Matthew Scotch
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Phone: 480-727-2985
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Cntr for Environ. Health Engineering Biodesign Institute B240B Tempe, AZ 85287
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Mail code: 9020Campus: Dtphx
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Matthew Scotch is Associate Dean of Research and Professor of Biomedical Informatics in the College of Health Solutions. He is also Assistant Director of the Biodesign Center for Environmental Health Engineering at Arizona State University. His research focuses on genomic epidemiology and bioinformatics of RNA viruses with a particular interest in influenza A viruses. Current projects include studying approaches to advance genomic epidemiology by enrichment of virus sequence metadata (funding: NIH/NIAID R01AI164481) and analysis of viruses from wastewater using bioinformatics (funding: NSF/BIO 2412446). The latter is part of a NSF Predictive Intelligence for Pandemic Prevention (PIPP) Phase II Center.
His lab group is also interested in the molecular epidemiology of viruses including the amplification and sequencing of influenza A and B viruses for short and long-read high-throughput sequencing (HTS) and public health surveillance.
In 2024, Dr. Scotch was elected as a fellow of the American College of Medical Informatics.
- Postdoctoral Fellowship, Yale University 2006-2008
- M.P.H. Yale University 2007
- Ph.D. Biomedical Informatics, University of Pittsburgh 2006
- M.A. Biomedical Informatics, Columbia University 2002
- B. A. Health and Society, University of Rochester, NY 1998
- Genomic epidemiology of RNA viruses with a focus on influenza A (human and avian)
- Phylodynamics
- Molecular epidemiology
- Wastewater-based epidemiology
- Bioinformatics
- DNA sequence databases and metadata enrichment
- Natural Language Processing (NLP)
Related Links:
(Last 10 publications out of 100 total)
- Bermudez-Rivera B*, Hampton B*, Wheeler C*, Vargas J*, Swaminathan S, Driver EM, Halden RU, Varsani A, Scotch M, Faleye TOC. Nine rhizobium phage genomes recovered from wastewater in Tempe, AZ, October 2019-March 2020. Microbiol Resour Announc. 2024 Oct 10;13(10):e0068024.
- Wang X*, Walker G, Kim KW, Stelzer-Braid S, Scotch M, Rawlinson WD. The resurgence of influenza A/H3N2 virus in Australia after the relaxation of COVID-19 restrictions during the 2022 season. J Med Virol. 2024 Sep;96(9):e29922.
- Faleye TOC, Skidmore P, Elyaderani A, Adhikari S, Kaiser N, Smith A, Yanez A, Perleberg T, Driver EM, Halden RU, Varsani A, Scotch M. Exploring canine picornavirus diversity in the USA using wastewater surveillance: from high-throughput genomic sequencing to immuno-informatics and capsid structure modeling. Viruses. 2024 Jul 24;16(8):1188.
- Wu Y, Namilae S, Srinivasan A, Mubayi A, Scotch M. Parametric analysis of SARS-CoV-2 dose-response models in transportation scenarios. PLoS One. 2024 Jun 12;19(6):e0301996.
- Zufle A, Salim F, Anderson T, Scotch M, Xiong L, Sokol K, Xue H, Kong R, Heslop D, Paik H-Y, MacIntyre CR. Leveraging Simulation Data to Understand Bias in Predictive Models of Infectious Disease Spread. ACM Trans Spatial Algorithms Syst. 2024. doi: 10.1145/3660631.
- Wang X*, Kim KW, Walker G, Stelzer-Braid S, Scotch M, Rawlinson WD. Genome characterization of influenza A and B viruses in New South Wales, Australia, in 2019: A retrospective study using high-throughput whole genome sequencing. Influenza Other Respir Viruses. 2024 Jan;18(1):e13252.
- Faleye TOC, Driver EM, Wright JM, Halden RU, Varsani A, Scotch M. Direct detection of canine picornavirus complete coding sequence in wastewater using long-range reverse-transcriptase polymerase chain reaction and long-read sequencing. Infect Genet Evol. 2024 Jan 8;118:105550.
- Scotch M, Lauer K, Wieben ED, Cherukuri Y, Cunningham JM, Klee EW, Harrington JJ, Lau JS, McDonough SJ, Mutawe M, O'Horo JC, Rentmeester CE, Schlicher NR, White VT, Schneider SK, Vedell PT, Wang X, Yao JD, Pritt BS, Norgan AP. Genomic epidemiology reveals the dominance of Hennepin County in the transmission of SARS-CoV-2 in Minnesota from 2020 to 2022. mSphere. 2023 Oct 26:e0023223. doi: 10.1128/msphere.00232-23.
- Faleye TOC, Driver EM, Bowes DA, Smith A, Kaiser NA, Wright JM, Chapman AR, Halden RU, Varsani A, Scotch M. Canine parvovirus 2C identified in dog feces from poop bags collected from outdoor waste bins in Arizona USA, June 2022. Transboundary and Emerging Diseases. 2023;2023:5596886. doi: 10.1155/2023/5596886.
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Bowes DA, Henke KB, Driver EM, Newell ME*, Block I, Shaffer G, Varsani A, Scotch M, Halden RU. Enhanced detection of mpox virus in wastewater using a pre-amplification approach: A pilot study informing population-level monitoring of low-titer pathogens. Sci Total Environ. 2023 Dec 10;903:166230.
*Student authors
ACTIVE GRANTS
2412446
NSF/DBI
Berry (PI) 09/01/2024-08/30/2031
PIPP Phase II: Environmental Surveillance for Assessing Pathogen Emergence (ESCAPE)
The goal of this PIPP phase II center is to develop and implement environmental surveillance systems that work for everyone, anywhere while advancing public health intelligence through communication, community-based science, and workforce development to predict and prevent infectious disease pandemics.
Role: Co-principal investigator
R21LM014467-01
NIH/NLM
Scotch, Gonzalez-Hernandez (PIs) 05/07/2024-04/30/2026
Real-time estimation of influenza vaccine effectiveness through social media mining
The goal of this project is to use natural language processing (NLP) to estimate influenza vaccine effectiveness from social media posts in order to supplement traditional studies that rely on a test-negative design.
U01IP001180
CDC
Murugan (PI) 09/30/2022-08/31/2027
Platform to Assess Influenza and COVID-19 Vaccine Effectiveness in Underserved Arizona Populations
The goal of this project is to assess seasonal influenza and SARS-CoV-2 vaccine effectiveness among diverse demographic and clinical populations in Arizona.
Role: Co-investigator
2302969
NSF/IIS
Zufle (PI) 04/01/2023-03/31/2026
Collaborative Research: NSF-CSIRO: HCC: Small: Understanding Bias in AI Models for the Prediction of Infectious Disease Spread
The goal of this study is to design, develop, and validate artificial intelligence models that consider various forms of bias in prediction of infectious disease spread.
Role: Co-principal investigator
R01AI164481
NIH/NIAID
Scotch, Gonzalez (PIs) 09/17/2021-08/30/2025
Enriching SARS-CoV-2 sequence data in public repositories with information extracted from full text articles
The goal of this project is to develop and evaluate a biomedical informatics framework for enriching SARS-CoV-2 sequence data in public repositories for studying genomic epidemiology and population health.
R15LM013382
NIH/NLM
Namilae, Srinivasan (PIs) 08/05/2021–07/31/2025
A data analytics framework for the application of pedestrian dynamics to public health
The goal of this project is to develop and evaluate an agnostic data analytics framework for the application of pedestrian dynamics to address a wide range of public health applications.
Role: Co-investigator
2154934
NSF/CCF
Berry S (PI) 08/01/2022-01/31/2025
PIPP Phase I: Advancing Environmental Surveillance for Pandemic Prediction in Remote and Resource Poor Settings
The goal of this planning grant is the founding of the Center for the Discovery of Emerging Environmental Pathogens (C-DEEP). The vision of C-DEEP is to advance the science of environmental surveillance and metagenomics, specifically in regions where pandemics are likely to emerge and where current disease surveillance processes are inadequate.
Role: Senior personnel (ASU PI)
Courses
2025 Summer
| Course Number | Course Title |
|---|---|
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 484 | Internship |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 482 | Capstone I |
| BMI 483 | Capstone II |
2025 Spring
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| BMI 484 | Internship |
| BMI 483 | Capstone II |
| BMI 584 | Internship |
| BMI 482 | Capstone I |
| BMI 590 | Reading and Conference |
| BMI 614 | Curr Persp Health Informatics |
2024 Fall
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| BMI 790 | Reading and Conference |
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| BMI 484 | Internship |
| BMI 461 | Advanced Topics in BMI I |
| BMI 482 | Capstone I |
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 590 | Reading and Conference |
| BMI 483 | Capstone II |
| BMI 792 | Research |
2024 Summer
| Course Number | Course Title |
|---|---|
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 484 | Internship |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 482 | Capstone I |
| BMI 483 | Capstone II |
2024 Spring
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| BMI 484 | Internship |
| BMI 483 | Capstone II |
| BMI 584 | Internship |
| BMI 482 | Capstone I |
| BMI 590 | Reading and Conference |
| BMI 614 | Curr Persp Health Informatics |
2023 Fall
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| BMI 790 | Reading and Conference |
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| BMI 484 | Internship |
| BMI 461 | Advanced Topics in BMI I |
| BMI 482 | Capstone I |
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 590 | Reading and Conference |
| BMI 483 | Capstone II |
2023 Summer
| Course Number | Course Title |
|---|---|
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 484 | Internship |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 482 | Capstone I |
| BMI 483 | Capstone II |
2023 Spring
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| MBB 495 | Undergraduate Research |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| BMI 484 | Internship |
| BMI 483 | Capstone II |
| BMI 584 | Internship |
| BMI 482 | Capstone I |
| BMI 590 | Reading and Conference |
| CHS 791 | Seminar |
2022 Fall
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| BMI 790 | Reading and Conference |
| MBB 495 | Undergraduate Research |
| BMI 484 | Internship |
| BMI 461 | Advanced Topics in BMI I |
| BMI 482 | Capstone I |
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 590 | Reading and Conference |
| BMI 483 | Capstone II |
2022 Summer
| Course Number | Course Title |
|---|---|
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 484 | Internship |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 482 | Capstone I |
| BMI 483 | Capstone II |
2022 Spring
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| MBB 495 | Undergraduate Research |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| BMI 484 | Internship |
| BMI 483 | Capstone II |
| BMI 584 | Internship |
| BMI 482 | Capstone I |
| BMI 590 | Reading and Conference |
| CHS 791 | Seminar |
2021 Fall
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| BMI 790 | Reading and Conference |
| MBB 495 | Undergraduate Research |
| BMI 484 | Internship |
| BMI 461 | Advanced Topics in BMI I |
| BMI 482 | Capstone I |
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 590 | Reading and Conference |
| BMI 483 | Capstone II |
2021 Summer
| Course Number | Course Title |
|---|---|
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 484 | Internship |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 482 | Capstone I |
| BMI 483 | Capstone II |
2021 Spring
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| MBB 495 | Undergraduate Research |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| BMI 484 | Internship |
| BMI 483 | Capstone II |
| BMI 584 | Internship |
| BMI 482 | Capstone I |
| BMI 590 | Reading and Conference |
| CHS 791 | Seminar |
2020 Fall
| Course Number | Course Title |
|---|---|
| BMI 799 | Dissertation |
| BMI 790 | Reading and Conference |
| MBB 495 | Undergraduate Research |
| BMI 484 | Internship |
| BMI 461 | Advanced Topics in BMI I |
| BMI 482 | Capstone I |
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 593 | Applied Project |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 590 | Reading and Conference |
2020 Summer
| Course Number | Course Title |
|---|---|
| BMI 584 | Internship |
| BMI 792 | Research |
| BMI 484 | Internship |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 482 | Capstone I |
| BMI 483 | Capstone II |
| BMI 799 | Dissertation |
2020 Spring
| Course Number | Course Title |
|---|---|
| BMI 595 | Continuing Registration |
| BMI 799 | Dissertation |
| MBB 495 | Undergraduate Research |
| BMI 792 | Research |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| BMI 593 | Applied Project |
| BMI 484 | Internship |
| BMI 483 | Capstone II |
| BMI 584 | Internship |
| BMI 595 | Continuing Registration |
| BMI 482 | Capstone I |
| CHS 493 | Honors Thesis |
| CHS 791 | Seminar |
2025, Fellow, American College of Medical Informatics
2024 Member, Advanced Leadership Initiative (ALI), Arizona State University
- Infection, Genetics, and Evolution (Elsevier)
American Medical Informatics Association (AMIA)
American Ornithological Society (AOS)
American Society for Microbiology (ASM)
International Society for Computational Biology (ISCB)
International Society for Influenza and other Respiratory Virus Diseases (ISIRV)
2023-2024: Chair (Appointed), NLM/NIH BILDS Review Committee
2021-Present: Member, Baccalaureate Educators Community, AMIA Academic Forum
2020–Present: Journal Editorial Board Member, Environment International (Elsevier)
2013–Present: Journal Editorial Board Member, Infection, Genetics and Evolution (Elsevier)