Jordan R. Yaron, Ph.D. is an assistant professor of chemical engineering in Arizona State University’s School for Engineering of Matter, Transport and Energy (SEMTE) and the Biodesign Institute Center for Biomaterials Innovation and Translation. Yaron's research focuses on elucidating the physiological and pathological response to tissue injury, characterizing tissue responses to biomaterials, and the development of novel therapeutics, dressings, and drug delivery scaffolds to enhance healing and repair described in more than 40 peer-reviewed publications. Yaron is a 2021 recipient of the highly competitive NIH K01 Career Development Award from the National Institute of Biomedical Imaging and Bioengineering, the 2022 recipient of the Wound Healing Foundation 3M Fellowship Award, the most prestigious early career award given by the society, and a 2023 recipient of an Arizona Biomedical Research Centre New Investigator Award and a Flinn Foundation Translational Seed Grant. He completed a postdoctoral fellowship at Mayo Clinic with Vijay Singh, MD, studying molecular factors leading to adverse outcomes of acute pancreatitis and a second postdoctoral fellowship at the ASU Biodesign Institute with Alexandra Lucas, MD, developing recombinant virus-derived therapeutics for dermal and corneal wound healing, spinal cord injury, liver ischemia-reperfusion injury, lupus-associated lung hemorrhage and lethal gammaherpesvirus vasculitis. Jordan received his PhD in biological design at ASU in 2015 with Deirdre Meldrum, PhD, for his work describing the regulation of the NLRP3 inflammasome pathway by the flux of potassium and calcium ions across macrophage membranes. He has editorial roles in the journals Pharmaceutics, Frontiers in Immunology, and PLOS ONE, is a member of the Society for Biomaterials and the Inflammation Research Association and holds leadership roles in the Arizona Imaging and Microanalysis Society and Wound Healing Society.
- Postdoctoral Training (2017-2020)
- The Biodesign Institute, Arizona State University
- Immunomodulation
- Postdoctoral Training (2015-2017)
- Department of Medicine, Mayo Clinic Arizona
- Acute Inflammatory Disease
- PhD, Biological Design (2010-2015)
- Arizona State University
- Innate immunology, inflammation, and ion imaging
- BS, Biological Sciences: Genetics, Cell and Developmental Biology (2006-2010)
- Arizona State University & Barrett Honors College
- Elucidation of fundamental mechanisms of health and disease in the skin and spine.
- Interrogation of biomaterial-tissue responses for next-generation biomaterials development at the transcriptional (RNAseq), translational (immunohistochemistry), and metabolic/ionic levels.
- Development of advance immuno-modulating platforms for drug delivery and tissue repair.
- Investigation and repurposing of virus-derived proteins for use as novel biologics.
2024
- Yaron JR*, Bakkaloglu S, Macko S, Rhodes S, Norvor-Davis S, Rege K. Inflammasome Modulation with P2X7 Inhibitor A438079-loaded Dressings for Diabetic Wound Healing. Accepted. (*Co/Corresponding Author)
- Ghosh D†, Yaron JR†, Abedin MR, Godeshala S, Kumar S, Kilbourne J, Berthiaume F, Rege K. Bioactive Nanomaterials Kickstart Early Repair Processes and Potentiate Temporally Modulated Healing of Healthy and Diabetic Wounds. Accepted. (†Equal Contributions)
- Yaron JR*, Gosangi M, Pallod S, Rege K*. In situ Light-activated Materials for Skin Wound Healing and Repair: A Narrative Review. Bioengineering & Translational Medicine. In Press. (*Co/Corresponding Author)
2023
- Inamdar S, Suresh AP, Mangal JL, Ng ND, Sundem A, Behbahani HS, Rubino Jr TE, Yaron JR, Khodaei T, Green M, Curtis M, Acharya AP (2023). Succinate in the tumor microenvironment affects tumor growth and modulates tumor associated macrophages. Biomaterials. 301. 122292
- Inamdar S, Suresh AP, Mangal JL, Ng ND, Sundem A, Wu C, Lintecum K, Thumsi A, Khodaei T, Halim M, Appel N, Jaggarapu MMCS, Esrafili A, Yaron JR, Curtis M, Acharya AP (2023). Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice. Nature Communications. 14(1), 5333.
- Inamdar S, Suresh AP, Mangal JL, Ng ND, Sundem A, Behbahani HS, Rubino Jr TE, Shi X, Loa ST, Yaron JR, Hitosugi T, Green M, Gu H, Curtis M, Acharya AP (2023). Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy. Journal of Controlled Release. 358, 541-554.
- Jaggarapu MMCS, Ghosh D, Johnston T, Yaron JR, Mangal JL, Inamdar S, Gosangi M, Rege, K, Acharya AP (2023). Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing. Journal of Biomedical Materials Research Part A. 1-7.
- Ghosh D, Salinas CM, Pallod S, Roberts J, Makin IRS, Yaron JR, Witte RS, Rege K (2022). Temporal evaluation of efficacy and quality of tissue repair upon laser‐activated sealing. Bioengineering & Translational Medicine. 8(2). e10412
2022
- Zanetti IR, Burgin M, Zhang L, Yeh S, Ambadapadi S, Kilbourne J, Yaron J, Lowe KM, Daggett-Vondras J, Fonseca D, Boyd R, Wakefield D, Clapp W, Lim E, Chen H, Lucas A (2022). Virus-derived Chemokine Modulating Protein Pre-treatment Blocks Chemokine-Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage. Pathogens. 11(5), 588.
- Varkoly K, Tan S, Beladi R, Fonseca D, Zanetti IR, Kraberger S, Shah C, Yaron JR, Zhang L, Juby L, Fath AR, Ambadapadi S, House M, Maranian P, Pepine C, Varsani A, Moreb J, Schutlz-Cherry S, Lucas AR (2022). RNA Virus Gene Signatures Detected in Patients with Cardiomyopathy after Chemotherapy. Frontiers in Cardiovascular Medicine. 9, 821162
2021
- Ju B, Guo O, Benissan-Messan DZ, Shawver MH, Chen P, Geng B, Wei S, Yaron JR, Lucas AR, Hua Z (2021). Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis. Frontiers in Cardiovascular Medicine. 8, 649124
- Yaron JR, Zhang L, Guo Q, Haydel SE, Lucas AR (2021). Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms. Frontiers in Cardiovascular Medicine. 8, 648947
- Beladi RN†, Varkoly KS†, Schutz L†, Zhang L, Yaron JR, Guo Q, Burgin M, Hogue I, Tierney W, Dabrowski W, Lucas AR (2021). Serine Proteases and Chemokines in Neurotrauma; New Targets for Immune Modulating Therapeutics in Spinal Cord Injury. Current Neuropharmacology. 19(11):1835-1854. (†Equal Contributions)
- Guo Q, Yaron JR, Wallen III JW, Browder KF, Boyd R, Olson TL, Burgin M, Ulrich P, Aliskevich E, Schutz LN, Fromme P, Zhang L, Lucas A (2021). PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion. Frontiers in Cardiovascular Medicine. 8, 633212
- Khatua B, El Kurdi B, Patel K, Rood C, Noel P, Crowell M, Yaron J, Kostenko S, Guerra A, Faigel DO, Lowe M, Singh VP (2021). Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox. Science Advances. 7(5) eabd6449
2020
- Yaron JR†, Zhang L†, Guo Q, Awo EA, Burgin M, Schutz LN, Zhang N, Kilbourne J, Daggett-Vondras J, Lowe KM, Lucas AR (2020). Recombinant Myxoma virus-derived immune modulator M-T7 accelerates cutaneous wound healing and improves tissue remodeling. Pharmaceutics. 12(11), 1003. (†Equal Contributions)
- Fath AR, Aglan A, Platt J, Yaron JR, Varkoly KS, Beladi R, Gorgas D, Jean JT, Dasni P, Eldaly AS, Jupy M, Lucas AR (2020). Chronological Impact of Earthquakes on Blood Pressure: A Literature Review and Retrospective Study of Hypertension in Haiti before and after the 2010 Earthquake. Frontiers in Public Health. 8, 600157
- Kwiecien JM, Dabrowski W, Kwiecien-Delaney BJ, Kwiecien-Delaney CJ, Siwicka-Gieroba D, Yaron JR, Zhang L, Delaney KH, Lucas AR (2020). Neuroprotective effect of subdural infusion of Serp-1 in spinal cord trauma. Biomedicines. 8(10), 372.
- Kwiecien JM, Dabrowski W, Yaron JR, Zhang L, Delaney KH, Lucas AR (2020). The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury. Current Neuropharmacology. 19(2), 972.
- Ghosh D, Godeshala S, Nitiyanandan R, Islam MS, Yaron JR, DiCaudo D, Kilbourne J, Rege K (2020). Copper-Eluting Fibers for Enhanced Tissue Sealing and Repair. ACS Applied Materials & Interfaces. 12(25), 27951-27960
- Kwiecien JM†, Zhang L†, Yaron JR†, Schutz LN, Kwiecien-Delaney CJ, Awo EA, Burgin M, Dabrowski W, Lucas AR (2020). Local Chitosan-Serpin Injection after Spinal Cord Injury Reduces Inflammatory Damage and Improves Neurologic Function. Journal of Clinical Medicine. 9(4), 1221 (†Equal Contributions)
- Yaron JR†, Zhang L†, Guo Q, Burgin M, Schutz L, Awo E, Wise L, Krause KL, Ildefonso CJ, Kwiecien JM, Juby M, Rahman MM, Chen H, Moyer RW, Alcami A, McFadden G, Lucas AR (2020). Deriving Immune Modulating Drugs from Viruses – A New Class of Biologics. Journal of Clinical Medicine. 9(4), 972 (†Equal Contributions)
- Kwiecien JM, Dabrowski W, Dabrowska-Bouta B, Sulkowski G, Oakden W, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Marzec-Kotarska B, Stanisz GJ, Karis JP, Struzynska L, Lucas AR (2020). Prolonged inflammation leads to ongoing damage after spinal cord injury. PLoS ONE. 15(3), e0226584
- Yaron JR†, Ambadapadi S†, Zhang L, Chavan RN, Tibbetts SA, Keinan S, Varsani A, Maldonado J, Tafoya AM, Bullard WL, Kilbourne J, Stern-Harbutte A, Krajmalnik-Brown R, Munk BH, Koppang EO, Lim ES, Lucas AR (2020). Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection. Scientific Reports. 10(1), 1-13 (†Equal Contributions)
- Khatua B, Yaron JR, El-Kurdi B, Kostenko S, Papachristou GI, Singh VP (2020). Ringer’s lactate prevents early organ failure by providing extracellular calcium. Journal of Clinical Medicine. 9(1), 263
2019
- Zhang L†, Yaron JR†, Tafoya AM, Wallace SE, Kilbourne J, Haydel S, Rege K, McFadden G, Lucas AR (2019). A virus-derived immune modulating SERPIN accelerates wound closure with improved collagen remodeling. Journal of Clinical Medicine. 8(1626), 1-17 (†Equal Contributions)
- Selected as issue cover
- Yaron JR†, Chen H†, Ambadapadi S†, Zhang L, Tafoya AM, Munk BH, Wakefield D, Fuentes J, Marques BJ, Harripersaud K, Bartee MY, Davids J, Zheng D, Rand K, Dixon L, Moyer R, Clapp W, Lucas AR (2019). Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice. Journal of Inflammation. 16(1), 12 (†Equal Contributions)
- Yaron JR†, Kwiecien JM†, Zhang L†, Ambadapadi S, Wakefield DN, Clapp WL, Dabrowski W, Burgin M, Munk BH, McFadden G, Chen H, Lucas AR (2019). Modifying the Organ Matrix Pre-Engraftment; A New Transplant Paradigm? Trends in Molecular Medicine. 25(7), 626-639 (†Equal Contributions)
- Kwiecien JM, Dabrowski W, Marzec-Kotarska B, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Lucas AR (2019). Myxoma virus derived immune modulating proteins, M-T7 and Serp-1, reduce early inflammation after spinal cord injury in the rat model. Folia Neuropathologica. 57(1), 41-50
2018
- Chen H, Bartee M, Yaron J, Liu L, Zhang L, Zheng D, Hogue I, Bullard W, Tibbetts S, Lucas A (2018). Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10. Viruses. 10(10), 518
- Kostenko S, Heu CC, Yaron JR, Singh G, Oliveira CD, Muller WJ, Singh VP (2018). c-Src Regulates Cargo Transit via the Golgi in Pancreatic Acinar Cells. Scientific Reports. 8(1), 11903
- Chen H, Ambadapadi S, Wakefield D, Bartee MY, Yaron JR, Zhang L, Archer-Hartmann SA, Azadi P, Burgin M, Borges C, Zheng D, Ergle K, Muppala V, Morshed S, Rand K, Clapp W, Proudfoot A, Lucas A (2018). Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection. Scientific Reports. 8(1), 13433
- Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas AR (2018). Crystal Structure of Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function. Biochemistry. 57(7), 1096-1107
2017
- Al-Ani M†, Ambadapadi S†, Yaron JR†, Zheng D, Fortunel A, Doroton-Guevara M, Liu L, Morshed S, Fricker J, Miles W, McKillop M, Lucas A (2017). Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation. Cardiovascular and Hematologic Disorders: Drug Targets. 17(3), 195-204 (†Equal Contributions)
- Lucas A, Ambadapadi S, Mahon B, Viswanathan K, Chen H, Liu L, Dai E, Munuswami-Ramanujam G, Kwiecien JM, Yaron JR, Narute PS, McKenna R, Keenan S, Brantly M, McFadden G (2017). The Serpintine Solution. Journal of Clinical and Experimental Cardiology. 8(1), e150
2016
- Yaron JR, Rao MY, Gangaraju S, Zhang L, Kong X, Su F, Tian Y, Glenn HL, Meldrum DR (2016). The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochemical and Biophysical Research Communications. 472(3), 545-550
- Oliveira CD, Patel K, Mishra V, Trivedi RN, Noel P, Singh A, Yaron JR, Singh VP (2016). Characterization and Predictive Value of Near Infrared 2-Deoxyglucose Optical Imaging in Severe Acute Pancreatitis. PLoS ONE. 11(2), e0149073
2015
- Yaron JR, Gangaraju S, Rao MY, Kong X, Zhang L, Su F, Tian Y, Glenn HL, Meldrum DR (2015). K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells. Cell Death and Disease. 6(10), e1954
- Kong X, Su F, Zhang L, Yaron J, Lee F, Shi Z, Tian Y, Meldrum DR (2015). A Highly Selective Mitochondria-Targeting Fluorescent K+ Sensor. Angewandte Chemie: International Edition. 54(41), 12053-12057
2014
- Yaron JR, Ziegler CP, Tran TH, Glenn HL, Meldrum DR (2014). A convenient, optimized pipeline for isolation, fluorescence microscopy and molecular analysis of live single cells. Biological Procedures Online. 16(9)
Courses
2025 Spring
Course Number | Course Title |
---|---|
MBB 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
2024 Fall
Course Number | Course Title |
---|---|
BDE 792 | Research |
BIO 495 | Undergraduate Research |
CHE 211 | Intro to Chemical Processing |
CHE 211 | Intro to Chemical Processing |
CHE 211 | Intro to Chemical Processing |
CHE 211 | Intro to Chemical Processing |
BDE 591 | Seminar |
2024 Spring
Course Number | Course Title |
---|---|
MBB 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
BDE 791 | Seminar |
2023 Fall
Course Number | Course Title |
---|---|
BIO 495 | Undergraduate Research |
BDE 791 | Seminar |
2023 Spring
Course Number | Course Title |
---|---|
MBB 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
BDE 791 | Seminar |
2022 Fall
Course Number | Course Title |
---|---|
BIO 495 | Undergraduate Research |
MBB 496 | Undergraduate Thesis |
2021 Fall
Course Number | Course Title |
---|---|
BIO 495 | Undergraduate Research |
2023
- Arizona Biomedical Research Centre New Investigator Award
- Competitive new investigator award to fund promising early-stage scientists in Arizona.
2022
- Wound Healing Foundation 3M Fellowship Award
- The Fellowship is the most prestigious young investigator fellowship grant that is offered by the Wound Healing Foundation. Competitively awarded to one early-stage investigator annually.
2021
- NIH/NIBIB K01 Mentored Research Scientist Development Award
- The Mentored Research Scientist Development Award (K01) provides support for a sustained period of “protected time” for intensive research career development under the guidance of an experienced mentor, or sponsor, leading to research independence. The NIBIB awarded two K01 awards in 2021.
2019
- Ehrlich Award for Immunology Applications, Biodesign FUSION Scientific Retreat, Phoenix, AZ
2017
- Best Oral Pres., 8th Int’l. Symposium on SERPINs & Proteases in Health & Disease, Shanghai, China
2016
- Poster of Distinction (x2), American Pancreatic Association 47th Annual Meeting, Boston, MA, USA
- Young Investigator Award, American Pancreatic Association 47th Annual Meeting, Boston, MA, USA
2014
- Travel Award, Graduate & Professional Students Association, Arizona State University
- Travel Award, School of Biological & Health Systems Engineering, Arizona State University
- Microscopy & Microanalysis 2014 Presidential Scholar Award
- Google for Entrepreneurs Start-Up Weekend, 1st Place Overall Winner (Team Leader)
2013
- Life Technologies/Ion Torrent Art of Breakthrough Contest, Finalist
2012
- Arizona Imaging & Microanalysis Society 2012 Meeting Poster Award
2011 – 12
- Doctoral Fellowship, Science Foundation Arizona
- Life Technologies/Molecular Probes Cell Imaging Contest, 2nd Place
2010
- Doctoral Recruitment Fellowship, Arizona State University
- Pharmaceutics
- Topics Editor
- Frontiers in Immunology
- Review Editor
- Frontiers in Cell and Developmental Biology
- Review Editor
- Associate Guest Editor
- “Anti-Cancer and Anti-Ageing: What Can We Learn from the Superstar Naked Mole-Rat?”
(Alphabetical)
- American Society for Cell Biology
- Full Member
- Arizona Imaging and Microanalysis Society
- Board Member
- Microscopy Society of America
- Full Member
- Society for Leukocyte Biology
- Full Member
- Wound Healing Society
- Full Member
- Communications Committee Member
- Awards Committee Member
- Mr. Andrew Shabilla (2010-12)
- Ms. Colleen Ziegler (2010-12) - Honors Thesis Committee
- Ms. Garima Khanal, PA-C (2013)
- Dr. Mounica Rao, MD (2013-15)
- Mr. Fred Lee (2014-15)
- Mr. Shubham Trivedi (2015)
- Ms. Saara Khan (2016)
- Ms. Quinn Urbaniak-Dornstauder (2017)
- Ms. Mercedeh Javadi (2017-19)
- Ms. Sarah Wallace, MBA (2018)
- Dr. Savanah McMahon, MD (2018-19)
- Dr. Ayman Fath, MD (2019-20)
- Ms. Enkidia Awo (2019-20)
- Dr. Michael Juby, DO (2019-20)
- Ms. Michelle Burgin, MS (2017-20) - Masters Thesis Committee
- Ms. Lauren Schutz (2018-21) - Honors Thesis Committee
- Mr. Deepanjan Ghosh (2019 - Present)
- Dr. Roxana Beladi, DO (2020)
- Dr. Kyle Varkoly, DO (2020)
- Ms. Antara Sira (2020 - 21)
- Ms. Jordan Roberts (2020 - 21)
- Ms. May Nguyen (2020 - 21)
- Ms. Jayda Hylton-Pelaia (2021)
- Mr. Michael Li (2021)
- Mr. Shrey Rathore (2021)
- Ms. Holly Gildar (2022 - 23)
- Mr. Dirghau Patel (2022 - 23)
- Ms. Selin Bakkaloglu (2022 - 23)
- Ms. Sophia Macko (2022 - 23)
- Ms. Samantha Rhodes (2022 - 23)
- Mr. Revanth Wubhayavedantapuram (2023)
- Mr. Shreevadsaa Mohanakrishnan (2023)
- Ms. Solenne Norvor-Davis (2023 - Present)
- Mr. Farhan Babur (2023 - Present)
- Mr. Shubham Pallod (2023 - Present)
- Ms. Carina Sandu (2024 - Present)
Study Sections
- Wound Healing Foundation 3M Fellowship 2023 Cohort
- NIH MOSAIC K99 Study Section (November 16-17, 2022)
- NIH ACTS Study Section (June 22-23, 2021)
Conferences
- Wound Healing Society 2024 Meeting
- Abstract Reviewer
- Session Moderator, "Wound Inflammation"
- Arizona Imaging & Microanalysis Society, 2021 Meeting
- Board member planner
- Image Analysis Workshop Instructor
- International Symposium on SERPINs & Proteases in Health & Disease, 2021 Virtual
- Co-organizer
Public Engagement
- Smiles on Seniors of Arizona, Invited Speaker (2020)
- Intel International Science & Engineering Fair, Grand Awards Judge (2019)
- Arizona Science Center, Science With a Twist Invited Speaker (2017)
- Phoenix Fanfest, Bioscience Panelist (2016)
- Tavan Elementary School, Career Fair Judge (2014)
- Phoenix ComiCon, Bioscience Panelist (2014, 2016, 2017)
- Arizona Science and Engineering Fair, Arizona Regionals Judge (2014)
- FIRST Robotics Competition, Arizona Regionals Judge (2014)
- Regenesis Biomedical, Inc.