Zhongxue Chen

Professor,

College of Health Solutions

425 N. 5th Street, #137 Phoenix, AZ 85004
Mail code: 9020

Campus: Dtphx
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Long Bio

Zhongxue Chen is a professor of biostatistics in the College of Health Solutions at ASU. Chen was trained in statistics and has extensive experiences and expertise in biostatistics, statistical genetics, and bioinformatics. He has taught many biostatistics courses and advised more than 30 graduate (master- and doctor-level) students. He has authored/coauthored many peer-reviewed journal articles, including results/findings from statistical methodology research and statistical real data applications.

Education

PhD. Statistics, Southern Methodist University.

Curriculum Vitae

Google Scholar URL

https://scholar.google.com/citations?user=3vyp3dQAAAAJ&hl=en

ORCID Profile ID

https://orcid.org/0000-0003-2537-7843

Research Interests

Dr. Chen's research interests include developing new theory and method in biostatistics, statistical genetics, bioinformatics, survival analysis, statistical hypothesis testing, meta-analysis, and machine learning. He is also interested in collaborative research through applying the state-of-the-art statistical methods to real data analysis.

Publications

Selected Recent Publications

Z. Wang, L. Phillips, T. Rohan, G. Ho, A. Shadyab, A. Bidulescu, C. Rudick, K. Pan, Z. Chen, J. Luo (2023) “Diabetes, metformin use, and risk of non-Hodgkin’s lymphoma in postmenopausal women: a prospective cohort analysis in the women’s health initiative”. International Journal of Cancer, 152 (8), 1556-1569.
Z. Chen (2022) “Robust tests for combining p-values under arbitrary dependency structures”. Scientific Reports, 12, Article number: 3158.
Z. Chen (2022) “Optimal tests for combining p-values”. Applied Sciences,12(1), 322.
C. Lyu, M. Huang, N. Liu, Z. Chen, P. Lupo, B. Tycko, J. Witte, C. Hobbs, M. Li (2022) “Random field modeling of multi-trait multi-locus association for detecting methylation quantitative trait loci”. Bioinformatics, 38(16), 3853-3862.
M. Huibregtse, S. Sweeney, M. Stephens, H. Cheng, Z. Chen, H. Block, S. Newman, K. Kawata (2022) “Association between serum NfL and GFAP levels and head impact burden in women’s collegiate water polo”. Journal of Neurotrauma, 40(11-12), 1130-1143.
R. Li, Z. Chen (2022)“Validation and comparison of two dietary indexes for predicting nonalcoholic fatty liver disease among US adults”. The Journal of Nutrition, 152 (12), 2865-2876.
Z. Wang, J. Luo, Y. Zhang, P. Xun, Z. Chen“Metformin and thyroid carcinoma incidence and prognosis: a systematic review and meta-analysis”. Plos One 17, no. 7 (2022): e0271038.
Z. Wang, R. Arthur, A. Shadyab, N. Saquib, K. Johnson, L. Snetselaar, L. Mu, Z. Chen, J. Luo (2022) “Association of tea-drinking habits with the risk of non-hodgkin’s lymphoma -- a prospective cohort study among US postmenopausal women”. British Journal of Nutrition,129(9), 1543-1551.
Z. Chen, Y. Zang (2021) “A robust statistical test for genetic association accounting for covariates”. Genes, 12(11), 1723.
C. Lyu, M. Huang, N. Liu, Z. Chen, P. Lupo, B. Tycko, J. Witte, C. Hobbs, M. Li (2021) “Detecting methylation quantitative trait loci using a methylation random field method”. Briefings in Bioinformatics, 22 (6), bbab323.
Z. Wang, A. Shadyab, R. Arthur, N. Saquib, L. Snetselaar, K. Johnson, L. Mu, Z. Chen, J. Luo (2021) “No association observed between coffee intake and risk of non-Hodgkin's lymphoma among postmenopausal women”. Journal of the Academy of Nutrition and Dietetics, 122 (9), 1725-1736.
S. Coon, Z. Bevilacqua , M. Ferris, Z. Chen, K. Kawata (2021) “Caution in clinical interpretation of near point of convergence: influence of time of day on ocular-motor function”. Athletic Training and Sports Health Care, 13(1):7-10.
M. Nowak, Z. Bevilacqua, K. Ejima, M. Huibregtse, Z. Chen, T. Mickleborough, S. Newman, K. Kawata (2020) "Neuro-ophthalmologic response to repetitive subconcussive head impacts: a randomized controlled trial". JAMA Ophthalmology, 138(4): 350-357.
K. Kawata, J. Steinfeldt, M. Huibregtse, M. K Nowak, J. Macy, K. Kercher, D. Rettke, A. Shin, Z. Chen, K. Ejima, S. Newman, H. Cheng (2020) “Association between proteomic blood biomarkers and DTI/NODDI metrics in adolescent football players: A pilot study”. Frontiers in Neurology, 11: 581781.
M. Huibregtse, K. Ejima, Z. Chen, R. Kalbfell, A. Koppineni, K. Kawata (2020) “Acute time-course changes in CCL11, CCL2, and IL-10 levels after controlled subconcussive head impacts: a pilot randomized clinical trial”. The Journal of Head Trauma Rehabilitation, 35(5): 308-316.
J. Arnaez, A. Krendl, B. McCormick, Z. Chen, A. Chomistek (2020) “The association of depression stigma with barriers to seeking mental health care: a cross-sectional analysis”. Journal of Mental Health, 29(2):182-190.
A. Holmes, Z. Chen, L. Yahng, D. Fletcher, K. Kawata (2020) "Return to learn: academic effects of concussion in high school and college student-athletes". Frontiers in Pediatrics, 8: 57.
Z. Chen, K. Wang (2019) “Gene-based sequential burden association test”. Statistics in Medicine, 38 (13), 2353-2363.
Z. Chen, Q. Liu, K. Wang (2019) “A novel gene-set association test based on variance-gamma distribution”. Statistical Methods in Medical Research, 28(9) 2868–2875.
Z. Chen, Q. Liu, K. Wang (2019) “A genetic association test through combining two independent tests”. Genomics, 111(5) 1152-1159.
K. Hu, S. Wang, Z. Wang, L. Li, Z. Huang, W. Yu, Z. Chen, Q. Wu (2019) "Clinicopathologic risk factors for gastric cancer: a retrospective cohort study in China", BMJ Open, 9(9): e030639.
Z. Bevilacqua, M. Kerby, D. Fletcher, Z. Chen, R. Merritt, M. Huibregste, K. Kawata (2019) "Preliminary evidence-based recommendations for return to learn: a novel pilot study tracking concussion recovery in college students". Concussion, 4(2), CNC63.
A. Wirsching, Z. Chen, Z. Bevilacqua, M. Huibregtse, K. Kawata (2019) “Association of acute increase in plasma neurofilament light with repetitive subconcussive head impacts: a pilot randomized control trial”. Journal of Neurotrauma, 36(4), 548-553.
Z. Chen, Y. Lu, T. Lin, Q. Liu, K. Wang (2018) “Gene-based genetic association test with adaptive optimal weights”. Genetic Epidemiology, 42:95–103.
E. Kwon, D. Seo, H. Lin, Z. Chen (2018) “Predictors of youth e-cigarette use susceptibility in a U.S. nationally representative sample”. Addictive Behaviors, 82: 79-85.
S. Chittiboyina, Z. Chen, E. Chiorean, L. Kamendulis, B. Hocevar (2018) “The role of the folate pathway in pancreatic cancer risk”. Plos One, 13(2): e0193298.
Z. Chen, T. Lin, and K. Wang (2017) “A powerful variant-set association test based on chi-square distribution”. Genetics, 207(3), 903-910.
Z. Chen, and K. Wang (2017) “A gene-based test for association through an orthogonal decomposition of genotype scores”. Human Genetics, 136(10), 1385-1394.
Z. Chen, S. Han, and K. Wang (2017) “Genetic association test based on principal component analysis”. Statistical Applications in Genetics and Molecular Biology, 16(3), 189-198.
Z. Chen (2017) “Testing for gene-gene interaction in case-control GWAS”. Statistics and Its Interface, 10(2) 267–277.
Z. Chen, HKT Ng, J. Li, Q. Liu, and H. Huang (2017) “Detecting associated SNPs on the X chromosome in case control genome-wide association studies”. Statistical Methods in Medical Research, 26(2), 567-582.
Z. Chen, H. Huang, P. Qiu (2017) “An improved two-stage procedure to compare two or more hazard curves”. Journal of Statistical Computation and Simulation, 87(9), 1877-1886.
Z. Chen (2017) “A nonparametric approach to detecting the difference of survival medians”. Communications in Statistics - Simulation and Computation, 46(1), 395-403.
T. Lin, T. Liu, Y. Lin, C. Zhang, L. Yan, Z. Chen, Z. He, J. Wang (2017) “Serum levels of chemical elements in esophageal squamous cell carcinoma in Anyang, China—a case-control study based on machine learning methods”. BMJ Open, 7(9):e015443.
T. Lin, T. Liu, Y. Lin, L. Yan, Z. Chen, J. Wang (2017) “Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods”. Journal of Trace Elements in Medicine and Biology, 43, 202-208.
Z. Chen, G. Zhang (2016) “Comparing survival curves based on medians”. BMC Medical Research Methodology, 16:33
Z. Chen, H. Huang, HKT Ng (2016) “Testing for association in case-control genome-wide association studies with shared controls”. Statistical Methods in Medical Research, 25(2), 954-967.
Z. Chen, H. Huang, P. Qiu (2016) “Comparison of multiple hazard rate functions”. Biometrics, 72(1), 39-45.

Courses

2025 Spring

Course Number	Course Title
BST 605	Biostatistics Data Analysis

2024 Fall

Course Number	Course Title
BST 604	Computational Biostatistics

2024 Spring

Course Number	Course Title
HCD 501	Biostatistics &Data Management

Editorships

Editorial Board Member, BMC Genomics
Academic Editor, Plos One
Editorial Board Member, Scientific Reports
Editorial Board Member, Current Bioinformatics
Guest Editor, Genes
Editor-in-Chief, European Journal of Statistics

Professional Associations

Delta Omega Honorary Society in Public Health, elected member
American Statistical Association, lifetime member
International Chinese Statistical Association, lifetime member
International Biometric Society, Eastern North American Region, member

Expertise Areas