Piplu Bhuiyan
Postdoctoral Research Scholar,
ASU-Banner Neurodegenerative Disease Research Center
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Mail code: 7601Campus: Tempe
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Long Bio
Piplu Bhuiyan is a young researcher and scholar specializing in neurodegeneration, particularly Alzheimer's disease. He is currently a postdoctoral research scholar at the ASU Banner Neurodegenerative Disease Research Center. His research investigates the role of SMAD2 in memory consolidation and gene regulation in aging and Alzheimer's disease. Previously, Piplu worked at the University of Pennsylvania (UPENN), where he concentrated on intracellular calcium dysregulation in neurodegeneration (AD, ALS) and the development of disease-modifying drugs (Dantrolene). He has significantly advanced the field with many published studies, including research on how mast cells relate to postoperative cognitive dysfunction (POCD), the connections between the immune system and the brain (gut-brain axis), neuroinflammation, and drugs that can modify progression of neurodegenerative diseases (intranasal dantrolene).
Education
- Research Training. Anesthesiology & Critical Care, University of Pennsylvania, PA
- MD. (Anesthesiology). Nanjing Medical University, China
- MS. Biotechnology & Genetic Engineering, UODA, Bangladesh
- BS. Pharmacology, UODA, Bangladesh
Google Scholar URL
ORCID Profile ID
Research Interests
Aging
Alzheimer's Disease
Neuroimmune Biology
Learning and Memory
Memory consolidation
Neuroinflammation
Single-cell transcriptome analysis
Behavioral Neuroscience
Publications
- Bhuiyan, P., Zhang, W., Chae, R., Kim, K., St Louis, L., Wang, Y., Liang, G., & Wei, H. (2025). Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in Alzheimer's disease model mouse brain. British journal of anaesthesia, 134(5), 1574–1577. https://doi.org/10.1016/j.bja.2025.02.018
- Bhuiyan, P., Zhang, W., Liang, G., Jiang, B., Vera, R., Chae, R., Kim, K., Louis, L. S., Wang, Y., Liu, J., Chuang, D. M., & Wei, H. (2025). Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology, 20(1), 26. https://doi.org/10.1007/s11481-025-10185-7
- Bhuiyan, P., Yi, Y., Wei, B., Yan, A., Dong, L., & Wei, H. (2025). Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug. bioRxiv : the preprint server for biology, 2025.05.21.655232. https://doi.org/10.1101/2025.05.21.655232
- Ying Wang#, Samuel Anchipolovsky#, Piplu Bhuiyan, Luna Sato, Ge Liang, De-Maw Chuang, and Huafeng Wei, Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer’s disease patient, doi: https://doi.org/10.1101/2025.08.28.672956
- Liu, J., Lu, Y., Bhuiyan, P., Gruttner, J., Louis, L. S., Yi, Y., Liang, G., & Wei, H. (2025). Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced helplessness and anxiety behavior in mice. bioRxiv : the preprint server for biology, 2024.09.06.611461. https://doi.org/10.1101/2024.09.06.611461
- Bhuiyan, P., Sun, Z., Khan, M. A., Hossain, M. A., Rahman, M. H., & Qian, Y. (2024). System biology approaches to identify hub genes linked with ECM organization and inflammatory signaling pathways in schizophrenia pathogenesis. Heliyon, 10(3), e25191. https://doi.org/10.1016/j.heliyon.2024.e25191
- Dong, H., Dai, X., Zhou, Y., Shi, C., Bhuiyan, P., Sun, Z., Li, N., & Jin, W. (2024). Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice. Journal of neuroinflammation, 21(1), 36. https://doi.org/10.1186/s12974-024-03028-4
- Zhang, W., Zhao, X., Bhuiyan, P., Liu, H., & Wei, H. (2024). Neuroprotective effects of dantrolene in neurodegenerative disease: Role of inhibition of pathological inflammation. Journal of anesthesia and translational medicine, 3(2), 27–35. https://doi.org/10.1016/j.jatmed.2024.04.002
- Bhuiyan, P., Sun, Z., Chen, Y., & Qian, Y. (2023). Peripheral surgery triggers mast cells activation: Focusing on neuroinflammation. Behavioural brain research, 452, 114593. https://doi.org/10.1016/j.bbr.2023.114593
- Vishal, K., Bhuiyan, P., Qi, J., Chen, Y., Zhang, J., Yang, F., & Li, J. (2023). Unraveling the Mechanism of Immunity and Inflammation Related to Molecular Signatures Crosstalk Among Obesity, T2D, and AD: Insights From Bioinformatics Approaches. Bioinformatics and biology insights, 17, 11779322231167977. https://doi.org/10.1177/11779322231167977
- Sun, Z., Bhuiyan, P., Lu, H., Qian, Y., & Xiao, H. (2022). Prognostic factors for trigeminocardiac reflex during cerebrovascular intervention operation. Frontiers in surgery, 9, 989644. https://doi.org/10.3389/fsurg.2022.989644
- Bhuiyan, P., Chuwdhury, G. S., Sun, Z., Chen, Y., Dong, H., Ahmed, F. F., Nana, L., Rahman, M. H., & Qian, Y. (2022). Network Biology Approaches to Uncover Therapeutic Targets Associated with Molecular Signaling Pathways from circRNA in Postoperative Cognitive Dysfunction Pathogenesis. Journal of molecular neuroscience : MN, 72(9), 1875–1901. https://doi.org/10.1007/s12031-022-02042-6
- Bhuiyan, P., Chen, Y., Karim, M., Dong, H., & Qian, Y. (2021). Bidirectional communication between mast cells and the gut-brain axis in neurodegenerative diseases: Avenues for therapeutic intervention. Brain research bulletin, 172, 61–78. https://doi.org/10.1016/j.brainresbull.2021.04.010
- Bhuiyan, P., Wang, Y. W., Sha, H. H., Dong, H. Q., & Qian, Y. N. (2021). Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases. Neural regeneration research, 16(11), 2184–2197. https://doi.org/10.4103/1673-5374.310608
- Chen, Y. N., Sha, H. H., Wang, Y. W., Zhou, Q., Bhuiyan, P., Li, N. N., Qian, Y. N., & Dong, H. Q. (2020). Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats. Journal of neuroinflammation, 17(1), 217. https://doi.org/10.1186/s12974-020-01886-2