Rajeev Misra
Professor,
School of Life Sciences
Other ASU affiliations
Associate Faculty,
Fundamental & Applied Microbiomics Associate Faculty
Biodesign Center for Fundamental & Applied Microbiomics
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Phone: 480-965-3320
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LSE 407 TEMPE, AZ 85287-4501
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Mail code: 4501Campus: Tempe
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Long Bio
Misra is a microbial geneticist who studies how a bacterium like Escherichia coli responses and endures various stresses, including those caused by antibiotics, defective envelop assembly, protein misfolding, heat, and osmotic-shock. Employing various genetic selection strategies, his lab has isolated several stress-alleviating mutations in a gene (rpoB) coding for an essential RNA polymerase beta-subunit. His current research involves investigating the mechanisms by which mutations in RNA polymerase overcome multiple and seemingly unrelated stresses.
A second project in his laboratory examines the mechanism of drug resistance, with an emphasis on the major multi-drug efflux pump system of clinical relevance. His research employs classical genetics and molecular biology approaches to investigate pathways of drug import and export that are crucial for drug resistance.
Education
PhD Adelaide University, Australia
Google Scholar URL
Publications
- Misra, R. 2026. Mutation-based antibiotic resistance mechanism. Microbiol Mol Biol Reviews. Accepted
- Yeh, M., K. Kelly, and R. Misra. 2025. Characterization of a novel RNA polymerase mutant of Escherichiacoli that confers thermotolerance and chaperone independence. Mol. Microbiol. 124(4):310-326.
- Kelly K., and R. Misra. 2025. Insights on the roles of stringent response, stringent-like response, and general stress response in hyperosmotic shock tolerance by Escherichiacoli strains. mBio. e02575-25.
- German, J.G., J.V. DeGiulio, J. Ramsey, A.M. Kropinski, and R. Misra. 2024. The TolC and lipopolysaccharide-specific (TLS) Escherichia coli bacteriophage TLS – the Tlsvirus archetype virus. Phage. 5(3):173-183.
- Gerken, H., Shetty, D., Kern, B., Kenney, L.J., and Misra R. 2024. Effects of pleiotropic ompR and envZ alleles of Escherichia coli on envelopes stress and antibiotic sensitivity. J. Bacteriol. 10.1128/jb.00172-24.
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- Cho, H.-J., and R. Misra. 2021. Mutational activation of antibiotic resistant pathways in the absence of two major antibiotic efflux systems of Escherichia coli. J. Bacteriol. 203:e00109-21.
- Nguyen, D., Kelly, K., Qiu, N., and R. Misra. 2020. YejM controls LpxC levels by regulating protease activity of the FtsH/YciM complex of Escherichia coli. J. Bacteriol. e00303-20.
- Gerken, H. P. Vuong, K. Soparkar, and R. Misra. 2020. New insights into the involvement of two-component systems in iron homeostasis and porin regulation in Escherichia coli. mBio. 11:e01192-20.
- Qiu, N., and Misra, R. 2019. Overcoming iron deficiency by altering outer membrane permeability. J. Bacteriol. 201:e00340-19.
- Kern, B., O.P. Leiser, and Misra, R. 2019. Suppressor mutations in degS overcome the acute temperature-sensitive phenotype of DdegP and DdegP Dtol-pal mutants of Escherichiacoli. J. Bacteriol. 201:e00742-18.
- Deb et al. 2017. Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide. PLoS One. 12(2): e0172529. https://doi.org/10.1371/journal.pone.0172529.
- Misra, R. 2016. Modulators of the bacterial two-component systems involved in envelope stress, transport and virulence. In Stress and Environmental Control of Gene Expression in Bacteria. Editor, Frans J. de Bruijn, Wiley-Blackwell Publishers.
- Morrison, K.D., R. Misra, and L.B. Williams. 2016. Unearthing the antibacterial mechanism of medicinal clay: A geochemical approach to combating antibiotic resistance. Scientific Reports (Nature). 6:19043.
- Soparkar, K., A.D. Kinana, J.W. Weeks, K.D. Morrison, H. Nikaido, and R. Misra. 2015. Reversal of the drug-binding pocket defects of the AcrB multidrug efflux pump protein of Escherichia coli. J. Bacteriol. 197:3255-3264.
- Misra, R. 2015. Entry and exit of bacterial outer membrane proteins. Trends Microbiol. 23: 452-453.
- Misra, R., K.D. Morrison, H.-J. Cho, T. Khuu. 2015. Importance of real-time assays to distinguish multidrug efflux pump inhibiting and Outer Membrane destabilizing activities in Escherichia coli. J. Bacteriol. 197:2479-2488.
- Misra, R., Stikeleather, R., and R. Gabriele. 2015. In vivo roles of BamA, BamB and BamD in the biogenesis of BamA, a core protein of the β-barrel assembly machine of Escherichiacoli. J. Mol. Biol. 427:1061-1074.
- Weeks, J. V. Bavro, and R. Misra. 2014. Genetic assessment of the role of AcrB β-hairpins in the assembly of the TolC-AcrAB multidrug efflux pump of Escherichia coli. Mol. Microbiol. 91:965-975.
- Misra, R. 2012. Assembly of the β-barrel outer membrane proteins in Gram-negative bacteria, mitochondria, and chloroplasts. Spotlight Article. ISRN Mol. Biol. Vol. 2012 doi:10.5402/2012/708203.
- Leonard-Rivera, M., and R. Misra. 2012. Conserved residues of the putative L6 loop of Escherichia coli BamA play a critical role in the assembly of β-barrel outer membrane proteins, including BamA itself. J. Bacteriol. 194:4662-4668.
- Workman, P., K. Heide, N. Giuliano, N. Lee, J. Mar, P. Vuong, D. Bennion, and R. Misra. 2012. Genetic, biochemical and molecular characterization of the polypeptide transport-associated domain of Escherichia coli BamA. J. Bacteriol. 194:3512-3521.
- Leiser, O.P., E.S. Charlson, H. Gerken, and R. Misra. 2012. Reversal of the ΔdegP phenotypes by a novel rpoE allele of Escherichia coli K-12. PLoS One. 7:e33979.
- Tellez, R. Jr., and R. Misra. 2012. Substitutions in the BamA β-barrel domain overcome the conditional lethal phenotype of a ΔbamB ΔbamE strain of Escherichiacoli. J. Bacteriol. 194:317-324.
- Vuong, P., and R. Misra. 2011. Guide to genome-wide bacterial transcription factor binding site prediction using OmpR as model, p. 41-56. In X. Xia (ed.) Selected Works in Bioinformatics. InTech (Publisher).
- Gerken, H., and R. Misra. 2010. MzrA-EnvZ interactions in the periplasm influence the EnvZ-OmpR two-component regulon. J. Bacteriol. 192:6271-6278.
- Bennion, D., E.S. Charlson, E. Coon, and R. Misra. 2010. Dissection of β-barrel outer membrane protein assembly pathways through characterizing BamA POTRA 1 mutants of Escherichiacoli. Mol. Microbiol. 77:1153-1171.
- Weeks, J.W., T. Celaya-Kolb, S. Pecora, and R. Misra. 2010. AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening. Mol. Microbiol. 75:1468-1483.
- Gerken, H., O. Leiser, D. Bennion, and R. Misra. 2010. Involvement and necessity of the Cpx regulon in the event of aberrant assembly of β-barrel outer membrane proteins. Mol. Microbiol. 75:1033-1046.
- Misra, R., and V.N. Bavro. 2009. Assembly and transport mechanism of tripartite drug efflux systems. Biochim. Biophys. Acta 1794:817-825.
- Gerken, H., E.S. Charlson, E.M. Cicirelli, L.J. Kenney, and R. Misra. 2009. MzrA, a novel modulator of the EnvZ/OmpR two-component regulon. Mol. Microbiol. 72:1408-1422.
- Masi, M., G. Duret, A.H. Delcour, and R. Misra. 2009. Folding and trimerization of signal sequence-less mature TolC in the cytoplasm of Escherichia coli. Microbiology. 155:1847-1857.
- Bavro, V.N., Z. Pietras, N. Furnham, L. Pérez-Cano, J. Fernández-Recio, X. Yuan Pei, R. Misra and B. Luisi. 2008. Channel-opening and assembly in a bacterial drug efflux machine. Mol. Cell. 30:114-121.
- Vuong, P., D. Bennion, J. Mantei, D. Frost, and R. Misra. 2008. Analysis of YfgL and YaeT Interactions through Bioinformatics, Mutagenesis, and Biochemistry. J. Bacteriol. 190:1507-1517.
- Misra, R. 2007. First glimpse of the crystal structure of YaeT’s POTRA domains. Chem. Biol. 2:649-651.
- Perry G. H., N. J. Dominy, K. G. Claw, A. S. Lee, H. Fiegler, R. Redon, J. Werner, F. A Villanea, J. L. Mountain, R. Misra, N. P. Carter, C. Lee and A. C. Stone. 2007. Diet and the evolution of copy number variation of the human amylase gene. Nature Genetics 39:1256-1260.
- Masi, M., P. Vuong, M. Humbard, K. Malone, and R. Misra. 2007. Initial steps of colicin E1 import across the outer membrane of Escherichia coli. J. Bacteriol. 189:2667-2676.
- Charlson, S. E., J. N. Werner, and R. Misra. 2006. Differential effects of yfgL mutation on the biogenesis of Escherichia coli outer membrane proteins and lipopolysaccharide. J. Bacteriol. 188:7186-7194.
- Malinverni, J. C., J. Werner, S. Kim, J. G. Sklar, D. Kahne, R. Misra, and T. J. Silhavy. 2006. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in E. coli. Mol. Microbiol. 61:151-164.
- Castillo-Keller, M., P. Vuong, and R. Misra. 2006. Novel mechanism of Escherichia coli porin regulation. J. Bacteriol. 188:576-586.
- German, G. J., R. Misra, and A. Kropinski. 2006. The T1-like bacteriophages. p 211-224. In The Bacteriophages. R. Calender (ed). Oxford University Press. New York, NY.
- Werner, J. and R. Misra. 2005. YaeT (Omp85) affects the assembly of lipid-dependent and lipid-independent outer membrane proteins of Escherichia coli. Mol. Microbiol. 57:1450-1459.
- Husain, F., M. Humbard, and R. Misra. 2004. Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli. J. Bacteriol. 186:8533-8536.
- Gerken, H., and R. Misra. 2004. Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli. Mol. Microbiol. 54:620-631.
- Augustus, A. M., T. Celaya, F. Husain, M. Humbard, and R. Misra. 2004. Antibiotic sensitive TolC mutants and their suppressors. J. Bacteriol. 186:1851-1860.
- Werner, J., A. M. Augustus, and R. Misra. 2003. Assembly of TolC, a structurally unique and multifunctional outer membrane protein of Escherichiacoli K-12. J. Bacteriol. 185:6540-6547.
- CastilloKeller, M., and R. Misra. 2003. Protease-deficient DegP suppresses lethal effects of a mutant OmpC protein by its capture. J. Bacteriol. 185:148-154.
- Landers C. J., O. Cohavy, R. Misra, H. Yang, Y. C. Lin, J. Braun, S. R. Targan. 2002. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 123:689-699.
- Vakharia, H., G. J. German, and R. Misra. 2001. Isolation and characterization of Escherichia coli tolC mutants defective in secreting enzymatically active a-hemolysin. J. Bacteriol. 183:6908-6916.
- German, G. J., and R. Misra. 2001. The TolC protein of Escherichia coli serves as a receptor for the newly characterized TLS bacteriophage. J. Mol. Biol. 301:579-585.
- Kloser, A. W., J. Reading, T. McDermott, R. Stidham, and R. Misra. 2001. Intragenic suppressors of an OmpF assembly mutant and assessment of the roles of various OmpF residues in assembly through informational suppressors. J. Bacteriol. 183:264-269.
- Misra, R., M. CastilloKeller, and M. Deng. 2000. Overexpression of protease deficient DegPS210A rescues the lethal phenotype of Escherichiacoli OmpF assembly mutants in a degP background. J. Bacteriol. 182: 4882-4888.
- O. Cohavy, D. Bruckner, L.K. Gordon, R. Misra. M.E. Eggena, S.R. Targan, and J. Braun. 2000. Colonic bacteria express an ulcerative colitis pANCA-ralated protein epitope. Infect. Imm. 68:1542-1548.
- Traurig, M., and R. Misra. 1999. Identification of bacteriophage K20 receptor binding regions of OmpF and lipopolysaccharide in Escherichia coli K12. FEMS Microbiol. Lett. 181:101-108.
- Fajardo, D.F., J. Cheung, C. Ito, E. Sugawara, H. Nikaido, and R. Misra. 1998. Biochemistry and regulation of a novel Escherichia coli K-12 porin, OmpG, which produces unusually large channels. J. Bacteriol. 180:4452-4459.
- Kloser, A.W., M.W. Laird, M. Deng, and R. Misra. 1998. Modulations in lipid A and phospholipid biosynthesis pathways influence outer membrane protein assembly in Escherichia coli K-12. Mol. Microbiol. 27:1003-1008.
- Kloser, A.W., M.W. Laird, and R. Misra. 1996. asmB, a suppressor locus for assembly defective outer membrane proteins of E. coli is allelic to envA (lpxC). J. Bacteriol. 178:5138-5143.
- Deng, M., and R. Misra. 1996. Examination of AsmA and its effect on the assembly of Escherichia coli outer membrane proteins. Mol. Microbiol. 21:605-612.
- Vakharia, H., and R. Misra. 1996. A genetic approach for analyzing surface-exposed regions of the OmpC protein of Escherichia coli K-12. Mol. Microbiol. 19:881-889.
- Xiong, X., J.N. Deeter, and R. Misra. 1996. Assembly-defective OmpC mutants of Escherichia coli K-12. J. Bacteriol. 178:1213-1215.
- Misra, R. and Y. Miao. 1995. Molecular analysis of amsA, a locus identified as the suppressor of OmpF assembly mutants of Escherichia coli K-12. Mol. Microbiol. 16:779-788.
- Laird, M.W., Kloser, A.W., and R. Misra. 1994. Assembly of LamB and OmpF in deep rough lipopolysaccharide mutants of Escherichia coli K-12. J. Bacteriol. 176:2259-2264.
- Misra, R. 1993. A novel ompC mutation of Escherichia coli K-12 that reduces OmpC and OmpF levels in the outer membrane. Mol. Microbiol. 10:1029-1035.
- Misra, R. 1993. OmpF assembly mutants of Escherichia coli K-12: isolation, characterization, and suppressor analysis. J. Bacteriol. 175:5049-5056.
- Singh, Bijay, Iwona Szamosi, J. Mark Hand and Rajeev Misra. 1992. Biochemical characterization of the Arabidopsis acetohydroxyacid synthase expressed in Escherichiacoli. Frontiers and new horizons in amino acid research. p 343-347. K. Takai (ed.). Elsevier Science Publishers B.V.
- Singh, B., I. Szamosi, J. M. Hand and R. Misra. 1992. The Arabidopsis acetohydroxy acid synthase is insensitive to the feedback inhibitors. Plant Physiol. 99 (3): 812-816.
- Misra, R., and T. J. Silhavy. 1992. Protein secretion in bacteria: a chemotherapeutic target? p. 164-176. In J. Sutcliffe and N. H. Georopapadakou (eds), Emerging Targets in Antibacterial and Antifungal Chemotherapy. Chapman and Hall, New York and London.
- Singh, B., G. Schmitt, M. Lillis, J. M. Hand and R. Misra. 1991. Over expression of acetohydroxy acid synthase from Arabidopsis as an inducible fusion protein in Escherichiacoli: production of plolyclonal antibodies and immunological characterization of the enzyme. Plant Physiol. 97:657-662.
- Misra, R., A. Peterson, T. Ferenci and T. J. Silhavy. 1991. A genetic approach for analyzing the pathway of LamB assembly into the outer membrane of Escherichia coli. J. Biol. Chem. 266:13592-13597.
- Sampson, B. A., R. Misra and S. A. Benson. 1989. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability. Genetics 122:491-501.
- Misra, R., and S. A. Benson. 1989. A novel mutation, cog, which results in the production of a new porin protein (OmpG) of Escherichia coli K-12. J. Bacteriol. 171:4105-4111.
- Misra, R., and S. A. Benson. 1988. Genetic identification of the pore domain of the OmpC porin of Escherichia coli K-12. J. Bacteriol. 170:3611-3617.
- Misra, R., and S. A. Benson. 1988. Isolation and characterization of OmpC porin mutants with altered pore properties. J. Bacteriol. 170:528-533.
- Misra, R., B. A. Sampson, J. L. Occi, and S. A. Benson. 1987. Identification of mutants with altered outer membrane permeability. p. 436-442. In P. Actor, L. Danoe-Moore, M. L. Higgins, M. R. J. Salton, and G. A. Schockman (eds), Antibiotic Inhibition of Bacterial Call Surface Assembly and Function. American Society for Microbiology, Washington, DC.
- Misra, R., and P. Reeves. 1987. Role of micF in the tolC-mediated regulation of OmpF, a major outer membrane protein of Escherichia coli K-12. J. Bacteriol. 169:4722-4730.
- Misra, R., and P. Reeves. 1985. Molecular characterization of the Stc- mutation of Escherichia coli K-12. Gene 40:337-342.
- Misra, R., and P. Reeves. 1985. Intermediates in the synthesis of TolC protein include an incomplete peptide stalled at a rare Arg codon. Eur. J. Biochem. 152:151-155.
- Hackett, J., R. Misra, and P. Reeves. 1983. The TolC protein of Escherichia coli K-12 is synthesized in a precursor form. FEBS Lett. 156:307-310.
Research Activity
- Misra,Rajeev*. Assembly of E coli Outer Membrane Proteins. HHS-NIH-NIGMS(6/5/2008 - 5/31/2013).
- Misra,Rajeev*. ASSEMBLY OF E. COLI OUTER MEMBRANE PROTEINS. HHS-NIH-NIGMS(5/1/2006 - 8/31/2008).
- Chang,Yung*, Brophy,Colleen M, Jacobs,Bertram Lewis, Misra,Rajeev, Pettit,George Robert, Sierks,Michael Richard, Zautra,Alex John. THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR(4/1/2004 - 3/31/2005).
- Misra,Rajeev*. EXPORT AND IMPORT OF LETHAL AGENTS MEDIATED BY TOLC. HHS-NIH-NIGMS(8/5/2003 - 7/31/2009).
- Gust,John Devens*, Arntzen,Charles, Bieber,Allan Leroy, Blankenship,Robert E, Brophy,Colleen M, Brune,Daniel Charles, Capco,David George, Chandler,Douglas E, Francisco,Wilson Alex, Hu,Qiang, Jacobs,Bertram Lewis, Leket-Mor,Tsafrir Shlomo, Lindsay,Stuart, Lorson,Christian L, Massia,Stephen Paul, Misra,Rajeev, Moore,Ana L, Moore,Thomas Andrew, Panitch,Alyssa, Sommerfeld,Milton R, Trelease,Richard Norman, Vermaas,Willem F J, Vernon,Brent, Williams,Peter, Woodbury,Neal Walter. PURCHASE OF A MALDI-TOF MASS SPECTROMETER. NSF-MPS(2/1/2002 - 1/31/2005).
- Misra,Rajeev*, Fajardo,Daniel Adrian. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM- NIGMS. HHS-NIH(1/1/1996 - 9/30/1996).
- Misra,Rajeev*. MINORITY PREDOCTORAL FELLOWSHIP TRAINING. HHS-NIH-NIGMS(1/1/1995 - 12/31/1995).
- Misra,Rajeev*. NOVEL ANTIBIOTIC TARGETS AMONG BACTERIAL PATHOGENS. ABRC(7/1/1994 - 6/30/1995).
- Misra,Rajeev*. MINORITY PREDOCTORAL FELLOWSHIP. HHS-NIH-NIGMS(1/1/1994 - 12/31/1994).
- Misra,Rajeev*. NOVEL ANTIBIOTIC TERGETS AMONG BACTERIAL PATHOGENS. ABRC(7/1/1993 - 6/30/1994).
- Misra,Rajeev*. MINORITY PREDOCTORAL FELLOWSHIP. HHS-NIH-NIGMS(1/1/1993 - 12/31/1993).
- Misra,Rajeev*. TARGETING & ASSEMBLY OF E COLI OUTER MEMBRANE PROTEINS. HHS-NIH-NIGMS(8/1/1992 - 4/30/2003).
- Misra,Rajeev*. NOVEL ANTIBIOTIC TARGETS AMONG BACTERIAL PATHOGENS. ABRC(7/1/1992 - 6/30/1993).
Courses
2026 Spring
| Course Number | Course Title |
|---|---|
| MBB 493 | Honors Thesis |
| MIC 401 | Research Paper |
| MIC 493 | Honors Thesis |
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
2025 Fall
| Course Number | Course Title |
|---|---|
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MIC 360 | Bacterial Physiology |
2025 Summer
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
2025 Spring
| Course Number | Course Title |
|---|---|
| MBB 493 | Honors Thesis |
| MIC 493 | Honors Thesis |
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
2024 Fall
| Course Number | Course Title |
|---|---|
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MIC 360 | Bacterial Physiology |
2024 Summer
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
2024 Spring
| Course Number | Course Title |
|---|---|
| MBB 493 | Honors Thesis |
| MIC 493 | Honors Thesis |
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
2023 Fall
| Course Number | Course Title |
|---|---|
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MIC 501 | Foundations in Microbiology |
| MIC 360 | Bacterial Physiology |
2023 Summer
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
2023 Spring
| Course Number | Course Title |
|---|---|
| MBB 493 | Honors Thesis |
| MIC 493 | Honors Thesis |
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
2022 Fall
| Course Number | Course Title |
|---|---|
| MIC 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MIC 501 | Foundations in Microbiology |
| MIC 360 | Bacterial Physiology |
2022 Summer
| Course Number | Course Title |
|---|---|
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
2022 Spring
| Course Number | Course Title |
|---|---|
| MBB 493 | Honors Thesis |
| MIC 493 | Honors Thesis |
| MIC 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
2021 Fall
| Course Number | Course Title |
|---|---|
| MBB 499 | Individualized Instruction |
| MIC 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MBB 495 | Undergraduate Research |
| MIC 501 | Foundations in Microbiology |
2021 Spring
| Course Number | Course Title |
|---|---|
| MBB 493 | Honors Thesis |
| MIC 493 | Honors Thesis |
| MIC 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
| MBB 495 | Undergraduate Research |
| BIO 495 | Undergraduate Research |
| MIC 442 | Bacterial Genetics Laboratory |
Presentations
- Rajeev Misra. Outer Membrane Protein Assembly and Envelope Stress: two sides of the same coin. Department of Microbiology Seminar, University of Illinois, Urbana-Champaign (Oct 2014).
- Rajeev Misra. In vivo Investigation of Bacterial Multidrug Efflux Pumps. University of Kentucky, Department of Chemistry (Sep 2014).
- Rajeev Misra. Biogenesis of BamA (Omp85), a core protein of the ß-barrel assembly machine of Gram negative bacteria, mitochondria and chloroplasts. Wind River Conference on Prokaryotic Biology, Estes Park, CO (Jun 2014).
- Hyun Jae Cho and Rajeev Misra. Mutational activation of drug efflux pump genes in Escherichia coli. Arizona/Nevada Chapter of American Society for Microbiology (Los Vegas, Nevada) (Apr 2014).
- Keith Morrison, Rajeev Misra and Lynda Williams. Mechanistic basis of antibacterial activities of clays. Arizona/Nevada Chapter of American Society for Microbiology (Los Vegas, Nevada) (Apr 2014).
- Rajeev Misra. Multidrug Resistance Bugs: why should we care?. Karcher/Barton Seminar, Department of Chemistry and Biochemistry, University of Oklahoma (Apr 2014).
- Rajeev Misra. Biogenesis of BamA (Omp85), a core protein of the ß-barrel assembly machine of Gram negative bacteria, mitochondria and chloroplasts. Departmental seminar, Chemistry and Biochemistry, University of Oklahoma, Noman (Apr 2014).
- Ryan Stikeleather and Rajeev Misra. Biochemical Analysis of the Highly Conserved ß-Barrel Assembly Machine. Arizona/Nevada Chapter of American Society for Microbiology (Tucson) (Apr 2013).
- Eric Linden, Dan Muongpack and Rajeev Misra. The Functional Analysis of TolC-AcrAB Tripartite Efflux and Operations of Channel Opening/Closing. Arizona/Nevada Chapter of American Society for Microbiology (Tucson) (Apr 2013).
- Rajeev Misra. Suppressors: easy to isolate, not always easy to interpret. Meeting on Genetic Approaches to Understanding Complex Biological Problems (Mar 2013).
- Jon Weeks and Rajeev Misra. Genetic interactions among the antibiotic efflux components. Arizona/Nevada Chapter of American Society for Microbiology (at ASU) (Apr 2012).
- Maggie Leonard-Rivera and Rajeev Misra. A conserved mechanism of beat-barrel outer membrane protein assembly from bacteria to human. Arizona/Nevada Chapter of American Society for Microbiology (at ASU) (Apr 2012).
- Hosnah Maududi, Jon Weeks and Rajeev Misra. Functional assembly of a major drug efflux system in Escherichia coli. Arizona/Nevada Chapter of American Society for Microbiology (at ASU) (Apr 2012).
- Misra, R. (Attended the meeting). Gordon Research Conference on Protein Secretion Across Cell Membranes (Apr 2012).
- Rajeev Misra, Owen P. Leiser, Emily S. Charlson, and Henri G. Gerken. A novel sigma factor gene allele overcomes the conditional lethal phenotype of a strain lacking the major periplasmic protease of Escherichia coli. 55th Wind River Conference on Prokaryotic Biology, CO (Jun 2011).
- Jon Weeks and Rajeev Misra. Genetic Analysis of AcrAB-TolC, the multidrug Efflux Complex of E coli. Annual General American Society for Microbiology, New Orleans (May 2011).
- Owen Leiser and Rajeev Misra. Envelope Homeostasis in Escherichia coli. Arizona/Nevada Chapter ASM (Northern Arizona University, Falgstaff, AZ) (Apr 2011).
- Rene Tellez Jr and Rajeev Misra. Conditional Lethal Phenotype of ?bamB ?bamE is Overcome by Alterations in the ß-barrel Domain of BamA. Arizona/Nevada Chapter ASM (Northern Arizona University, Falgstaff, AZ) (Apr 2011).
- Rajeev Misra and Owen Leiser. Novel aspects of envelope stress response. Gordon Research Conference on Protein Secretion Across the Membranes, Galveston (Mar 2011).
- Rajeev Misra. Transport across membranes: Multiple drug resistance, mechanisms and new tools. 462th WE Heraeus Seminar, Jacobs University Bremen, Germany (Jul 2010).
- Rajeev Misra, Henri Gerken, Owen Leiser and Drew Bennion. New insights into bacterial envelope stress response. Gordon Research Conference on Bacterial Cell Surfaces, New Hamshire (Jun 2010).
- Jon Weeks and Rajeev Misra. Genetic Analysis of the Role of TolC's Periplasmic Turn 1 in Antibiotic Efflux. Molecular Genetics of Bacteria and Phage (Madison WI) (Aug 2009).
- Qwen Leiser and Rajeev Misra. Envelope Stress Response in Escherichia coli. Molecular Genetics of Bacteria and Phage (Madison WI): (Aug 2009).
- Jon Weeks and Rajeev Misra. Genetic Analysis of the Role of TolC's Periplasmic Turn 1 in Antibiotic Efflux. Annual General American Society for Microbiology, Philadelphia (May 2009).
- Owen Leiser and Rajeev Misra. Relief of Envelope Stress in Escherichia coli. Arizona/Nevada Chapter ASM (Tucson AZ) (Mar 2009).
- Jon Weeks and Rajeev Misra. Investigation of the Role of AcrB Hairpin Loops in Antibiotic Efflux, presentation. Arizona/Nevada Chapter ASM (Tucson AZ) (Mar 2009).
- H. Gerken, E. Charlson, R. Misra. A novel protein, MzrA, links the two two-component envelope regulatory systems of Escherichia coli. Molecular Genetics of Bacteria and Phages, Cold Spring Harbor, NY (Aug 2008).
- O.P. Leiser, and R. Misra. Stress responses and outer membrane biogenesis in E coli. Molecular Genetics of Bacteria and Phages, Cold Spring Harbor, NY (Aug 2008).
- R. Misra, H. Gerken, E. Charlson. A novel protein, MzrA, links the two two-component envelope regulatory systems of Escherichia coli. Gordon Research Conference (Jun 2008).
- J. Weeks, and R. Misra. Opening and closing of TolC's aperture during antibiotic efflux. West Coast Biological Sciences Undergraduaet Research Conferences (Apr 2008).
- J. Weeks and R. Misra. Import of colicin E1. American Society for Microbiology, AZ and NV branch (Apr 2008).
- Gerken, H., Charlson, E., Misra, R., Misra, Rajeev. Suppressor Analysis of Escherichia coli Lacking Periplasmic Protease DegP and Assembly Factor YfgL. Molecular Genetics of Bacteria and Phages (Aug 2007).
- Leiser, O., Misra, Rajeev. Role of YfgC in Outer Membrane Biogenesis and Periplasmic Stress Response in Escherichia coli. Molecular Genetics of Bacteria and Phages (Aug 2007).
- Masi, M., Misra, R., Misra, Rajeev. Signal sequenceless TolC in Escherichia coli: in vivo biogenesis, in vitro activity and suppressor analysis. Molecular Genetics of Bacteria and Phages (Aug 2007).
- Misra, Rajeev. Identification of YfgL residues that are important for interaction with YaeT. Molecular Genetics of Bacteria and Phages (Aug 2007).
- Treuer, R., Weeks, J., Misra, R., Misra, Rajeev. Interaction between TolC and AcrA Proteins of the Major Antibiotic Efflux System of Escherichia coli. Molecular Genetics of Bacteria and Phages (Aug 2007).
- Masi, M, Vuong, P, Humbard, M, Malone, K, Misra, Rajeev. Initial steps of colicin E1 import across the outer membrane of Escherichi coli. Gordon Conference of Bacterial Cell Surfaces (Jun 2007).
- Al-Khatib, S, Husian, F, Misra, Rajeev. Genetic analysis of the role of AcrB hairpin loop in antibiotic efflux. American Society for Microbiology Annual Meeting, AZ-NV Branch (Feb 2006).
- Charlson, E, Werner, J, Coon, E, Misra, Rajeev. Selective role of YfgL in Escherichia coli outer membrane protein biogenesis. American Society for Microbiology Annual Meeting, AZ-NV Branch (Feb 2006).
- Kob, T, Pecora, S, Treuer, R, Misra, Rajeev. Importance of TolC periplasmic turns in protein-protein interactions. American Society for Microbiology Annual Meeting, AZ-NV Branch (Feb 2006).
- CastilloKeller, M, Wong, F, Misra, Rajeev. A novel mechanism of regulating porin gene expression in Escherichia coli. Molecular Genetics of Bacteria and Phages (Aug 2005).
- Charlson, E, Werner, J, Coon, E, Misra, Rajeev. Parallel but converging pathways of outer membrane protein assembly in Escherichia coli. Molecular Genetics of Bacteria and Phages (Aug 2005).
- Kolb, T, Husain, F, Pecora, S, Al-Khatib, S, Misra, Rajeev. Importance of TolC turns and AcrB hairpins in protein-protein interactions. Molecular Genetics of Bacteria and Phages (Aug 2005).
- Werner, J, Charlson, E, Coon, E, Misra, Rajeev. New factors in Escherichia coli outer membrane assembly. Gordon Research Conference (Jun 2005).
- Pecora, S, Celaya, T, Husain, F, Misra, Rajeev. Loops and turns of TolC, an outer membrane component of the bacterial antibiotic efflux pump. American Society for Microbiology, Arizona-Navada Branch (Apr 2005).
- Charlson, E, Coon, E, Werner, J, Misra, Rajeev. Genetics of outer membrane protein assembly in Escherichia coli. American Society for Microbiology (Apr 2005).
- Husain, Fasahath, Gerken, Henri, Misra, Rajeev. Interaction between TolC and AcrA components of a multidrug efflux pump of E. coli. Molecular Genetics of Bacteria and Phages Annual Meeting (Jul 2004).
- Werner, John, Misra, Rajeev. The essential E. coli protein YaeT is involved in the assembly of outer membrane proteins. Molecular Genetics of Bacteria and Phages Annual Meeting (Jul 2004).
- Werner, John, Misra, Rajeev. Unique assembly pathway of a multifunctional TolC protein of E. coli. American Society for Microbiology Annual Meeting (May 2004).
- Husain, Fasahath, Gerken, Henri, Misra, Rajeev. Suppression of the antibiotic sensitivity phenotype of mutant TolC proteins by mutations that alter AcrA structure or its expression. American Society for Microbiology Annual Meeting (May 2004).
- CastilloKeller, Maria, Misra, Rajeev. A samll regulatory RNA affects expression of porin expression in Escherichia coli. American Society for Microbiology Annual Meeting (May 2004).
- Misra, Rajeev. Assembly of a multifunctional outer membrane protein. Molecular Genetics of Bacteria and Phages (Aug 2003).
- Misra, Rajeev. The role TolC in antibiotic efflux and colicin import. Molecular Genetics of Bacteria and Phages (Aug 2003).
- Misra, Rajeev. The T1-like TolC & LPS-specific (TLS) pahge genome & the evolution and taxonomy of virulent phages. American Society for Microbiology (May 2003).
- Misra, Rajeev. Two novel multicopy suppressors rescue mutant OmpC lethlaity. American Society for Microbiology (May 2003).
Service
- Microbiome Faculty Search Committee, Member (2014 - Present)
- National Science Foundation, Graduate Research Fellowship, Genomics, Proteomics and Bioinformatics, Panel member (2014 - Present)
- Biotechnology and Biological Sciences Research Council, United Kingdom, Expert Reviewer (2014 - Present)
- American Society for Microbiology, Arizona and Southern Nevada Branch, Student talks Judge (2014 - Present)
- NIH, Transformative Research Award, Expert Reviewer (2014 - Present)
- National Science Foundation, Graduate Research Fellowship, Microbiology Panel, Panel member (2013 - Present)
- Standing Review Committee, Office of Knowledge Enterprise Development, Member (2013 - Present)
- Standing Review Committee, Office of Knowledge Enterprise Development, Member (2013 - Present)
- NIH, Special Emphasis Panel: Topics in Drug Resistance, Member (2013 - Present)
- NIH, Special Emphasis Panel: collaborations for macromolecular interactions in cells, Expert Reviewer (2013 - Present)
- Nature, PNAS(USA), Genetics, Expert Reviewer (2013 - Present)
- School of Life Sciences Undergraduate Committee, Member (2013 - Present)
- Cellular and Molecular Biosciences Faculty Personnel Committee, Committee member (2012 - Present)
- Cellular and Molecular Biosciences Faculty Personnel Committee, Committee member (2012 - Present)
- Cellular and Molecular Biosciences Faculty Personnel Committee, Committee member (2012 - Present)
- Current Microbiology; Biochemistry; PLoS ONE, Membrane Molecular Biology, Reviewer (2012 - Present)
- Molecular Microbiology, Editorial Board Member (2012 - Present)
- NIH, IDM-A 80S (Bacterial Pathogenesis Focus), Panel Member (2011 - Present)
- PLoS ONE, Academic Editor (2011 - Present)
- PLoS ONE, Academic Editor (2011 - Present)
- National Science Foundation, Grant Proposal Reviewer (2011 - Present)
- Pasteur Institute, Grant Reviewer (2011 - Present)
- NIH, Special Emphasis Panel, Bacterial Pathogenesis (R21 proposals), Panel Member (2011 - Present)
- DFG, Germany, Grant Proposal Reviewer (2011 - Present)
- Wellcome Trust, UK, Grant Proposal Reviewer (2011 - Present)
- Mol Microbiol, J. Bact., JBC, PLoS ONE, FASEB, Microbiology, AEM, Chem & Biol (Cell), Expert Reviewer (2011 - Present)
- Microbiology Graduate Program, Member (2008 - Present)
- Microbiology Graduate Program, Member (2008 - Present)
- Microbiology Graduate Program, Executive Committee Member (2008 - Present)
- Microbiology Graduate Program Committee, Member (2008 - Present)
- Microbiology, Expert Reviewer (2007 - Present)
- Antimicrobial and Chemptherapy, Reviewer (2006 - Present)
- Molecular Microbiology, Expert reviewer (2006 - Present)
- Executive Committee/School of Life Sciences, Member (2005 - Present)
- Nature, Reviewer (2005 - Present)
- Bacterial Pathogenesis Faculty Search Committee, Member (2005 - Present)
- National Graduate Fellowship Award Panel, National Science Foundation, Panel Member (2005 - Present)
- CMB Personnel Committee, Member (2004 - Present)
- Molecular and Cellular Biology Colloquium, Organizer (2004 - Present)
- Mycobacterium tuberculosis Faculty Search Committee, Member (2004 - Present)
- Journal of Bacteriology, Editorial Board Member (2000 - 2015)
- Molecular Microbiology, Editorial Board Member (2012 - 2014)
- PLoS ONE, Academic Editor (2011 - 2014)
- NIH, Special Emphasis Panel, Bacterial Pathogenesis, Panel Member (2011 - 2014)
- American Society for Microbiology, Arizona and Southern Nevada Branch, President (2012 - 2013)
- American Society for Microbiology, Arizona and Southern Nevada Branch, President (2012 - 2013)
- Molecular Microbiology, Editorial Board Member (2012 - 2013)
- PLoS ONE, Academic Editor (2011 - 2013)
- Journal of Bacteriology, Editorial Board Member (2000 - 2012)
- Journal of Bacteriology, Member Editorial Board (2000 - 2012)
- Quality of Instruction, Member (2009 - 2012)
- Microbiology Graduate Program, Member (2008 - 2012)
- NIH, Special Emphasis Panel, Bacterial Pathogenesis, Panel Member (2011 - 2011)
- Quality of Instruction, Member (2009 - 2011)
- Microbiology Graduate Program, Member (2008 - 2011)
- Applied and Environmental Microbiology, Reviewer (2010 - 2010)
- BMC Microbiology, Reviewer (2010 - 2010)
- Biochemistry, Reviewer (2010 - 2010)
- Genetics, Reviewer (2010 - 2010)
- Molecular Microbiology, Expert Reviewer (2010 - 2010)
- NIH, Topics in Microbiology, Special Emphasis Panel, Member (2010 - 2010)
- NIH, Prokaryote Cellular and Molecular Biology Study Section, National Institutes of Health, Permanent Panel Member (2005 - 2010)
- CMB Personnel Committee, Member (2004 - 2010)
- Immunology/Virology Faculty Search Committee, Member (2009 - 2010)
- Microbiology, Expert Reviewer (2009 - 2009)
- Molecular Microbiology, Expert Reviewer (2009 - 2009)
- Journal of Bacteriology, Member Editorial Board (2000 - 2009)
- Executive Committee, Member (2005 - 2008)
- Graduate Programs, School of Life Sciences, Associate Director (2005 - 2008)
- Journal of Bacteriology (American Society for Microbiology), Editorial Board Member (2000 - 2006)
- Research and Training Initiative, Member (2003 - 2005)
- Evolutionary and Systems Biology Faculty Search Committee, Committee Member (2003 - 2004)
- NIGMS Study Section MBC II, Ad Hoc Member (2002 - 2004)
- Journal of Applied and Environmental Microbiology, Peer reviewer (2004)
- Mutation, Peer reviewer (2004)
- National Institutes of Health, Ad Hoc Panel Member (MCB-I Section) (2004)
- National Science Foundation, Ad Hoc Grant Reviewer (2004)
- Prokaryote Cellular and Molecular Biology Section, National Instiutes of Health, Panel Member (2004)
- See ASU, Organizer of lab research exhibits (2004)
- School of Life Sciences Graduate Program Re-organization Committee, Member (2003 - 2003)
- Microbiology Graduate Program, Director (2000 - 2003)
- Graduate Program, Director (2003)
- Jounal of Bacteriology, Editororial Board Member (2003)
- National Institutes of Health, Ad Hoc grant reviewer (2003)
- National Science Foundation, Grant reviewer (2003)
- Seminar Committee, Committee Member (2003)
- University & College Academic Assembly, Senator (1999 - 2002)
- NSF Microbial Genetics Panel, Member (2001 - 2001)
- American Society for Microbiology, Arizona & Nevada branch, President (2000 - 2001)
- Department Septennial Review Committee, Chair (2000 - 2001)
- Quality of Instruction Committee, CLAS, Member (1999 - 2001)
- Virology Search Committee, Member (1999 - 2000)
- Department's Budget & Personal Committee, Member (1997 - 2000)