Jeffrey Kleim
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Phone: 480-727-8354
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ECG 327 Tempe, AZ 85257
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Jeffrey Kleim is an associate professor and associate director of the School of Biological and Health Systems Engineering at Arizona State University. He studies how neural plasticity supports learning in the intact brain and “relearning” in the damaged or diseased brain. His research is directed at developing therapies that optimize plasticity in order to enhance recovery after stroke and Parkinson’s Disease. The brain is a highly dynamic organ that is capable of structural and functional reorganization in response to a variety of manipulations. This neural plasticity is the mechanism by which the brain encodes experience. His laboratory examines how plasticity within rat and human motor cortex supports learning in the intact brain and “relearning” after stroke. His group uses intracortical microstimulation in rats and transcranial magnetic stimulation in humans to examine how motor training alters the functional organization of motor cortex. This work has demonstrated that rehabilitation-dependent recovery of motor function after stroke is associated with a reorganization of movement representations in rodent motor cortex. Furthermore, there are specific behavioral and neural signals that drive both recovery and plasticity. These experiments are being used to test novel therapies for enhancing motor recovery in stroke patients.
Ph.D. Psychology, University of Illinois 1997
Jeffrey Kleim studies how neural plasticity supports learning in the intact brain and “relearning” in the damaged or diseased brain. His research is directed at developing therapies that optimize plasticity in order to enhance recovery after stroke and Parkinson’s Disease. The brain is a highly dynamic organ that is capable of structural and functional reorganization in response to a variety of manipulations. This neural plasticity is the mechanism by which the brain encodes experience. His laboratory examines how plasticity within rat and human motor cortex supports learning in the intact brain and “relearning” after stroke. Kleim's group uses intracortical microstimulation in rats and transcranial magnetic stimulation in humans to examine how motor training alters the functional organization of motor cortex. This work has demonstrated that rehabilitation-dependent recovery of motor function after stroke is associated with a reorganization of movement representations in rodent motor cortex. Furthermore, there are specific behavioral and neural signals that drive both recovery and plasticity. These experiments are being used to test novel therapies for enhancing motor recovery in stroke patients.
- Santello,Marco*, Frakes,David, Frakes,David, Greger,Bradley, Helms Tillery,Stephen I, Honeycutt,Claire, Kleim,Jeffrey Allan, Lockhart,Thurmon Eddy. Planning Grant: Collaborative Research: IUCRC for Building Reliable Advances and Innovation in Neurotechnology (BRAIN). NSF(9/15/2015 - 8/31/2016).
- Kleim,Jeffrey Allan*, Stabenfeldt,Sarah E. A Novel TrkB Agonist To Promote Motor Recovery After TBI. HHS-NIH-NINDS(4/1/2015 - 3/31/2017).
- Stabenfeldt,Sarah E*, Kleim,Jeffrey Allan, Kodibagkar,Vikram D, Rege,Kaushal, Sierks,Michael Richard. Detecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out. HHS-NIH-NICHD(9/15/2014 - 8/31/2019).
- Kleim,Jeffrey Allan*. Investigating the role of Novel Pharmacological Agents to Enhance Recovery Following Brain Injury. (9/15/2014 - 9/14/2015).
- Kleim,Jeffrey Allan*. Neural Mechanisms of Compensating For Brain Damage. UTAustin(9/26/2012 - 6/30/2017).
- Kleim,Jeffrey Allan*. NEURAL MECHANISMS OF COMPENSATING FOR BRAIN DAMAGE. UTAustin(5/1/2011 - 9/25/2012).
- Kleim,Jeffrey Allan*. TrkB Receptors, Cortical Plasticity and Recovery After Stroke. AHA(4/2/2011 - 6/30/2012).
- Kleim,Jeffrey Allan*. BDNF Genotype Cortical Plasticity and Recovery From Stroke. HHS-NIH-NINDS(1/18/2011 - 2/28/2013).
Courses
2024 Spring
Course Number | Course Title |
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NEU 556 | Human Systems Neuroscience |
BME 556 | Human Systems Neuroscience |
2023 Fall
Course Number | Course Title |
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BME 494 | Special Topics |
BME 598 | Special Topics |
2023 Spring
Course Number | Course Title |
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BME 494 | Special Topics |
BME 598 | Special Topics |
BME 182 | Biomedical Prod Dsgn & Dev I |
BME 182 | Biomedical Prod Dsgn & Dev I |
2022 Fall
Course Number | Course Title |
---|---|
BME 182 | Biomedical Prod Dsgn & Dev I |
BME 394 | Special Topics |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
2022 Spring
Course Number | Course Title |
---|---|
NEU 598 | Special Topics |
NEU 556 | Human Systems Neuroscience |
BME 494 | Special Topics |
BME 598 | Special Topics |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 556 | Human Systems Neuroscience |
2021 Fall
Course Number | Course Title |
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ASU 101-BME | The ASU Experience |
ASU 101-BME | The ASU Experience |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
ASU 101-BME | The ASU Experience |
2021 Spring
Course Number | Course Title |
---|---|
NEU 598 | Special Topics |
BME 494 | Special Topics |
BME 598 | Special Topics |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
2020 Fall
Course Number | Course Title |
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BME 492 | Honors Directed Study |
BME 493 | Honors Thesis |
BME 592 | Research |
BME 599 | Thesis |
BME 792 | Research |
BME 493 | Honors Thesis |
BME 492 | Honors Directed Study |
BME 394 | Special Topics |
BME 394 | Special Topics |
BME 394 | Special Topics |
BME 394 | Special Topics |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
2020 Summer
Course Number | Course Title |
---|---|
NEU 598 | Special Topics |
BME 494 | Special Topics |
BME 598 | Special Topics |
2020 Spring
Course Number | Course Title |
---|---|
BME 792 | Research |
BME 493 | Honors Thesis |
BME 592 | Research |
BME 492 | Honors Directed Study |
BME 599 | Thesis |
BME 394 | Special Topics |
BME 394 | Special Topics |
NEU 598 | Special Topics |
BME 494 | Special Topics |
BME 598 | Special Topics |
BME 492 | Honors Directed Study |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 394 | Special Topics |
BME 493 | Honors Thesis |
BME 394 | Special Topics |
2019 Fall
Course Number | Course Title |
---|---|
BME 492 | Honors Directed Study |
BME 493 | Honors Thesis |
BME 592 | Research |
BME 599 | Thesis |
BME 792 | Research |
BME 493 | Honors Thesis |
BME 492 | Honors Directed Study |
BME 394 | Special Topics |
BME 394 | Special Topics |
BME 394 | Special Topics |
BME 394 | Special Topics |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |
BME 100 | Intro to Biomed Engineering |