Sharon Crook
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GWC 648 TEMPE, AZ 85287-1804
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Mail code: 1804Campus: Tempe
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Professor Crook holds an appointment with the School of Mathematical and Statistical Sciences at Arizona State University. She uses computational approaches to study the dynamics of neurons and networks of neurons, as well as the mechanisms underlying changes in these cells and networks due to trauma, learning, or disease. She also contributes to the development of NeuroML, an international effort to create a common standard for describing computational models for neuroscience research. NeuroML is part of an ecosystem of tools to promote reproducibility, model sharing, and community-based collaborative model development in computational neuroscience research.
Sharon Crook earned her doctorate in applied mathematics at the University of Maryland in College Park and performed her dissertation research with John Rinzel at the Mathematical Research Branch of the National Institutes of Health. While there she developed coupled oscillator models to represent the dynamics of the cortex in collaboration with Bard Ermentrout of the University of Pittsburgh. She then held a Postdoctoral Fellowship at the Center for Computational Biology at Montana State University with John Miller and Gwen Jacobs. There she performed joint work in neurophysiology, mathematical modeling, and neuroinformatics.
Ph.D. Applied Mathematics, University of Maryland-College Park 1996
Sharon Crook studies the mechanisms and algorithms underlying neural computation. Using mathematical models, analysis and computer simulations, she and her research team examine the dynamics of neurons and networks of neurons. In particular, their focus is on understanding the ability that neurons have to change at a cellular or network level due to trauma, rehabilitation, learning, development, or aging.
Professor Crook and her collaborators are also developing a cyber infrastructure for describing and sharing neuroscience models, as well as new formats to describe neuron anatomy at macro and micro levels, neural network connectivity, and the membrane properties of neurons. This approach is used by software applications to help reproduce simulations of complex models and share models after publication.
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Selected Peer-reviewed Publications
Berger, S, S Crook (2015) Modeling the influence of ion channels on neuron dynamics in Drosophila. Frontiers in Computational Neuroscience. 9:139. doi:10.3389/fncom/2015.00139.
Birgiolas, J, S Dietrich, S Crook, A Rajadesingan, C Zhang, S Velugoti Penchala, V Addepalli (2015) Ontology-assisted keyword search for NeuroML models. In Amarnath Gupta and Susan Rathbun, Eds, Proceedings of the 27th International Conference on Scientific and Statistical Database Management, ACM, New York, NY. Article 37. doi=10.1145/2791347.2791360.
Gardner, C, JR Jones, SM Baer, SM Crook (2014) Drift-diffusion simulation of the ephaptic effect in the triad synapse of the retina. Journal of Computational Neuroscience. 38:129-142.PubMed
Cannon, RC, P Gleeson, S Crook, G Gnapathy, B Marin, E Piasini, RA Silver (2014) LEMS: A language for expressing complex biological models in concise and hierarchical form and its use in underpinning NeuroML 2. Frontiers in Neuroinformatics. 8:79. PubMed
Vella, M, RC Cannon, S Crook, AP Davison, G Ganapathy, HPC Robinson, RA Silver, P Gleeson (2014) libNeuroML and PyLEMS: using Python to combine procedural and declarative modeing approaches in computational neuroscience. Frontiers in Neuroinformatics. 8:38. PubMed
Crook, SM, JA Bednar, SD Berger, RC Cannon, AP Davison, M Djurfeldt, J Eppler, B Kriener, S Furber, B Graham, M Hull, HE Plesser, L Schwabe, L Smith, V Steuber, S van Albada (2012) Creating, documenting and sharing network models. Network: Computation in Neural Systems.23(4):131-149. PubMed
Kurian, M, SM Crook, R Jung (2011) Motoneuron models of self-sustained firing after spinal cord injury. Journal of Computational Neuroscience. 31(3):625-645. PubMed, ModelDB
Gleeson, P, S Crook, R Cannon, M Hines, G Billings, M Farinella, TM Morse, A Davison, S Ray, U Bhalla, SR Barnes, YD Dimitrova and RA Silver (2010) NeuroML: a simulator-independent language for describing data-driven models of neurons and networks with a high degree of biological realism. PLoS Computational Biology. 6(6): e1000815. PubMed
Crook SM, M Dur-e-Ahmad and SM Baer (2007) A model of activity-dependent changes in dendritic spine density and spine structure. Mathematical Biosciences and Engineering. 4(4):617-631. PubMed, ModelDB
Crook, S, P Gleeson, F Howell, J Svitak and RA Silver (2007) MorphML: Level 1 of the NeuroML standards for neuronal morphology data and model specification. Neuroinformatics. 5(2):96-104. PubMed
Selected Book Chapters
Crook, S, HE Plesser, A Davison (2013) Lessons from the past: approaches for reproducibility in computational neuroscience. In JM Bower, ed. 20 Years of Computational Neuroscience, Springer.
Gleeson, P, V Steuber, RA Silver and S Crook (2012) NeuroML. In Le Novere, ed. Computational Systems Biology, Springer.
Venugopal, S, S Crook, M Srivatsan and R Jung (2011) Principles of computational neuroscience. In Jung, ed. Biomimetic and Biohybrid Living-Hardware Systems, Wiley.
Crook, S and F Howell (2007) XML for data representation and model specification in neuroscience. in Crasto, ed. Methods in Molecular Biology Book Series: Neuroinformatics, Humana Press. PubMed
- Gerkin,Richard C*, Crook,Sharon Marie, Crook,Sharon Marie. CRCNS Data Sharing: Exchange and Evaluation of Reduced Neuron Modles. HHS-NIH-NIBIB(9/30/2015 - 7/31/2018).
- Crook,Sharon Marie*, Crook,Sharon Marie*, Dietrich,Suzanne Wagner, Gerkin,Richard C. Tools for Model Discovery Validation and Selection in Neuroscience. HHS-NIH-NIMH(9/25/2015 - 6/30/2019).
- Dietrich,Suzanne Wagner*, Ball,Rebecca, Borror,Connie Margaret, Crook,Sharon Marie, Crook,Sharon Marie, Kobojek,Kimberly Sue. Collaborative Research: Databases for Many Majors: Customizable Visualizations to Improve STEM Learning. NSF-EHR(9/1/2014 - 8/31/2017).
- Smith,Brian*, Crook,Sharon Marie, Crook,Sharon Marie. 2014 CRCNS PI Conference. NSF-CISE-IIS(9/1/2014 - 8/31/2015).
- Crook,Sharon Marie*, Crook,Sharon Marie*, Dietrich,Suzanne Wagner. CRCNS Data Sharing: NeuroML Database for Multiscale Neuroscience Models. HHS-NIH-NIBIB(9/1/2011 - 8/31/2015).
- Dietrich,Suzanne Wagner*, Clark,Patricia J, Crook,Sharon Marie, Crook,Sharon Marie. Collaborative Research: Databases for Many Majors: A Student-Centered Approach. NSF-EHR(3/15/2010 - 2/28/2013).
- Crook,Sharon Marie*, Crook,Sharon Marie*, Dietrich,Suzanne Wagner. NeuroML: Standards and Tools for Multiscale Model Specification and Exchange. HHS-NIH-NIMH(7/1/2009 - 5/31/2014).
- Crook,Sharon Marie*, Crook,Sharon Marie*. NeuroML Development Workshop: Biophysical Single Cell Modeling. NSF-CISE(4/1/2009 - 3/31/2010).
- Kostelich,Eric John*, Armbruster,Hans Dieter, Crook,Sharon Marie, Crook,Sharon Marie, Gardner,Carl L, Gelb,Anne, Jackiewicz,Zdzislaw, Jones,Donald, Lopez,Juan Manuel, Mahalov,Alex, Renaut,Rosemary Anne, Ringhofer,Christian, Welfert,Bruno Denis. CSUMS: Undergraduate research Experiences for Computational Math Science Majors at ASU. NSF-MPS-DMS(9/15/2007 - 8/31/2014).
- Baer,Steven M*, Crook,Sharon Marie, Gardner,Carl L, Ringhofer,Christian. Multiscale Modeling of the Neural Subcircuits in the Outer-Plexiform Layer of the Retina. NSF-MPS-DMS(9/1/2007 - 8/31/2011).
- Crook,Sharon Marie*, Crook,Sharon Marie*, Duch,Carsten Juergen. Behaviorally Relevant Neuronal Modification During Postembryonic Development. NSF-CISE(10/1/2006 - 9/30/2010).
- Jung,Ranu*, Abbas,James, Castillo-Chavez,Carlos, Crook,Sharon Marie, Crook,Sharon Marie, Garcia,Antonio Agustin, Joshi,Lokesh, Kuang,Yang, Phillips,Stephen M, Razdan,Anshuman, Santello,Marco, Wang,Joseph, Wang,Joseph. Catalyst: Center for Excellence in Adaptive Neuro-Biomechatronic Systems (CEANS). NSF-SBE(8/15/2005 - 1/31/2009).
- Crook,Sharon Marie*, Crook,Sharon Marie*. Collaborative Research: A Dynamic Atlas of the Cricket Cercal Sensory System. NSF-BIO(8/1/2004 - 7/31/2005).
Courses
2023 Spring
Course Number | Course Title |
---|---|
NEU 591 | Seminar |
APM 799 | Dissertation |
MAT 492 | Honors Directed Study |
MAT 493 | Honors Thesis |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
AML 799 | Dissertation |
AML 792 | Research |
CSE 590 | Reading and Conference |
CSE 790 | Reading and Conference |
APM 792 | Research |
MAT 792 | Research |
MAT 799 | Dissertation |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
APM 795 | Continuing Registration |
MAT 494 | Special Topics |
BIO 494 | Special Topics |
NEU 494 | Special Topics |
APM 598 | Special Topics |
2022 Fall
Course Number | Course Title |
---|---|
MAT 792 | Research |
MAT 492 | Honors Directed Study |
MAT 493 | Honors Thesis |
APM 792 | Research |
MAT 792 | Research |
APM 799 | Dissertation |
APM 795 | Continuing Registration |
APM 792 | Research |
MAT 451 | Mathematical Modeling |
2022 Summer
Course Number | Course Title |
---|---|
APM 795 | Continuing Registration |
APM 792 | Research |
APM 792 | Research |
APM 792 | Research |
APM 799 | Dissertation |
APM 792 | Research |
APM 795 | Continuing Registration |
2022 Spring
Course Number | Course Title |
---|---|
CSE 790 | Reading and Conference |
MAT 492 | Honors Directed Study |
MAT 493 | Honors Thesis |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
AML 799 | Dissertation |
AML 792 | Research |
CSE 590 | Reading and Conference |
MAT 275 | Modern Differential Equations |
APM 792 | Research |
MAT 799 | Dissertation |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
APM 790 | Reading and Conference |
APM 795 | Continuing Registration |
APM 792 | Research |
APM 799 | Dissertation |
2021 Fall
Course Number | Course Title |
---|---|
MAT 792 | Research |
MAT 493 | Honors Thesis |
APM 792 | Research |
MAT 492 | Honors Directed Study |
APM 799 | Dissertation |
APM 795 | Continuing Registration |
MAT 451 | Mathematical Modeling |
2021 Summer
Course Number | Course Title |
---|---|
APM 799 | Dissertation |
APM 795 | Continuing Registration |
APM 792 | Research |
APM 792 | Research |
APM 792 | Research |
2021 Spring
Course Number | Course Title |
---|---|
CSE 599 | Thesis |
APM 792 | Research |
APM 799 | Dissertation |
CSE 595 | Continuing Registration |
MAT 275 | Modern Differential Equations |
CSE 790 | Reading and Conference |
APM 795 | Continuing Registration |
MAT 275 | Modern Differential Equations |
CSE 590 | Reading and Conference |
CSE 790 | Reading and Conference |
AML 792 | Research |
CSE 599 | Thesis |
CSE 595 | Continuing Registration |
MAT 493 | Honors Thesis |
MAT 492 | Honors Directed Study |
AML 799 | Dissertation |
2020 Fall
Course Number | Course Title |
---|---|
APM 795 | Continuing Registration |
MAT 451 | Mathematical Modeling |
APM 799 | Dissertation |
MAT 792 | Research |
APM 792 | Research |
MAT 493 | Honors Thesis |
MAT 492 | Honors Directed Study |
2020 Summer
Course Number | Course Title |
---|---|
APM 792 | Research |
APM 792 | Research |
APM 792 | Research |
APM 795 | Continuing Registration |
APM 799 | Dissertation |
2020 Spring
Course Number | Course Title |
---|---|
CSE 590 | Reading and Conference |
MAT 493 | Honors Thesis |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
AML 799 | Dissertation |
AML 792 | Research |
APM 792 | Research |
CSE 790 | Reading and Conference |
BIO 493 | Honors Thesis |
APM 799 | Dissertation |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
CSE 790 | Reading and Conference |
APM 795 | Continuing Registration |
MAT 492 | Honors Directed Study |
2019 Fall
Course Number | Course Title |
---|---|
BIO 492 | Honors Directed Study |
MAT 493 | Honors Thesis |
MAT 492 | Honors Directed Study |
APM 792 | Research |
MAT 792 | Research |
APM 795 | Continuing Registration |
2019 Summer
Course Number | Course Title |
---|---|
APM 799 | Dissertation |
APM 792 | Research |
APM 792 | Research |
APM 792 | Research |
2019 Spring
Course Number | Course Title |
---|---|
AML 799 | Dissertation |
AML 792 | Research |
BIO 493 | Honors Thesis |
MAT 492 | Honors Directed Study |
MAT 493 | Honors Thesis |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
BIO 355 | Intro to Computation Molec Bio |
MAT 355 | Intro to Computation Molec Bio |
CSE 590 | Reading and Conference |
CSE 790 | Reading and Conference |
MBB 355 | Intro to Computation Molec Bio |
APM 792 | Research |
APM 799 | Dissertation |
CSE 595 | Continuing Registration |
CSE 599 | Thesis |
CSE 790 | Reading and Conference |
APM 530 | Mathematical Cell Physiology. |
2018 Fall
Course Number | Course Title |
---|---|
MAT 451 | Mathematical Modeling |
MAT 792 | Research |
APM 792 | Research |
MAT 492 | Honors Directed Study |
BIO 492 | Honors Directed Study |
2018 Summer
Course Number | Course Title |
---|---|
APM 792 | Research |
APM 792 | Research |
2018 Spring
Course Number | Course Title |
---|---|
AML 799 | Dissertation |
BIO 355 | Intro to Computation Molec Bio |
MAT 355 | Intro to Computation Molec Bio |
CSE 792 | Research |
AML 792 | Research |
MBB 355 | Intro to Computation Molec Bio |
APM 792 | Research |
APM 799 | Dissertation |
BIO 493 | Honors Thesis |