Wade Van Horn

"Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells," Hutchison, J.M., Capone, R., Luu, D.D., Shah, K.H., Hadziselimovic, A., Van Horn, W., Sanders, C.R. 297, 2, 100940 (2021).

"Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation," Journigan, V.B., Alarcón-Alarcón, D., Feng, Z., Wang, Y., Liang, T., Dawley, D.C., Ruhul Amin, A.R.M., Montano, C., Van Horn, W.D., Xie, X-Q, Ferrer-Montiel, A., Fernández-Carvajal, A., 12, 5, 758-767 (2021).

"Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity," Modi, T., Risso, V.A., Martinez-Rodriguez, S., Gavira, J.A., Mebrat, M.D., Van Horn, W.D., Sanchez-Ruiz, J.M., Banu Ozkan, S., Nature Communications 12, 1 (2021)

"Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing," Kim, M., Sisco, N.J., Hilton, J.K., Montano, C.M., Castro, M.A., Cherry, B.R.; Levitus, M., Van Horn, W.D., Nature Communications 11, 1 (2020)

"Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis," Garami, A., Shimansky, Y.P., Rumbus, Z., Vizin, R.C. L., Farkas, N., Hegyi, J., Szakacs, Z., Solymar, M., Csenkey, A., Chiche, D.A., Kapil, R., Kyle, D.J., Van Horn, W.D., Hegyi, P., Romanovsky, A.A., Pharmacology & Therapeutics 208 (2020) 

"Characterization of HTRPM8 Conformational Dynamic Utilizing Solution NMR," Mebrat, M., Hilton, J.K., Morelan, D., Van Horn, W.D., Biophysical Journal 118  413A-413A (2020)

"Contributions of the Transmembrane Domain to Heat Activation of Human TRPV1," Pratt, A.M., Luu, D., Kim, M., Van Horn, W.D., Biophysical Journal 118 411A-411A (2020)

"Mechanistic and Structural Studies of PIRT Regulation of TRPM8," Van Horn, W..D.; Luu, D.D., Kim, M., Hilton, J.K., Montano, C., Biophysical Journal 118, 413A-414A (2020)

"PIRT the TRP Channel Regulating Protein Binds Calmodulin and Cholesterol-Like Ligands," Sisco, N.J., Luu, D.D., Kim, M., Van Horn, W.D., Biomolecules 10 (2020)

"Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies," Journigan, V.B., Feng, Z., Rahman, S., Wang, Y., Amin, A.R.M.R., Heffner, C.E., Bachtel, N., Wang, S., Gonzalez-Rodriguez, S., Fernandez-Carvajal, A., Fernandez-Ballester, G., Hilton, J.K., Van Horn, W.D., Ferrer-Montiel, A., Xie, X.-Q., Rahman, T., ACS Chemical Neuroscience 11, 268-290 (2020)

"Isolation of Functional Temperature Activated Transmembrane Domain of Human TRPM8," Luu, D, Chiu, P-L, Van Horn, WD, Biophysical Journal 118 413A-413A (2020)

"Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation," Sisco, N.J., Helsell, C.V. M., Van Horn, W.D., Scientific Reports 9 (2019)

"Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels," Hilton, J.K.; Kim, M.; Van Horn, W.D., Accounts of Chemical Research 52 (6) 1643-1652 (2019)

"Phosphoinositide lipid interaction studies between TRPM8 and PIRT membrane proteins suggest a lipid shuttling-sequestering regulatory mechanism," Van Horn, W., Abstracts of Papers of the American Chemical Society 257 (2019)

“New Pieces to an Old Puzzle: Identifying the Warfarin-binding Site that Prevents Clotting,” Hilton JK, Van Horn WD, Nature Structure Molecular Biology 24 5-6 (2017)

“A Parallel Stranded G-quadruplex Composed of Threose Nucleic Acid (TNA),” Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC, Biopolymers 10 e22999 (2017)

“The structural diversity of artificial genetic polymers,” Anosova I, Kowal, EA, Dunn MR, Chaput JC, Van Horn WD, Egli M, Nucleic Acids Res 44 1007-1021 (2016)

“Structural Basis for KCNE3 Modulation of Potassium Recycling in Epithelia,” Kronce BM, Van Horn WD*, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Sisco NJ, George AL, Meiler J, Vanoye CG, Sanders CR, Science Advances 2 e1501228 (2016)

“Structural Insights into Conformational Differences between DNA/TNA and RNA/TNA Chimeric Duplexes,” Anosova I, Kowal EA, Sisco NJ, Sau S, Liao J, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD, ChemBioChem 17 1705-1708 (2016)

“Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain,” Rath P, Hilton JK, Sisco NH, Van Horn WD, Biochemistry 55 114-124 (2016)

“Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors,” Hilton JK, Rath P, Helsell CV, Beckstein O, Van Horn WD, Biochemistry 54 2401-2413 (2015)

“NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins,” Zook, J., Mo, G, Sisco, NJ, Craciunescu, FM, Hansen, DT, Baravati, B, Cherry, B, Sykes, K, Wachter, R, Van Horn, WD, Fromme, P., Structure 23 1116-1122 (2015)

"Bicelles at low concentrations," Z. Lu, W.D. Van Horn, J. Chen, S. Mathew, R. Zent, C.R. Sanders, Mol. Pharm. 336 752-761 (2012)

"The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol," P.J. Barrett, Y. Song, W.D. Van Horn, E.J. Hustedt, J.M Schafer, A. Hadziselimovic, A.J. Beel, C.R. Sanders, Science 336 1168-1171 (2012)

"Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase," W.D. Van Horn, C.R. Sanders, Annu. Rev. Biophys. 41 61-81 (2012)

"Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel," W.D. Van Horn, C.G. Vanoye, C.R. Sanders,Curr. Opin. Struct. Biol. 21 283-291 (2011)

"Functional Delivery of a Membrane Protein into Oocyte Membranes Using Bicelles," C. Kang, C.G. Vanoye, R.C. Welch, W.D. Van Horn, C.R. Sanders, Biochemistry 49 653-655 (2010)

"The Impact of Window Functions on NMR-Based Paramagnetic Relaxation Enhancement Measurements in Membrane Proteins," W.D. Van Horn, A.J. Beel, C. Kang, C.R. Sanders, Biochim. Biophys. Acta 1798 140-149 (2010)

"Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins," H. Kim, S.C. Howell, W.D. Van Horn, Y.H. Jeon, C.R. Sanders, Prog. Nucl. Magn. Reson. Spectrosc. 55 335-360 (2009)

"Reverse Micelle Encapsulation as a Model for Intracellular Crowding," W.D. Van Horn, M.E. Ogilvie, P.F. Flynn, J. Am. Chem. Soc. 131 8030-8039(2009)

"NMR Solution Structure of the Membrane-Integral Diacylglycerol Kinase," W.D. Van Horn, H. Kim, C.D. Ellis, A. Hadziselimovic, E.S. Sulistijo, M.D. Karra, C. Tian, F.D. Sönnichsen, C.R. Sanders, Science 324 1726-1729 (2009)

"Use of reverse micelles in membrane protein structural biology," W.D. Van Horn, M.E. Ogilvie, P.F. Flynn, J. Biomol. NMR 40 203-211 (2008)

"NMR Studies of Encapsulated Macromolecules," P.F. Flynn, A.K. Simorellis, W.D. Van Horn, Annual Reports in NMR Spectroscopy 62 179-219(2007)

"Dynamics of Low Temperature Induced Water Shedding from AOT Reverse Micelles," A.K. Simorellis, W.D. Van Horn, P.F. Flynn, J. Am. Chem. Soc. 128 5080-5090 (2006)

"Low Temperature Studies of Encapsulated Proteins," W.D. Van Horn, A.K. Simorellis, P.F. Flynn, J. Am. Chem. Soc. 127 13553-13560 (2005)

"Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels," J.K. Hilton, T. Salepour, N.J. Sisco, P. Rath, W.D. Van Horn*.  Journal of Biological Chemistry 293 9423-9434 (2018)