Li Liu
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Phone: 480-727-9813
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1001 S. McAllister Ave Biodesign Institute BDB220B Tempe, AZ 85287-5301
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Mail code: 8620Campus: Dtphx
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Dr. Li Liu is an associate professor of biomedical informatics and the director of the Bioinformatics Core Facility at Arizona State University. She holds an MD in medicine and a master's degree in information systems. As a trained clinician and a bioinformatics researcher, she fully appreciates the critical roles genomic medicine and bioinformatics play in advancing precision medicine. By integrating genomic, phylogenetic, population genetic, statistical and machine-learning techniques, Dr. Liu and her research team investigate clinical and molecular signatures of human diseases, and develop novel computational methods to discover biomarkers for early diagnosis and accurate prediction of therapeutic responses for individual patients. Before joining ASU, Dr. Liu helped build and directed the bioinformatics core facility at University of Florida.
- M.S. Information System, New Jersey Institute of Technology 2001
- M.D. Medicine, Peking Union Medical College 1999
Dr. Liu’s research focuses on developing and applying computational methods to advance precision medicine, with a special aspect of incorporating evolutionary and functional information in model construction. Via close collaborations with biomedical and clinical researchers world-wide, she aims to translate bioinformatics discoveries into improvements in patient care. Her past and current research projects include:
- Development of a novel evolution-informed modeling approach to discover biomarkers for accurate prediction of treatment outcomes. This method has been applied to leukemia, prostate cancer, breast cancer and bladder cancer.
- Optimization of anticancer therapy by understanding intratumor heterogeneity via subclonal reconstruction.
- Multi-task learning to discover biomarkers for complex diseases in under-represented populations. This method has been applied to type-2 diabetes and Alzheimer’s disease.
- Novel method for eQTL analysis with flexible LD structure and tree-guided group lasso. This method has been applied to inflammatory bowel disease.
- Diagnosis of deleterious variants in personal exomes using evolutionary profiles. Methods have been developed for Mendelian diseases and differential drug responses.
- Investigate evolutionary origins of human disease.
- Assessment of biodiversity in immunoglobulin pools for autoimmune diseases.
- Method development and analysis of metagenomics data.
Related Links:
Complete List of Published Work in MyBibliography:
Selected Publications
Kumar S, Sanderford M, Gray VE, Ye J, Liu L (2012) Evolutionary Diagnosis Method for Variants in Personal Exomes. Nature Methods 9(9):855-6
Kumar S, Liu L. (2014) No positive selection for G-allele in a p53 response element in Europeans. Cell 157(7):1497-1499
Liu L, Tamura K, Sanderford M, Gray VE, Kumar S (2016) A Molecular Evolutionary Reference for the Human Variome. Molecular Biology and Evolution 33(1):245-54
Liu L, Kumar S. (2013) Evolutionary balancing is critical for correctly forecasting disease associated amino acid variants. Molecular Biology and Evolution 30(6):1252-7
Liu L, Chang Y, Yang T, Noren DP, Long B, Kornblau S. Qutub A, Ye J (2016) Evolution-informed Modeling Improves Outcome Prediction for Cancers. Evolutionary Applications 10.1111/eva.12417
Gerek ZN, Liu L, Gerold K, Biparva P, Thomas ED, Kumar S. (2015) Evolutionary Diagnosis of non-synonymous variants involved in differential drug response. BMC Medical Genomics 8(1):534
Yin L, Liu L, Sun Y, Hou W, Lowe AC, Gardner BP, Salemi M, Williams WB, Farmerie WG, Sleasman JW, Goodenow MM (2012) High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems. Retrovirology 9:108
Sun Y, Cai YP, Liu L, Yu F, Farrell M, McKendree W, Farmerie WG. (2009) ESPRIT: estimating species richness using large collectins of 16S rRNA shotgun sequences. Nucleic Acid Research 37(10):e76
Moroz LL, Edwards JR, Puthanveettil SV, Kohn A, Ha T, Heyland A, Knudsen B, Sahni A, Yu F, Liu L, Jezzini S, Sadreyev R, Lovell P, Iannucculli W, Chen M, Nguyen T, Sheng H, Shaw R, Kalachikov S, Panchin Y, Farmerie WG, Russo JJ, Ju J, Kandel ER (2006) The Neuronal Transcriptome of Aplysia californica: A Platform for the Neurogenomics of Defined Neurons, Neuronal Compartments and Neuronal Circuitry. Cell. 127(7):1453-1467
Cousins RJ, Blanchard RK, Popp MP, Liu L, Cao J, Moore JB and Green CL. (2003) A Global View of the Selectivity of Zinc Deprivation and Excess on Genes Expressed in Human THP-1 Mononuclear Cells, PNAS, 100:6952-6957.
Courses
2025 Spring
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 790 | Reading and Conference |
BMI 484 | Internship |
BMI 483 | Capstone II |
BMI 584 | Internship |
BMI 482 | Capstone I |
BMI 590 | Reading and Conference |
NTR 598 | Special Topics |
2024 Fall
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 790 | Reading and Conference |
BMI 484 | Internship |
BMI 482 | Capstone I |
BMI 584 | Internship |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 590 | Reading and Conference |
BMI 483 | Capstone II |
2024 Summer
Course Number | Course Title |
---|---|
BMI 584 | Internship |
BMI 792 | Research |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
2024 Spring
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 790 | Reading and Conference |
BMI 330 | Topics Trans Bioinformatics |
BMI 484 | Internship |
BMI 483 | Capstone II |
BMI 584 | Internship |
BMI 482 | Capstone I |
BMI 590 | Reading and Conference |
2023 Fall
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 790 | Reading and Conference |
BMI 484 | Internship |
BMI 311 | Modeling Biomedical Knowledge |
BMI 482 | Capstone I |
BMI 584 | Internship |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 590 | Reading and Conference |
BMI 483 | Capstone II |
EXW 780 | Practicum |
2023 Summer
Course Number | Course Title |
---|---|
BMI 584 | Internship |
BMI 792 | Research |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
2023 Spring
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 790 | Reading and Conference |
BMI 330 | Topics Trans Bioinformatics |
BMI 484 | Internship |
BMI 483 | Capstone II |
BMI 584 | Internship |
BMI 482 | Capstone I |
BMI 590 | Reading and Conference |
2022 Fall
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 790 | Reading and Conference |
BMI 484 | Internship |
BMI 311 | Modeling Biomedical Knowledge |
BMI 482 | Capstone I |
BMI 584 | Internship |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 590 | Reading and Conference |
BMI 483 | Capstone II |
2022 Summer
Course Number | Course Title |
---|---|
BMI 584 | Internship |
BMI 792 | Research |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
2022 Spring
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 790 | Reading and Conference |
BMI 330 | Topics Trans Bioinformatics |
BMI 312 | Modeling Biomedical Data |
BMI 484 | Internship |
BMI 483 | Capstone II |
BMI 584 | Internship |
BMI 482 | Capstone I |
BMI 590 | Reading and Conference |
CHS 494 | Special Topics |
2021 Fall
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 790 | Reading and Conference |
BMI 484 | Internship |
BMI 311 | Modeling Biomedical Knowledge |
BMI 482 | Capstone I |
BMI 584 | Internship |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 590 | Reading and Conference |
BMI 483 | Capstone II |
2021 Summer
Course Number | Course Title |
---|---|
BMI 584 | Internship |
BMI 792 | Research |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
2021 Spring
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 790 | Reading and Conference |
BMI 330 | Topics Trans Bioinformatics |
BMI 312 | Modeling Biomedical Data |
BMI 484 | Internship |
BMI 483 | Capstone II |
BMI 584 | Internship |
BMI 482 | Capstone I |
BMI 590 | Reading and Conference |
2020 Fall
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 790 | Reading and Conference |
BMI 484 | Internship |
BMI 311 | Modeling Biomedical Knowledge |
BMI 201 | Intro to Clinical Informatics |
BMI 201 | Intro to Clinical Informatics |
BMI 482 | Capstone I |
BMI 584 | Internship |
BMI 792 | Research |
BMI 593 | Applied Project |
BMI 560 | Teachng Biomedical Informatics |
BMI 590 | Reading and Conference |
2020 Summer
Course Number | Course Title |
---|---|
BMI 584 | Internship |
BMI 792 | Research |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
2020 Spring
Course Number | Course Title |
---|---|
BMI 799 | Dissertation |
BMI 792 | Research |
BMI 560 | Teachng Biomedical Informatics |
BMI 790 | Reading and Conference |
BMI 593 | Applied Project |
BMI 330 | Topics Trans Bioinformatics |
BMI 312 | Modeling Biomedical Data |
BMI 484 | Internship |
BMI 483 | Capstone II |
BMI 584 | Internship |
BMI 482 | Capstone I |