Jeffrey Jensen
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Center for Evolution & Medicine LSC 222 MC: 1701 Tempe, AZ 85287-1701
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Mail code: 4501Campus: Tempe
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Jeff Jensen is a population geneticist and Professor in the ASU School of Life Sciences, the Center for Evolution and Medicine, and the Center for Mechanisms of Evolution.
The Jensen Lab develops theory and statistical methodology for describing and quantifying evolutionary processes, and analyzes population sequencing data to study the relative roles of these processes.
- Postdoctoral. NSF Biological Informatics Fellow at UCSD and UC Berkeley, co-advised by Doris Bachtrog, Peter Andolfatto, and Rasmus Nielsen. 2007-2009
- Ph.D. Molecular Biology & Genetics, Cornell University, co-advised by Charles Aquadro and Carlos Bustamante. 2002-2006
- BS/BA Ecology & Evolutionary Biology and Biological Anthropology, University of Arizona, co-advised by Michael Nachman and Brian Charlesworth. 1998-2002
We are a dry lab, using a variety of approaches from population genetics in order to study fundamental evolutionary processes. This work can be summarized in to two primary research areas:
(i) Population Genetic Theory, Methodology, & Analysis: This line of research involves developing theory, as well as likelihood and approximate Bayesian based statistical approaches, for quantifying and untangling the evolutionary pressures driving populations. Our empirical applications of these developments are generally focused upon the forces at play during the colonization of novel environments.
(ii) Experimental & Virus Evolution: We also work in systems where we can control aspects of demography experimentally, and artificially generate mutations, in order to study the shape of the distribution of fitness effects and the underlying fitness landscapes. Within this context, we have a major interest in the evolution of drug resistance in influenza virus, and in the demographic and selective processes underlying human cytomegalovirus (HCMV) infection.
Biomedicine & Biotechnology
15 Representative Publications from the past decade (lab members in bold)
- Johri P, C Aquadro, M Beaumont, B Charlesworth, L Excoffier, A Eyre-Walker, P Keightley, M Lynch, G McVean, B Payseur, S Pfeifer, W Stephan, and JD Jensen, 2022. Recommendations for improving statistical inference in population genomics. PLOS Biology.
- Charlesworth B, and JD Jensen, 2022. How can we resolve Lewontin's Paradox? Genome Biology & Evolution.
- Johri P, K Riall, H Becher, L Excoffier, B Charlesworth, and JD Jensen, 2021. The impact of purifying and background selection on the inference of population history. Molecular Biology & Evolution.
- Charlesworth B, and JD Jensen, 2021. Effects of selection at linked sites on patterns of genetic variability. AREES.
- Johri P, B Charlesworth, and JD Jensen, 2020. Towards an evolutionarily appropriate null model: jointly inferring demography and purifying selection. Genetics.
- Jensen JD, R Stikeleather, T Kowalik, and M Lynch, 2020. Imposed mutational meltdown as an antiviral strategy. Evolution.
- Sackman A, RB Harris, and JD Jensen, 2019. Inferring demography and selection in organisms characterized by skewed offspring distributions. Genetics.
- Jensen JD, BA Payseur, W Stephan, CF Aquadro, M Lynch, D Charlesworth, and B Charlesworth, 2019. The importance of the Neutral Theory in 1968 and 50 years on. Evolution.
- Harris RB, A Sackman, and JD Jensen, 2018. On the unfounded enthusiasm for soft selective sweeps II: examining recent evidence from humans, flies, and viruses. PLOS Genetics.
- Matuszewski S, M Hildebrandt, G Achaz, and JD Jensen, 2018. Coalescent processes with skewed offspring distributions and non-equilibrium demography. Genetics.
- Pfeifer S, S Laurent, V Sousa, C Linnen, M Foll, L Excoffier, H Hoekstra, and JD Jensen, 2018. The evolutionary history of Nebraska deer mice: local adaptation in the face of strong gene flow. Molecular Biology & Evolution.
- Renzette N, S Pfeifer, S Matuszewski, T Kowalik, and JD Jensen, 2017. On the analysis of intra-host and inter-host viral populations: human cytomegalovirus as a case study of pitfalls and expectations. Journal of Virology.
- Bank C, S Matuszewski, R Hietpas, and JD Jensen, 2016. On the (un)predictability of a large intragenic fitness landscape. PNAS.
- Bank C, R Hietpas, A Wong, D Bolon, and JD Jensen, 2014. A Bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments. Genetics.
- Foll M, YP Poh, N Renzette, A Ferrer-Admetlla, H Shim, AS Malaspinas, G Ewing, C Bank, P Liu, D Wegmann, D Caffrey, K Zeldovich, D Bolon, J Wang, T Kowalik, C Schiffer, R Finberg, and JD Jensen, 2014. Influenza drug resistance: a time-sampled population genetics perspective. PLOS Genetics.
Courses
2023 Spring
Course Number | Course Title |
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BIO 492 | Honors Directed Study |
ASM 446 | Principles of Human Genetics |
BIO 446 | Principles of Human Genetics |
BIO 546 | Principles of Human Genetics |
2022 Fall
Course Number | Course Title |
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BIO 493 | Honors Thesis |
BIO 498 | Pro-Seminar |
BIO 591 | Seminar |
EVO 598 | Special Topics |
EVO 498 | Pro-Seminar |
2022 Spring
Course Number | Course Title |
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BIO 492 | Honors Directed Study |
2021 Fall
Course Number | Course Title |
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BIO 493 | Honors Thesis |
2021 Spring
Course Number | Course Title |
---|---|
BIO 492 | Honors Directed Study |
BIO 591 | Seminar |
BIO 498 | Pro-Seminar |
2020 Fall
Course Number | Course Title |
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BIO 493 | Honors Thesis |
BIO 498 | Pro-Seminar |
BIO 591 | Seminar |
EVO 498 | Pro-Seminar |
EVO 598 | Special Topics |
2020 Spring
Course Number | Course Title |
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BIO 492 | Honors Directed Study |
2019 Fall
Course Number | Course Title |
---|---|
BIO 493 | Honors Thesis |
BIO 498 | Pro-Seminar |
BIO 591 | Seminar |
EVO 498 | Pro-Seminar |
EVO 598 | Special Topics |
2019 Spring
Course Number | Course Title |
---|---|
BIO 492 | Honors Directed Study |
2018 Fall
Course Number | Course Title |
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BIO 498 | Pro-Seminar |
BIO 591 | Seminar |