Amanda Acuna
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950 S. McAllister Ave Tempe, AZ 85281
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Mail code: 4501Campus: Tempe
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Student Information
Graduate StudentNeuroscience
The College of Lib Arts & Sci
Amanda Acuña is a PhD candidate in the Interdisciplinary Graduate Program in Neuroscience under the mentorship of Dr. M. Foster Olive. Her research in the Addiction Neuroscience laboratory focuses on the impact of neuroinflammation following psychostimulant use on adaptive decision making. An important goal of this work is to investigate novel targets of pharmacotherapies to aid in restoring behavioral control to those with methamphetamine use disorders.
In addition to her research, Amanda is an enthusiastic mentor to undergraduate students in the laboratory and classroom, and has recently completed a Certificate in Scientific Teaching in Higher Education. She is currently the instructor of record for a special topics course at ASU - NEU 494, Psychiatric Medications – helping students to understand the neuroscience that underlies psychiatric disorders and their pharmacologic treatments.
Amanda earned concurrent bachelor’s degrees in psychology and neuroscience from Arizona State University, having completed a Barrett honor’s thesis in the Behavioral Neuroscience in Stress laboratory of Cheryl Conrad. A non-traditional transfer student, Amanda completed her associate’s degree in psychology prior to transferring to ASU while working full time as the Aquatic Director for a local swim school and a Training Center Director for a nationally recognized CPR/first aid/lifeguard certification agency. She hopes to inspire other re-entry students with nonlinear career paths to never stop learning and pushing themselves to achieve their goals.
2021 - Present | Arizona State University | PhD Candidate | Interdisciplinary Graduate Program in Neuroscience
2025 | Arizona State University | Certificate in Scientific Teaching in Higher Education
2021 | Arizona State University and Barrett, the Honors College | Summa Cum Laude | Concurrent Bachelor of Science in Neuroscience and Psychology
2018 | Chandler Gilbert Community College | Associate Degree in Psychology
Behavioral Pharmacology
Neuroimmunology
Decision Making
Basic Behavior
Cellular and Molecular Neuroscience
Immunohistochemistry
- Conrad C.D., Peay D.N., Sladkova, S., Kim, J.L., Donnay M.E., Acuña A.M., & Whittaker K. (2025). Chronic 17β-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats. In Press.
- Acuña, A. M., Rodarte, S. E., Bickley, S., Nagy, E. K., Peacock, E., Carlson, A., Overby, P. F., & Olive, M. F. (2025). Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats. Addiction Neuroscience, 15, 100207. https://doi.org/10.1016/j.addicn.2025.100207
- Acuña, A. M., Nagy, E. K., Legg, J. L., Rodarte, S. E., & Olive, M. F. (2025). Characterization of serum and brain cytokine levels following prolonged binge-like methamphetamine self-administration and cued methamphetamine seeking. Journal of Neuroimmunology, 400, 578530. Advance online publication. https://doi.org/10.1016/j.jneuroim.2025.578530
- Judd, J. M., Peay, D. N., Kim, J. L., Smith, E. A., Donnay, M. E., Miller, J., Klein, J. P., Nagy, E. K., Acuña, A. M., Olive, M. F., & Conrad, C. D. (2025). Inhibition of prefrontal glutamatergic neuron activity during the recovery period following chronic stress disrupts fear memory in male rats: potential role of the infralimbic cortex. Learning & memory (Cold Spring Harbor, N.Y.), 32(1), a053957. https://doi.org/10.1101/lm.053957.124
- Conrad C.D., Peay D.N., Acuña A.M., Whittaker K., & Donnay M.E. (2024). Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats. Hormones and Behavior (164). DOI: 10.1016/j.yhbeh.2024.105600.
- Acuña A.M., Park C., Leyrer-Jackson J.M., & Olive M.F. (2024) Promising immunomodulators for management of substance and alcohol use disorders. Expert Opinion on Pharmacotherapy 25(7):867-884. DOI: 10.1080/14656566.2024.2360653
- Nagy E.K., Overby P.F., Leyrer-Jackson J.M., Carfagno V.F., Acuña A.M., & Olive M.F. (2024). Methamphetamine and the Synthetic Cathinone 3,4-Methylenedioxypyrovalerone (MDPV) Produce Persistent Effects on Prefrontal and Striatal Microglial Morphology and Neuroimmune Signaling Following Repeated Binge-like Intake in Male and Female Rats. Brain Sciences,14(5):435. DIO: 10.3390/brainsci14050435.
- Serrano G.E., Walker J., Nelson C., Glass M., Arce R., Intorcia A., Cline M.P., Nabaty N., Acuña A., Huppert Steed A., Sue L.I., Belden C., Choudhury P., Reiman E., Atri A., & Beach T.G. (2024). Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer's Disease. International Journal of Molecular Sciences, 25(6):3130. DOI: 10.3390/ijms25063130.
- Acuña A.M. & Olive M.F. Influence of gut microbiome metabolites on cocaine demand and cocaine-seeking behavior. (2024). Neuropsychopharmacology, 49(2):357-358. DOI: 10.1038/s41386-023-01743-9.
- Nagy E.K., Leyrer-Jackson J.M., Hood L.E., Acuña A.M., & Olive M.F. (2023). Effects of repeated binge intake of the pyrovalerone cathinone derivative 3,4-methylenedioxypyrovalerone on prefrontal cytokine levels in rats - a preliminary study. Frontiers in Behavioral Neuroscience, 17:1275968. DOI: 10.3389/fnbeh.2023.1275968.
- Peay D.N., Acuna A., Reynolds C.M., Willis C., Takalkar R., Ortiz B.J., & Conrad C.D. (2023). Chronic stress leads to persistent and contrasting stellate neuron dendritic hypertrophy in the amygdala of male and female rats, an effect not found in the hippocampus. Neuroscience Letters, 24;812:137403. DOI: 10.1016/j.neulet.2023.137403.
- Acuña A.M. & Olive M.F. (2023). Purine-cytokine interactions in methamphetamine-induced behaviors. Brain, Behavior and Immunity, 55-56. DOI: 10.1016/j.bbi.2022.11.015.
- Leyrer-Jackson J.M., Acuña A.M. & Olive M.F. Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update. (2022). Expert Opinion on Pharmacotherapy, 23(16):1819-1830. DOI: 10.1080/14656566.2022.2140039.
Courses
2025 Fall
| Course Number | Course Title |
|---|---|
| NEU 394 | Special Topics |
| NEU 494 | Special Topics |
2025 Spring
| Course Number | Course Title |
|---|---|
| NEU 494 | Special Topics |
2025 College on Problems of Drug Dependence (CPDD) Travel Award
2025 Graduate Excellence Award
2025 Achievement Rewards for College Scientists (ARCS) Award, Spetzler Scholar
2024 First Prize AZBIO Student Discovery Zone, University Student Researcher
2024 ASU Graduate and Professional Student Association Outstanding Mentor Award
2023 Cold Spring Harbor Laboratories Neuroscience of Addiction Course and travel Award
2021 Best Psychology Honors Thesis 2021
2019 American Association of University Women (AAUW) Northwest Valley Scholarship
2019 College of Liberal Arts and Sciences Student Leader, Psychology
2019 Women Inspiring Scientific Progress (WISP) Summer Neuroscience Scholarship
2018 Barrett, the Honors College Scholarship, annually
2018 All Arizona Academic Team Scholarship
2018 Barrett, the Honors College Garcia Family Scholarship
These are some of the organizations I volunteer for and highly recommend others check out!
- Letters to a pre-scientist
Pen-pal program linking elementary and middle school students with scientists to foster enthusiasm for science and higher learning by making science-related professionals accessible and relatable. Researchers and other professionals in STEM can become a pen pal for a school year, inspiring students across the U.S. to learn more about careers in science. - Ask A Biologist
K-12 (and adult learners too!) biology learning resource that runs a website (in 2023, we had over 35 million visits to the site) with articles, games, and other resources as well as the option to write in and Ask A Biologist biology questions. Researchers can answer questions regarding their specific area of expertise. - AZ Junior Science and Humanities Symposium
Allowing high school students to practice their oral presentation skills and show off the scientific research they engaged in through science classes and after-school science clubs. ASU graduate students and faculty can serve as judges - helping to shape future scientists.