Ashley Keiser
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Mail code: 7601Campus: Tempe
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Ashley Keiser is an Assistant Professor at the Biodesign ASU-Banner Neurodegenerative Disease Research Center and School of Life Sciences. Her research examines molecular and epigenetic mechanisms that mediate learning and memory in the adult, aging and Alzheimer’s female and male brain. She hopes that her work will provide insight into treatments for disorders impacting memory, many of which afflict women at a higher rate compared to men.
Postdoctoral Training. University of California, Irvine, Irvine, CA
Ph.D. University of Michigan, Ann Arbor, MI
B.S. Northern Michigan University, Marquette, MI
LaTour S, Shaikh H, Beardwood JH, Augustynski AS, Wood MA, Keiser AA (2024) The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits. Neurobiology of Learning and Memory.
Keiser AA, Dong T, Kramár EA, Butler CW, Chen S, Matheos DP, Beardwood J, Augustynski AS, Al-Shammari A, Alaghband Y, Alizo Vera V, Berchtold NC, Shanur S, Baldi P, Cotman CW, Wood MA (2024) Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory. Nature Communications.
Perez-Sisques L, Bhatt S, Matuleviciute R, Gileadi T, Kramár EA, Graham A, Garcia F, Keiser AA, Matheos DP, Cain J, Pittman A, Andreae L, Fernandes C, Wood MA, Giese K, Basson M (2024) The intellectual disability risk gene kdm5b regulates long term memory consolidation in the hippocampus. Journal of Neuroscience.
Dong T, Kramár EA, Beardwood J, Al-Shammari A, Wood MA, Keiser AA (2022) Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice. Neurobiology of Learning & Memory, 194.
Alexander DC, Corman T, Mendoza M, Glass A, Belity T, Wu R, Campbell RR, Han J, Keiser AA, Winkler J, Wood MA, Kim T, Garcia BA, Cohen H, Mews P, Egervari G, Berger SL (2022) Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Proceedings of the National Academy of Sciences.
Campbell R, Chen S, Beardwood J, Lopez A, Pham L, Keiser AA, Childs J, Matheos D, Swarup V, Baldi, P, Wood MA (2021) Cocaine induces paradigm-specific changes to the transcriptome within the Ventral Tegmental Area. Neuropsychopharmacology.
Keiser AA, Kramár EA, Dong T, Shanur S, Pirodan M, Ru N, Acharya MA, Baulch JE, Limoli CL, Wood MA (2021) Systemic HDAC3 inhibition ameliorates impairments in synaptic plasticity caused by simulated galactic cosmic radiation exposure in male mice. Neurobiology of Learning & Memory, 178.
Butler CW, Keiser AA, Kwapis JL, Berchtold NC, Wall VL, Wood MA, Cotman CW (2019) Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity. Learning & Memory, 26(12):485-492.
Tronson NC, Keiser AA (2019) A dynamic memory systems framework for sex differences in learning and memory. Trends in neuroscience, 42(10):680-692.
Keiser AA, Wood MA (2019) Examining the contribution of histone modification to sex differences in learning and memory. Learning & Memory, 26(9):318-331.
Kwapis JL, Alaghband Y, Keiser AA, Dong TN, Michael CM, Rhee D, Shu G, Dang RT, Matheos DP, Wood MA (2020) Aging mice show impaired memory updating in novel OUL updating paradigm. Neuropsychopharmacology, 45, 337-346.
Keiser AA, Turnbull LM, Darian MA, Feldman DE, Song I, Tronson NC (2017) Sex differences in context fear generalization and recruitment of hippocampus and amygdala during retrieval. Neuropsychopharmacology, 42(2):397-407.
Keiser AA, Tronson NC (2015) Molecular mechanisms of memory in males and females. In R.M. Shansky (Ed.) Sex differences in the central nervous system (1st ed., pp. 27–51). Boston: Elsevier Academic Press.
Keiser AA, Matazel K, Esser M, Feifel D, and Prus AJ (2014) Systemic administration of the neurotensin NTS1-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown norway rats. Experimental Clinical Psychopharmacology.
Hillhouse TM, Shankland Z, Matazel KS, Keiser AA, Prus AJ (2014) The quetiapine active metabolite N-Desalkylquetiapine and the Neurotensin NTS1 Receptor Agonist PD149163 exhibit antidepressant-like effects on operant responding in male rats. Experimental Clinical Psychopharmacology.