Sharon Crook
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Phone: 480-965-0403
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ECA 345 TEMPE, AZ 85287-1804
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Mail code: 1804Campus: Tempe
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Professor Crook holds an appointment with the School of Mathematical and Statistical Sciences at Arizona State University. She uses theory, computation, and data analysis to study the dynamics of neurons and networks of neurons, as well as the mechanisms underlying changes in these cells and networks due to trauma, learning, disorders, or disease. She is one of the leaders for an international effort to create a common standard for describing computational models for neuroscience research. Through her work in neuroinformatics, she contributes to an ecosystem of tools that promote reproducibility, model sharing, and community-based collaborative model development in computational neuroscience research.
Ph.D. Applied Mathematics, University of Maryland-College Park 1996
Sharon Crook studies the mechanisms and algorithms underlying neural computation. Using mathematical models, analysis and computer simulations, she and her research team examine the dynamics of neurons and networks of neurons. In particular, their focus is on understanding the ability that neurons have to change at a cellular or network level due to trauma, rehabilitation, learning, development, or aging.
Professor Crook and her collaborators are also developing a cyber infrastructure for describing and sharing neuroscience models, as well as new formats to describe neuron anatomy at macro and micro levels, neural network connectivity, and the membrane properties of neurons. This approach is used by software applications to help reproduce simulations of complex models and share models after publication.
Selected Peer-reviewed Publications
Haynes, VR, Y Zhou, S Crook (2024) Discovering optimal features for neuron type identification from extracellular recordings. Frontiers in Neuroinformatics. 18.1303993. DOI:10.3389/ninf.2024.1303993
Birgiolas, J, VR Haynes, P Gleeson, RC Gerkin, SW Dietrich, S Crook (2023) NeuroML-DB: Sharing and characterizing data-driven neuroscience models described in NeuroML. PLoS Computational Biology. 19(3):e1010941. DOI:10.1371/journal.pcbi.1010941
Gleeson, P, S Crook, D Turner, K Mantel, M Raunak, T Willke, JD Cohen (2023) Integrating model development across computational neuroscience, cognitive science, and machine learning. Neuron. 111(10):1526-1530. DOI:10.1016/j.neuron.2023.03.037
Eriksson, O, US Bhalla, KT Blackwell, SM Crook, D Keller, A Kramer, M Linne, A Saudargiene, RC Wade, J Hellgren Kotaleski (2022) Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows. eLife. 11:e69013. DOI:10.7554/eLife.69013
Eke, DO, A Bernard, JG Bjaalie, R Chavarriaga, T Hanakawa, AJ Hannan, SL Hill, ME Martone, A McMahon, O Ruebel, S Crook, E Thiels, F Pestilli (2022) International Data Governance for Neuroscience. NEURON. 110(4):600-612. DOI:10.1016/j.neuron.2021.11.017
Baer, SM, S Chang, SM Crook, CL Gardner, JR Jones, C Ringhofer, FR Nelson (2021) A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement. Journal of Theoretical Biology. DOI:10.1016/j.jtbi.2021.110763.
Reckell, T, K Nguyen, *T Phan, SM Crook, E Kostelich, Y Kuang (2021) Modeling the synergistic properties of drugs in hormonal treatment for prostate cancer. Journal of Theoretial Biology. 514:110570. DOI:10:1016/j.jtbi.2020.110570
Ruhani, M, SM Baer, SM Crook (2021) A stage-structured population model for activity-dependent dendritic spines, Journal of Biological Dynamics. DOI:10.1080/17513758.2020.1839136
Gleeson, P, M Cantarelli, B Marin, A Quintana, M Earnshaw, S Sadeh, E Piasini, *J Birgiolas, RC Cannon, NA Cayco-Gajic, S Crook, AP Davison, S Dura-Bernal, A Ecker, ML Hines, G Idili, F Lanore, SD Larson, WW Lytton, A Mujumdar, RA McDougal, S Sivagnanam, S Solinas, R Stanislovas, SJ van Albada, W van Geit, RA Silver (2019) Open Source Brain: a collaborative resource for visualizing, analyzing, simulating and developing standardized models of neurons and circuits. Neuron. DOI:10.1016/j.neuron.2019.05.019
Neal, M, M Koenig, D Nickerson, G Misirli, R Kalbasi, A Drager, K Atalag, V Chelliah, M Cooling, D Cook, S Crook, M de Alba, S Friedman, A Garny, J Gennari, P Gleeson, M Golebiewski, M Hucka, N Juty, C Myers, B Oivier, H Sauro, M Scharm, J Snoep, V Toure, A Wipat, O Wolkenhauer, D Waltemath (2018) Harmonizing semantic annotations for computational models in biology. Briefings in Bioinformatics. DOI:10.1093/bib/bby087
Gerkin, RC, *RJ Jarvis, SM Crook (2018) Towards systematic, data-driven validation of a collaborative, multi-scale model of C. elegans. Philosophical Transactions of the Royal Society B. 373:20170381. DOI:10.1098.rstb.2017.0381.
Berger, S, S Crook (2015) Modeling the influence of ion channels on neuron dynamics in Drosophila. Frontiers in Computational Neuroscience. 9:139. DOI:10.3389/fncom/2015.00139.
Gardner, C, JR Jones, SM Baer, SM Crook (2015) Drift-diffusion simulation of the ephaptic effect in the triad synapse of the retina. Journal of Computational Neuroscience. 38:129-142. DOI:10.1007/s10827-014-0531-7.
Cannon, RC, P Gleeson, S Crook, G Gnapathy, B Marin, E Piasini, RA Silver (2014) LEMS: A language for expressing complex biological models in concise and hierarchical form and its use in underpinning NeuroML 2. Frontiers in Neuroinformatics. 8:79. DOI:10.3389/fninf.2014.00079.
Vella, M, RC Cannon, S Crook, AP Davison, G Ganapathy, HPC Robinson, RA Silver, P Gleeson (2014) libNeuroML and PyLEMS: using Python to combine procedural and declarative modeling approaches in computational neuroscience. Frontiers in Neuroinformatics. 8:38. DOI:10.3389/fninf.2014.00038
Herrera-Valdez, M, EC McKiernan, *SD Berger, S Ryglewski, C Duch, S Crook (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. Journal of Computational Neuroscience. 34(2):211-229. DOI:10.1007/s10827-012-0416-6
Crook, SM, JA Bednar, SD Berger, RC Cannon, AP Davison, M Djurfeldt, J Eppler, B Kreiner, S Furber, B Graham, M Hull, HE Plesser, L Schwabe, L Smith, V Steuber, S van Albada (2012) Creating, documenting and sharing network models. Network: Computation in Neural Systems. 23(4):131-149.
Kurian, M, SM Crook and R Jung (2011) Motoneuron models of self-sustained firing after spinal cord injury. Journal of Computational Neuroscience. 31(3):625-645.
Gleeson, P, S Crook, R Cannon, M Hines, G Billings, M Farinella, TM Morse, A Davison, S Ray, U Bhalla, SR Barnes, YD Dimitrova and RA Silver (2010) NeuroML: a simulator-independent language for describing data-driven models of neurons and networks with a high degree of biological realism. PLoS Computational Biology. 6(6): e1000815. DOI:10.1371/journal.pcbi.1000815.
Baer, SM, S Crook, M Dur-e-Ahmad and Z Jackiewicz (2009) Numerical solution of calcium-mediated dendritic branch model. Journal of Computational and Applied Mathematics. 229:416-424.
Crook, S, M Dur-e-Ahmad and SM Baer (2007) A model of activity-dependent changes in dendritic spine density and spine structure. Mathematical Biosciences and Engineering. 4:617-631.
Cummins, GI, SM Crook, AG Dimitrov, T Ganje, GA Jacobs and JP Miller (2003) Structural and biophysical mechanisms underlying dynamic sensitivity of primary sensory interneurons in the cricket cercal sensory system. Neurocomputing. 52:45-52.
Crook, S, J Miller and G Jacobs (2002) Modeling frequency encoding in the cricket cercal sensory system. Neurocomputing 44:769-773.
Crook, SM, GB Ermentrout and JM Bower. (1998) Spike frequency adaptation affects the synchronization properties of cortical networks. Neural Computation 10:837-854.
Crook, SM, GB Ermentrout and JM Bower (1998) Dendritic and synaptic effects in systems of coupled cortical oscillators. Journal of Computational Neuroscience 5:315-329.
Crook, SM, GB Ermentrout, MC Vanier and JM Bower (1997) The role of axonal delay in the synchronization of networks of coupled cortical oscillators. Journal of Computational Neuroscience 4:161-172.
Zhou, Yi, Sharon Crook. CRCNS Research Proposal: Visual Modulation of Panoramic Auditory Spatial Processing. HHS-NIH-NIDCD (6/1/2020-5/31/2025).
Birgiolas, Justas, Sharon Crook. Integrated Understanding of Tufted and Mitral Pathways in the Olfactory Bulb. HHS-NIH-NIDCD (2/1/2018-1/31/2020).
Gerkin, Richard, Sharon Crook. CRCNS Data Sharing: Exchange and Evaluation of Reduced Neuron Models. HHS-NIH-NIBIB (9/30/2015-7/31/2018).
Crook, Sharon, Suzanne Dietrich, Richard Gerkin. Tools for Model Discovery Validation and Selection in Neuroscience. HHS-NIH-NIMH (9/25/2015 - 6/30/2019).
Dietrich, Suzanne, Rebecca Ball, Connie Borror, Sharon Crook, Kimberly Kobojek. Collaborative Research: Databases for Many Majors: Customizable Visualizations to Improve STEM Learning. NSF-EHR (9/1/2014 - 8/31/2017).
Smith, Brian, Sharon Crook. 2014 CRCNS PI Conference. NSF-CISE-IIS (9/1/2014 - 8/31/2015).
Crook, Sharon, Suzanne Dietrich. CRCNS Data Sharing: NeuroML Database for Multiscale Neuroscience Models. HHS-NIH-NIBIB (9/1/2011 - 8/31/2015).
Dietrich, Suzanne, Patricia Clark, Sharon Crook. Collaborative Research: Databases for Many Majors: A Student-Centered Approach. NSF-EHR (3/15/2010 - 2/28/2013).
Crook, Sharon, Suzanne Dietrich. NeuroML: Standards and Tools for Multiscale Model Specification and Exchange. HHS-NIH-NIMH (7/1/2009 - 5/31/2014).
Crook,Sharon. NeuroML Development Workshop: Biophysical Single Cell Modeling. NSF-CISE (4/1/2009 - 3/31/2010).
Kostelich, Eric, Dieter Armbruster, Sharon Crook, Carl Gardner, Anne Gelb, Zdzislaw Jackiewicz, Don Jones, Juan Lopez, Alex Mahalov, Rosemary Renaut, Christian Ringhofer, Bruno Welfert. CSUMS: Undergraduate research Experiences for Computational Math Science Majors at ASU. NSF-MPS-DMS (9/15/2007 - 8/31/2014).
Baer, Steven M, Sharon Crook, Carl Gardner, Christian Ringhofer. Multiscale Modeling of the Neural Subcircuits in the Outer-Plexiform Layer of the Retina. NSF-MPS-DMS (9/1/2007 - 8/31/2011).
Crook, Sharon, Carsten Duch. Behaviorally Relevant Neuronal Modification During Postembryonic Development. NSF-CISE (10/1/2006 - 9/30/2010).
Jung, Ranu, James Abbas, Carlos Castillo-Chavez, Sharon Crook, Antonio Garcia, Lokesh Joshi, Yang Kuang, Stephen Phillips, Anshuman Razdan, Marco Santello, Joseph Wang. Catalyst: Center for Excellence in Adaptive Neuro-Biomechatronic Systems (CEANS). NSF-SBE (8/15/2005 - 1/31/2009).
Crook, Sharon. Collaborative Research: A Dynamic Atlas of the Cricket Cercal Sensory System. NSF-BIO (8/1/2004 - 7/31/2005).
Courses
2026 Spring
| Course Number | Course Title |
|---|---|
| STP 792 | Research |
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| AML 792 | Research |
| APM 792 | Research |
| APM 799 | Dissertation |
| MAT 792 | Research |
| MAT 799 | Dissertation |
| MAT 495 | Undergraduate Research |
| MAT 795 | Continuing Registration |
| MAT 591 | Seminar |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| APM 792 | Research |
2025 Fall
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| APM 792 | Research |
| MAT 792 | Research |
| APM 799 | Dissertation |
| MAT 451 | Mathematical Modeling |
| MAT 591 | Seminar |
| APM 795 | Continuing Registration |
| MAT 792 | Research |
| MAT 795 | Continuing Registration |
| DAT 492 | Honors Directed Study |
| APM 792 | Research |
2025 Summer
| Course Number | Course Title |
|---|---|
| MAT 792 | Research |
| APM 792 | Research |
| APM 792 | Research |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| MAT 784 | Internship |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| APM 799 | Dissertation |
| APM 799 | Dissertation |
2025 Spring
| Course Number | Course Title |
|---|---|
| STP 792 | Research |
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| AML 792 | Research |
| APM 792 | Research |
| APM 799 | Dissertation |
| MAT 792 | Research |
| MAT 799 | Dissertation |
| MAT 795 | Continuing Registration |
| MAT 591 | Seminar |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| MAT 494 | Special Topics |
| APM 598 | Special Topics |
| APM 792 | Research |
2024 Fall
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| APM 792 | Research |
| MAT 792 | Research |
| APM 799 | Dissertation |
| MAT 591 | Seminar |
| APM 795 | Continuing Registration |
| MAT 792 | Research |
| MAT 795 | Continuing Registration |
| APM 792 | Research |
2024 Summer
| Course Number | Course Title |
|---|---|
| APM 792 | Research |
| APM 792 | Research |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| MAT 784 | Internship |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| APM 799 | Dissertation |
2024 Spring
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| AML 799 | Dissertation |
| AML 792 | Research |
| CSE 590 | Reading and Conference |
| CSE 790 | Reading and Conference |
| APM 792 | Research |
| APM 799 | Dissertation |
| MAT 792 | Research |
| MAT 799 | Dissertation |
| STP 792 | Research |
| CSE 599 | Thesis |
| MAT 795 | Continuing Registration |
| APM 795 | Continuing Registration |
| APM 530 | Mathematical Cell Physiology. |
| APM 799 | Dissertation |
| APM 790 | Reading and Conference |
2023 Fall
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| APM 792 | Research |
| MAT 792 | Research |
| APM 799 | Dissertation |
| MAT 451 | Mathematical Modeling |
| APM 795 | Continuing Registration |
| MAT 792 | Research |
| MAT 795 | Continuing Registration |
| APM 792 | Research |
2023 Summer
| Course Number | Course Title |
|---|---|
| APM 792 | Research |
| APM 792 | Research |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| APM 799 | Dissertation |
2023 Spring
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| AML 799 | Dissertation |
| AML 792 | Research |
| CSE 590 | Reading and Conference |
| CSE 790 | Reading and Conference |
| APM 792 | Research |
| APM 799 | Dissertation |
| MAT 792 | Research |
| MAT 799 | Dissertation |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| APM 795 | Continuing Registration |
| APM 792 | Research |
| MAT 494 | Special Topics |
| BIO 494 | Special Topics |
| NEU 494 | Special Topics |
| APM 598 | Special Topics |
| NEU 591 | Seminar |
2022 Fall
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| APM 792 | Research |
| MAT 792 | Research |
| APM 799 | Dissertation |
| MAT 451 | Mathematical Modeling |
| APM 795 | Continuing Registration |
| MAT 792 | Research |
| APM 792 | Research |
2022 Summer
| Course Number | Course Title |
|---|---|
| APM 792 | Research |
| APM 792 | Research |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
| APM 792 | Research |
| APM 795 | Continuing Registration |
2022 Spring
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| AML 799 | Dissertation |
| AML 792 | Research |
| CSE 590 | Reading and Conference |
| APM 792 | Research |
| APM 799 | Dissertation |
| MAT 799 | Dissertation |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| APM 790 | Reading and Conference |
| APM 795 | Continuing Registration |
| APM 792 | Research |
| MAT 275 | Modern Differential Equations |
2021 Fall
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| APM 792 | Research |
| MAT 792 | Research |
| APM 799 | Dissertation |
| MAT 451 | Mathematical Modeling |
| APM 795 | Continuing Registration |
2021 Summer
| Course Number | Course Title |
|---|---|
| APM 792 | Research |
| APM 792 | Research |
| APM 792 | Research |
| APM 795 | Continuing Registration |
| APM 799 | Dissertation |
2021 Spring
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| AML 799 | Dissertation |
| AML 792 | Research |
| CSE 590 | Reading and Conference |
| APM 792 | Research |
| APM 799 | Dissertation |
| CSE 595 | Continuing Registration |
| CSE 599 | Thesis |
| CSE 790 | Reading and Conference |
| APM 795 | Continuing Registration |
| MAT 275 | Modern Differential Equations |
| MAT 275 | Modern Differential Equations |
2020 Fall
| Course Number | Course Title |
|---|---|
| MAT 492 | Honors Directed Study |
| MAT 493 | Honors Thesis |
| APM 792 | Research |
| MAT 792 | Research |
| APM 799 | Dissertation |
| MAT 451 | Mathematical Modeling |
| APM 795 | Continuing Registration |
Organization for Computational Neuroscience, Society for Neuroscience, Society for Mathematical Biology, Society for Industrial and Applied Mathematics, Association for Women in Mathematics, American Association for the Advancement of Science, International Neuroinformatics Coordinating Facility Member
Select Grant Reviews:
NIH BRAIN Initiative Study Sections: Data Archives, Integration, and Standards 2019, Data Analysis 2020, Data Analysis (chair) 2021, Data Archives, Integration, and Standards (chair) 2022, Research Education: Short Courses 2022, 2023, 2024
NIH NRSA Individual Postdoctoral Fellowships 2019, 2020
Interagency (NIH, ARO, DOE, FDA, NASA, NSF, ONR) Predictive Multiscale Modeling for Biomedical, Biological, Behavioral, Environmental and Clinical Research Review Panel 2017
NIH Study Section Member: Neuro-, Opthalmic and Imaging Technology July 1, 2012-June 30, 2015
NIH Study Sections (Ad hoc Member): Sensorimotor Integration 2005, 2006, 2020; Neurotechnology 2007, 2008, 2010; MABS 2018
NIH Challenge Grants 2009
Joint NSF/NIH Review Panel for Collaborative Research in Computational Neuroscience (CRCNS) 2002, 2004, 2008, 2009
NSF Panel and Ad Hoc Reviewer: Computational Neuroscience, Applied Mathematics, Computational Mathematics, Bioengineering, Mathematical Biology, Joint DMS/NIGMS
UK Medical Research Council (MRC) Ad Hoc Reviewer
AWM-NSF Mentoring Travel Grants 2011-2013
Other Regional, National, and International Service:
2024-2025 National Institute for Theory and Mathematics in Biology (NITMB) MathBio Convergence Conference, Organizing Committee
2025 Organizer, NEURON Simulator International Training Week at Arizona State University
2023-2028 Society for Industrial and Applied Mathematics (SIAM) Committee on Science Policy
2021- Scientific Steering Group, NIH BRAIN Initiative Grant Advancing bio-realistic modeling via the Brain Modeling Toolkit and SONATA Data Format
2020-2025 International BRAIN Initiative: Data Standards and Sharing Working Group, Chair: Training Task Force
2019- NeuroML Scientific Committee
2019- Steering Committee, NIH SPARC (Stimulating Peripheral Activity to Relieve Conditions) Data Resource Center
2016-2019 Vice President, Organization for Computational Neuroscience (Elected International)
2017 Advisory Role, NICT-NSF Collaborative Workshop on Computational Neuroscience, Osaka, Japan
2016-2017 Program Committee, 2017 International Neuroinformatics Coordinating Facility (INCF) Annual Meeting, Kuala Lumpur
2016-2017 Scientific Advisory Committee, 2017 Society for Mathematical Biology Meeting in Salt Lake City
2014-2016 Editorial Board (elected), NeuroML Project
2013-2015 Board of Directors, Organization for Computational Neuroscience
2015 Organizer (with Brian Smith), Large-scale Modeling of the Olfactory System, NIMBioS Funded Workshop, University of Tennessee, Knoxville, Tennessee
2014 Organizer (with Brian Smith), 2014 Collaborative Research in Computational Neuroscience PI Meeting, Tempe, Arizona
2013 Program Committee Member, 29th Annual Southern Biomedical Engineering Conference, Miami, Florida
2011-2013 Association for Women in Mathematics Mentoring Grant Review Committee (2013 Chair)
2008-2011 Member, Oversight Committee for Description Standards in Neural Network Modeling, International Neuroinformatics Coordinating Facility
March 2007 Invited Participant, NSF and Santa Fe Institute Workshop, Brain Science at the Interface of Biological, Physical and Mathematical Sciences, Computer Science and Engineering: Analysis of New Opportunities
2005-2008 Program Committee, Organization for Computational Neuroscience (Annual Computational Neuroscience International Meeting)
2003-2005 Board of Directors, Organization for Computational Neuroscience