Aditya Pandharinath SARNAIK

Aditya Pandharinath SARNAIK

Associate Research Professional,
SSEBE AzCATI
  • asarnaik@asu.edu
  • 7418 Innovation Way S #103 Arizona State University Polytechnic Campus AzCATI, Interdisciplinary Science and Technology Buildi MESA, AZ 85212
  • Mail code: 4380
    Campus: Poly
  • ‌
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Long Bio

Aditya Pandharinath Sarnaik is an Associate Research Professional in the School for Sustainable Engineering and Built Environment (SSEBE) at Arizona State University (Polytechnic campus). He works at Arizona Centre for Algal Technology and Innovation (AzCATI). He is a Biotechnology graduate and a trained biochemical engineer, with specific expertise in bacterial (photosynthetic and non-photosynthetic) metabolic and protein engineering. He has experience with upstream as well as downstream processing/ process optimization of (engineered and wild-type) cyanobacteria at pilot scale. 

Education
  1. Research Scientist, Indian Institute of Technology Bombay (IITB), IN (2021-2023)
  2. Post-doc, Arizona State University, Tempe, AZ, USA (2019-2021)
  3. Ph.D., Institute of Chemical Technology, Mumbai, IN (2013-2019)
  4. M.Sc. Biotechnology, Ramanarain Ruia College, University of Mumbai, IN (2008-2010)
  5. B.Sc. Biotechnology, Ramnarain Ruia College, University of Mumbai, IN (2005-2008)
Research Website URL
https://www.researchgate.net/profile/Aditya-Sarnaik
Google Scholar URL
https://scholar.google.co.in/citations?user=o2a9neEAAAAJ&hl=en
Research Interests

Protein and bacterial metabolic engineering, Reactive extraction, Outdoor scale-up cultivation and downstream processing of microalgae/ cyanobacteria

Research Group

Arizona Centre for Algal Technology and Innovation (AzCATI)

Publications
  1. Swati Madhu, Annesha Sengupta, Sarnaik AP, Pramod P. Wangikar; Expanding the synthetic biology repertoire of a fast-growing cyanobacterium Synechococcus elongatus PCC 11801, Biotechnology and Bioengineering; May 2024:1-7. DOI: 10.1002/bit.28740
  2. Nima Hajinajaf, Alireza Fallahi, Everett Eustance, Sarnaik AP, Anis Askari, Mahsa Najafi, Ryan W. Davis, Bruce E. Rittmann, Arul M. Varman; Managing carbon dioxide mass transfer in photobioreactors for enhancing microalgal biomass productivity, Algal Research. 80 (2024) 103506, April 2024. https://doi.org/10.1016/j.algal.2024.103506
  3. Faisal M, Sarnaik AP*, Kannoju N, Hajinajaf N, Asad MJ, Davis RW, Varman AM; RuBisCO activity assays: a simplified biochemical redox approach for in vitro quantification and an RNA sensor approach for in vivo monitoring, Microbial Cell Factories, Mar 2024; 23:83.
  4. Jain VS, Schubert MG, Sarnaik AP, Pritam P, Jaiswal D, Church George M and Wangikar PP; De novo genome assembly and pan-genome analysis of the fast-growing Indian isolates of Synechococcus elongatus: Potential chassis for bioproduction, The Microbe. Feb 2024; 2: 100048.
  5. Kaustubh Sawant, Sarnaik AP*, Singh R, Baier T, Kruse O, Jutur PP, Reena Pandit; Outdoor cultivation and metabolomics exploration of Chlamydomonas engineered for bisabolene production, Bioresource Technology. Feb 2024; 398: 130513.
  6. Pritam P, Sarnaik AP, Wangikar PP. Metabolic engineering of Synechococcus elongatus for photoautotrophic production of mannitol, June 2023. Biotechnology and Bioengineering, 1– 8. https://doi.org/10.1002/bit.28479
  7. Madhu S, Sengupta A, Sarnaik AP, Sahasrabuddhe D, Wangikar PP. Global transcriptome guided identification of neutral sites for engineering Synechococcus elongatus PCC 11801, ACS Synthetic Biology, May 2023. Vol 12-6, 1677-1685. https://doi.org/10.1021/acssynbio.3c00019
  8. Sawant KR, Sarnaik AP*, Savvashe P, Hajinajaf N, Poole P, Varman AM, Pandit RA. One cell-two wells bio-refinery: Demonstrating cyanobacterial chassis for co-production of heterologous and natural hydrocarbons. Bioresource Technology. 2022; 363:127921.
  9. Sawant KR, Savvashe P, Pal D, Sarnaik AP, Pandit R, Lali A. Progressive transitional studies of engineered Synechococcus from laboratory to outdoor pilot-scale cultivation for production of ethylene. Bioresource Technology, 341, 125852, 2021. https://doi.org/10.1016/j.biortech.2021.125852
  10. Book chapters: Sarnaik AP*, Sawant K, Khadilkar J, Pillai G, Pandit R, Lali A. Cyanobacterial Cell Factories for Improved Carotenoid Biosynthesis through a Synthetic Biology Approach, ACS, Next Generation Bio-manufacturing Technologies, 23-39, 2019.
  11. Sarnaik AP*, Abernathy MH, Han X, Ouyang Y, Xia K, Chen Y, Cress B, Zhang F, Lali A, Pandit R, Linhardt R, Tang Y, Koffas M. Metabolic engineering of cyanobacteria for photoautotrophic production of heparosan, a pharmaceutical precursor of heparin. Algal Res. 2019;37 (November 2018):57-63. doi:10.1016/j.algal.2018.11.010.
  12. Sarnaik AP*, Nambissan V, Pandit R, Lali A. Recombinant Synechococcus elongatus PCC7942 for improved zeaxanthin production under natural light conditions. Algal Res. 2018:36 (December 2018): 139-151. doi:10.1016/j.algal.2018.10.021
  13. Sarnaik AP*, Pandit R, Lali A. Growth engineering of Synechococcus elongatus PCC 7942 for mixotrophy under natural light conditions for improved feedstock production. Biotechnol Prog. 2017;33(5):1182-1192. doi:10.1002/btpr.2490
  14. Sarnaik AP*, Shinde S, Mhatre A, Jansen A, Jha AK, McKeown H, Davis R, Mozhy AM. Unravelling the hidden power of esterases for bio-manufacturing of short-chain esters. Nature-Scientific Reports,13, 10766, June 2023. https://doi.org/10.1038/s41598-023-37542-x
  15. Mhatre AM, Kalscheur B, Mckeown H, Bhakta K, Sarnaik AP, Flores A, Nielsen DR, Wang X, Soundappan T, Varman AM. Consolidated bioprocessing of hemicellulose to value-added chemicals through and engineered B. subtilis-E. coli consortium, Renewable Energy, 193, 288-298, 2022. https://doi.org/10.1016/j.renene.2022.04.124
  16. Book chapter: Manali Das, Sarnaik AP, Pradipta Patra, Arul M. Varman and Amit Ghosh; Biofuel production from renewable feedstocks: worldwide scenario and progress through metabolic engineering; Current developments in Biotechnology and Bioengineering. 417-448, 2022.
  17. Flores AD, Holland SC, Mhatre AM, Sarnaik AP, Godar A, Onyeabor M, Varman AM, Wang X, Nielsen DR, A coculture-coproduction system designed for enhanced carbon conservation through inter-strain CO2 recycling, Metabolic Engineering, 67, 387-395, 2021. DOI: 10.1016/j.ymben.2021.08.001
  18. Sarnaik AP*, Mhatre A, Faisal M, Varman AM. Novel perspective on a conventional technique: Impact of ultra-low temperature on bacterial viability and protein extraction, PLoSOne, May 2021, doi.org/10.1371/journal.pone.0251640.
  19. Sarnaik AP*, Liu A, Nielsen D, Varman AM. High-throughput screening for efficient microbial biotechnology, Current Opinion in Biotechnology, 64, 141-150, 2020. DOI: 10.1016/j.copbio.2020.02.019
Research Activity

Downstream process optimization at pilot scales

Professional Associations

Chair, Mentorship Program, Students and Postdoc Association (SPA), Engineering Biology Research Consortium (EBRC)

Graduate Faculties / Mentoring History

Mentored >15 graduate, undergraduate and PhD students; and two high-school students

Expertise Areas
Bioenergy
Biotechnology
Chemical Engineering
Molecular Biology
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