Fang Yu

Current External Grants

Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic Fitness (The FIT-AD SMART Trial) (NIH National Institute on Aging: 1R01AG076566-01A1; Principal Investigator: Fang Yu; Co-Investigators: Dereck L. Salisbury, Jeremy J. Pruzin, Molly Maxfield, Yi Su, Rodney Joseph, Michael Todd, Elsa Baena, Danni Li, David Coon; Award Dates: April 1, 2023 – March 31, 2028; Funded Amount : $4,535,544.00)

Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer’s Disease and Related Dementias: A Randomized Mechanistic Proof-of-Concept Trial (NIH National Institute on Aging: R61AG078089; Principal Investigator: Molly Maxfield & Rodney Joseph; Co-Investigators: Elsa Baena, Thomas Beach, Fang Yu; Award Dates: September 15, 2022 – August 30, 2027; Funded Amount: $2,707,125)

Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial: ClinicalTrials.gov Identifier NCT03313895) (NIH National Institute on Aging: R01AG055469–01A1; Project Investigator: Fang Yu & Feng Vankee Lin; Co-Investigators: Dereck Salisbury, Lisa Chow, Dereck Salisbury, David Vock, Anton Porsteinsson; Award Dates: September 15, 2017 – May 31, 2023; Funded Amount: $3,670,000.00)

Blood Biomarkers as Surrogate Endpoints of Treatment Responses to Aerobic Exercise and/or Cognitive Training in Amnestic Mild Cognitive Impairment (NIH National Institute on Aging: R01AG059654–01; Principal Investigator: Li, Danni; Co-Investigators: Fang Yu, Cavan Reilly, Lin Zhang; Award Dates: August 1, 2018 – May 31, 2023; Funded Amount: $1,930,000.00)

Selected Completed External Grants

Measuring Nucleotide Excision Repair in Alzheimer’s Disease Patients (NIH National Institute of Environmental Health Sciences: 5U01ES029603–02; Principal Investigator: Niedernhofer, Laura Jane; Co-Investigators: Fang Yu, Danni Li, Dereck Salisbury, Feng Vankee Lin; Award Dates: September 14, 2020 – June 30, 2022; Funded Amount: $434,780.00)

Phase II Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer’s in at at–risk Older Adults (The Exergame Study: ClinicalTrials.gov Identifier NCT02963415; NIH National Institute on Aging: 1R44AG055176–01; Principal Investigators: Tom Plocher & Fang Yu; Co-Investigators: Carolyn Porta, Dereck Salisbury; Award Dates: April 1, 2018 – March 31, 2021; Funded Amount: $1,150,000.00)

An informatics framework for discovery and ascertainment of drug–supplement interactions (NIH National Center for Complementary and Integrative Health: 3R01AT009457–04S1; Principal Investigator: Rui Zhang; Co-Investigators: Fang Yu, Julian Wolfson; Award Dates: April 1, 2017 – March 31, 2021; Funded Amount: $608,798.00)

Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume Effects (The FIT-AD Trial: ClinicalTrials.gov Identifier NCT01954550; NIH National Institute on Aging: R01AG043392–01A1; Principal Investigator: Fang Yu; Co-Investigators: Dereck Salisbury, Lisa Chow, Arthur Leon, Maurice Dysken, Jean Wyman, David Vock; Award Dates: May 1, 2013 – April 30, 2019; Funded Amount: $3,040,000.00)

Identification of proteins in plasma lipoproteins as biomarkers to aid in diagnosing and predicting progression of Alzheimer's disease in older adults (NIH National Institute on Aging: 5R21AG061372–02; Principal Investigator: Danni Li; Co-Investigators: Fang Yu, Lin Zhang; Award Dates: February 15, 2019 – January 31, 2021; Funded Amount: $499,000.00)

Hydroxysphingolipids as a Pathological Mechanism and Plasma Biomarkers of Physical Function Decline in Older Adults (NIH National Institute on Aging: 1R21AG059068–01; Principal Investigator: Danni Li; Co-Investigator: Fang Yu; Award Dates: July 1, 2018 – May 31, 2020; Funded Amount: $451,528.00)

Memory Matters: A mobile Aid to Stimulate Reminiscing in Persons with Memory Loss Phase II (NIH National Institute on Aging: 9R44AG053923–02; Principal Investigator: Dan Klassen; Co-Investigators: Fang Yu, Joseph Gaugler; Award Dates: June 1, 2016 – November 30, 2018; Funded Amount: $1,385,470.00)

Vascular Biomarkers to Predict Response to Exercise in Alzheimer's Disease (Alzheimer's Association: NIRG–15–362393; Principal Investigator: Danni Li; Co-Investigators: Fang Yu, David Vock; Award Dates: December 1, 2015 – November 30, 2018; Funded Amount: $99,999.00)

Building a Workforce to Provide Exercise to People with Alzheimer's Disease: The FIT–AD Certification Program (Minnesota Board on Aging: 333–16–SDEM–033/PO41518; Principal Investigator: Fang Yu; Co-Investigators: Dereck Salisbury, Jean Wyman; Award Dates: January 1, 2016 – June 30, 2017; Funded Amount: $98,000.00)

Cognition Linked to Endurance & Vigorous Exercise Research in Parkinson’s Disease (The CLEVER – PD Pilot Study) (HealthPartners Foundation; Principal Investigator: Leah Hansen; Co-Investigators: Fang Yu, Julia Johnson; Award Dates: August 1, 2014 – December 31, 2015;

Funded Amount: $35,000.00)

Feasibility and Impact of Aerobic Exercise in Alzheimer's Disease (BrightFocus Foundation: A2009344; Principal Investigator: Fang Yu; Co-Investigators: Maurice Dysken, Jean Wyman, Patricia Painter; Award Dates: April 1, 2009 – February 28, 2012; Funded Amount: $150,000)

The Effect of Aerobic Fitness Exercise on Executive Functioning and Function in Alzheimer's Disease (American Nurses Foundation: 2005102; Principal Investigator: Fang Yu; Award Dates: November 1, 2005 – July 31, 2007; Funded Amount: $4,998.00)