Jennifer Barrila

A full list of publications can be found at: https://scholar.google.com/citations?user=1OTTAdAAAAAJ

PEER-REVIEWED PUBLICATIONS

1. Sullivan DT, MacIntyre R, Fuda N, Fiori J, Barrila J*, Ramizel L. Analysis of glycolytic enzyme co-localization in Drosophila flight muscle. (2003) The Journal of Experimental Biology.  206: 2031-2038. * Misspelled as “Barrilla” in print
2. Bacha U*, Barrila J*, Velazquez-Campoy A, Leavitt SA, Freire E. (2004) Identification of Novel Inhibitors of the SARS Associated Coronavirus Main Protease 3CLpro. Biochemistry. 43:4906-4912. * Co-first author
3. Nadella M, Bianchet MA, Gabelli SB, Barrila J, Amzel LM. (2005) Structure and Activity of the axon guidance protein MICAL. Proceedings of the National Academy of Sciences. 102(46): 16830-16835.
4. Sydnes MO, Hayashi Y, Sharma VK, Hamada T., Bacha U., Barrila J, Freire E, Kiso Y. (2006) Synthesis of Glutamic Acid and Glutamine Peptides Possessing a Trifluoromethyl Ketone Group as SARS-CoV 3CL Protease Inhibitors. Tetrahedron. 62: 8601 – 8609.
5. Barrila J, Bacha U, Freire E. (2006) Long-Range Cooperative Interactions Modulate Dimerization in SARS 3CLpro.  Biochemistry. 45(50): 14908 – 14916.
6. Bacha U, Barrila J, Gabelli SB, Kiso Y, Amzel LM, Freire E. (2008) Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro. Chemical Biology and Drug Design. 72: 34-49.
7. Wilson JW, Ott CM, Quick L, Davis R, Höner zu Bentrup K, Crabbé A, Richter E, Sarker S, Barrila J, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Shah M, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, CdeBaca A, Narayan S, Benjamin J, Goulart C, Rupert M, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Porter MD, Pierson DL, Smith SM, Mergeay M, Leys N, Stefanyshyn-Piper HM, Gorie D, and Nickerson CA. (2008) Media ion composition controls regulatory and virulence response of Salmonella in spaceflight. PLoS ONE. 3(12):e3923. Epub 2008 Dec 12.
8. Barrila J, Gabelli SB, Bacha U, Amzel LM, Freire E. (2010) Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CLpro. Biochemistry. 49(20): 4308-17
9. Sarker S, Ott CM, Barrila J, and Nickerson CA. (2010) Discovery of Spaceflight-related virulence mechanisms in Salmonella and other microbial pathogens:  Novel approaches to commercial vaccine development. Gravitational and Space Biology 23(2): 75-78.
10. Barrila J*, Radtke AL*, Crabbé A, Sarker SF, Herbst-Kravoletz MM, Ott, CM, Nickerson CA. (2010) Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions. Nature Reviews Microbiology.  8: 791-801. * Co-first author; Received the cover image of Nature Reviews Microbiology
11. Nickerson, CA, Ott, CM, Castro, SL, Garcia, VM, Molina, TC, Briggler, JT, Pitt, AL, Tavano, JJ, Byram, JK; Barrila, J, Nickerson, MA. (2011) Evaluation of Microorganisms Cultured from Injured and Repressed Tissue Regeneration Sites in Endangered Giant Aquatic Ozark Hellbender Salamanders. PLoS ONE. 6(12): e28906.
12. Crabbé A, Nielsen-Preiss SM, Woolley CM, Barrila J, Buchanan K, McCracken J, Searles, SC, Ott CM, Gonzalez MN, Wilson JW, Pierson D, Stefanyshyn-Piper HM, Hyman L, Nickerson CA. (2013) Spaceflight enhances cell aggregation and random budding in Candida albicans. PLoS ONE. 8(12): e80677.
13. Crabbé A, Liu Y, Sarker SF, Bonenfant NR, Barrila J, Borg ZD, Lee JJ, Weiss DJ, Nickerson CA. (2015) Recellularization of Decellularized Lung Scaffolds Is Enhanced by Dynamic Suspension Culture. PLoS ONE. 10(5): e0126846.
14. Yang J*, Barrila J*, Roland KL, Kilbourne J, Ott CM, Forsyth R, Nickerson CA. (2015) Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella strain D23580 in a Murine Model of Infection. PLoS Neglected Tropical Diseases. 9(6): e0003839. *Co-first author
15. Yang J*, Barrila J*, Roland KL, Ott CM, and Nickerson CA. (2016) Physiological Fluid Shear Alters the Virulence Potential of Invasive Non-typhoidal Salmonella Typhimurium D23580. npj Microgravity. 2: 16021. DOI: 10.1038/npjmgrav.2016.21; * Co-first author
16. Barrila J*, Ott CM*, LeBlanc C, Mehta SK, Crabbé A, Stafford P, Pierson DL, Nickerson CA. (2016) Spaceflight modulates gene expression in the whole blood of astronauts. npj Microgravity. 2, 16039. *Co-first author
17. Barrila J*, Yang J*, Crabbé A, Sarker SF, Liu Y, Ott CM, Nelman-Gonzalez MA, Clemett SJ, Nydam S, Forsyth RJ, Davis RR, Crucian BE, Quiriarte H, Brenneman K, Sams C, Loscher C, Nickerson CA. (2017) Three-dimensional organotypic model of intestinal epithelial cells and macrophages reveals oxygen-dependent Salmonella enterica colonization patterns. npj Microgravity. 3:10. *Co-first author
18. Barrila J, Crabbé A, Yang J, Franco K, Nydam S, Forsyth RJ, Davis R, Ott CM, Gangaraju S, Coyne CB, Bissell MJ, and Nickerson CA. (2018) Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age. Infect Immun. 86(11): e00282-18. (Invited Review)
19. Barrila J, Sarker SF, Hansmeier N, Yang S, Buss K, Briones N, Park J, Davis RR, Forsyth RJ, Ott CM, Sato K, Kosnik C, Yang A, Shimoda C, Rayl N, Ly D, Landenberger A, Wilson SD, Yamazaki N, Steel J, Montano C, Halden RU, Cannon T, Castro-Wallace SL and Nickerson CA. (2021) Evaluating the effect of spaceflight on the host-pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium. npj Microgravity 7:9.
20. Yang J, Barrila J, Ott CM, King O, Bruce R, McLean RJ, Nickerson CA. (2021) Longitudinal Characterization of Social Interactions of Multispecies Microbial Populations Recovered from Spaceflight Potable Water. npj Biofilms and Microbiomes. 7, 70.
21. Nickerson CA, Colorado AA, Barrila J, Poste G, Ott CM. (2021) A Vision for the Next Generation of Spaceflight Microbiology: Human Health and Habitat Sustainability. Nature Microbiology. https://doi.org/10.1038/s41564-021-01015-6
22. Barrila J*, Yang J, Franco K, Yang S, Buss K, Davis TJ, Aronow BJ, Bean HD, Davis RR, Forsyth RJ, Ott CM, Gangaraju S, Kang B, Hanratty B, Nydam SD, Nauman EA, Kong W, Steel J, and Nickerson CA*. (2022) Spaceflight analogue culture enhances the host-pathogen interaction between Salmonella and a 3-D biomimetic intestinal co-culture model. *Co-corresponding author. Frontiers in Cellular and Infection Microbiology. 12: 705647. https://doi.org/10.3389/fcimb.2022.705647
23. Franco K, Crenshaw K, Barrila J, Yang J, Gangaraju S, Davis RR, Forsyth RJ, Ott CM, Roland K, Curtiss III R, and Nickerson CA. (2022) Role of RpoS in regulating stationary phase Salmonella Typhimurium phenotypic responses under physiological low fluid shear conditions. mSphere. https://doi.org/10.1128/msphere.00210-22
24. Yang J, Barrila J, Nauman EA, Nydam SD, Yang S, Park J, Gutierrez-Jensen AD, Castro CL, Ott CM, Buss K, Steel J, Zakrajsek AD, Schuff MM, and Nickerson CA. (2023) Incremental increases in physiological fluid shear progressively alter pathogenic phenotypes and gene expression in multidrug resistant Salmonella. (2024) Gut Microbes. 16 (1): 2357767. https://doi.org/10.1080/19490976.2024.2357767

25. Nickerson CA, McLean RC, Barrila J, Yang J, Thornhill SJ, Banken LL, and Ott CM. Microbiology of Human Spaceflight: Implications for Microbial Responses to Mechanical Forces in Space and on Earth. (2024) Microbiology and Molecular Biology Reviews. Invited Review. In Press.

BOOK CHAPTERS

1. Ott CM, Crabbé A, Wilson JW, Barrila J, Castro S, and Nickerson CA.  (2012) Microbial Stress:  Spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew, in Stress Challenges and Immunity in Space, Ed. Alexander Chouker. Springer, 2012. 482 pp.
2. Barrila J, Wilson JW, Soni A, Yang J, Ott CM, Nickerson CA.  (2016) Using spaceflight and spaceflight analogue culture for novel mechanistic insight into Salmonella pathogenesis, in Effect of Spaceflight and Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms.  Eds. Nickerson, Ott, Pellis. Springer.
3. Crabbé A, Barrila J, Ott CM, Nickerson CA. (2016) Outpacing Infectious Disease:  Mimicking the Host-Pathogen Microenvironment, in Effect of Spaceflight and Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms.  Eds. Nickerson, Ott, Pellis. Springer.
4. Castro SL, Niesel DW, Barrila J, and Ott CM.  (2016) Spaceflight and spaceflight analogue induced responses in Gram positive bacteria, in Effect of Spaceflight and Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms.  Ed. C. A. Nickerson, C. M. Ott, N. Pellis. Springer.
5. Yang J, Thornhill SG, Barrila J, Nickerson CA, Ott CM, and McLean JC. (2018) Microbiology of the Built Environment in Spacecraft Used for Human Flight, in Microbiology of Atypical Environments. Ed. Gurtler and Trevors. Elsevier.
6. Ott CM, Crabbé A, Wilson JW, Barrila J, Castro S, and Nickerson CA. (2020) Microbial Stress:  Spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew, in Stress Challenges and Immunity in Space, 2nd edition. Ed. Alexander Chouker. Springer.
7. National Academies of Sciences, Engineering, and Medicine (Barrila J, as a member of Biological Sciences panel) (2023) Thriving in Space: Ensuring the Future of Biological and Physical Sciences Research: A Decadal Survey for 2023-2032. Washington, DC: The National Academies Press. https://doi.org/10.17226/26750.