Tatiana Ugarova
Professor, School of Life Sciences
Professor, School of Life Sciences Human Dimensions
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ISTB1, Room 424 TEMPE, AZ 85287
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Mail code: 4501Campus: Tempe
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Publications
- Owaynat, H., Yermolenko, I.S., Turaga, R., Lishko, V.K., Sheller, M. and Ugarova, T.P. Limiting mechanisms of thrombus propagation: Deposition of fibrinogen on the surface of blood clots prevents platelet adhesion. Thrombosis Research (2015).
- Podolnikova, N.P. Podolnikov, A.V., Lishko, VK, T. Haas, T and Ugarova, T.P. Ligand 2. recognition specificity of leukocyte integrin aMß2 (Mac-1, CD11b/CD18) and its functional 3. consequences,. Biochemistry (2015).
- Podolnikova, N.P., Brothwell, J.A., Ugarova, T.P. The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (aMß2, CD11b/CD18). Molecular Pain (2015).
- Safiullin, R., Christenson, W., Owaynat, H., Yermolenko, I.S., Kadirov, M.K., Ros, R., Ugarova, T.P. Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating. Biomaterials (2015).
- Tsen, S.D.; Kibler, K., Jacobs, B., Fay, J.C., Podolnikova, N.P., Ugarova, T.P., Achilefu, S., Tsen, K. Selective photonic disinfection of cell culture using a visible ultrashort pulsed laser. Selected Topics in Quantum Electronics (2015).
- Lishko, V., Moreno, B., Podolnikova, N., Ugarova, T. Identification of the Antimicrobial Peptide LL-37 as a Ligand for Integrin aMß2 (Mac-1, CD11b/CD18) Reveals its Role in Macrophage Phagocytosis. FASEB Journal (2015).
- Podolnikova, N., Lishko, V., Haas, T. and Ugarova, T. Recognition Specificity of Leukocyte Integrin aMß2 (Mac-1, CD11b/CD18) and its Functional Consequences. FASEB Journal (2015).
- Christenson, W.B., *Yermolenko, I.S., Plochberger, B., Camacho-Alanis, F., Ros, A., Ugarova, T.P. and Ros, R. Combined single cell AFM manipulation and TIRFM for probing the molecular stability of multilayer fibrinogen matrices. Ultramicroscopy (2014).
- Gorbatyuk, v., Nguyen, K., Podolnikova, N.P., Deshmukh, L., Lin, X., Ugarova, T.P., Vinogradova, O. Skelemin association with aIIbß3 integrin: A structural model. Biochemistry (2014).
- V. K. Lishko, I. S. Yermolenko, N. P. Podolnikova and T. P. Ugarova. A NOVEL MECHANISM CONTROLLING THE GROWTH OF HEMOSTATIC THROMBI. Ukrainian Biochemical Journal. Anniversary Issue (2014).
- Safiullin, R., Yermolenko, I.S., Lishko, V.K., Kadirov, M.K., Ros, R., Ugarova, T.P. Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating. Proceedings of the XXIII International Fibrinogen Workshop, Marseille, France (2014).
- Yermolenko, I.S., Turaga, R., Sheller, M., Ugarova, T.P. Self-limiting mechanisms of thrombus propagation: the role of fibrinogen. Proceedings of the XXIII International Fibrinogen Workshop, Marseille, France (2014).
- Christenson, W.B., Yermolenko, I.S., Plochberger, B., Camacho-Alanis, F., Ros, A., Ugarova, T.P. and Ros, R. Combined single cell AFM manipulation and TIRFM for probing the molecular stability of multilayer fibrinogen matrices. Ultramicroscopy (2013).
- Podolnikova, N.P., Yakovlev, S., Yakubenko, V.P., Wang, X., Gorkun, O.V., Ugarova, T.P. The interaction of integrin aiibß3 with fibrin occurs through multiple binding sites in the aiib ß-propeller domain. Journal of Biological Chemostry (2013).
- Christenson, W.B., Yermolenko, I.S., Alanis, F.C., Ros, A., Ugarova, T.P., Ros, R. Molecular stability of the nonadhesive fibrinogen multilayer. Biophysical Journal 57th Annual Meeting of Biophysical Society, February, 2013 (2013).
- Kyubeom Oh, Podolnikova, N.P., Mandarino, L., Ugarova, T. Weight gain and changes in the polarization of fat macrophages towards the M1-Like proinflammatory phenotype in integrin Mac-1 (CD11b/CD18) deficient mice. Proceedings of the 73rd scientific sessions of the American Diabetes Association (2013).
- Owaynat, H., Lishko, V.K., Faust, J.J., Ugarova, T.P. The dual role of platelets in thrombus formation. Blood (2013).
- Podolnikova, N.P., Kyubeom Oh, Yermolenko, I.S., Ugarova, T.P. An altered An altered macrophage migration in adipose tissue of integrin Mac-1 (CD11b/CD18) deficient mice. Blood (2013).
- Lishko, V.K., Yermolenko, I.S., Owaynat H., Ugarova T. Fibrinogen counteracts the anti-adhesive effect of fibrin-plasminogen by preventing its activation by adherent U937 cells. Journal of Thrombosis and Hemostasis (2012).
- Yermolenko, I.S., Gorkun, O.V., Fuhrmann, A., Podolnikova, N.P. Lishko, V.K., Lord, S.T., Ros, R., Ugarova, T.P. The assembly of nonadhesive fibrinogen matrices depends on the aC regions of the fibrinogen molecule. Journal of Biological Chemistry (2012).
- Wu, Y., Kushchaeva, Y., Ugarova, T.P. The role of integrins aMb2 (CD11b/CD18) and adb2 (CD11d/CD18) in macrophage fusion. Blood (2012).
- Yermolenko, I.S., Bryant, Doss, Robert Ros, Tatiana P. Ugarova. The mechanism of the formation of nonadhesive fibrinogen matrices examined by atomic force microscopy. Biophysical Journal (2012).
- Yermolenko, I.S., Lishko, V.K., Ugarova, T.P., Magonov, S.N. High-resolution visualization of fibrinogen molecules and fibrin fibrils with atomic force microscopy. Biomacromolecules (2011).
- Podolnikova, N., Yakubenko, V. Ugarova, T. Molecular basis for fibrin binding by platelet integrin aIIbb3. Journal of Thrombosis and Hemostasis (2011).
- Yermolenko, IS, Gorkun, OV, Fuhrmann, A, Lishko, VK, Lord, ST, Ros, R, Ugarova, TP,. The role of the gammaC domains in the formation of nonadhesive fibrinogen matrices. Blood (2011).
- Derkach, D.N., Wadekar, S.A., Perkins, K.B., Rousseau, E., Dreiza, C.M., Cheung-Flynn, J., Ramos, H.C., Ugarova, T.P. and Sheller, M.R. RGD-dependent binding of TP508 to integrin ?v?3 mediates cell adhesion and induction of nitric oxide. Thrombosis and Hemostasis (2010).
- Lishko, V.K., Yermolenko, I.S. and Ugarova, T.P. Plasminogen on the surface of fibrin clot prevents adhesion of leukocytes and platelets. Journal of Thrombosis and Haemostasis (2010).
- Lishko, V.K., Yermolenko, I.S. and Ugarova, T.P. Plasminogen on the surface of fibrin clot prevents adhesion of leukocytes and platelets. Journal of Thrombosis and Haemostasis, (2010).
- Podolnikova, N., Yermolenko, I., Fuhrmann, A., Lishko, V., Magonov, S.,Bowen, B., Podolnikov, A., Ros, R. and Ugarova, T.P. Control of integrin ?IIb?3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. Biochemistry (2010).
- Yermolenko, I.S., Fuhrmann, A. Magonov, S.N., Lishko, V.K., Oshkadyerov, S.P., Ros R., Ugarova, T.P. Origin of the nonadhesive properties of fibrinogen matrices probed by force spectroscopy. Langmuir (2010).
- Yermolenko, I., Fuhrmann, A., Ugarova, T.P., Ros, R. Physical Properties of Fibrinogen Substrates Control Integrin Mediated Cell Adhesion. Biophysical Journal (2010).
- Podolnikova N.P, O’Toole T.E, Haas, T.A., Lam S.C, Fox J.E.B and Ugarova TP. Adhesion-induced unclasping of cytoplasmic tails of integrin aIIbb3. Biochemistry (2009).
- Valentin Yakubenko, Tatiana Ugarova. The role of integrin aDb2 in monocyte/macrophage migration. Experimental Cell Research (2008).
- Derkach D, Wadekar S, Rousseau E, Ugarova T, Perkins K, Sheller M. Cell Adhesion to Thrombin Peptide, TP508, is RGD-Dependent and Mediated by Integrin aVb3. American Society of Cell Biology 48th Annual Metting, San Francisco, CA (2008).
- Podolnikova, N., Bowen, B., Lishko, V., Ugarova, T. Control of integrin-mediated platelet adhesion by rigidity sensing at the surface of fibrin(ogen) sustrates. FASEB J (2008).
- Podolnikova, N., Bowen, B., Lishko, V., Ugarova, T. Control of integrin-mediated platelet adhesion by rigidity sensing at the surface of fibrin(ogen) substrates. Proceedings of the XXth International Fibrinogen Workshop (2008).
- V Lishko, T Burke, Tatiana Ugarova. Anti-adhesive effect of fibrinogen: A safeguard for thrombus stability. Blood (2007).
- V Yakubenko, S Yadav, Tatiana Ugarova. Integrin alphaDbeta2, an adhesion receptor upregulated in macrophage foam cells, exhibits multiligand binding properties. Blood (2006).
- Lishko, Valeryi, Ugarova, Tatiana. Plasminogen protects fibrin clot from leukocyte invasion. (2006).
- Podolnikova, N, O'Toole, T, Fox, J, Lam, S, Ugarova, Tatiana. Conformational changes in the cytoplasmic domain of integrin alphaIIbbeta3 induced by adhesion of resting platelets to fibrin(ogen). (2006).
- N Podolnikova, O Gorkun, R Loreth, S Lord, V Yee, Tatiana Ugarova. A cluster of basic amino acid residues in the ?370-381 sequence of fibrinogen comprises a binding site for platelet integrin ??IIb?3 (GPIIb/IIIa). Biochemistry (2005).
- S Yakovlev, L Zhang, Tatiana Ugarova. Interaction of fibrin(ogen) with leukocyte receptor ?M?2: Further characterization and identification of a novel binding region within the central domain of the fibrinogen ?-module. Biochemistry (2005).
- N Podolnikova, G Volkov, Tatiana Ugarova. Structure function analysis of the P3 peptide identical to ?370-383, the binding site for integrin ?IIb?3 within the ?C-domain of fibrinogen. Ukr. Biochem. J (2004).
- V Lishko, N Podolnikova, V Yakubenko, S Yakovlev, L Medved, S Yadav, Tatiana Ugarova. Multiple binding sites in fibrinogen for integrin ?M?2 (Mac-1). J Biol Chem (2004).
- V Lishko, V Novokhatny, V Yakubenko, H Skomorovskaja-Prokvolit, Tatiana Ugarova. Characterization of plasminogen as an adhesive ligand for integrins ?M?2(Mac-1) and ?5?1(VLA-5). Blood (2004).
- J Schober, Lester Lau, Tatiana Ugarova, S Lam. Identification of a novel integrin ?M?2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions. J. Biol. Chem (2003).
- N Podolnikova, V Yakubenko, E Plow, Tatiana Ugarova. Identification of a novel binding site for platelet integrins ?IIb?3(GPIIbIIIa) and ?5?1 in the ?C-domain of fibrinogen. J. Biol. Chem (2003).
- Tatiana Ugarova, V Lishko, N Podolnikova, N Okumura, S Merkulov, V Yakubenko, V Yee, S Lord, T Haas. Sequence ?383-395 (P2-C) but not ?190-202 (P1) is binding site for the ?MI-domain of integrin ?M?2??in the ?C-domain of fibrinogen. Biochemistry (2003).
- V Lishko, V Yakubenko, Tatiana Ugarova. The interplay between integrins ?M?2 and ?5?1 during cell migration to fibronectin. Exp. Cell Research (2003).
- J Schober, N Chen, T Grzeskiewich, E Emeson, Tatiana Ugarova, R Yee, L Lau, S Lam. Identification of integrin ?M?2 as an adhesion receptor on peripheral blood monocytes for Cyr61 and connective tissue growth factor, immediate-early gene products expressed in atherosclerotic lesions. Blood (2002).
- V Lishko, B Kudryk, V Yee, Tatiana Ugarova. Regulated exposure of the cryptic binding site for leukocyte integrin ?M?2 in the ?C-domain of fibrinogen. Biochemistry (2002).
- V Yakubenko, V Lishko, S Lam, Tatiana Ugarova. A molecular basis for inetgrin ?M?2 ligand binding promiscuity. J. Biol. Chem (2002).
- C Forsyth, D Solovjov, Tatiana Ugarova, E Plow. Integrin ?M?2-mediated cell migration to fibrinogen and recognition peptides. J. Exp. Med (2001).
- Tatiana Ugarova, V Yakubenko. Recognition of fibrinogen by leukocyte integrins: A molecular link between hemostasis and inflammation. Ann. New York Acad. Sci (2001).
- V Lishko, V Yakubenko, K Hertzberg, G Grieninger, Tatiana Ugarova. The alternatively spliced ?EC domain of fibrinogen-420 is a novel ligand for leukocyte integrins ?M?2 and ?X?2 integrins. Blood (2001).
- V Yakubenko, D Solovjov, L Zhang, V Yee, E Plow, Tatiana Ugarova. Identification of the binding site for fibrinogen recognition peptide ?383-395 within the ?MI- domain of integrin ?M?2. J. Biol. Chem (2001).
- W Hu, J Eaton, Tatiana Ugarova, L Tang. Molecular basis of biomaterial-mediated foreign body reactions. Blood (2001).
- B Johnston, A Chee, T Issekutz, Tatiana Ugarova, A Fox-Robinchaud, M Hichey, P Kubes. ?4-integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation. J. Immunology (2000).
- K McClary, Tatiana Ugarova, D Grainger. Modulating fibroblast adhesion, spreading and proliferation using self-assembled monolayer films of alkylthiolates on gold. Journal of Biomedical Materials Research (2000).
- V Yakubenko, R Lobb, E Plow, Tatiana Ugarova. Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T-lymphocytes through ?4?1-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp. Cell. Res (2000).
Research Activity
- Ugarova,Tatiana P*, Ros,Robert. Molecular basis for nonadhesive properties of fibrinogen matrices. HHS-NIH-NHLBI(4/6/2011 - 8/31/2016).
- Ugarova,Tatiana P*, Ugarova,Tatiana P*. Recognition of Fibrinogen by Leukocyte Integrins. HHS-NIH-NHLBI(12/1/2010 - 7/31/2019).
- Ugarova,Tatiana P. Origin of the nonadhesive properties of fibrinogen matrices probed by atomic force spectroscopy. (7/1/2010 - 6/30/2012).
- Ugarova,Tatiana P. Recognition of Fibrinogen by Leukocyte Integrins. HHS-NIH-NHLBI(10/1/2007 - 11/30/2010).
- Ugarova,Tatiana P. Recognition of Fibrinogen by Leukocyte Integrins. HHS-NIH-NHLBI(8/15/2006 - 10/1/2007).
Courses
2023 Fall
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MCB 555 | Adv Molecular & Cellular Sci |
2023 Summer
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
2023 Spring
| Course Number | Course Title |
|---|---|
| BIO 493 | Honors Thesis |
| BIO 353 | Cell Biology |
| BIO 495 | Undergraduate Research |
2022 Fall
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MCB 555 | Adv Molecular & Cellular Sci |
2022 Summer
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
2022 Spring
| Course Number | Course Title |
|---|---|
| BIO 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
2021 Fall
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MCB 555 | Adv Molecular & Cellular Sci |
2021 Summer
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
2021 Spring
| Course Number | Course Title |
|---|---|
| BIO 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| BIO 394 | Special Topics |
2020 Fall
| Course Number | Course Title |
|---|---|
| BIO 492 | Honors Directed Study |
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MCB 555 | Adv Molecular & Cellular Sci |
| NEU 555 | Adv Molecular & Cellular Sci |
2020 Summer
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
2020 Spring
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| BIO 394 | Special Topics |
2019 Fall
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MCB 555 | Adv Molecular & Cellular Sci |
| NEU 555 | Adv Molecular & Cellular Sci |
2019 Summer
| Course Number | Course Title |
|---|---|
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
2019 Spring
| Course Number | Course Title |
|---|---|
| BIO 353 | Cell Biology |
| BIO 495 | Undergraduate Research |
| BIO 394 | Special Topics |
2018 Fall
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MCB 555 | Adv Molecular & Cellular Sci |
| NEU 555 | Adv Molecular & Cellular Sci |
Service
- The International Fibrinogen Research Society, Elected Treasurer (2014 - Present)
- The International Fibrinogen Research Society, Elected Treasurer (2014 - Present)
- Faculty Search Committee for a position in Biomarkers at the rank of Assistant Professor, SoLS, Member (2012 - Present)
- Keck Bioimaging Laboratory Advisory Committee, Member (2012 - Present)
- Keck Bioimaging Laboratory Advisory Committee, Member (2012 - Present)
- Maryland Industrial Partnership, Reviewer (2011 - Present)
- Search Committee for two positions in metabolic biology for SoLS, Member (2010 - Present)
- Search Committee for two positions in microbiology for SoLS and Biodesign Institute, Member (2010 - Present)
- Search Committee for two positions for the Department of Chemistry and Biochemistry, Member (2009 - Present)
- NIH HT Study Section, Reviewer (2008 - Present)
- Search Committee for two positions in Metabolic Biology, Member (2007 - Present)
- SoLS Research and Training Initiatives Committee, Member (2007 - Present)
- SoLS Research and Training Initiatives Committee, Member (2007 - Present)
- SoLS Research and Training Initiatives Committee, Member (2007 - Present)
- SoLS Research and Training Initiatives Committee, Member (2007 - Present)
- American Heart Association Thrombosis Study Section, Reviewer (2006 - Present)
- Thrombosis and Hamostasis, Reviewer (2006 - Present)
- Thrombosis and Hemostasis, Reviewer (2006 - Present)
- The International Fibrinogen Research Society, Member, Board of Gobernors (2003 - Present)
- The International Fibrinogen Research Society, Member, Board of Counselors (2003 - Present)
- The International Fibrinogen Research Society, Board of Counselors (2003 - Present)
- The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
- The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
- The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
- The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
- NIH Hemostasis and Thrombosis Study section, Member (2011 - 2016)
- NIH Hemostasis and Thrpmbosis Study section, Member (2011 - 2016)
- NIH HT Study section, Member (2011 - 2015)
- NIH HT Study section, NIH HT Study section (2011 - 2015)
- Faculty Search Committee for a position in Biomarkers at the rank of Assistant Professor, SoLS, Memeber (2014 - 2015)
- Faculty Search Committee for a position in Biomarkers at the rank of Assistant Professor, SoLS, Memeber (2012 - 2013)
- School of Life Sciences Research and Training Initiatives Committee, Member (2007 - 2012)
- The International Fibrinogen Research Society, Board of Counselors (2003 - 2010)
- Search Committee for two positions for the Department of Chemistry and Biochemistry, Member (2009 - 2010)
- Georgian National Science Foundation, Reviewer (2007 - 2007)
- NIH Study Section, Reviewer (2007 - 2007)
- American Heart Association, Member of the Thrombosis Study Section (2006 - 2006)
- 11th Midwest Platelet Conference, Chicago, Invited Speaker (2006 - 2006)
- XIX international Fibrinogen Workshop, Surrey, UK, Speaker (2006 - 2006)
- Interactions of fibrinogen with cells and receptor, XVII International Fibrinogen Workshop, Chairman (2004 - 2004)
- XVIIIth International Fibrinogen Workshop, Chapel Hill, NC, Speaker (2004 - 2004)
- 16th International Congress of the International Society for Fibrinolysis and Proteolysis, Munich, Speaker (2002 - 2002)
- 75th session of the American Heart Association, Chicago, Speaker (2002 - 2002)
- Interactions of fibrinogen with biomaterials, 16th International Congress of the International Society for Fibrinolysis and Proteolysis (ISFP), Chairman (2002 - 2002)
- XVIIIth Congress of ISTH, Paris, France, Speaker (2001 - 2001)
- XVIIth Congress of ISTH, Washington, D.C, Invited Speaker (2000 - 2000)
- XVIth International Fibrinogen Workshop, Leiden, Netherlands, Invited Speaker (2000 - 2000)