Michael Caplan

Michael Caplan

Adjunct Faculty, School of Biological and Health Systems Engineering
  • michael.caplan@asu.edu
  • 602-955-8200
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  • ISTB1 281M ,
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Biography Research Teaching Public Work
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Long Bio

Michael Caplan earned his undergraduate degrees from the University of Texas at Austin and his doctorate from the Massachusetts Institute of Technology. Following postdoctoral research at Duke University Medical Center in Cell Biology, he joined the faculty of Arizona State University in 2003, and he is now an associate professor in biomedical engineering.

Professor Caplan’s research focuses on molecular cooperativity in drug targeting, bio-sensing, and cell signaling. Current projects align along three main themes: local drug delivery, endothelial dysfunction in diabetes, and cooperative DNA diagnostics. Recent awards include the Jeanette Wilkins Award for the best basic science paper at the Musculoskeletal Infection Society.

He teaches several classes including Biotransport Phenomena, Biomedical Product Design and Development II (alpha prototyping of a blood glucose meter), and co-teaches Biomedical Capstone Design. Professor Caplan also conducts educational research to assess the effectiveness of interactive learning strategies in large classes (~150 students).

Education
  • Ph.D. Chemical Engineering, Massachusetts Institute of Technology 2001
  • B.S. Chemical Engineering, University of Texas-Austin 1996
  • B.A. Plan II, University of Texas-Austin 1996
Research Interests

  • Rational Design of Bioactive Materials

  • Biomaterials

  • Mathematical modeling of drug delivery

  • Drug-targeting, Targeting of imaging molecules

  • Systems Biology

Publications

  • Chi Lin, Lindsey Ryder, David Probst, Michael Caplan, Mark Spano, Jeffrey LaBelle. (2017) Feasibility in the development of a multi-marker detection platform. Biosensors and Bioelectronics. Volume 89, Part 2, 15 March 2017, Pages 743–749.

  • Emma Frow, Michael R. Caplan (2016) “Work in Progress: Promoting Career Reflection Among Freshman BME Students.” Paper presented at 2016 ASEE Annual Conference & Exposition, New Orleans, Louisiana. doi: 10.18260/p.27026

  • Aldin Malkoc, Edgar Sanchez, Michael R. Caplan, Jeffrey T. La Belle (2015) “Electrochemical-Nucleic Acid Detection with Enhanced Specificity and Sensitivity” Journal of Biosensors & Bioelectronics, 6(2): 171. doi: 10.4172/2155-6210.1000171

  • Alex McLaren, Morgan B. Giers, James Fraser, Luke Hosack, Michael R. Caplan, Ryan McLemore (2014) "Antimicrobial Distribution From Local Delivery Depends on Dose: A Pilot Study with MRI" Clinical Orthopaedic Related Research, 472 (11): 3324-9. doi: 10.1007/s11999-014-3493-1

  • Caroline P. Addington, Christine M. Pauken, Michael R. Caplan, Sarah E. Stabenfeldt (2014) “The Role of SDF-1α-ECM Crosstalk in Determining Neural Stem Cell Fate.” Biomaterials. 35(10): 3263-3272. doi: 10.1016/j.biomaterials.2013.12.102

  • Morgan B. Giers, Alex C. McLaren, Kenneth J. Schmidt, Michael R. Caplan, Ryan McLemore (2014) “Distribution of Molecules Locally Delivered from Bone Cement” Journal of Biomedical Materials Research – Part B, 102(4): 806-14. doi: 10.1002/jbm.b.33062

  • Morgan B. Giers, Alex C. McLaren, Jonathan D. Placencia, David Frakes, Ryan McLemore, Michael R. Caplan. Spatiotemporal Quantification of Local Drug Delivery Using MRI. Computational and Mathematical Methods in Imaging (2013).
  • Addie Hicks, Michael R. Caplan, Alyssa Panitch, James Sweeney. An Incubatable Direct Current Stimulation System for In Vitro Studies of Mammalian Cells. BioResearch Open Access (2012).
  • Liping Xu, Jatinder S. Josan, Josef Vagner, Michael R. Caplan, Victor J. Hruby, Eugene A. Mash, Ronald M. Lynch, David L. Morse, and Robert J. Gillies. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proceedings of the National Academy of Sciences USA (2012).
  • Morgan B. Giers, Chris S. Estes, Alex C. McLaren, Michael R. Caplan, Ryan McLemore. Jeannette Wilkins award: can locally delivered gadolinium be visualized on MRI? A pilot study. Clinical Orthopaedic Related Research (2012).
  • Venkat Shankarraman, Grace Davis-Gorman, Jack G. Copeland, Michael R. Caplan and Paul F. McDonagh. Standardized Methods to Quantify Thrombogenicity of Blood-contacting Materials via Thromboelastography. Journal of Biomedical Materials Research – Part B: Applied Biomaterials (2012).
  • Venkat Shankarraman, Grace Davis-Gorman, Paul F. McDonagh and Michael R. Caplan. Intracellular Signaling Controls Endothelial Cell Prostacyclin Secretion and Regulation of Blood Clotting Time. Journal of Biomedical Materials Research – Part A (2012).
  • Bret G. Kelso, Jeremy B. Brower, Jerome H. Targovnik, Michael R. Caplan. Pyridoxine Restores Endothelial Cell Function in High Glucose. Metabolic Syndrome and Related Disorders (2011).
  • Christine M. Pauken and Michael R. Caplan. Temporal differences in Erk1/2 activity distinguish among combinations of extracellular matrix components. Acta Biomaterialia (2011).
  • Doris Hom Eng, Michael Caplan, Mark Preul, Alyssa Panitch. Hyaluronan scaffolds: a balance between backbone functionalization and bioactivity. Acta Biomaterialia (2010).
  • Elena V. Rosca, Michael R. Caplan. Mathematical Modeling of Nanoparticle Targeting. Methods in Bioengineering: Nanoscale Bioengineering and Nanomedicine (2010).
  • Jeremy Brower, Jerome Targovnik, Michael R. Caplan, Stephen P. Massia. High glucose-mediated loss of cell surface heparan sulfate proteoglycan impairs the endothelial shear stress response. Cell Motility and the Cytoskeleton (2010).
  • Karen C. Butterfield, Michael R. Caplan, Alyssa Panitch. Identification and Sequence Composition Characterization of Chondroitin Sulfate-Binding Peptides through Peptide Array Screening. Biochemistry (2010).
  • Karen Chao Butterfield, Aaron Conovaloff, Michael Caplan, Alyssa Panitch. Chondroitin sulfate-binding peptides block chondroitin 6-sulfate inhibition of cortical neurite growth. Neuroscience Letters (2010).
  • Satterfield BC, Bartosiewicz M, West JA, Caplan MR. Surpassing specificity limits of nucleic acid probes via cooperativity. J Mol Diagn (2010).
  • Venkat Shankarraman, Miti M. Shah and Michael R. Caplan. Substrates Elicit Different Patterns of Intracellular Signaling Which in Turn Cause Differences in Cell Adhesion. Cellular and Molecular Bioengineering (2010).
  • Veronica Clavijo-Jordan, Michael R. Caplan, Kevin M. Bennett. Simplified Synthesis and Relaxometry of Magnetoferritin for Magnetic Resonance Imaging. Magnetic Resonance in Medicine (2010).
  • Elena V. Rosca, Robert J. Gillies, Michael R. Caplan. Glioblastoma Targeting via Integrins is Concentration Dependent. Biotechnology & Bioengineering (2009).
  • Jeremy Brower, Jerome Targovnik, Michael R. Caplan, Stephen P. Massia. Elevated Glucose Impairs the Endothelial Cell Response to Shear Stress. Cellular and Molecular Engineering (2009).
  • Jill M. Stukel and Michael R. Caplan. Targeted Drug Delivery for Treatment and Imaging of Glioblastoma Multiforme. Expert Opinion in Drug Delivery (2009).
  • Jill M. Stukel, Ronald Li, Heather Maynard, Michael R. Caplan. Two-step synthesis of multivalent cancer-targeting constructs. Biomacromolecules (2009).
  • Michael R. Caplan, Miti M. Shah. Translating Biomaterial Properties to Intracellular Signaling. Cell Biochemistry and Biophysics (2009).
  • Rosca EV, Gillies RJ, Caplan MR. Glioblastoma targeting via integrins is concentration dependent. Biotect & Bioeng (2009).
  • Ryan McLemore, Stephanie A. Robb, Bae Hoon Lee, Michael R. Caplan, Brent L. Vernon. NIPAAm based Michael-Type addition reactions follow Second Order Rate Laws. Ann Biomed Eng (2009).
  • Brent C. Satterfield, Michael R. Caplan, Jay A. A. West. Tentacle Probe Sandwich Assay on Porous Polymer Monolith Increases Sensitivity and Selectivity. Nucleic Acids Research (2008).
  • Jill Stukel, Jason Parks, Michael R. Caplan, Stephen Helms-Tillery. Temporal and Spatial Control of Neural Effects Following Intracerebral Microinfusion. Journal of Drug Targeting (2008).
  • Jill Stukel, Jeffrey J. Heys, Michael R. Caplan. Optimizing Delivery of Multivalent Targeting Constructs for Detection of Secondary Tumors. Annals of Biomedical Engineering (2008).
  • Thomas A. Shewmake, Francisco J. Solis, Robert J. Gillies, Michael R. Caplan. Effects of Linker Properties on Multivalent Targeting. Biomacromolecules (2008).
  • Brent C. Satterfield, David Kulesh, David Norwood, Leonard Wasieloski, Jay A. A. West, Michael R. Caplan. Tentacle Probes™: differentiation of difficult single nucleotide polymorphisms and deletions by presence or absence of a signal in real time PCR. Clinical Chemistry (2007).
  • Brent C. Satterfield, Jay A. A. West, and Michael R. Caplan. Tentacle probes: eliminating false positives without sacrificing sensitivity. Nucleic Acids Research (2007).
  • Brent C. Satterfield, Seth Stern, Michael R. Caplan, Kyle W. Hukari, and Jay A. A. West. Microfluidic purification and preconcentration of mRNA by flow-through polymeric monolith. Analytical Chemistry (2007).
  • Christopher L Klaver and Michael R. Caplan. Bioactive surface for neural electrodes: decreasing astrocyte proliferation via transforming growth factor-beta1. J Biomed Mater Res A (2007).
  • Elena V. Rosca, Jill Stukel, Robert J. Gillies, Joseph Vagner, Michael R. Caplan. Specificity and Mobility of Polymeric, Multivalent Constructs for Cellular Targeting. Biomacromolecules (2007).
  • Satterfield, Brent C., Jay A. A. West, and Michael R. Caplan. When Flow Rates Matter: a dimensionless analysis of the effect of heat energy convection on microfluidic chip power consumption and temperature homogeneity. Journal of Undergraduate Research In Bioengineering (JURIBE) (2007).
  • Michael R. Caplan and Elena V. Rosca. Targeting drugs to combinations of receptors: a modeling analysis of potential specificity. Annals of Biomedical Engineering (2005).
  • Caplan, Michael R. and Harold P. Erickson. Apparent Cooperative Assembly of the Bacterial Cell-Division Protein FtsZ Determined by Isothermal Titration Calorimetry. Journal of Biological Chemistry (2003).
  • Michael Caplan, Douglas Lauffenburger. Nature's Complex Copolymers: Engineering Design of Oligopeptide Materials. Industrial & Engineering Chemistry Research (2002).
  • Michael Caplan, Elissa Schwartzfarb, Shuguang Zhang, Roger Kamm, Douglas Lauffenburger. Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials (2002).
  • Michael Caplan, Elissa Schwartzfarb, Shuguang Zhang, Roger Kamm, Douglas Lauffenburger. Effects of Systematic Variation of Amino Acid Sequence on the Mechanical Properties of a Self-assembling, Oligopeptide Biomaterial. J Biomaterial Science - Polymer Edition (2002).
  • Caplan, Michael R., Peter N. Moore, Shuguang Zhang, Roger D. Kamm, Douglas A. Lauffenburger. Self-assembly of a ß sheet protein is governed by relief of electrostatic repulsion relative to van der Waals attraction. Biomacromolecules (2000).
  • Michael Caplan, Chung-Yuan Chiang, Douglas Lloyd, Larry Yen. Formation of microporous Teflon® PFA membranes via thermally induced phase separation. Journal of Membrane Science (1997).
Courses
2023 Fall
Course Number Course Title
CHE 592 Research
CHE 792 Research
BIO 495 Undergraduate Research
2022 Fall
Course Number Course Title
CHE 792 Research
BIO 495 Undergraduate Research
2021 Fall
Course Number Course Title
CHE 592 Research
CHE 792 Research
BIO 495 Undergraduate Research
2020 Fall
Course Number Course Title
CHE 592 Research
CHE 792 Research
BIO 495 Undergraduate Research
2019 Fall
Course Number Course Title
CHE 792 Research
BIO 495 Undergraduate Research
2018 Fall
Course Number Course Title
BME 599 Thesis
BME 792 Research
CHE 592 Research
CHE 792 Research
BIO 495 Undergraduate Research
BME 394 Special Topics
Honors / Awards

Award for Excellence: For Championing Safety Culture at ASU (2014)

Jeanette Wilkins Award, best basic sci. paper, Musculoskeletal Infection Soc. (2011)

Fulton Top 5% Teaching Award (2010-11)

Fulton Teaching Excellence Award (2006)

NIDCR Career Development & Faculty Transition Award (2003-2008)

Service
  • ABET, Program Evaluator (2012 - Present)
  • Institutional Biosafety Committee, Vice-Chair (2007 - Present)
  • American Association of Engineering Education, Member (2005 - Present)
  • Biomedical Engineering Society, Member (1999 - Present)
  • Society For Biomaterials, Member (1997 - Present)
Expertise Areas
Bioengineering
Science and Engineering Education
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