Pope Moseley
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Mail code: 9020Campus: Dtphx
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Pope L. Moseley is a lung and intensive care physician and biomedical sciences researcher. He obtained his MD from the University of Illinois and MS in Preventive Medicine and Environmental Health from the University of Iowa. He completed a combined residency in Internal Medicine and Occupational and Environmental Medicine at the University of Iowa followed by a Fellowship in Pulmonary and Critical Care Medicine.
At the University of New Mexico School of Medicine, Dr. Moseley served as Senior Associate Dean for Research and Chief of Pulmonary and Critical Care Medicine. From 2001-2015, he served as Chair of the Department of Internal Medicine. He was named a Distinguished Professor of the University of New Mexico in 2013. He moved to the University of Arkansas for Medical Sciences to become Dean of the College of Medicine and Executive Vice Chancellor for Health Sciences. While at the University of New Mexico and the University of Arkansas for Medical Sciences, Dr. Moseley was also honored as an Affiliated Professor of the University of Copenhagen's NovoNordisk Center for Protein Research, Program of Disease Systems Biology. He became a Professor of the University of Copenhagen in 2018.
For more than 30 years, Dr. Moseley has led NIH funded multidisciplinary translational research groups focused on heat related illness and the role of cellular responses in the adaptation of humans to heat stress. His team identified gut injury and the loss of epithelial barrier integrity as the early and pivotal events in the pathogenesis of heat stroke. His research team also defined the role of heat shock proteins in modulating inflammation and autophagy in humans during heat stress. These data help explain the anti-inflammatory and health benefits of exercise as well as the inflammatory injury caused by heat stress.
Since 2012, Dr. Moseley has worked with colleagues at the University of Copenhagen Faculty of Health Sciences to understand inter-relationships of disease comorbidities and the importance of time dependent networks of these comorbidities (temporal disease trajectories) in disease progression. Using these temporal disease trajectories, the group has developed machine learning based decision support tools to predict individual patient outcomes in heart disease, critical illness, and sepsis.
Dr. Moseley is a Strongfirst SFG level II certified kettlebell instructor and writes on the role of strength training, particularly grip strength and posture, in preserving function in aging.
B.S. (cum laude), Davidson College, Davidson, NC
M.D, University of Illinois College of Medicine, Chicago, IL
M.S. Preventive Medicine and Environmental Health, University of Iowa College of Medicine, Iowa City, IA
Dr. Moseley has led NIH funded multidisciplinary translational research groups focused on heat related illness and the role of cellular responses in the adaptation of humans to heat stress. His team identified gut injury and the loss of epithelial barrier integrity as the early and pivotal events in the pathogenesis of heat stroke. His research team also defined the role of heat shock proteins in modulating inflammation and autophagy in humans during heat stress. These data help explain the anti-inflammatory and health benefits of exercise as well as the inflammatory injury caused by heat stress.
Since 2012, Dr. Moseley has worked with colleagues at the University of Copenhagen Faculty of Health Sciences to understand inter-relationships of disease comorbidities and the importance of time dependent networks of these comorbidities (temporal disease trajectories) in disease progression. Using these temporal disease trajectories, the group has developed machine learning based decision support tools to predict individual patient outcomes in heart disease, critical illness, and sepsis.
Representative publications from papers published 2013-present:
Haue AD, Armenteros JJ, Holm PC, Eriksson R, Moseley PL, Køber LV, Henning Bundgaard H, Brunak S: Temporal patterns of multi-morbidity in 570157 ischemic heart disease patients: a nationwide cohort study. Cardiovascular Diabetology 21 (1): 1-13, 2022.
Aguayo-Orozco A, Haue AD. Jørgensen IF, Westergaard D, Moseley PL, Mortensen LH, Brunak S. Optimizing drug selection from a prescription trajectory of one patient. npj Digit. Med. 4, 150 (2021).
Moseley PL and Brunak SB. Identifying Sepsis Phenotypes. JAMA 322(14):1416-1417, 2019.
Nielsen AB,-Meyer HCT, Belling K, Nielsen AP, Thomas CE, Chmura PJ, Lademann M, Moseley PL, Heimann M,, Spangsege L, Hulsen P, Perne AS, Brunak S: Survival prediction in intensive-care units based on aggregation of long-term disease history and acute physiology: a retrospective study of the Danish National Patient Registry and electronic patient records. The Lancet Digital Health 1(2), 2019.
Westergaard D, Moseley PL, Sørup FKH, Baldi P, Brunak S: Population-wide analysis of differences in disease progression patterns in men and women. Nature Communications 10: 666, 2019.
Dokladny K, Zuhl MN, Moseley PL: Intestinal epithelial barrier function and tight junction proteins with heat and exercise. Journal of Applied Physiology. 120 (6), 692-701, 2016.
Beck MK, Jensen AB, Nielsen AB, Perner A, Moseley PL, Brunak S: Diagnosis trajectories of prior multi-morbidity predict sepsis mortality Nature Sci Reports 6(1), 1-9, 2016.
Dokladny K, Zuhl MN. Moseley PL: Intestinal epithelial barrier function and tight junction proteins with heat and exercise. J Appl Physiol 120(6): 692–701, 2016.
Dokladny K, Myers O, Moseley PL: The Effect of Acute Exercise on Heat Stress Response and Autophagy Induction in Humans: Meta‐Analysis. The FASEB Journal 29, 821-4, 2015
Deretic V, Kimura T, Timmins G, Moseley PL, Chauhan S, Mandell M: Immunological Manifestations of Autophagy. J Clin Invest 125(1):75-84, 2015.
Jensen AB, Moseley PL, Oprea TI, Ellese SG, Eriksson R, Schmock H, Jensen PB, Jensen LJ, Brunak S: Temporal Disease Trajectories Condensed from Population-Wide Registry Data Covering 6.2 Million Patients. Nature Communications 5: 4022, 2014.
Dokladny K, Zuhl MN, Mandell M, Bhattacharya D, Schneider S, Deretic V, Moseley PL. Regulatory Coordination Between Two Major Intracellular Homeostatic Systems: Heat Shock Response and Autophagy. J Biol Chem; 288:14959-72, 2013
Patents:
1. Mapping Longitudinal Prescription Trajectories to Increase Personalized Treatment Accuracy, Reduce Side Effects and Toxicity, and Exploit Drug Repurposing PossibilitiesMapping Longitudinal Prescription Trajectories to Increase Personalized Treatment Accuracy, Reduce Side Effects and Toxicity, and Exploit Drug Repurposing Possibilities. Danish Patent Office: invention 521-0768/21-7000Danish Patent Office: invention 521-0768/21-7000
\2. Methods for Purifying and Synthesizing Heat Shock Protein ComplexesMethods for Purifying and Synthesizing Heat Shock Protein Complexes US Patent 5747332US Patent 5747332
3. Methods for Synthesizing Heat Shock Protein ComplexesMethods for Synthesizing Heat Shock Protein Complexes US Patent 5981706US Patent 5981706
4. Methods for Synthesizing Heat Shock Protein ComplexesMethods for Synthesizing Heat Shock Protein Complexes. Federal Republic of German Patent 297 24 684.4Federal Republic of German Patent 297 24 684.4
5. Methods for Using Heat Shock Protein ComplexesMethods for Using Heat Shock Protein Complexes US Patent 6455493US Patent 6455493
6. Purified Heat Shock Protein ComplexesPurified Heat Shock Protein Complexes
US Patent 6433141US Patent 6433141
7. Purified Heat Shock Protein ComplexesPurified Heat Shock Protein Complexes US Patent 6713608US Patent 6713608
8. Purified Heat Shock Protein ComplexesPurified Heat Shock Protein Complexes US Patent 6066716
PATENTS AWARDED
U.S. Patent Number 5,747,332 Awarded, “Methods for Purifying and Synthesizing Heat Shock Protein Complexes”
Federal Republic of German Patent Number 297 24 684.4 Awarded "Methods for Synthesizing Heat Shock Protein Complexes”
U.S. Patent Number 5,981,706 Awarded, "Methods for Synthesizing Heat Shock Protein Complexes”
U.S. Patent Number 6,066,716 Awarded, "Purified Heat Shock Protein Complexes”
U.S. Patent Number 6,433,141 Awarded, “Purified Heat Shock Protein Complexes”
U.S. Patent Number 6,455,493 Awarded, “Methods for Using Heat Shock Protein Complexes”
U.S. Patent Number 6,713,608 Awarded “Purified Heat Shock Protein Complexes”
Danish Patent Office: invention 521-0768/21-7000, “Mapping Longitudinal Prescription Trajectories to Increase Personalized Treatment Accuracy, Reduce Side Effects and Toxicity, and Exploit Drug Repurposing Possibilities.”