Samantha Bartholomew
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Mail code: 4501Campus: Tempe
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Student Information
Graduate StudentNeuroscience
The College of Lib Arts & Sci
4th year Neuroscience PhD Candidate studying the effects of a novel Dyrk1a inhibitor, DYR533, on Alzheimer's Disease and Related Dementias (ADRD). My dissertation work focuses on how DYR533 affects microglia, where the protein is highly expressed, and neuroinflammation using both in vivo and in vitro techniques. The goal of my research is to uncover what role Dyrk1a has in microglia, since little is known, and to understand if changes in neuroinflammation seen in our studies of DYR533 treatment in models of ADRD can be directly tied to changes in microglial Dyrk1a or if they're due to a reduction in ADRD pathology.
Florida State University, Bachelor's of Science, Psychology 2014 - 2018
Cellular/molecular neuroscience, in vivo and in vitro techniques, neuroinflammation
ASU - Banner Neurodegenerative Disease Research Center within The Biodesign Institute
Bartholomew, S.K., Turk, J., Winslow, W., Foley, C., Shaw, A., Rokey, S., Tallino, S., Judd, J.M., Beach, T.G., Serrano, G.E., Wilms, G., Kushwaha, R., McMahon, A., Ginn, S., Becker, W., Hulme, C., Dunckley, T., & Velazquez, R. Dyrk1a inhibition with the Novel Compound DYR533: A Cross-Disease Therapeutic Strategy Targeting Amyloidosis, Tau Pathogenesis, and Neuroinflammation. bioRxiv, 2026.01.20.700091. (2026) doi: 10.64898/2026.01.20.700091. PMID: 41648480; PMCID: PMC12871710
Bartholomew, S.K., Winslow, W., Sharma, R. Pathak, K.V., Tallino, S., Judd, J.M., Leon, H., Turk, J., Pirrottee, P., Velazquez, R. Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice. J Neuroinflammation 21, 316 (2024). doi:10.1186/s12974-024-03290-6. PMID: 39633366; PMCID: PMC11619132.
Tallino S, Etebari R, McDonough I, Leon H, Sepulveda I, Winslow W, Bartholomew SK, Perez SE, Mufson EJ, Velazquez R. Assessing the Benefit of Dietary Choline Supplementation Throughout Adulthood in the Ts65Dn Mouse Model of Down Syndrome. Nutrients. 2024 Nov 30;16(23):4167. doi: 10.3390/nu16234167. PMID: 39683562; PMCID: PMC11644426.
Nikhil Dave, Jessica M. Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar V. Espinosa, Savannah Tallino, Samantha K. Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K Winstone, Erik A. Blackwood, Christopher Glembotski, Timothy Karr1, Ramon Velazquez, Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer’s disease hallmarks. Aging Cell. February 2023. doi: 10.1111/acel.13775. PMID: 36642814; PMCID: PMC9924938
Tallino, S., Winslow, W., Bartholomew, S.K, Velazquez, R. Temporal and brain region specific elevations of soluble Amyloid-ß40-42 in the Ts65Dn mouse model of Down syndrome. Aging Cell. December 2021. DOI: 10.1111/acel.13590. PMID: 35290711; PMCID: PMC9009111
Invited Oral Presentations
DYR533: A novel Dyrk1a Inhibitor and its therapeutic potential in Alzheimer’s Disease and related tauopathies. Neurodegenerative Disease Research Center Annual Symposium. Tempe AZ (October 2024)
DYR533: A novel Dyrk1a Inhibitor and its therapeutic potential in Alzheimer’s Disease and related tauopathies. Arizona Alzheimer’s Consortium, Arizona State University, Tempe AZ (September 2024)
2-minute Rapid Fire: Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery in mice. ASU Biodesign Institute Fusion, Phoenix AZ (April 2024)
Press Releases
Title: Lasting effects of common herbicide on brain health
Publication: Science Daily
Date: December 4, 2024
Summary: New research identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. This study tracks both the presence and impact of glyphosate's byproducts in the brain long after exposure ends, showing an array of persistent, damaging effects on brain health. The findings suggest the brain may be much more susceptible to the damaging effects of the herbicide than previously thought. Glyphosate is one of the most pervasive herbicides used in the U.S. and worldwide.
Title: TGen-ASU study reveals lasting effects of common herbicide on brain health
Publication: TGen News
Date: December 4, 2024
Description: Glyphosate exposure linked to Alzheimer’s disease-like pathology in pre-clinical models
Title: Study reveals lasting effects of common weed killer on brain health
Publication: ASU News
Date: December 4, 2024
Description: For the first time, new research shows even brief contact with a common weed killer can cause lasting damage to the brain, which may persist long after direct exposure ends.
ARCS Recipient - Kunkel Scholar (2026 - 2027)
IGPN Travel Award Winner (Spring 2026)
The Penelope Davis Neuroscience Scholarship Winner (Fall 2025)
Edwin Hubble Best Scientific Research Award at ASU Biodesign Institute Fusion Retreat (Apil 2024)
Arizona State University Graudate College Q2 Travel Award (Fall 2022)
Graduate Association of Interdisciplinary Neuroscience (GAINS) Secretary (2024 - 2025)
AAAS Arizona State University Elemental Member (2025 - Present)
Alzheimer’s Association ISTART Member (2023 - Present)
Society for Neuroscience Member (2022 - Present)
Open Door – Neuroscience is for Everyone (February 2025)
Judge for Undergraduate Research Symposium, Tempe, AZ (April 2024)