z Li. “Single Molecule Charge Transport and Electrochemical Gating in Redox-Active Perylene Diimide Junctions,” The Journal of Physical Chemistry C, vol. 120, pp. 22646–22654, 2016. DOI: 10.1021/acs.jpcc.6b06229

30. Y. Li, J.M. Artés, J. Qi, I.A. Morelan, P. Feldstein, M.P. Anantram, and J. Hihath. “Comparing Charge Transport in Oligonucleotides: RNA:DNA Hybrids and DNA Duplexes,” The Journal of Physical Chemistry Letters, vol. 7, pp. 1888, 2016. DOI: 10.1021/acs.jpclett.6b00749

29. A. C. Aragones, D. Aravena, J. I. Cerda, Z. Acis-Castillo, H. Li, J. A. Real, F. Sanz, J. Hihath, E. Ruiz, and I. Díez-Pérez. “Large Conductance Switching in a Single-Molecule Device through Room Temperature Spin-dependent Transport,” Nano Letters, vol. 16, pp. 218, 2016. DOI: 10.1021/acs.nanolett.5b03571

28. Y. Li, J. M. Artés, and J. Hihath. “Long-Range Charge Transport in Adenine-Stacked RNA:DNA Hybrids,” Small, vol. 12, pp 432, 2016. DOI: 10.1002/smll.201502399

27. J. M. Artés, Y. Li, J. Qi, M. P. Anantram, and J. Hihath. “Conformational Gating of DNA Conductance,” Nature Communications, vol. 6, pp. 8870, 2015. DOI: 10.1038/ncomms9870

26. C. E. McCold, Q. Fu, J. Y. Howe and J. Hihath, ” Conductance based characterization of structure and hopping site density in 2D molecule-nanoparticle arrays,” Nanoscale, vol. 7, pp. 14937-14945, 2015. DOI: 10.1039/c5nr04460j

25. J. C. Zhou, B. Feller, B. Hinsberg, G. Sethi, P. Feldstein, J. Hihath, E. Seker, M. Marco, A. Knoesen, and R. Miller, “Immobilization-mediated Reduction in Melting Temperatures of DNA-DNA and DNA-RNA Hybrids: Immobilized DNA Probe Hybridization Studied by SPR,” Colloids and Surfaces A, v. 481, pp. 72-79, 2015. DOI: 10.1016/j.colsurfa.2015.04.046

24. H. Rascón-Ramos, J. M. Artés, Y. Li, and J. Hihath. “Binding Configurations and Intramolecular Strain in Single-Molecule Devices,” Nature Materials. vol. 15, pp. 517-522, 2015. DOI: 10.1038/nmat4216

23. J. Hihath and N. Tao. “The Role of Molecule-Electrode Contact in Single-Molecule Electronics,” Semiconductor Science and Technology, vol. 29, pp. 054007, 2014. DOI: 10.1088/0268-1242/29/5/054007

22. J. Hihath and N. Tao. “Electron-Phonon Interactions in Atomic and Molecular Devices,” Progress in Surface Science, vol. 87, pp. 189-208, 2012. DOI: 10.1016/j.progsurf.2012.07.001

21. J. Hihath, S. Guo, P. Zhang, and N. Tao. “Effects of Cytosine Methylation on DNA Charge Transport,” Journal of Physics: Condensed Matter, vol. 24, pp. 164204, 2012. DOI: 10.1088/0953-8984/24/16/164204

20. C. Bruot, J. Hihath, and N. Tao. “Mechanically Controlled Molecular Orbital Alignment in Single Molecule Junctions,” Nature Nanotechnology, vol. 7, pp. 35-40, 2012. DOI: 10.1038/nnano.2011.212

19. S. Guo, J. Hihath, I. Díez-Pérez, and N. Tao. “Measurement and Statistical Analysis of Single-Molecule Current-Voltage Characteristics, Transition Voltage Spectoscopy, and Tunneling Barrier Height,” Journal of the American Chemical Society, vol. 133, pp. 19189-19197, 2011. DOI: 10.1021/ja2076857

18. J. Hihath, C. Bruot, H. Nakamura, Y. Asai, I. Diez-Perez, Y. Lee, L.P. Yu, and N. Tao. “Inelastic Transport and Low-Bias Rectification in a Single-Molecule Diode,” ACS Nano, vol. 5, pp. 8831-8339, 2011. DOI: 10.1021/nn2030644

17. H. Nakamura, Y. Asai, J. Hihath, C. Bruot, N. Tao. “Switch of Conducting Orbital by Bias-Induced Electronic Contact Asymmetry in a Bipyrimidinyl-Byphenyl Diblock Molecule: Mechanism to Achieve a pn Directional Molecular Diode,” Journal of Physical Chemistry C, vol. 115, pp. 19931-19938, 2011. DOI: 10.1021/jp205723g

16. Y. Asai, H. Nakamura, J. Hihath, N. Tao. “Electron Correlation Enhancement of the Diode Property of Asymmetric Molecule.” Physical Review B, vol. 84, pp. 115436, 2011. DOI: 10.1103/PhysRevB.84.115436

15. S. Guo, J. Hihath, and N. Tao. “Breakdown of Atomic-Sized Metallic Contacts Measured on Nanosceond-Scale,” Nano Letters, vol. 11, pp. 927-933, 2011. DOI: 10.1021/nl1026748

14. I. Díez-Pérez, J. Hihath, T. Hines, Z. Wan, K. Müllen, and N. Tao. “Controlling Single Molecule Conductance through Lateral Coupling of π-orbitals,” Nature Nanotechnology, vol. 6, pp. 226-231, 2011. DOI: 10.1038/nnano.2011.20

13. T. Hines, I. Díez-Pérez, J. Hihath, H. Liu, Z.S. Wang, J. Zhao, G. Zhou, K. Müllen and N. Tao. “Transition from Tunneling to Hopping in Single Molecular Junctions by Measuring Length and Temperature Dependence.” Journal of the American Chemical Society, vol. 132, pp. 11658-11664, 2010. DOI: 10.1021/ja1040946

12. I. Díez-Pérez, Z. Li, J. Hihath, J. Li, C. Zhang, X. Yang, L. Zang, Y. Dai, X. Feng, K. Mullen, and N. Tao. “Gate-Controlled Electron Transport in Coronenes as a Bottom-up Approach Towards Graphene Transistors,” Nature: Communications, vol. 1, pp. 31-35, 2010. DOI: 10.1038/ncomms1029

11. J. Hihath, C. Bruot, and N. Tao. “Electron-Phonon Interactions in Single Octanedithiol Molecular Junctions.” ACS Nano, vol. 4, pp. 3823-3830, 2010. DOI: 10.1021/nn100470s

10. I. Díez-Pérez, J. Hihath, Y. Lee, L. Yu, L. Adamska, M.A. Kozhushner, I. Oleynik, N. Tao, “Rectification and Stability of a Single Molecular Diode with Controlled Orientation,” Nature: Chemistry, vol. 1, pp. 635-641, 2009. DOI: 10.1038/nchem.392

9. J. Hihath and N. Tao. “Rapid Measurement of Single Molecule Conductance,” Nanotechnology, vol. 19, pp. 265204/7, 2008. DOI: 10.1088/0957-4484/19/26/265204

8. J. Hihath, C. R. Arroyo, G. Rubio-Bollinger, N. Tao and N. Agrait. “Study of Electron-Phonon Interactions in a Single Molecule Covalently Connected to Two Electrodes,” Nano Letters, vol. 8, pp. 1673-1678, 2008. DOI: 10.1021/nl080580e

7. X. Li, J. Hihath, F. Chen, T. Masuda, L. Zang, and N. Tao, "Thermally Activated Electron Transport in Single Redox Molecules," Journal of the American Chemical Society, vol. 129, pp. 11535-11542, 2007. DOI: 10.1021/ja072990v

6. F. Chen, J. Hihath, Z. Huang, X. Li, and N. J. Tao, "Measurement of Single-Molecule Conductance," Annual Review of Physical Chemistry, vol. 58, pp. 535-564, 2007. DOI: 10.1146/annurev.physchem.58.032806.104523

5. J. Hihath, F. Chen, P. Zhang, and N. Tao, "Thermal and Electrochemical Gate Effects on DNA Conductance," Journal of Physics: Condensed Matter, vol. 19, pp. 215202/1-215202/9, 2007. DOI: 10.1088/0953-8984/19/21/215202

4. F. Chen, X. Li, J. Hihath, Z. Huang, and N. Tao, "Effect of Anchoring Groups on Single-Molecule Conductance: Comparative Study of Thiol-, Amine-, and Carboxylic-Acid-Terminated Molecules," Journal of the American Chemical Society, vol. 128, pp. 15874-15881, 2006. DOI: 10.1021/ja065864k

3. X. Li, J. He, J. Hihath, B. Xu, S. M. Lindsay, and N. Tao, "Conductance of Single Alkanedithiols. Conduction Mechanism and Effect of Molecule-Electrode Contacts," Journal of the American Chemical Society, vol. 128, pp. 2135-2141, 2006. DOI: 10.1021/ja057316x

2. J. Hihath, B. Xu, P. Zhang, and N. Tao, "Study of Single-Nucleotide Polymorphisms by Means of Electrical Conductance Measurements," Proceedings of the National Academy of Sciences of the United States of America, vol. 102, pp. 16979-16983, 2005. DOI: 10.1073/pnas.0505175102

1. X. Li, B. Xu, X. Xiao, J. Hihath, and N. Tao, "Measurement of Electron Transport Properties of Single Molecules," Japanese Journal of Applied Physics, Part 1, vol. 44, pp. 5344-5347, 2005. DOI: 10.1143/JJAP.44.5344

Book Chapters:

3. N. Darwish, C. Foroutan-Nejad, L. Domulevicz, J. Hihath, and I. Diez-Perez, “Principles of Molecular Devices Operated by Electric Fields,” In Effects of Electric Fields on Structure and Reactivity. S. Shaik and T. Stuyver (Ed.). Royal Society of Chemistry, pp. 147-194, 2021. DOI: 10.1039/9781839163043-00147

2. J. M. Artés, J. Hihath, and I. Díez-Pérez, “Biomolecular Electronics,” In Molecular Electronics: An Experimental and Theoretical Approach. I. Baldea (Ed.). Pan Stanford Publishing, pp. 462, 2015. DOI: 10.1201/b18763-6

1. J. Hihath. “Controlling the Molecule-Electrode Contact in Single-Molecule Devices,” In Handbook of Single-Molecule Electronics. K. Moth-Poulsen (Ed.). Pan Stanford Publishing, pp. 448, 2015. DOI: 10.1201/b19368-9

Courses

2023 Spring

Course Number	Course Title
EEE 792	Research

2022 Fall

Course Number	Course Title
EEE 492	Honors Directed Study
EEE 493	Honors Thesis
EEE 499	Individualized Instruction
EEE 590	Reading and Conference
EEE 595	Continuing Registration
EEE 599	Thesis
EEE 690	Reading and Conference
EEE 790	Reading and Conference
EEE 792	Research
EEE 795	Continuing Registration
EEE 799	Dissertation
EEE 592	Research
MSE 792	Research
EEE 492	Honors Directed Study
EEE 493	Honors Thesis
EEE 499	Individualized Instruction
EEE 499	Individualized Instruction