Qiang Chen

Professor,

School of Life Sciences

Other ASU affiliations

Biodesign Center for Bioelectronics and Biosensors

BDA 330D TEMPE, AZ 85287-5401
Mail code: 5801

Campus: Tempe
‌

Long Bio

Qiang “Shawn” Chen is a molecular biologist who specializes in developing novel human therapeutics and vaccines in plants to combat infectious diseases, cancer, and biological warfare agents. His research aims to ameliorate diseases and improve human health, as well as to contribute new knowledge to the basic understanding of how gene expression and protein modification are regulated in plants.

Professor Chen and his team use rational design strategies to develop biologics that possess superior efficacy and safety. Flavivirus therapeutics and vaccine development and the modulation of antibody-dependent enhancement (ADE) of viral infections are part of their research focus. His team has developed monoclonal antibody (MAb) variants in plants that have shown promise in improving brain targeting, eliminating ADE, and enhancing efficacy against West Nile, Dengue and Chikungunya virus compared to their parent MAbs. The disease targets also include SARS-CoV-2, Zika virus, Ebola virus and colorectal cancer.

In addition, Professor Chen has expertise in QA/QC and biochemistry research under FDA’s cGMP regulations, drawn from his more than a decade of experience in the biotechnology and pharmaceutical industry directing research in both plant and mammalian cell culture systems. He is interested in mentoring students and scientists in these areas of translational research for conducting human clinical trials. He is a professor at School of Life Sciences. He is also a professor at the Biodesign Center for Bioelectronics and Biosensors.

Education

PhD

Video

Google Scholar URL

https://scholar.google.com/citations?user=UJVBYAIAAAAJ&hl=en&authuser=1

Publications

Melendez J, Sun H, Bonner J, Chen Q*, Characterization of a Plant-Derived Monoclonal Antibody Targeting Extracellular Enveloped Virions of Monkeypox Virus. Front. Plant Sci (2024).
Kallolimath S, Sun L,..., Chen Q,...,Steinkellner H, IgG1 versus IgG3: Influence of antibody-specificity and allotypic variance on virus neutralization efficacy. Front. Immunol (2024).
Sun H, Yang M, Lai H, Neupane B, Teh A, Jugler C, Ma J, Steinkellner H, Bai F, Chen Q*, A Dual-Approach Strategy to Optimize the Safety and Efficacy of Anti-Zika Virus Monoclonal Antibody Therapeutics. Viruses (2023).
Esqueda A, Sun H, Bonner J, Lai H, Jugler C, Kibler K, Steinkellner H, Chen Q*, A monoclonal antibody produced in glycoengineered plants potently neutralizes monkeypox virus. Vaccines (2023).
Kallolimath S, Palt R, Foderl-Hobenreich E, Chen Q*, Pruckner F, Eidenberger L, Strasser R, Steinkellner H, Glyco-engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues. Front. Immunol (2023).
Yang M, Sun H, Lai H, Neupane B, Bai F, Steinkellner H, Chen Q*, Plant-Produced Anti-Zika Virus Monoclonal Antibody Glycovariant Exhibits Abrogated Antibody-Dependent Enhancement of Infection. Vaccines (2023).
Sun H, Acharya D, Paul A, Lai H, He J, Bai F, Chen Q*, Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine againstWest Nile Virus. Vaccines. (2023).
Sun H, Jugler C, Nguyen K, Steinkellner H, Chen Q*, The potency and synergy of plant-made monoclonal antibodies against the BA.5 variant of SARS-CoV-2. Plant Biotech J. (2023)
Kallolimath S, Palt R...Chen Q,..Herta Steinkellner, Glycoengineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues. Plant Biotech J. (2023)
Jugler C, Sun H, Nguyen K, Palt R, Felder M, Steinkellner H, Chen Q* A novel plant-made monoclonal antibody enhances the synergetic potency of an antibody cocktail against the SARS-CoV-2 Omicron variant. Plant Biotech J (2023)
Jugler C, Sun H, Grill F, Kibler K, Esqueda A, Lai H, Li Y, Lake D, Chen Q*, Potential for a Plant-Made SARS-CoV-2 Neutralizing Monoclonal Antibody as a Synergetic Cocktail Component. Vaccines (2022)
Jugler C, Grill F, Eidenberger L, Karr T, Steinkellner H, Lake D, Chen Q*, Humanization and Expression of IgG and IgM Antibodies in Plants as Potential Diagnostic Reagents for Valley Fever. Front. Plant Sci (2022)
Grill F, Jugler C, Kaleta E, Chen Q,..Lake D, Clinical laboratory utility of a humanized antibody in commercially available enzyme immunoassays for coccidioidomycosis. Microbiol. Spectr. (2022)
Esqueda A, Chen Q*, Producing Biologics with Defined N-Glycosylation in Plants. Chemokine-Glycosaminoglycan Interactions (2022)
Sun H, Lesio J, Chen Q*, Development of Antibody-Based Therapeutics Against West Nile Virus in Plants. West Nile Virus (2022)
Kallolimath S, Sun L,..Chen Q, Steinkellner H Highly active engineered IgG3 antibodies against SARS-CoV-2. PNAS (2021)
Jugler C, Sun H, Chen Q* SARS-CoV-2 Spike protein-induced interleukin 6 signaling is blocked by a plant-produced anti-interleukin 6 receptor monoclonal antibody. Vaccines (2021)
Chen Q* Development of plant-made monoclonal antibodies against viral infections. Current Opinion in Virology (2021)
Zhang P, Zhang* F, Lei F, Roorda R, Duan B, Hari S, Chen Q*, Esqueda A, Lai H, Jugler C and Sun H Enhancing Sensitivity of Lateral Flow Assays By Immobilization of Affinity Molecules in Hydrogel Polymer Embedded Test Lines. ECS (2021)
Esqueda A, Jugler C, Chen Q* Design and expression of a bispecific antibody against dengue and chikungunya virus in plants. Methods in Enzymology (2021)
He J, Lai H, Esqueda A, Chen Q* Plant-Produced Antigen Displaying Virus-Like Particles Evokes Potent Antibody Responses against West Nile Virus in Mice. Vaccines (2020)
Diamos A, Pardhe M, Sun H, .., Chen Q, Mason H A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant. Front. Immunol (2020)
Esqueda A, Chen Q* Development and Expression of Subunit Vaccines Against Viruses in Plants. Viruses as Therapeutics (2020)
Jugler C, Joensuu J, Chen Q* Hydrophobin-Protein A Fusion Protein Produced in Plants Efficiently Purified an Anti-West Nile Virus Monoclonal Antibody from Plant Extracts via Aqueous Two-Phase Separation. IJMS (2020).
Diamos A, Pardhe M, Sun H, Hunter J, Tsafrir M, Chen Q, Mason H Codelivery of improved immune complex and virus-like particle vaccines containing Zika virus envelope domain III synergistically enhances immunogenicity. Vaccine (2020).
Diamos A, Hunter J, Pardhe M, Rosenthal S, Sun H, Chen Q, Mason H High Level Production of Monoclonal Antibodies Using an Optimized Plant Expression System. Front Bioeng. Biotechnol (2019).
Hurtado H, Acharya D, Lai H, Sun H, Kallolimath S, Steinkellner H, Bai F, Chen Q* In vitro and in vivo efficacy of anti‐chikungunya virus monoclonal antibodies produced in wild‐type and glycoengineered N. benthamiana plants. Plant Biotech J. (2019).
Zhang B, Song W, Pang P, Lai H, Chen Q, Zhang P, Lindsay P. The Role of Contacts in Long-Range Protein Conductance. PNAS (2019).
Sun H, Chen Qiang*. Vaccines against West Nile virus. Prospects of Plant-Based Vaccines in Veterinary Medicine (2018).
Lai H, Paul AM, Sun H, He J, Yang M, Bai F, Chen Q*. A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or Dengue virus infectivity. Vaccine (2018).
Chen Q*, Dent M, Mason H. Plant-made vaccines. Molecular Pharming: Applications, Challenges and Emerging Areas (2018)
Chen Qiang. Recombinant Therapeutic Molecules Produced in Plants. Advances in Botanical Research (2018)
Sun H, Chen Q*, Lai H. Development of Antibody Therapeutics against Flaviviruses. IJMS (2017).
Yang M, Lai H, Sun H, Chen Qiang. Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice. Scientific Reports (2017).
Yang M, Sun H, Lai H, Hurtado J, Chen Qiang. Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice. Plant Biotech J. (2017).
Yang M, Dent M, Lai H, Sun H, Chen Qiang. Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus. Vaccine (2017).
Chen Q. Glycoengineering of plants yields glycoproteins with polysialylation and other defined N-glycoforms. PNAS (2016) (doi: 10.1073/pnas.1610803113).
Dent M, Hurtado J, Paul AM, Sun H, Lai H, Yang M, Esqueda, A, Bai F, Steinkellner H, Chen Q *. Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity. J. Gen Virology 2016; doi:10.1099/jgv.0.000635
Chen Q and Davis KR. The potential of plants as a system for the development and production of human biologics. F1000Rsearch 2016, 5: 912 (doi:10.12688/f1000research.8010.1)
J. Pwowell, Qiang Chen, H. Mason. A cytometry microparticle platform approach for screening tobacco microRNA changes after Agrobacterium delivery. J. Micro. Met. (2016).
Qiang Chen, M. Dent, J. Hurtado, J. Stahnke, A. McNulty, K. Leuzinger, H. Lai. Transient protein expression by agroinfiltration in lettuce. Recombinant Proteins from Plants. Springer (2016).
A Fulton, H. Lai; Qiang Chen, C. Zhang. Purification of Monoclonal Antibody against Ebola GP1 Protein Expressed in Nicotiana benthamiana. Journal of Chromatography A (2015).
Qiang Chen. Plant-made vaccines against West Nile virus are potent, safe, and economically feasible. Biotechnology Journal (2015).
Qiang Chen * and Huafang Lai. Gene Delivery into Plant Cells for Recombinant Protein Production. BioMed Research International (2015).
Chen Q. Lai H.. The growing potential of plant-made monoclonal antibodies. Drug Target Review (2015) .
Chen Q *, Santi L and Zhang C. Plant-Made Biologics. BioMed Research International (2014).
He J, Lai H, M Engle, S gorlatov, C Gruber, H Steinkellner, M Diamond, Chen Qiang*. Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus. PLOS ONE (2014).
He J, Peng L, Lai H, Hurtado J, Stahnke J, Chen Q. A plant-produced antigen elicits potent immune responses against West Nile virus in mice. Biomed Res Int (2014).
Lai H, He J, Hurtado J, Stahnke J, Fuchs A, Mehlhop E, Gorlatov S, Loos A, Diamond M, Chen Qiang*. Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants. Plant Biotech J (2014).
Qiang Chen* and Huafang Lai. Plant-derived Monoclonal Antibodies as Human Biologics for Infectious Disease and Cancer: Principles and Applications for Developing Countries (2014).
K Leuzinger, M Dent, J Hurtado, J Stahnke, H Lai, X Zhou, Qiang Chen*. Efficient Agroinfiltration of Plants for High-level Transient Expression of Recombinant Proteins. Journal of visualized experiments: JoVE (2013).
Qiang Chen*, H Lai, J Hurtado, J Stahnke, K Leuzinger, M Dent. Agroinfiltration as an Effective and Scalable Strategy of Gene Delivery for Production of Pharmaceutical Proteins. ATBM (2013).
Qiang Chen. Virus-like Particle Vaccines for Norovirus Gastroenteritis. Molecular Vaccines: From Prophylaxis to Therapy (2013).
Chen Qiang * and Lai H. Plant-derived Virus-like Particles as Vaccines. Human Vaccines (2012).
He J†, Lai H† (†co-first authors), Brock C, Chen Qiang*. A novel system for rapid and cost-effective production of detection and diagnostic reagents of West Nile virus in plants. J Biomed Biotechnol (2012).
Lai H, Chen Qiang *. Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations. Plant Cell Reports (2012).
Chen, Qiang. Turning a new leaf. European BioPharmaceutical Review (2011).
Lai H, He J, Engle M, Diamond M, Chen Qiang*. Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce. Plant Biotech J (2011).
Phoolcharoen W, Bhoo S, Lai H. Ma J, Arntzen C, Chen Qiang*, Mason H. Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotech J (2011).
Phoolcharoen W, Dye J, Kilbourne J, Pratt W, Arntzen C, Chen Qiang, . Mason H, et al. A non-replicating subunit vaccine protects mice against lethal Ebola virus challenge. PNAS (2011).
Qiang Chen. Expression and manufacture of pharmaceutical proteins in genetically engineered horticultural plants. Transgenic Horticultural Crops: Challenges, and Opportunities --Essays by Experts (2011).
Chen Qiang, He J, Phoolcharoen W, Mason H. Geminiviral Vectors Based on Bean Yellow Dwarf Virus for Production of Vaccine Antigens and Monoclonal Antibodies in Plants. Human Vaccines (2010).
Huang Z, Phoolcharoen W, Lai H, Zeitlin L, Whaley K, Arntzen C, Mason H, and Qiang Chen*. High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotech. and Bioeng (2010).
Kralovetz M. Mason H. and Chen Qiang. Norwalk Virus-like Particles as Vaccines. Expert Review of Vaccines (2010).
Lai H, Engle M, Fuchs A, Keller T, Johnson S, Gorlatov S, Diamond M, Chen Q*. A monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice. PNAS (2010).
S. Slater, B. Goonder, .... Q. Chen, .... D. Wood. Genome Sequences of Three Agrobacterium Biovars Help Elucidate the Evolution of Multichromosome Genomes in Bacteria. Agrobacterium tumefaciens C58. J. Bact (2009).
Zhong Huang, Qiang Chen, Brooke Hjelm, Charles Arntzen, Hugh Mason. A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnology and Bioengineering (2009).
Chen Qiang, Tacket C, Mason H, Mor T, Cardineau G, Arntzen C. Subunit Vaccines Produced Using Plant Biotechnology. New Generation Vaccines (2009).
Chen Q, Morris G , Lai H. cGMP processing of a plant-produced human vaccine candidate for sexually transmitted infections. ASABE (2009).
C Lico, Qiang Chen, L Santi. Viral Vectors for Production of Recombinant Proteins in Plants. Journal of Cellular Physiology (2008).
L Santi, L Batchelor, C Arntzen, Qiang Chen, H Mason. An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine (2008).
Qiang Chen. Expression and Purification of Pharmaceutical Proteins in Plants. Biological Engineering (2008).
C Arntzen, H Mason, Qiang Chen. Designing and delivering plant-based vaccines for the developing world. Plant Pathology (Petria) (2007).
Chen, Qiang. Translational Research to Bridge Bench Discovery and Clinical Products for Plant Made Pharmaceuticals. (2006).
S Buswell, Qiang Chen, K Van Cott, C Zhang. Expression of porcine prorelaxin in transgenic tobacco. Ann. N.Y. Acad. Sci (2005).
Qiang Chen, S Malhotra, N McMaster, BWS Sobral. Proteome Analysis of the Microsymbiont Sinorhizobium meliloti and Host Plant Medicago truncatula Provides a Global Perspective of the Nodulation Process. CSHM Genome Informatics (2003).
E. Vierling, Qiang Chen. Characterization and Expresssion of Chloroplast Heat-Shock Proteins in Pea and Petunia. J. Cell Biochem.
E. Vierling, L. Harris, Qiang Chen. The Major Low Molecular Weight Heat Shock Protein in Chloroplasts Shows Antigenic Conservation Among Diverse Higher Plant Species. Mol. and Cell Biol.
Qiang Chen, K. Osteryoung, Elizabeth Vierling. Molecular and Functional-Analysis of a Chloroplast-localized Heat-Shock Protein. Photosynthesis Research.
Qiang Chen, C. Silflow. Isolation and Characterization of Glutamine Synthetase Genes in Chlamydomonas reinhardtii. Plant Physiol.
Qiang Chen, Elizabeth Verling. Analysis of Conserved Domains Identifies a Unique Structural Feature of a Chloroplast Heat Shock Protein. Mol. Gen. Genetics.
Qiang Chen, K. Osteryong, E. Vierling. A 21 kDa Chloroplast heat Shock Protein Assembles into High Molecular Weight Complex In Vivo and In Organelle. J. Biol. Chem.
Qiang Chen, L. Lauzon, A. DeRocher, E. Vierling. Accumulation, Stability and Localization of a Major Chloroplast Heat Shock Protein. J. Cell Biol.

Patents and Patent Applications:

Q. Chen, H. Lai. Production of a Monoclonal Antibody Therapeutic against West Nile Virus in Plants.
U.S. Patent 8663950.
Qiang Chen, H. Lai, J. He MAb Therapeutics against West Nile Virus with Improved CNS Penetration.
U. S. Patent 9499608
Q. Chen, H. Lai, J. Hurtado. Plant-derived antibodies and derivatives that reduce risk of antibody-dependent. enhancement (ADE) of infection. U. S. Patent 10982221
Z. Huang, Q. Chen, C. Arntzen, H. Mason. A DNA Replication System for High-level Rapid Production of Vaccines and Monoclonal Antibody Therapeutics in Plants. U. S. Patent 8513397
Q. Chen, M. Yang, H. Lai, H. Sun. Vaccines against Zika virus based on Zika structure proteins. U. S. Patent 11078491
Q. Chen, M. Yang, H. Lai. Reducing the toxicity of Agrobacterium endotoxin. U. S. Patent 11130956. International Patent PCT/US2018/035422
Z. Huang, Q. Chen, C. Arntzen, H. Mason. DNA Replicon System for High-level Rapid Production of Vaccines and Monoclonal Antibody Therapeutics in Plants. U. S. Patent 9506079
Q. Chen, J. Hurtardo, H. Lai, H. Sun. Plant-produced mAbs against chikungunya virus with enhanced effector function and efficacy. US Patent application #62/857,081, #17/615,803, PCT International Patent Application No. PCT/US2020/036136.
Q. Chen, M. Yang, H. Sun, H. Lai. Plant produced anti-EGFR mAbs with specific glycosylation to improve the efficacy against cancer. US Patent Application #63/188,360
Q. Chen, M. Felder. Monoclonal antibody for SARS-CoV-2 Spike protein. US Patent application #63/116,561
Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. COVID-19 Inflammatory Cytokine Storm Treatment. PCT International Application # PCT/US21/26386
Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Humanized Antibody for SARS-CoV-2 Spike Protein Infusion. PCT International Application #63/173,763
Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Treating and Curing COVID-19 Infection Utilizing a Laser. PCT International Application # PCT/US21/28368
Q. Chen. Plant-Produced VLPs and RIC Vaccines against COVID-19. US Patent Application #63/168,135.
Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Antibody Assay for SARS-CoV-2. US Patent Application # 63/178,354
Q. Chen, B. Hogue, B. Jacobs. Produced VLPs and RIC Vaccines. US Patent Application #63/168,135
B. Hogue, B. Jacobs, Q. Chen. Optimal Production of SARS-COV-2 Virus-Like Particles (VLPs) produced in Mammalian Cells. US Patent Application #63/168,148
B. Jacobs, Q. Chen. Highly Attenuated Replication-Competent Recombinant Poxviruses as a Vaccine Platform for Expressing S Protein/VLP/IC and Methods of Their Use to Elicit Protective Immune Response. US Patent Application #63/168,140.
Q. Chen, H. Sun, M. Felder. Antibody Conjugated nanoparticle assay and treatment for SARS-CoV-2. US Patent Application #63/190,398
Q. Chen, M. Felder. Extracorporeal treatment for aging. US Patent Application #63/193,880
Q. Chen, M. Felder. Method for the rapic identification of COVID-19 infection. US Patent Application #63/049,441
Q. Chen, M. Felder. Treating Alzheimer's Disease Utilizing a Laser. US Patent Application #63/231,929
Q. Chen, M. Felder. Treating Alzheimer's Disease Utilizing Extracorporeal Radiofrequency. US Patent Application #63/231,986
Q. Chen, H. Sun, C. Jugler, H. Lai. A method of production of self-replicating, nucleic acid loaded, virus-like particles (VLP-NA) and the uses thereof. US Patent Application #63/274,148
Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Treating and Curing COVID-19 Infection Utilizing a Laser. US Non-Provisional Patent application #17/920,680
Q. Chen, M. Felder. Monoclonal antibody for SARS-CoV-2 Spike protein. US Non-Provisional Patent application #17/528,891
Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. COVID-19 Inflammatory Cytokine Storm Treatment. US Non-Provisional Patent application #17/917,592
Q. Chen, M. Felder. Humanized Antibody for SARS-CoV-2 Spike Protein Infusion. US Non-Provisional Patent application #17/717,703
Q. Chen, H. Sun, C. Jugler, A. Esqueda, M. Felder. Antibody Assay for SARS-CoV-2. US Non-Provisional Patent application # 17/726,109
Q. Chen, H. Sun, C. M. Felder. Antibody Conjugated nanoparticle assay and treatment for SARS-CoV-2. US Non-Provisional Patent application # 17/747,322
Q. Chen, M. Felder. Extracorporeal treatment for aging. US Non-Provisional Patent Application #17/825,132
Q. Chen, M. Yang, H. Sun, H. Lai. Plant produced anti-EGFR mAbs with specific glycosylation to improve the efficacy against cancer. PCT International Application # PCT/US22/29130
Q. Chen, M. Felder. Treating Alzheimer's Disease Utilizing a Laser. US Non-Provisional Patent Application #17/883,801
Q. Chen, M. Felder. Treating Alzheimer's Disease Utilizing Extracorporeal Radiofrequency. US Non-Provisional Patent Application #17/883,821
Q. Chen, H. Sun, C. Jugler, H. Lai. A method of production of self-replicating, nucleic acid loaded, PLANT virus-like particles (PLANT VLP-NA) and the uses thereof. US Patent Application #63/381,807
Q. Chen, H. Sun, C. Jugler, H. Lai. A method of production of self-replicating, nucleic acid loaded, virus-like particles (VLP-NA) and the uses thereof. PCT International Application # PCT/US22/79031

Research Activity

Chen,Qiang*. Nanoparticle-based therapeutics against viral pathogens. GreenBio (5/1/2022 - 4/30/2026).
Chen,Qiang*. A novel vaccine platform that eliminates the side effect of antibody-dependent enhancement of infection Women and Philanthropy (7/1/2022 - 6/30/2023).
Chen,Qiang*. Extracorporeal treatment of COVID-19. Halberd (9/15/2020 - 12/31/2023).
Chen,Qiang*. COVID-19 diagnostics development. UST (4/10/2020 - 12/31/2021).
Chen,Qiang*. Plant-produced monoclonal antibody-therapeutics against cancer. GreenBio (5/10/2019 - 12/31/2022).
Chen,Qiang*. Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2014 - 5/31/2017).
Zhang, Peiming* and Chen, Qiang*. Biochemical construction of a tripod antibody to target glycoproteins of Ebola virus for immunotherapy. Multicenter Research BDI (7/1/2015-6/30/2016).
Chen, Qiang* and Zhang Peiming*. Trackable molecular Trojan horse as a platform for delivery of monoclonal antibody-based biologics into the brain to treat CNS diseases. Multi-Center Research Initiatives BDI (8/1/2014-7/31/2015).
Chen,Qiang*. Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2012 - 5/31/2014).
Chen,Qiang*. Alternative Delivery of Human Milk Proteins to Infants. GATES (BILL & MELINDA) FDN (11/1/2011 - 10/31/2013).
Arntzen,Charles, Chen,Qiang, Mason,Hugh S. SBC: Commercialization of Norovirus Vaccine Technology in an Arizona Spin-off Company. SFAz (7/1/2008 - 12/31/2009).
Chen,Qiang*. Plant-derived MAb therapeutics for West Nile Virus. HHS-NIH-NIAID (8/1/2007 - 7/31/2012).
Chen,Qiang*. Targeted Homologous Recombination in Meiotic Plant Cells. USDA (5/15/2007 - 8/31/2008).
Chen,Qiang*. Protein Production in Tobacco from an Amplified Inducible System. DOD 8/1/2006 - 1/31/2007).
Arntzen,Charles*, Chen,Qiang, Mason,Hugh S. Plant-Derived Vaccines Against Hepatitis C Cooperative Research Center. HHS-NIH-NIAID(8/1/2005 - 7/31/2012).
Arntzen,Charles*, Chen,Qiang, Mason,Hugh S. Development of a Vaccine for Ebola Virus in Plant System. HHS-NIH-NIAID(3/15/2005 - 2/28/2011).
Arntzen,Charles*, Chen,Qiang, Leket-Mor,Tsafrir Shlomo, Mason,Hugh S. Plant-Made Microbicides and Mucosal Vaccines for STIs. HHS-NIH-NIAID(9/1/2004 - 8/31/2011).

Courses

2025 Spring

Course Number	Course Title
BIO 493	Honors Thesis
BCH 392	Intro to Research Techniques
BCH 492	Honors Directed Study
BCH 493	Honors Thesis
BIO 492	Honors Directed Study
CHM 392	Intro to Research Techniques
CHM 492	Honors Directed Study
CHM 493	Honors Thesis
MBB 492	Honors Directed Study
MBB 493	Honors Thesis
MIC 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 495	Undergraduate Research
BDE 799	Dissertation
BDE 792	Research
CHM 392	Intro to Research Techniques
BCH 392	Intro to Research Techniques
BDE 795	Continuing Registration
MIC 492	Honors Directed Study
BDE 799	Dissertation
BCH 392	Intro to Research Techniques

2024 Fall

Course Number	Course Title
BCH 392	Intro to Research Techniques
BCH 492	Honors Directed Study
BCH 493	Honors Thesis
BIO 492	Honors Directed Study
BIO 493	Honors Thesis
CHM 392	Intro to Research Techniques
CHM 492	Honors Directed Study
MBB 492	Honors Directed Study
MIC 492	Honors Directed Study
MIC 495	Undergraduate Research
BIO 494	Special Topics
BIO 495	Undergraduate Research
MBB 495	Undergraduate Research
CHM 493	Honors Thesis
BCH 392	Intro to Research Techniques
BIO 353	Cell Biology
MCB 598	Special Topics
CHM 392	Intro to Research Techniques
MBB 493	Honors Thesis

2024 Summer

Course Number	Course Title
BDE 792	Research

2024 Spring

Course Number	Course Title
BIO 493	Honors Thesis
MBB 492	Honors Directed Study
MBB 493	Honors Thesis
MIC 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 495	Undergraduate Research
BDE 799	Dissertation
BDE 792	Research
MCB 598	Special Topics
BDE 795	Continuing Registration
BDE 799	Dissertation

2023 Fall

Course Number	Course Title
BIO 492	Honors Directed Study
BIO 493	Honors Thesis
MBB 492	Honors Directed Study
MIC 492	Honors Directed Study
MIC 495	Undergraduate Research
BIO 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 353	Cell Biology
MCB 598	Special Topics

2023 Summer

Course Number	Course Title
BDE 792	Research

2023 Spring

Course Number	Course Title
BIO 492	Honors Directed Study
BIO 493	Honors Thesis
MBB 493	Honors Thesis
MIC 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 495	Undergraduate Research
BDE 799	Dissertation
BDE 792	Research
MCB 598	Special Topics
BDE 795	Continuing Registration
BDE 799	Dissertation

2022 Fall

Course Number	Course Title
BIO 492	Honors Directed Study
MBB 492	Honors Directed Study
MIC 492	Honors Directed Study
MIC 495	Undergraduate Research
BIO 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 353	Cell Biology
MCB 598	Special Topics

2022 Summer

Course Number	Course Title
BDE 792	Research

2022 Spring

Course Number	Course Title
BIO 493	Honors Thesis
MBB 493	Honors Thesis
MIC 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 495	Undergraduate Research
BDE 799	Dissertation
BDE 792	Research
BDE 792	Research
MCB 598	Special Topics
BDE 795	Continuing Registration
BDE 799	Dissertation

2021 Fall

Course Number	Course Title
BIO 492	Honors Directed Study
MBB 492	Honors Directed Study
MBB 493	Honors Thesis
MIC 492	Honors Directed Study
MIC 495	Undergraduate Research
BIO 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 353	Cell Biology
MCB 598	Special Topics

2021 Summer

Course Number	Course Title
BDE 792	Research

2021 Spring

Course Number	Course Title
BIO 493	Honors Thesis
MBB 493	Honors Thesis
MIC 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 495	Undergraduate Research
BDE 799	Dissertation
BDE 792	Research

2020 Fall

Course Number	Course Title
BIO 492	Honors Directed Study
MBB 492	Honors Directed Study
MBB 493	Honors Thesis
MIC 495	Undergraduate Research
BIO 495	Undergraduate Research
MBB 495	Undergraduate Research

2020 Summer

Course Number	Course Title
BDE 792	Research

2020 Spring

Course Number	Course Title
BIO 493	Honors Thesis
MBB 493	Honors Thesis
MIC 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 495	Undergraduate Research
BDE 799	Dissertation
BDE 792	Research
MCB 598	Special Topics

2019 Fall

Course Number	Course Title
BIO 353	Cell Biology
BIO 492	Honors Directed Study
MBB 492	Honors Directed Study
MBB 493	Honors Thesis
MIC 495	Undergraduate Research
BIO 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 353	Cell Biology
MCB 598	Special Topics
BIO 353	Cell Biology

Editorships

PLOS ONE, Editorial Board Member
Frontiers in Plant Science, Associate Editor
Frontiers in Immunology, Associate Editor
BioTech, Editorial Board Member
International Journal of Molecular Sciences, Editorial Board Member
Heliyon (Elsevier), Editorial Board member
Scientific Advisory Board, Plant-based Vaccines, Antibodies, and Biologics, Member
Scientific Advisory Board, BioStrategies, Member
International advisory board: PhytoMab/Songan University (Korea), Member
Advisory Board, GreenBio Pharmaceutical, Member

Service

National Science Fundation (NSF), Panelist (2010 - Present)
National Institutes of Health (NIH), Panelist (2008 - Present)
Canadian Ministry of agriculture research grant peer reviewer (2006 - Present)
NIH Peer Review: Gene and Drug Delivery, Panelist (2015)
Czech Science Foundation, Grant reviewer (2015, 2022)
Natural Sciences and Engineering Research Council of Canada (NSERC), Grant reviewer (2015)
NIH Peer Review: Cell, computational and Molecular Biology : 2015/10 ZRG1 IMST-J (15), Panelist (2015)
BioMed Research International, Special Issue: Plant-Made Biologics, Lead Editor (2013 - 2014)
IJMS, Special Issue: Protein Engineering, Editor (2014-2015)
Biomedical Sciences Honors advisor, Barrett Honors College (2022-

Board

Scientific Advisory Board, BioStrategies, Member
International advisory board: PhytoMab/Songan University (Korea), Member
Advisory Board, GreenBio Pharmaceutical, Member

Expertise Areas