Jiseon Yang

Assistant Research Professor,

Biodesign Center for Fundamental & Applied Microbiomics

Jiseon.Yang@asu.edu

BIODESIGN BLDG B340A TEMPE, AZ 85287
Mail code: 6101

Campus: Tempe
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Student Information

Graduate Student
Statistics
The College of Lib Arts & Sci

Long Bio

I specialize in the fields of bacteriology and space life science, with extensive research experience in bacterial pathogenesis, molecular genetic engineering, biofilms, space biology, vaccine development, and host-pathogen interaction. To conduct my research, I have utilized a range of human surrogate infection models, such as 3-D tissue culture models, worms, mice, and chickens, with a focus on vaccine development.

My current research interests are focused on understanding microbial interactions in mixed populations and their long-term effects on human health and the environment, both on Earth and in space. Specifically, I aim to explore how the interactions between microbial communities within complex ecosystems can contribute to their pathogenicity, persistence, and species evolution. The ultimate goal of my study is to better understand complex bacterial interactions within heterogeneous populations and their long-term impact on human health and living environments, thus contributing to enhancing the sustainability of life on Earth and in space.

I was awarded an Alfred P. Sloan Postdoctoral Fellowship, jointly funded by NASA, to study microbiome of the International Space Station. I published on genomics, bacterial pathogenesis, vaccine development, 3-D tissue engineering, microbiome, and space microbiology. I am currently participating multiple spaceflight projects and serving as a single PI for a NASA-funded project focused on investigating bacterial interspecies interactions and the long-term changes in Earth or space environment. My approach involves utilizing multi-directional comparison analysis and systemic approaches to advance our understanding of microbial interactions in complex environments. I have been the recipient of several awards and research funding, including the ASM Peggy Cotter Early Career Award and an Outstanding Teaching Award.

Education

Alfred P. Sloan Postdoctoral Fellow 2017-2019
Ph.D. Microbiology, Arizona State University 2015

Google Scholar URL

https://scholar.google.com/citations?user=__yH8X4AAAAJ&hl=en

Publications

Publications (peer-reviewed)

1. Nickerson CA, McLean RJC, Barrila J, Yang J., Thornhill S, Banken L, Porterfield DM, Poste G, Pellis N, and Mark Ott C. Microbiology of Human Spaceflight: Microbial Responses to Mechanical Forces that Impact Health and Habitat Sustainability. Microbio Mol Biol Rev. Aug 19:e0014423. doi: 10.1128/mmbr.00144-23 (2024) (IF 12.9).

2. Yang J.†, Barrila J, Nauman EA, Nydam SD, Yang S, Jin Park, Gutierrez-Jensen AD, Castro CL, Mark Ott C, Buss K, Steel J, Zakrajsek AD, Schuff MM, Nickerson CA†. (May 2024) Incremental increases in physiological fluid shear progressively alter pathogenic phenotypes and gene expression in multidrug resistant Salmonella. Gut Microbes DOI - 10.1080/19490976.2024.2357767 †Corresponding author (IF 12.2)

3. Koroli, S., Buss, K., Blain, J. M., Nakka, G. S., Hong, M., McLean, R. J., Plugge, C. M. and Yang, J. (Jan 17 2024) 'Draft genome sequence of', Microbiol Resour Announc, 13(1), pp. e0034523. doi:10.1128/MRA.00345-23 †Corresponding author

4. Santomartino, R., Averesch, N. J. H., Bhuiyan, M., Cockell, C. S., Colangelo, J., Gumulya, Y., Lehner, B., Lopez-Ayala, I., McMahon, S., Mohanty, A., Santa Maria, S. R., Urbaniak, C., Volger, R., Yang, J. and Zea, L. (Mar 21 2023) 'Toward sustainable space exploration: a roadmap for harnessing the power of microorganisms', Nat Commun, 14(1), pp. 1391. doi:10.1038/s41467-023-37070-2 *Authors alphabetically ordered, equally contributed (IF 17.7)

5. Vélez Justiniano, Y. A., Goeres, D. M., Sandvik, E. L., Kjellerup, B. V., Sysoeva, T. A., Harris, J. S., Warnat, S., McGlennen, M., Foreman, C. M., Yang, J., Li, W., Cassilly, C. D., Lott, K. and HerrNeckar, L. E. (Dec 2023) 'Mitigation and use of biofilms in space for the benefit of human space exploration', Biofilm, 5, pp. 100102. doi:10.1016/j.bioflm.2022.100102 (IF 5.27)

6. Franco Meléndez, K., Crenshaw, K., Barrila, J., Yang, J., Gangaraju, S., Davis, R. R., Forsyth, R. J., Ott, C. M., Kader, R., Curtiss, R., Roland, K. and Nickerson, C. A. (Aug 31 2022) 'Role of RpoS in Regulating Stationary Phase Salmonella Typhimurium Pathogenesis-Related Stress Responses under Physiological Low Fluid Shear Force Conditions', mSphere, 7(4), pp. e0021022. doi:10.1128/msphere.00210-22 (IF 4.17)

7. Barrila, J., Yang, J., Franco Meléndez, K. P., Yang, S., Buss, K., Davis, T. J., Aronow, B. J., Bean, H. D., Davis, R. R., Forsyth, R. J., Ott, C. M., Gangaraju, S., Kang, B. Y., Hanratty, B., Nydam, S. D., Nauman, E. A., Kong, W., Steel, J. and Nickerson, C. A. (May 31 2022) 'Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model', Front Cell Infect Microbiol, 12, pp. 705647. doi:10.3389/fcimb.2022.705647 (IF 6.073)

8. Yang, J., Barrila, J., Mark Ott, C., King, O., Bruce, R., McLean, R. J. C. and Nickerson, C. A. (Sep 06 2021) 'Longitudinal characterization of multispecies microbial populations recovered from spaceflight potable water', NPJ Biofilms Microbiomes, 7(1), pp. 70. doi:10.1038/s41522-021-00240-5 †Corresponding author (IF 8.462)

9. Barrila, J., Crabbé, A., Yang, J., Franco, K., Nydam, S. D., Forsyth, R. J., Davis, R. R., Gangaraju, S., Ott, C. M., Coyne, C. B., Bissell, M. J. and Nickerson, C. A. (Nov 2018) 'Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age', Infect Immun, 86(11). e00282-18 doi:10.1128/IAI.00282-18 (IF 3.256)

10. Barrila, J., Yang, J., Crabbe, A., Sarker, S. F., Liu, Y., Ott, C. M., Nelman-Gonzalez, M. A., Clemett, S. J., Nydam, S. D., Forsyth, R. J., Davis, R. R., Crucian, B. E., Quiriarte, H., Roland, K. L., Brenneman, K., Sams, C., Loscher, C. and Nickerson, C. A. (Feb 28 2017) 'Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns', NPJ Microgravity, 3, pp. 10. doi:10.1038/s41526-017-0011-2 *Co-first author. (IF 5.1)

11. Yang, J., Barrila, J., Roland, K. L., Ott, C. M. and Nickerson, C. A. (Jun 2016) 'Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella Typhimurium D23580', NPJ Microgravity, 2, pp. 16021. doi:10.1038/npjmgrav.2016.21 *Co-first author. (IF 5.1)

12.Yang, J., Barrila, J., Roland, K. L., Kilbourne, J., Ott, C. M., Forsyth, R. J. and Nickerson, C. A. (Jun 2015) 'Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection', PLoS Negl Trop Dis, 9(6), pp. e0003839. el of Infection. PLoS Negl Trop Dis. Jun 2015;9(6):e0003839. doi:10.1371/journal.pntd.0003839 (IF 3.256)

13.Luo, Y. Q., Kong, Q. K., Yang, J., Mitra, A., Golden, G., Wanda, S. Y., Roland, K. L., Jensen, R. V., Ernst, P. B. and Curtiss, R. (Jul 2012) 'Comparative Genome Analysis of the High Pathogenicity Salmonella Typhimurium Strain UK-1', Plos One, 7(7). doi:ARTN e4064510.1371/journal.pone.0040645 (IF 4.41)

14. Juarez-Rodriguez, M. D., Yang, J., Kader, R., Alamuri, P., Curtiss, R. and Clark-Curtiss, J. E. (Feb 2012) 'Live Attenuated Salmonella Vaccines Displaying Regulated Delayed Lysis and Delayed Antigen Synthesis To Confer Protection against Mycobacterium tuberculosis', Infection and Immunity, 80(2), pp. 815-831. doi:10.1128/Iai.05526-11 (IF 3.256)

15.Kong, Q. K., Yang, J. S., Liu, Q., Alamuri, P., Roland, K. L. and Curtiss, R. (Oct 2011) 'Effect of Deletion of Genes Involved in Lipopolysaccharide Core and O-Antigen Synthesis on Virulence and Immunogenicity of Salmonella enterica Serovar Typhimurium', Infection and Immunity, 79(10), pp. 4227-4239. doi:10.1128/Iai.05398-11 (IF 3.256)

16.Luo, Y. Q., Kong, Q. K., Yang, J., Golden, G., Wanda, S. Y., Jensen, R. V., Ernst, P. B. and Curtiss, R. (Aug 2011) 'Complete Genome Sequence of the Universal Killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169)', Journal of Bacteriology, 193(15), pp. 4035-4036. doi:10.1128/Jb.05224-11 (IF 3.825)

17. Ashraf, S., Kong, W., Wang, S. F., Yang, J. S. and Curtiss, R. (May 23 2011) 'Protective cellular responses elicited by vaccination with influenza nucleoprotein delivered by a live recombinant attenuated Salmonella vaccine', Vaccine, 29(23), pp. 3990-4002. doi:10.1016/j.vaccine.2011.03.066 (IF 3.49)

18.Yoo, A.Y., Yu, J. E., Yang, J, Kim, Y. H., Baek, C. H., Oh, J. I., Kang, H. Y. (2008) Regulation of an outer membrane protein, OmpW, expression and its biological function in Salmonella Typhimurium. Kor J Life Sci 18(11): 1606-1611

Book Chapter and Non-peer-revied publications

19.Barrila, J., Wilson, J. W., Soni, A., Yang, J., Ott, C. M. and Nickerson, C. A. (2016) 'Using Spaceflight and Spaceflight Analogue Culture for Novel Mechanistic Insight into Salmonella Pathogenesis', in Cheryl A. Nickerson, Neal R. Pellis and Ott, C.M. (eds.) Effect of spaceflight and spaceflight analogue culture on human and microbial cells : novel insights into disease mechanisms. New York, NY: Springer Science+Business Media, pp. 209-235.

20. Yang, J., Thornhill, S. G., Barrila, J., Nickerson, C. A., Ott, C. M. and McLean, R. J. C. (2018) 'Microbiology of the Built Environment in Spacecraft Used for Human Flight', Microbiology of Atypical Environments, 45, pp. 3-26. doi:10.1016/bs.mim.2018.07.002

21. Mark Ott C, Nickerson CA, Poste G, Curtiss R, Wilson J, McLean R.JC, Pellis N, Niesel D, Buchanan K, Yang J, Blakely E, Shelhamer M, Bohórquez D, Broddrick J, Stafford P, Goldschmidt ME, Kaplan HB, Antonsen E, Nauman E, Oubre C. (2021) A Vision for the Next Generation of Spaceflight Microbiology: Human Health and Habitat Sustainability. Submitted to the Decadal Survey on Biological and Physical Sciences Research in Space 2023-2032 conducted by the National Academies of Science, Engineering and Medicine.

22. Vélez Justiniano, Y. A., Goeres, D. M., Sandvik, E. L., Kjellerup, B. V., Sysoeva, T. A., Harris, J. S., Warnat, S., McGlennen, M., Foreman, C. M., Yang, J., Li, W., Cassilly, C. D., Lott, K. and HerrNeckar, L. E. (2021) Topical: Mitigation and Use of Biofilms in Space for the Benefit of Human Space Exploration. Submitted to the Decadal Survey on Biological and Physical Sciences Research in Space 2023-2032 conducted by the National Academies of Science

23.Santomartino, R., Averesch, N. J. H., Bhuiyan, M., Cockell, C. S., Colangelo, J., Gumulya, Y., Lehner, B., Lopez-Ayala, I., McMahon, S., Mohanty, A., Santa Maria, S. R., Urbaniak, C., Volger, R., Yang, J. (2021) Biologically Facilitated Processes Towards Sustainable Space Exploration. Topical White Paper submitted to the Biological and Physical Sciences in Space Decadal Survey 2023-2032

Academic Press

1. Jiseon Yang. 2015. Characterizing the Molecular Genetic, Phenotypic and Virulence Properties of the Invasive Nontyphoidal Salmonella Strain D23580: An Integrated Approach. Dissertation paper. Arizona State University.

2. Jiseon Yang. 2005. Identification and characterization of outer membrane proteins in Salmonella Typhimurium. Master’s Thesis. Pusan National University. Academic press.

Research Activity

Understanding the evolution of microbial interactions during spaceflight. Jiseon Yang Ph.D. (PI, Arizona State University). NASA (11/01/2019-10/30/2023). $749,999
Spaceflight-Induced Changes in Microbial Virulence and the Impact to the Host Immune Response. Mark Ott, Ph.D. (PI); Cheryl A. Nickerson, Ph.D. (PI, Arizona State University). NASA (12/1/2019 - 11/30/2024). $2,100,000
Polymicrobial biofilm growth and control during spaceflight. Robert McLean Ph.D. (PI); Cheryl A. Nickerson, Ph.D. (Co-PI); Jiseon Yang (Senior Person). NASA (10/1/2016-8/31/25) $1,255,879
Biofilm Inhibition with Germicidal Light Side-Emitted from Nano-enabled Flexible Optical Fibers in Water Systems. Paul Westerhoff, Ph.D., (PI); Cheryl A. Nickerson, Ph.D., (Co-PI); Jennifer Barrila, Ph.D. (Co-PI); Francois Perreault, Ph.D. (Co-PI); Jiseon Yang (Senior Person). NSF, NASA (10/1/2022 - 9/30/2025). $380,000
Developing Predictive Model Systems of Polymicrobial Biofilm Formation and Susceptibility to Chemical Disinfectant: A longitudinal study with implications for spaceflight systems integrity and health risks. Jiseon Yang (sponsor PI), Cheryl Nickerson (internal PI). Sloan (Alfred P.) Foundation. $140,000

Honors / Awards

(Selected)

NASA, Alfred P. Sloan Foundation Award Fellowships ($140,000) 2017
ASM Peggy Cotter Early Career Award, the American Society for Microbiology. March 1, 2019.
Outstanding Teaching Associate of the Year for 2013-2014 at Arizona State University, School of Life Sciences. May 12, 2014.
Fellowship for Graduate Training Award ($2,500) 2014
University Graduate Fellowship (UGF) awards

Expertise Areas