In 2006 Dr. Geidy Serrano completed a doctoral degree in Anatomy at the University of Puerto Rico, Medical Science Campus. While pursuing her doctoral degree, she received the Minority in Neuroscience Fellowship from the Society of Neuroscience and had the honor to do an Internship at the Marine Biological Laboratory at Woods Whole, MA. In 2007 she did a postdoctoral appointment at Emory University’s School of Medicine and received a National Research Service Award Training Grant (F32-NINDS). Her worked primarily focus in understanding the molecular basis of neuron-degeneration and neuroinflammation at the hippocampus after status epilepticus. After three years of postdoctoral training, she joined the Brain and Body Donation program at Banner Sun Health Research Institute (BSHRI), Arizona and has been supervising all laboratory operations in the BBDP for 12 years. Dr. Serrano assumed the directorship of the Civin Laboratory for Neuropathology at BSHRI in 2020. She is Co-Director of the Neuropathology Core of the National Institute on Aging Arizona Alzheimer’s Disease Core Center (ADCC) and helped lead the Central Pathology Laboratory for Avid Radiopharmaceuticals’ Phase III AV-45 amyloid (florbetapir) and AV-1451 (flortaucipir) FDA-licensing tau imaging studies, as well as Navidea Biopharmaceuticals’ Phase III PET trial of NAV4694. Her work allows her to contribute to brain and biospecimen research that pursues the understanding of neurological disorders around the world. She had contributed to over one hundred publications. Some of the work that she led includes studies in neurodegeneration synaptic loss of aging in humans and sex differences. Other relevant work includes an unbiased study exploring wide transcriptomics modifications in isolated whole human brain cells in progressive supranuclear palsy and other neurodegenerative disorders common in aging and most recently she also studied the presence of SARS-CoV-2 genomic in human organs and its possible effects on histopathology, gene expression and immune response in brains and organs from subjects that died of COVID-19.
- University of Puerto Rico (CUC), Cayey, PR B.S. 05/2000 Biology
- University of Puerto Rico (RCM), San Juan, PR Ph.D. 01/2006 Anatomy
- Emory University School of Medicine, Atlanta, GA Postdoctoral 12/2010 Pharmacology
Some of the work that Dr. Serrano has led includes in neurodegeneration of aging in humans and gender differences. One of her publications suggest that, when affected by AD, females progress more often to severe cognitive dysfunction, due to more severe neurofibrillary degeneration and greater loss of brain parenchyma. Other relevant work include the feasibility study of frontal cortex needle core biopsy for detection of characteristic proteinopathies of neurodegenerative diseases, a study on the impaired hepatic amyloid-beta degradation in Alzheimer's disease, SARS-CoV-2 genomic presence and its possible effects on histopathology, gene expression and immune response in brains and organs from subjects that died of COVID-19, and a study on sympathetic cardiac denervation possibly driven by a-syn pathology. The latter being the first report with a substantial number of autopsied cases, and nerve bundles analyzed, showing a statistically significant separation of AD/DLB cases from controls and AD cases based on cardiac TH- and NF-immunoreactive nerve fiber density. Her results strengthen the rationale for using sympathetic cardiac nuclear imaging methods, to distinguish between patients having AD alone and those with AD/DLB, an advance for dementia epidemiologic and treatment studies
Filon JR, Intorcia AJ, Sue LI, Vazquez Arreola E, Wilson J, Davis KJ, Sabbagh MN, Belden CM, Caselli RJ, Adler CH, Woodruff BK, Rapscak SZ, Ahern GL, Burke AD, Jacobson S, Shill HA, Driver-Dunckley E, Chen K, Reiman EM, Beach TG, Serrano GE. Gender Differences in Alzheimer Disease: Brain Atrophy, Histopathology Burden, and Cognition. J Neuropathol Exp Neurol. 2016 Aug;75(8):748-754. PMID: 27297671 PMCID: PMC7299435
Serrano GE, Shprecher D, Callan M, Cutler B, Glass M, Zhang N, Walker J, Intorcia A, Adler CH, Shill HA, Driver-Dunckley E, Mehta SH, Belden CM, Zamrini E, Sue LI, Vargas D, Beach TG. Cardiac sympathetic denervation and synucleinopathy in Alzheimer's disease with brain Lewy body disease. Brain Commun. 2020;2(1)
Serrano GE, Intorcia A, Carew J, Chiarolanza G, Hidalgo JA, Sue LI, Dugger BN, Saxon-LaBelle M, Filon J, Scroggins A, Pullen J, Fornwalt BE, Scott S, Sabbagh MN, Adler CH, Akiyama H, Beach TG. Feasibility Study: Comparison of Frontal Cortex Needle Core Versus Open Biopsy for Detection of Characteristic Proteinopathies of Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2015 Sep;74(9):934-42.
Complete List of Published Work in My Bibliography
https://www.ncbi.nlm.nih.gov/myncbi/1TyxvhrCb10kf/bibliography/public/